NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells by Jianfen Shen, Shuo Zhang, Shuo Zhang, Yan Song, Yan Song, Leiming Yang, Leiming Yang, Qi Huang, Qi Huang, Pengyu Wang, Pengyu Wang, Youzhi Zhang, Youzhi Zhang

“…Moreover, THSG could induce cell cycle arrest in G2/M stage and reduce ferroptosis-related protein expression (xCT and GPx4). …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…., generating VapB that is prone to cleavage); free VapC during tolerance will arrest bacterial growth and prevent susceptibility to antibiotics. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…However, treatment with the NAT10 inhibitor Remodelin induced only a limited and reversible growth arrest in CRC cells. Further epigenetic and transcriptomic analysis revealed that NAT10 enhances the stability of ERRFI1 mRNA by binding to its coding sequence region in an ac4C-dependent manner. …”
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Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient by Rosalinda Yasato Camargo, Cristina Takami Kanamura, Celso Ubirajara Friguglietti, Célia Regina Nogueira, Sonia Iorcansky, Alfio José Tincani, Ana Karina Bezerra, Ester Brust, Fernanda Christtanini Koyama, Anamaria Aranha Camargo, Fernanda Orpinelli R. Rego, Pedro Alexandre Favoretto Galante, Geraldo Medeiros-Neto, Ileana Gabriela Sanchez Rubio

“…This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. …”
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3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

“…In summary, PNMC exposure impairs the maternal-to-zygotic transition, likely through mitochondrial dysfunction and histone modification, culminating in developmental arrest and apoptosis in mouse preimplantation embryos.…”
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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

“…Restoration of NPRL2 induces DNA damage, apoptosis, and cell-cycle arrest. We investigated NPRL2 antitumor immune responses in aPD1R/KRAS/STK11mt NSCLC in humanized-mice. …”
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Gender differences in efficiency of the telemedicine care of heart failure patients. The results from the TeleEduCare-HF study by Agata Bielecka-Dąbrowa, Dariusz Trzmielak, Agata Sakowicz, Kamil Janikowski, Maciej Banach

“…Men more often survived sudden cardiac arrest (7.8% vs. 1.2%; p = 0.004) and had implantable cardiac devices compared to women (16% vs. 3%; p = 0.001). …”
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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…Here, we show that VPA reduced medulloblastoma (MB) cell viability and led to cell cycle arrest. These effects were accompanied by enhanced H3K9 histone acetylation (H3K9ac) and decreased expression of the <i>MYC</i> oncogene. …”
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Mina53 catalyzes arginine demethylation of p53 to promote tumor growth by Lixiao Zhou, Liyang Yu, Shushu Song, Yong Wang, Qiang Zhu, Meng Li, Yutong Sha, Liang Xu, Xin Shu, Qingqing Liao, Ting Wu, Bing Yang, Siyuan Chai, Bingyi Lin, Liming Wu, Ruhong Zhou, Xiaotao Duan, Chenggang Zhu, Yuanyuan Ruan, Wen Yi

“…Mina53-mediated demethylation reduces p53 stability and oligomerization and alters chromatin modifications at the gene promoter, thereby suppressing p53-mediated transcriptional activation and cell-cycle arrest. Mina53 represses p53-dependent tumor suppression both in mouse xenografts and spontaneous tumor models. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Inhibition of the IL-6 receptor by tocilizumab in these cells led to a reduction in cellular senescence, accompanied by decreased of the cell cycle regulatory proteins P53 and P21 in mRNA and protein levels, while alleviating cell cycle arrest. Additionally, a dual-luciferase reporter assay confirmed that GATA2 binds to the promoter of SERPINE1 (PAI-1), thereby initiating its transcription.ConclusionThe IL-6/GATA2/SERPINE1 pathway mediates cellular senescence after acute kidney injury, and inhibiting IL-6 can alleviate AKI-induced cellular senescence, providing an important basis for exploring new therapeutic strategies.…”
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Does age still matter? An age-group comparison of self-efficacy, initial interest and performance when learning bystander resuscitation in secondary schools

“…Background: CPR training is recommended for secondary school students in many countries to improve bystander resuscitation and survival rates after cardiac arrest. The recommended age for implementing first aid interventions varies between studies. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…CaO2@ZIF8:CUR@PAA NPs can induce cell S cycle arrest and apoptosis to inhibit tumor multiplication and growth. …”
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Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set... by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…After functional enrichment analyses and mapping to the global AOP network, we found that the increased ROS level, cell cycle arrest, and increased apoptosis are key events (KEs) involved in DEHP-mediated MRT, which was validated in TM3 Leydig cell model. …”
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Heart disease in pregnancy and adverse outcomes: an umbrella review by Jiani Zhang, Jiani Zhang, Yuxin Ren, Yuxin Ren, Bingjie Li, Qi Cao, Qi Cao, Xiaodong Wang, Xiaodong Wang, Haiyan Yu, Haiyan Yu

“…Adverse outcomes for mothers were death, cardiac events (cardiac arrest, heart failure, surgery, arrhythmia, anesthesia or sedation, endocarditis, mitral regurgitation, myocardial infarction, NYHA III–IV, restenosis, syncope, and others), pulmonary events (respiratory failure, pulmonary edema, and respiratory support), embolism, cerebrovascular events, postpartum hemorrhage, arterial events, delivery mode, and hospital stay. …”
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Effect of Drying Methods on the Phenolic Profile and Antioxidant Capacity of <i>Pithecellobium dulce</i> (Roxb.) Benth. Aril and Its Inhibitory Properties on Human SW480 Colon Aden... by Ángel Félix Vargas-Madriz, Aarón Kuri-García, Ivan Luzardo-Ocampo, Roberto Augusto Ferriz-Martínez, Teresa García-Gasca, Carlos Saldaña, Haidel Vargas-Madriz, Salvador Horacio Guzmán-Maldonado, Jorge Luis Chávez-Servín

“…The extract led to cell cycle arrest in the G1 phase and an increase in apoptosis-induced cell death. …”
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Thoraco-abdominal normothermic regional perfusion does not restore cerebral blood flow or electrical activity despite collateral supra-aortic blood flow in a porcine model by Matthieu Glorion, MD MSc, Joel Neves Briard, MD MSc, Louise Roquebert, Sabina Pizzi, Ahmed Menaouar, PhD, Mélanie Borie, MSc, Manon Robert, MSc, Dang Khoa Nguyen, MD PhD, Michaël Chassé, MD PhD, Basil Nasir, MD, Pasquale Ferraro, MD, Shant Der Sarkissian, PhD, MBA, Pierre-Emmanuel Noly, MD PhD, Nicolas Noiseux, MD PhD

“…Our objective was to determine if ligation of the supra-aortic vessels during TA-NRP prevents resumption of intracranial blood flow, brain electrical activity and clinical brain function in a porcine model of organ donation after circulatory arrest. Methods: Neuromonitoring was performed in 9 porcine experiments, in which supra-aortic vessels were ligated. …”
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Evaluation of a 90-minute school-based resuscitation course with 340 middle school students – a multicenter intervention study by Josephina Kehlert

“…The findings of this study support the statewide implementation of resuscitation training for middle school students as part of a greater ambition to increase bystander assistance in out-of-hospital cardiac arrest. HintergrundZiel dieser Studie war es, den Lernerfolg eines 90-minütigen Reanimationsunterrichts, der von zuvor speziell ausgebildeten Lehrkräften in Brandenburg unterrichtet wurde, vor einer landesweiten Einführung dieser Kurse explorativ zu evaluieren.MethodenIn fünf öffentlichen Schulen unterrichteten Lehrkräfte, die von professionellen Erste-Hilfe-Ausbildern geschult wurden, 340 Schüler der siebten Klasse (7. …”
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Stage-dependent changes in culture medium osmolality promote porcine oocyte maturation in vitro by Lixiang Liu, Lixiang Liu, Yu Tang, Yu Tang, Jing Shao, Jing Shao, Bingfeng Fan, Bingfeng Fan, Yifeng Yang, Yifeng Yang, Ying Zhang, Ying Zhang, Xiangyuan Zhao, Xiangyuan Zhao, Hailong Xue, Hailong Xue, Huimin Sun, Huimin Sun, Xulin Zhang, Xulin Zhang, Yushi Zhang, Yushi Zhang, Baozeng Xu, Baozeng Xu

“…The reduction of medium osmolarity or the supplementation with organic osmolytes can eliminate this arrest. Therefore, cell volume homeostasis is essential for embryonic development in vitro. …”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Accelerated lung aging and inflammation mutually reinforce each other, creating a detrimental cycle that contributes to disease progression. Growth arrest and DNA damage-inducible (GADD45) family has been reported to involve in multiple biological processes, including inflammation and senescence. …”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…Cell-cycle analysis showed a complete loss of proliferating cells with a simultaneous increase in S-phase arrest beginning at a threshold dose of 30 μM. I-ol also reduced xenograft tumour growth in nude mice. …”
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