Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2 by Bin Ke, Ting Wei, Yuanyuan Huang, Yuxin Gong, Gang Wu, Junfang Liu, Xiaoting Chen, Lin Shi

“…We observed that IL-7 treatment significantly enhanced DDP-induced effects in A549 and A549/DDP cells (DDP-resistant cells), including decreased cell viability and proliferation, as well as increased cell apoptosis and S arrest, indicating that IL-7 treatment resensitized DDP-resistant NSCLC cells to DDP. …”
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Exploitation of Unconventional CD8 T-Cell Responses Induced by Engineered Cytomegaloviruses for the Development of an HIV-1 Vaccine by Joseph Bruton, Tomáš Hanke

“…The RhCMV68-1.SIV-induced responses mediated a post-infection replication arrest of the challenge virus and eventually cleared it from the body. …”
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Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy by Ruizhe Mao, Jian Shi, Xuyi Ma, Haiyan Xu

“…In recent years, peroxisome proliferator-activated receptor-α (PPARα) antagonists have been reported as a targeted therapeutic drug capable of inducing apoptosis and cell cycle arrest in the ccRCC cell line. Autophagy, which can be induced by stress in eukaryotic cells, plays a complex role in the proliferation, survival, and death of tumor cells. …”
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Thromboelastography for rapid diagnosis of heparin-like anticoagulant release during anaphylaxis-induced coagulopathy in systemic mastocytosis: a case report by Rajkumar Rajendram, Abdul Hadi Al-Qahtani, Farrukh Sheikh

“…We report a unique case of a 44-year-old man with undiagnosed systemic mastocytosis who developed peanut-induced anaphylactic shock, resulting in cardiac arrest. Laboratory tests revealed elevated serum tryptase and severe coagulopathy. …”
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Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines by Lizeth Salazar, María José Vallejo López, Marcelo Grijalva, Luis Castillo, Alexander Maldonado

“…Cell viability assays along with gene expression levels in treated MCF-7 cells support a cancer cell population undergoing cell cycle arrest. The selective toxicity of biosynthesized piton/avocado AgNPs on MCF-7 cells might be of value for novel therapeutics.…”
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Characterization of Pregnant Women with Heart Disease at the “Ramón Gonzalez Coro” Gynecologic and Obstetric Teaching Hospital by Yanara Gutierrez Aliaga, Ileana Chio Naranjo, Elena Guerra Chang, Marlén Rodríguez Jorge, Mario Joel Arroyo Díaz, Mayelin Díaz Gutiérrez

“…Complications were registered in 29,9 % of patients, being pulmonary acute edema (6,4 %), cardiac arrest (4,3 %) and arrhythmias (3,5 %), the most common ones. …”
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Fracture evolution in steel fiber reinforced concrete (SFRC) of tunnel under static and dynamic loading based on DEM-FDM coupling model by Yu Chen, Dongfeng Yu, Yixian Wang, Yanlin Zhao, Hang Lin, Jingjing Meng, Haoliang Wu

“…Finally, based on the advantages of DEM analysis at the mesoscopic level, this study analyzed mechanisms of enhancement and crack arrest in SFRC. It shed a light on the perspectives of interface failure process, microcrack propagation, contact force field evolution and energy analysis, offering valuable insights for related mining engineering applications.…”
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Mortal consequences of a cooperative action between Takotsubo syndrome and increased intracranial pressure by Gennaro Alfano, Deasy Ciervo, Teresa Migliore, Antonia Sorbo, Manuela Ariello, Andrea Vitale, Mikko O. Laukkanen, Salvatore Del Gaudio

“…One week later, the patient died because of cardiac arrest. The diagnosis was Takotsubo syndrome enforced by gliomatosis cerebri and COPD. …”
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The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…And apoptosis, cell cycle arrest, and cell motility rates were stronger when anlotinib combined with 5-FU than in the anlotinib or 5-FU alone. …”
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The GRACE Scale in the Prognosis of Patients with Takotsubo Syndrome by Malgorzata Zalewska-Adamiec, Lukasz Kuzma, Slawomir Dobrzycki, Hanna Bachorzewska-Gajewska

“…The in-hospital stay of Takotsubo in the patients with higher GRACE scores was associated with higher incidence of pneumonia (36.7% vs 7.69%, p=0.0004), rhythm abnormalities (17.3% vs 3.85%, p=0.026), and serious complications (cardiogenic shock, pulmonary edema, and sudden cardiac arrest) (30.6% vs 5.77%, p=0.001). The mean observation period was 7.2 years. …”
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…In addition, exposure to a combination of celastrol and tamoxifen inhibited cell proliferation by causing G1 phase cell cycle arrest. Moreover, the distribution of LC3 was monitored by immunofluorescence, and the changes in the LC3II and P62 levels detected by western blot analysis suggested that celastrol in combination with tamoxifen triggered autophagy. …”
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A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes by Gang Ren, Jingwei Feng, Ila Datar, Aaron H. Yeung, Srinivas Vinod Saladi, Yongqing Feng, Ivana de la Serna, Kam C. Yeung

“…Ectopic expression of some of these induced microRNAs increased the expression of senescence markers and induced growth arrest and senescence in primary melanocytes. Taken together, our results suggest that the change in microRNA expression rates may play a vital role in senescence induced by the oncogenic BRaf.…”
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Al2O3/Al hybrid nanolaminates with superior toughness, strength and ductility by Paul Baral, Sahar Jaddi, Hui Wang, Andrey Orekhov, Nicolas Gauquelin, Alireza Bagherpour, Frederik Van Loock, Michaël Coulombier, Audrey Favache, Morgan Rusinowicz, Johan Verbeeck, Stéphane Lucas, Jean-Pierre Raskin, Hosni Idrissi, Thomas Pardoen

“…The combination of constrained alumina layers with ductile behavior, strong “accommodating” interfaces, giant shear deformability of Al layers, and plasticity-controlled crack shielding cooperate to stabilize deformation, dissipate energy and arrest cracks. These performances unlock several options of applications of Al2O3 in which brittleness under contacts prevents benefiting from remarkable functional properties and chemical stability.…”
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AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…KEGG enrichment analysis indicated that the cell cycle and ubiquitination degradation pathways may be involved in the regulation of radiation resistance by AdipoR1.The knockdown of AdipoR1 can attenuate the radiation-induced G2/M phase arrest through cyclin B1.By the ubiquitination IP assay and a rescue experiment, we confirmed that CCNB1IP1 regulated the ubiquitination and degradation of cyclin B1. …”
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Impact of Hyperoxia and Hypocapnia on Neurological Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study by Kin Chio Li, Catherine Wing Yan Tam, Hoi-Ping Shum, Wing Wa Yan

“…In recent decades, there is increasing evidence suggesting that hyperoxia and hypocapnia are associated with poor outcomes in critically ill patients with cardiac arrest or traumatic brain injury. Yet, the impact of hyperoxia and hypocapnia on neurological outcome in patients with subarachnoid hemorrhage (SAH) has not been well studied. …”
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The Rise of Transradial Artery Access for Percutaneous Coronary Intervention in Patients with Acute Coronary Syndromes in Australia by Ryan James Ocsan, Ata Doost, Paul Marley, Ahmad Farshid

“…On multivariate Cox regression analysis, TFA, age ≥ 75, prior PCI, use of bare metal stents, cardiogenic shock, cardiac arrest, and multivessel coronary artery disease were associated with an increased risk of MACE. …”
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Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis by Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar

“…Furthermore, MBZ induced G2/M cell cycle arrest by modulating Cyclin B1, CDC25C, and WEE1. …”
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Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…Cisplatin-induced G2/M arrest of renal tubular cells was also reduced by caspase-1 inhibition. …”
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The knowledge mapping of traditional Chinese medicine for hepatocellular carcinoma: A bibliometric study by Wenya Pei, Boyu Jiao, Zexiong Chen, Jingchun Zeng, Yancheng Fu, Zhanmou Liang, Baoguo Sun, Jingwen Ruan, Shijun Zhang

“…The analysis indicated that traditional Chinese medicine may enhance immunity and regulate the local tumor microenvironment through mechanisms involving DNA damage, cell cycle arrest, and apoptosis by signaling pathways. Discussion: This study provides insights into the trends of traditional Chinese medicine for hepatocellular carcinoma, which may inform clinical practice and identify potential targets for further research. …”
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