Second-generation BRAF inhibitor Encorafenib resistance is regulated by NCOA4-mediated iron trafficking in the drug-resistant malignant melanoma cells by Ceyda Colakoglu Bergel, Isil Ezgi Eryilmaz, Gulsah Cecener, Unal Egeli

“…The viability, apoptosis, and G0/G1 arrest reflected the acquired chemoresistance. Autophagic Beclin and LC3 proteins, and AKT signaling increased in the A375-R. …”
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A Rare Case of Pneumonia Caused by Shewanella putrefaciens by Rajshree Patel, Albin Abraham, Johnson Thomas, Wanqing Zhi, Shadab Ahmed, Janice Verley

“…We present a case of 63-year-old male who was presented to emergency room status after cardiac arrest, fell into sea water face down. On the second day of hospitalization, he was diagnosed to have pneumonia based on the clinical, radiological, and laboratory findings. …”
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Recurrent Multivalvular Staphylococcus Lugdunensis Endocarditis Causing Complete Heart Block after TAVR by Preeti Singhal, Somsupha Kanjanauthai, Wilson Kwan

“…While awaiting surgery, the patient developed cardiac arrest; she was resuscitated and taken to surgery emergently. …”
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Critical Management of Haemodynamically Unstable Acute Pulmonary Embolism in COVID-19 by Eka Adip Pradipta, Vienna Rossimarina, Indira Kemalasari, Siska Suridanda Danny

“…In the isolation ward, he had a cardiac arrest, and bedside echocardiography showed a fresh thrombus had developed in the right atria with signs of acute right ventricular dysfunction. …”
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Pre-surgery Factors to Predict Mortality and Major Complications in Coronary Surgery with no Extracorporeal Circulation by Yanier Coll Muñoz, Francisco Javier Vázquez Roche, Dayan García Cuesta, René M. Cabrera Núñez, Claudio R. Pérez Alfonso, Lázaro de la Cruz Avilés

“…It would be important to know their effectiveness in patients who underwent surgery with no extracorporeal circulation and cardioplegic cardiac arrest. <strong><br />Objective:</strong> To determine risk factors to predict mortality and major complications in revascularized patients with no use of extracorporeal circulation and to analyze the behaviour of two stratification models of preoperative risk in cardiac surgery. …”
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Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring by Ruixue Song, Xiaomin Ling, Mengyuan Peng, Zhanggang Xue, Jing Cang, Fang Fang

“…With the assessment of cell cycle dynamics, we established that these effects were mediated through cell cycle arrest in neural progenitors. Our research has provided insights into the cell cycle-related mechanisms by which maternal sevoflurane exposure can induce neurodevelopmental abnormalities and learning dysfunction and appeals people to consider the neurotoxicity of anesthetics when considering the benefits and risks of nonobstetric surgical procedures.…”
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Association of Training in Basic Life Support with the Evolution of Cardiopulmonary Resuscitation Performed by Firefighters by Marcelo Donizeti Silva, Ricardo Augusto Barbieri, Yan Figueiredo Foresti, Jônatas Augusto Cursiol, Fernando Antônio Viana, Ednei Fernando dos Santos, Karine Pereira Rodrigues, Guilherme da Silva Rodrigues, Juliana da Silva Garcia Nascimento, Maria Celia Barcellos Dalri

“…The study underscores the critical role of professional firefighters in performing and maintaining high-quality external chest compressions, which has the potential to reduce morbidity and mortality in cases of cardiorespiratory arrest.…”
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The Effects of Forodesine in Murine and Human Multiple Myeloma Cells by Liesbeth Bieghs, Jo Caers, Elke De Bruyne, Els Van Valckenborgh, Fiona Higginbotham, Karin Vanderkerken, Eline Menu

“…When investigating the pathways leading to cell cycle arrest and apoptosis, we observed an upregulation of p27, caspase 3, and BIM. …”
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Cardiovascular manifestations in COVID-19 patients by Jyotsna Maddury, Mani Krishna, Achukatla Kumar

“…COVID-19 disease induces multiple cardiovascular manifestations, such as myocarditis, acute myocardial injury, acute myocardial infarction (MI), stress-induced cardiomyopathy, cardiogenic shock, arrhythmias, and, subsequently, heart failure (HF) and cardiac arrest. Increase of troponin suggests a hyperinflammatory state or may be due to acute myocarditis. …”
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Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis by María M. Adeva-Andany, Carlos Fernández-Fernández, David Mouriño-Bayolo, Elvira Castro-Quintela, Alberto Domínguez-Montero

“…Replacement of sodium bicarbonate to patients with sodium bicarbonate loss due to diarrhea or renal proximal tubular acidosis is useful, but there is no definite evidence that sodium bicarbonate administration to patients with acute metabolic acidosis, including diabetic ketoacidosis, lactic acidosis, septic shock, intraoperative metabolic acidosis, or cardiac arrest, is beneficial regarding clinical outcomes or mortality rate. …”
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Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A by Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu

“…Downregulation of cyclin-CDK complexes led to the restoration of CDKN2A, which caused cell cycle arrest in the G1 phase via regulation of the CDKN2A/RB/E2F pathway. …”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…CVD was defined as ischaemic heart disease, ischaemic stroke, and cardiac arrest. Incidence rate and incidence rate ratio (IRR) of CVD were calculated using generalised estimating equation models. …”
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COVID-19 Mortality in a Pediatric Patient with Hemoglobin SC Disease and Alpha-Thalassemia Trait by Joshua E. Motelow, Stacie Kahn, Patrick T. Wilson

“…Despite showing clinical signs of improvement, he became acutely hypoxemic and suffered a cardiac arrest. We believe this to be an unusual case of a pediatric patient with HbSC disease and COVID-19. …”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Effects were attributed to necrotic as well as apoptotic cell death as determined by increased Caspase 3/7 levels, raised numbers of cells with sub-G1-DNA, and induced p expression, indicative for cell cycle arrest. Besides, CT effectively stimulated human peripheral blood leukocytes (huPBL) from healthy volunteers. …”
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Real-World Experience with Cangrelor as Adjuvant to Percutaneous Coronary Intervention: A Single-Centre Observational Study by Troels Thim, Lars Jakobsen, Rebekka Vibjerg Jensen, Nicolaj Støttrup, Ashkan Eftekhari, Erik Lerkevang Grove, Sanne Bøjet Larsen, Jacob Thorsted Sørensen, Steen Carstensen, Sahar Amiri, Karsten Tange Veien, Evald Høj Christiansen, Christian Juhl Terkelsen, Michael Maeng, Steen Dalby Kristensen

“…Among acute procedures, patients were mainly treated for STEMI (n = 723) and the remaining were treated for cardiac arrest and acute heart failure. Use of oral P2Y12 inhibitors prior to percutaneous coronary intervention was rare. …”
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Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in differen... by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Pt NCs possess the ability to impede cell proliferation by inducing DNA damage and arresting the cell cycle in the G1 phase and possess the ability to promote BAX/Bcl-2/Caspase-3/mitochondrial apoptosis. …”
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Gamma knife thalamotomy for essential and Parkinson’s tremor by A. Radžiūnas, O. Laucius, L. Kudrevičius, P. Sėdžius, I. Čelpačenko

“…During the phone call, 16 (72%) of 22 patients reported major improvement in hand tremor or full tremor arrest on the contralateral side of thalamotomy. Meanwhile, 6 (28%) patients did not feel any improvement after the treatment. …”
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Manual Compression versus Suture-Mediated Closure Device Technique for VA-ECMO Decannulation by Clemens Scherer, Christopher Stremmel, Enzo Lüsebrink, Thomas J. Stocker, Konstantin Stark, Carmen Schönegger, Antonia Kellnar, Jan Kleeberger, Maja Hanuna, Tobias Petzold, Sven Peterss, Daniel Braun, Jörg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban

“…We retrospectively analyzed 180 consecutive patients weaned from VA-ECMO after cardiac arrest or cardiogenic shock from January 2012 to June 2020. …”
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Andrographolide suppresses cervical cancer progression by targeting angiogenesis and inducing apoptosis in a CAM-PDX model by Wanwan Zou, Jun Lou, Yun Yi, Yiming Cui, Xiaoyan Chu

“…These results indicate that AND not only disrupts tumor angiogenesis but also induces cell cycle arrest and promotes apoptosis in cervical cancer cells. …”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Here, we showed that morusinol exerted antitumor effects on DLBCL in vitro by inducing apoptosis and cell cycle arrest. Impressively, morusinol treatment exhibited potent tumor growth inhibition in vivo, proving both well-tolerated and safe in mouse models. …”
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