Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer by Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

“…Our findings not only augment the understanding of the genetic architecture underlying NSCLC susceptibility but also provide strategy to advance NSCLC risk stratification.…”
Get full text

A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…At the best of authors’ knowledge, following the paper Ponsiglione et al. (2023) where monovariable systems where dealt with, the proposed methodology is the first attempt to represent and investigate homeostasis from the molecular up to systemic level by exploiting a unified multivariable biomodeling architecture, which makes it a novel approach to understanding homeostatic control from a broader perspective.…”
Get full text

Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…Both also show a profound dynamism in the architectural and decorative choices, manifested very early on (from the first days of the Empire), until very late (shortly before their disuse at the end of Antiquity). …”
Get full text

Most prevalent jobs of young master’s degree graduates by detailed field of study by Marc Frenette, Tomasz Handler

“…For male master’s degree graduates aged 25 to 34 in 2021 (Appendix Table A.1), the academic programs most strongly associated with a specific job include physical therapy/therapist (physiotherapists, 95.8%); structural engineering (civil engineers, 87.3%); occupational therapy/therapist (occupational therapists, 83.9%); advanced legal research/studies, general (lawyers and Quebec notaries, 78.7%); and architecture (architects, 75.2%). From Appendix Table A.2, the female master’s graduates aged 25 to 34 in 2021 most highly concentrated in specific jobs were all from health and related fields: speech-language pathology/pathologist (audiologists and speech-language pathologists, 96.3%), audiology/audiologist (audiologists and speech-language pathologists, 95.2%), physical therapy/therapist (physiotherapists, 94.0%), occupational therapy/therapist (occupational therapists, 91.3%) and pharmacy (pharmacists, 90.5%). …”
Get full text

Molecular insights into the functional role of PbNRT2.4 in potassium homeostasis and nutrient transport in Pyrus ussuriensis by Han Yang, Hao Xu, Yujie Shi, Liyan Chen, Lijuan Zhang, Liping Kan, Yumeng Jin, Xinlan Mei, Yangchun Xu, Nazir Ahmed, Caixia Dong

Get full text

Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…Nevertheless, it requires innovative thinking to imagine alternative provisions that can complement today’s legal architecture but revolutionise our restricted thinking on this topic. …”
Get full text

Citizen science platforms can effectively support early detection of invasive alien species according to species traits by Pablo González‐Moreno, Ana A. Anđelković, Tim Adriaens, Christophe Botella, Jakovos Demetriou, Rita Bastos, Sandro Bertolino, Celia López‐Cañizares, Franz Essl, Živa Fišer, Milka Glavendekić, Marc Herremans, Philip E. Hulme, Viola Jani, Dimitra Katsada, Periklis Kleitou, Nicola La Porta, Katharina Lapin, Marta López‐Darias, Vanessa Lozano, Angeliki F. Martinou, Damiano Oldoni, Esra Per, Stephanie Rorke, Helen E. Roy, Karl‐Manfred Schweinzer, Kristijn Swinnen, Elena Tricarico, Joana R. Vicente, Maarten de Groot, Michael J. O. Pocock

Get full text

Path and Practice of Gap Management in National Parks: A Comparison Between China and the US and Inspirations Therefrom by Yun MA, Siyuan HE

Get full text

Pengembangan Deep Learning untuk Sistem Deteksi Dini Komplikasi Kaki Diabetik Menggunakan Citra Termogram by Medycha Emhandyksa, Indah Soesanti, Rina Susilowati

“…In addition to the deep convolutional neural network architecture model 4, the research contribution obtained from this research is the use of filter size variations of 3x3, 2x2, and 1x1 with a fixed number of convolutional layers and a reduction in the number of hidden layers in the algorithm structure can reduce the number of model parameters while maintaining high detection capability. …”
Get full text

Predicting Insemination Outcome in Holstein Dairy Cattle using Deep Learning by Mohammad Alishahi, Mahdi Ravakhah

“…The LSTM model, with its architecture of three consecutive LSTM layers, was able to demonstrate the best performance across all evaluation metrics on average over the 10 training runs. …”
Get full text

Comparative genomics of Aspergillus nidulans and section Nidulantes by Sebastian Theobald, Tammi Vesth, Jane L. Nybo, Jens C. Frisvad, Inge Kjærbølling, Stephen Mondo, Kurt LaButti, Sajeet Haridas, Robert Riley, Alan A. Kuo, Asaf A. Salamov, Jasmyn Pangilinan, Anna Lipzen, Maxim Koriabine, Mi Yan, Kerrie Barry, Alicia Clum, Ellen K. Lyhne, Elodie Drula, Ad Wiebenga, Astrid Müller, Ronnie J.M. Lubbers, Roland S. Kun, Ana Carolina dos Santos Gomes, Miia R. Mäkelä, Bernard Henrissat, Blake A. Simmons, Jon K. Magnuson, Jakob B. Hoof, Uffe H. Mortensen, Paul S. Dyer, Michelle Momany, Thomas O. Larsen, Igor V Grigoriev, Scott E. Baker, Ronald P. de Vries, Mikael R. Andersen

Get full text

Long-Term Evaluation of GCOM-C/SGLI Reflectance and Water Quality Products: Variability Among JAXA G-Portal and JASMES by Salem Ibrahim Salem, Mitsuhiro Toratani, Hiroto Higa, SeungHyun Son, Eko Siswanto, Joji Ishizaka

Get full text

Diagnostics of lung cancer by fragmentated blood circulating cell-free DNA based on machine learning methods by Ivan O. Meshkov, Alexander P. Koturgin, Pavel V. Ershov, Liubov A. Safonova, Julia A. Remizova, Valentina V. Maksyutina, Ekaterina D. Maralova, Vasilisa A. Astafieva, Alexey A. Ivashechkin, Boris D. Ignatiev, Antonida V. Makhotenko, Ekaterina A. Snigir, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Sergey M. Yudin, Anna S. Makarova, Veronika I. Skvortsova

“…The current method for LC detection has some advantages for future clinical implementation as a decision-making support system due to the performance of the CM requires data exclusively from NGS-analysis of blood plasma cfDNA fragmentation; the accuracy of the CM does not depend on any additional clinical data; the CM is highly interpretable and traceable; CM has appropriate modular architecture.…”
Get full text

La ferme à enclos quadrangulaire du Bois des Olivettes à Roncourt (Moselle) : une catégorie d’établissement romain largement diffusée dans la vallée mosellane by Gaël Brkojewitsch, Brice Chevaux

“…More complex structures, composed of three or more buildings, appear in minimal proportions. The architecture and internal organization of the buildings demonstrate a number of similarities, in terms of: room layout, equipment and activities. …”
Get full text

Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…It can therefore be said that, just as the Archaic and Early and Middle Hellenistic city received and reworked in its architecture and urban planning knowledge, practice and models taken from both Etruscan-Italic and Greek sources, Pompeii also implemented techniques and devices for water collection and conservation that were clearly derived from the mix of knowledge and engineering practices in use in the most important civilisations evidenced between the Archaic and Early Hellenistic periods in the Tyrrhenian area.With regard to water catchment wells, which may have already been in use in the Archaic age, but were certainly widespread and used in the Samnite city at least until the advent of aqueduct dependent water supplies, it is also possible to trace their historical evolution, which follows the urban development of Pompeii over time.Contrary to the oldest forms of water storage, which seem to have a continuity of use and in some cases coexist with the later chambered cisterns, wells seem gradually to have lost their original function, especially those associated with production contexts or located along minor roads. …”
Get full text

Connecting climate science and society: reflections from early and mid-career researchers at the World Climate Research Programme Open Science Conference 2023 by Leandro B. Díaz, Leandro B. Díaz, Leandro B. Díaz, Carla Gulizia, Carla Gulizia, Carla Gulizia, Shipra Jain, Shipra Jain, Gaby S. Langendijk, Hindumathi Palanisamy, Valentina Rabanal, Valentina Rabanal, Candice S. Charlton, Alima Dajuma, Felix K. Donkor, Temitope S. Egbebiyi, Temitope S. Egbebiyi, Ghafi Kondi Akara, Ghafi Kondi Akara, Amna Jrrar, Md Rezwan Siddiqui, Yassine Ait Brahim, Yassine Ait Brahim, Bapentire D. Angnuureng, Anna-Adriana Anschütz, Founi M. Awo, Founi M. Awo, Alejandro Builes-Jaramillo, Alison Cobb, Mohamadou A. Diallo, Mohamadou A. Diallo, Houda Er-Retby, Houda Er-Retby, Houda Er-Retby, Thierry C. Fotso-Nguemo, Benjamin Gwinneth, Masilin Gudoshava, Franck E. Kemgang Ghomsi, Franck E. Kemgang Ghomsi, Franck E. Kemgang Ghomsi, Inés M. Leyba, Inés M. Leyba, Redouane Lguensat, Redouane Lguensat, Roché Mahon, Shailendra K. Mandal, Lucia Mumo, Meshel Muzuva, Meshel Muzuva, Rodric M. Nonki, Juan A. Rivera, Juan A. Rivera, Alcade C. Segnon, Alcade C. Segnon, Laouali I. Tanimoune, Erlich-Honest E. I. Zauisomue, Gilbert Siame

Get full text

Evaluation of Arabic lesson teaching in higher education based on the Kirkpatrick model by Ali Akbar Mollaie, Mohammad Aslam Raiesi

“…Various factors are involved in the formation of the national identity of a nation, for example, in the cultural dimension, important indicators can be mentioned such as rituals and traditions, celebrations and holidays and public culture, traditional values, clothing and dress, architecture of buildings and places, customs, national and native arts. …”
Get full text

Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury by Ali Khadim, Georgios Kiliaris, Ana Ivonne Vazquez-Armendariz, Tara Procida-Kowalski, David Glaser, Marek Bartkuhn, Tanya Malik, Xuran Chu, Alena Moiseenko, Irina Kuznetsova, Negah Ahmadvand, Arun Lingampally, Stefan Hadzic, Ioannis Alexopoulos, Yuexin Chen, Andreas Günther, Jürgen Behr, Jens Neumann, Herbert B. Schiller, Xiaokun Li, Norbert Weissmann, Thomas Braun, Werner Seeger, Malgorzata Wygrecka, Rory E. Morty, Susanne Herold, Elie El Agha

“…Summary: Alveolar regeneration requires the coordinated engagement of epithelial stem cells and mesenchymal niche cells to restore the intricate alveolar architecture of the lung. The current paradigm is that certain aspects of lung organogenesis are mimicked during injury repair in the adult stage. …”
Get full text