Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial by Geneviève Héry-Arnaud, Christophe Burucoa, Marie Kempf, David Boutoille, Yohann Foucher, Philippe Lanotte, Maxime Pichon, Stéphane Corvec, Cécile Le Brun, Helene Pailhories

“…Considering that without an identified pathogen, a 10% mortality rate can ensue, documentation is essential to the optimisation of antibiotic therapy. However, blood culture (the reference test) is limited for several reasons: such as fastidious culture, antibiotic treatment prior to sampling or insufficient sample volume. …”
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Activity of Phosvitin in Hydroxyapatite Acid-Damage Immersion and Antimicrobial Assays by Richard D. Shipman, Sean D. Doering, Jack R. Hemsath, Eun Joo Lee, Jennifer E. Grant

“…Because of published reports describing phosvitin’s affinity for calcium and potential antibiotic activity, this study was undertaken in order to evaluate phosvitin for both antibiotic activity against common microorganisms and the ability to protect hydroxyapatite surfaces from acid damage. …”
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An Optimized Anti-adherence and Anti-biofilm Assay: Case Study of Zinc Oxide Nanoparticles versus MRSA Biofilm by Hefa Mangzira Kemung, Loh Teng-Hern Tan, Kooi Yeong Khaw, Yong Sze Ong, Chim Kei Chan, Darren Yi Sern Low, Siah Ying Tang, Bey-Hing Goh

“…Biofilms form protective layers over bacteria that are associated with a majority of the hospital infections contributing to antibiotic resistance development in susceptible strains. …”
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Antimicrobial resistance profile among bacteria isolated from patients presenting with wounds at Kabale Regional Referral Hospital, South western Uganda by Andrew, Baguma, Benson, Musinguzi, Kagirita, Atek Atwiine, Joel, Bazira

“…Data on profile of clinical significant bacteria and their respective antibiotic drug resistance in Uganda is still limited. …”
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Asymptomatic Periprosthetic Joint Infection of the Hip with High-Virulence Pathogens: Report of Two Cases by Ruben A. Mazzucchelli, Christoph Meier, Yvonne Achermann, Peter Wahl

“…While it remains difficult to recommend postponing treatment in such cases, this option may be an alternative to suppressive antibiotic therapy.…”
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Urinary Tract Infection Diagnosis and Response to Therapy in Long-Term Care: A Prospective Observational Study by Peter Daley, Carla Penney, Susan Wakeham, Glenda Compton, Aaron McKim, Judy O’Keefe, Brendan Barrett, Lindsay Nicolle

“…BACKGROUND: The prevalence of asymptomatic bacteriuria among residents of long-term care (LTC) facilities is high, and is a source of inappropriate antibiotic prescription.…”
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Neglected adult PFAPA syndrome by Aiping Zhang, Ruifeng Zhang, Yiling Jiang, Ling Shi, Meihong Luo

“…Here we present a case of a 69-year-old woman with PFAPA syndrome, initially misdiagnosed as pharyngitis or lymphadenitis and received multiple antibiotic therapy without any clinical benefit. This report emphasizes the importance of early identification of the disease. …”
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Phenotypic and Molecular Characterization of β-Lactamases among Enterobacterial Uropathogens in Southeastern Nigeria by M. C. Ugwu, M. Shariff, C.M. Nnajide, K Beri, U. M. Okezie, I. R. Iroha, C. O. Esimone

“…Little is known about the molecular basis of antibiotic resistance among uropathogens in Southeast Nigeria. …”
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Synthesis, characterization and evaluation biological activity of some 2-mercaptobinzemidazol complexes by Anfal Salam Al-Mahdawi, Noor Sabah Al-Obaidi, Amna Ali Ahmad, Tabarak Ali Jumaa, Zahraa Ali Abas, Haider Salah Mahdi

“…The synthesized complexes were assessed for their biological activity against different four types of bacteria (Staphylococcus aureus, Escherichia coli, spherical bacteria, Staphylococcus epidermidis, and Klebsiella pneumoniae), in addition to a type of Fungus, Candida albicans, the comparison include the activity of the complexes in relation to the antibiotic penicillin and the activity of 2-mercaptobenzomidazole, the prepared complexes had the highest biological activity compared to ligand and the antibiotic penicillin, the best prepared complex was the cadmium complex, the diameter of inhibition ranged between (27–36 nm) against bacteria and (40 nm) against the fungus, the complexes can be suggested as a more activity antibiotic than ligand and penicillin.…”
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A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation. by Kyle Rosinke, Shoichi Tachiyama, Jan Mrásek, Jun Liu, Timothy R Hoover

“…Introducing a plasmid-borne copy of hp0838 into the H. pylori Δhp0838 mutant suppressed the fitness defect and antibiotic sensitivity of the strain. A variant of the Δhp0838 mutant containing a frameshift mutation in pflA, which resulted in paralyzed flagella, displayed wild-type growth rate and resistance to bacitracin, suggesting the fitness defect and antibiotic sensitivity of the Δhp0838 mutant are dependent on flagellar rotation. …”
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Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait by Dalal Alkazemi, Munirah Albeajan, Stan Kubow

“…FA is highly prevalent among children in Kuwait, and our data indicate that early nutrition-related and antibiotic exposures are associated with FA risk.…”
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Adjacent Segment Infection after Lumbar Fusion: A Case Report and the Literature Review by Wenlong Wang, Zheng Liu, Sijun Wu

“…However, the patient complained of severe back pain again after long-term oral antibiotic treatment and was rehospitalized 6 months after surgery. …”
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Oral Fluoroquinolones in the Treatment of Pneumonia, Bronchitis and Sinusitis by Nicole Mittmann, Farah Jivraj, Angelina Wong, Alice Yoon

“…BACKGROUND: Despite a relatively large number of clinical studies comparing oral fluoroquinolones to one antibiotic class comparator, there is limited information on the relative efficacy of different fluoroquinolones.…”
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Photodegradation of Lincomycin in Aqueous Solution

“…Differently, the treatment with <mml:math> <mml:mrow> <mml:msub> <mml:mrow> <mml:mtext>TiO</mml:mtext> </mml:mrow> <mml:mtext>2</mml:mtext> </mml:msub> </mml:mrow> </mml:math> and UV light resulted in a complete mineralization of the antibiotic. The degradation pathways involved S- and N-demethylation and propyldealkylation. …”
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Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy by Veronica Ojetti, Giovanni Bruno, Maria Elena Ainora, Giovanni Gigante, Gianluca Rizzo, Davide Roccarina, Antonio Gasbarrini

“…Helicobacter pylori eradication therapy has the potential burden of antibiotic-associated gastrointestinal (GI) side effects. …”
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Role of metabolism, resistance, and/or antagonism as drivers of endomicrobiomes assemblage in Origanum heracleoticum L by Giulia Semenzato, Francesco Vitali, Arcangela Frascella, Ludovica Lollini, Stefano Mocali, Alessio Papini, Renato Fani, Giovanni Emiliani

“…Contrarily, the patterns of antibiotic resistance appeared closely aligned with the taxonomical classification of the endophytes. …”
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Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance by Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao

“…Abstract Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases. …”
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Micromonas micros Infection of a Prosthetic Hip Joint: A Case Report and Review of the Literature by Abhimanyu Aggarwal, Durane Walker

“…We conducted a literature review of prosthetic hip joint infections caused by Micromonas micros as well as briefly discuss current guidelines on antibiotic prophylaxis in patients with prosthetic joints undergoing dental procedures and some knowledge gaps.…”
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Safety of vancomycin-loaded cement spacers for treating gram-positive periprosthetic joint infections in two-stage resection arthroplasty among patients with renal insufficiency by Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Yung-Chieh Liang, Pang-Hsin Hsieh, Sheng-Hsun Lee, Sheng-Hsuan Lin

“…Abstract Background The standard treatment for periprosthetic joint infections (PJI) typically involves a two-stage resection arthroplasty using antibiotic-loaded bone cement (ALBC) spacers. This study hypothesizes that there is no significant correlation between antibiotic levels in blood and synovial fluid and the patient’s kidney function, and that the success rates of staged resection arthroplasty are comparable between groups, specifically targeting gram-positive bacterial infections. …”
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Binocular Diplopia: A Possible Adverse Effect of Fluoroquinolone Therapy by Mariama Touray, Victoria Ando, Erwin Samutelela, Jean-Philippe Zuber

“…We present an interesting case of a 41-year-old male with binocular diplopia most likely induced by the use of a fluoroquinolone antibiotic.…”
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