The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis by Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V. Damania, Matthew C. Wong, Julijana Ivanisevic, Nadim J. Ajami, Jennifer A. Wargo, Johanna A. Joyce

“…We thus evaluated the impact of antibiotics and BrM outgrowth on the gut-brain axis. …”
Get full text

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment by Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Nina Schweintzger, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. Pollard, Colin Fink, Taco T. Kuijpers, Suzanne Anderson, Ulrich Von Both, Marko Pokorn, Dace Zavadska, María Tsolia, Henriëtte A. Moll, Clementien Vermont, Michael Levin, Federico Martinón-Torres, Antonio Salas, On behalf of EUCLIDS, PERFORM, and DIAMONDS consortia

“…Current diagnostic tests are time-consuming and have low specificity, leading clinicians to administer empirical antibiotics. Using a LASSO regression simulation approach and blood microarray data from 107 children with pneumonia (including 30 M. pneumoniae) we identify eight different transcriptomic signatures, ranging from 3-10 transcripts, that differentiate mycoplasma pneumonia from other bacterial/viral pneumonias with high accuracy (AUC: 0.84–0.95). …”
Get full text

Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

“…As a result, 269ΔSTM0343 increased resistance to various antibiotics, as well as to acidic conditions, oxidative stress, and disinfectants. …”
Get full text

Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…The study included 13,588,837 patients aged 35 or older who initiated systemic fluoroquinolones (FQs) or comparable antibiotics (trimethoprim with or without sulfamethoxazole [TMP] or cephalosporins [CPHs]) for UTI treatment in the outpatient setting between JAN 01, 2010 and DEC 31, 2019. …”
Get full text

Analysis of factors affecting the clinical management of infection in culture-negative patients following percutaneous endoscopic decompression: a retrospective study by Changpeng Qu, Haixin Wei, Hao Zhang, Zheng Lian, Hui Lu, Shuo Han

“…BackgroundCulture-negative spinal infections after prophylactic antibiotic use in percutaneous endoscopic decompression are rare, and diagnostic difficulties and the risk of antibiotic-resistant infections complicate treatment. …”
Get full text

Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting by Douglas Slain, Arif R. Sarwari, Karen O. Petros, Richard L. McKnight, Renee B. Sager, Charles J. Mullett, Alison Wilson, John G. Thomas, Kathryn Moffett, H. Carlton Palmer, Harakh V. Dedhia

“…To study the impact of our multimodal antibiotic stewardship program on Pseudomonas aeruginosa susceptibility and antibiotic use in the intensive care unit (ICU) setting. …”
Get full text

Exploring the Impact of Helicobacter pylori and Potential Gut Microbiome Modulation by Isaac Jingkhai Ong, Ke-Yan Loo, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Vengadesh Letchumanan

“…However, the decreasing efficacy of antibiotic therapy due to the rising antibiotic resistance and high incidence of dysbiosis-related adverse effects resulted in eradication failure. …”
Get full text

Genomic Landscape Reveals Chromosomally-Mediated Antimicrobial Resistome and Virulome of a High-Risk International Clone II Acinetobacter baumannii AB073 from Thailand by Rattiya Cheewapat, Jadsadaporn Redkimned, Sirikran Lekuthai, Thawatchai Kitti, Kannipa Tasanapak, Aunchalee Thanwisai, Sutthirat Sitthisak, Thanet Sornda, Hathaichanok Impheng, Sudarat Onsurathum, Udomluk Leungtongkam, Supaporn Lamlertthon, Siriwat Kucharoenphaibul, Jintana Wongwigkarn, Pantira Singkum, Pattrarat Chanchaithong, Rapee Thummeepak

“…These resistance phenotypes are related to various chromosomal-located antibiotic resistance determinants involved in different mechanisms such as reduced permeability, antibiotic target protection, antibiotic target alteration, antibiotic inactivation, and antibiotic efflux. …”
Get full text

Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty by Ronak A. Patel, Hayden P. Baker, Sara B. Smith

“…However, it remains important for physicians and pharmacists to be aware of antibiotic associated complications in knee revisions. …”
Get full text

Involvement of Tunisian General Practitioners in the Management of Patients at Risk of Infective Endocarditis: A Cross-Sectional Study by Malek Lagha, Mehdi Khemiss, Ines Kallel, Asma Araissia, Chems Belkhir, Saida Sahtout, Sana Bagga

“…Only 9.8% followed the right modality of antibiotic prophylaxis prescription; 4.9% of the dentists prescribed antibiotic only 1 hour before the act and 4.9% of them prescribed antibiotic 1 hour before the act and continued the treatment in case of the presence of an infectious site. …”
Get full text

Influence of an Infectious Diseases Specialist on ICU Multidisciplinary Rounds by David N. Gilbert

“…To ascertain the influence of a physician infectious diseases specialist (IDS) on antibiotic use in a medical/surgical intensive care unit. …”
Get full text

Characterization of Enterobacterales growing on selective CPE screening plates with a focus on non-carbapenemase-producing strains by Reut Efrati Epchtien, Elizabeth Temkin, Mor N. Lurie-Weinberger, Ophir Kastel, Alona Keren-Paz, David Schwartz, Yehuda Carmeli

“…Species identification and antibiotic susceptibility testing were performed using VITEK systems. …”
Get full text

The Management of Acute Uncomplicated Cystitis in Adult Women by Family Physicians in Canada by Warren J McIsaac, Preeti Prakash, Susan Ross

“…INTRODUCTION: There are few Canadian studies that have assessed prescribing patterns and antibiotic preferences of physicians for acute uncomplicated cystitis. …”
Get full text

BioFire FilmArray Blood Culture Identification (BCID) Panel and Clinical Usefulness: A Systematic Review by Niti Gor, Devesh Joshi

“…Conclusion: In conclusion, the judicious use of the BCID panel, coupled with background knowledge, facilitates early decision-making in antibiotic selection. This tool proves valuable for antibiotic stewardship, aiding in the cessation of unnecessary antibiotic use. …”
Get full text

Evaluation of Antimicrobial Resistance in Staphylococcus aureus Isolates by Years by Cennet Rağbetli, Mehmet Parlak, Yasemin Bayram, Huseyin Guducuoglu, Nesrin Ceylan

“…Recently, community and hospital-acquired infections with Staphylococcus aureus have increased and raised antibiotic resistant isolates. In this study, we aimed to evaluate the antibiotic resistance profile of S. aureus isolates over several years in various clinical specimens from our hospital. …”
Get full text

Changing dynamics of bloodstream infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium in Germany, 2017–2023: a continued burd... by Simon Brinkwirth, Marcel Feig, Ines Noll, Tim Eckmanns, Achim Dörre, Sebastian Haller, Niklas Willrich

Get full text

Molecular Detection and Multidrug Resistance of Shigella spp. Isolated from Wild Waterfowl and Migratory Birds in Bangladesh by Jarna Karmoker, Md. Saiful Islam, Md. Liton Rana, Md. Ashek Ullah, Fahim Haque Neloy, Nahian Muniath Oishy, Pritom Kumar Pramanik, Mahbubul Pratik Siddique, Sukumar Saha, Md. Tanvir Rahman

“…Furthermore, the isolates had a multiple antibiotic resistance index of up to 0.47. Antibiotic resistance genes tetA and SHV were found in 69.23% and 50% of relevant antibiotic-resistant Shigella spp. isolates, respectively. …”
Get full text

Evaluation of cold atmospheric pressure plasma effects on Pseudomonas aeruginosa wound infection in a mouse model by Reyhaneh Shekari, Gholamreza Zarrini, Vahid Siahpoush, Farzam Sheikhzadeh Hesari

“… Background and Objectives: Antibiotic resistance in microorganisms is a significant global health concern. …”
Get full text

Prevalence and Characterization of Staphylococcus aureus Isolated from Meat and Milk in Northeastern Italy by Debora Pinamonti, Marisa Manzano, Michela Maifreni, Silvia Bianco, Beki Domi, Alessia Ferrin, Jamila Anba-Mondoloni, Julien Dechamps, Roman Briandet, Jasmina Vidic

“…Staphylococcus aureus is a pathogenic microorganism often found in animal-derived foods and is known for its ability to readily develop resistance to antibiotic treatments. This study was designed to determine the prevalence of S. aureus strains in raw milk and meat in Italy and to evaluate their antibiotic resistance profiles and biofilm production. …”
Get full text

The Evolution of Antimicrobial Resistance in Respiratory Pathogens in Canada: What are the Clinical Consequences? by Donald E Low

“…More important, the prevention and control of such resistance must be addressed by reducing the burden of antibiotic selective pressure by curtailing inappropriate antibiotic use.…”
Get full text