Evaluating the effects of continuous veno-venous hemodiafiltration on O2 and CO2 removal and energy expenditure measurement using indirect calorimetry by Weronika Wasyluk, Robert Fiut, Marcin Czop, Agnieszka Zwolak, Wojciech Dąbrowski, Manu L N G Malbrain, Joop Jonckheer

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Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study by Youli Tian, Jintong Li, Minggen Jin, YiHua Piao, Jisheng Sheng, Zhixiong Mei, Qingsong Cui, Lilin Li

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Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis by Cheng-Hsin Ma, Jack Healy, Ebrima Kinteh, Cheng-Chin Ma, Ching-Fang Tiffany Tzeng, Eric H. Chou, Chin-Chieh Wu, Shih-Chieh Shao, Kuan-Fu Chen

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Renin–angiotensin–aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study by Katharina Krenn, Felix Kraft, Luana Mandroiu, Verena Tretter, Roman Reindl-Schwaighofer, Theresa Clement, Oliver Domenig, Matthias G. Vossen, Gregor Riemann, Marko Poglitsch, Roman Ullrich

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Guyton’s hemodynamic mosaic: crafting fluid management with precision by Rogerio Da Hora Passos, Luciano Ribeiro Pereira Silva, Leonardo Van De Wiel Barros Urbano Andari, Uri Adrian Prync Flato, Murillo Santucci Cesar Assunção, Thiago Domingos Corrêa

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Formal guidelines from an expert panel: intensive care unit medical staffing, organisation and working hours to improve quality of life at work in France by Nicolas Terzi, Guillaume Thiery, Nicolas Bèle, Naike Bigé, David Brossier, Alexandre Boyer, Edouard Couty, Laëtitia Flender, Cyril Manzon, Jean-Paul Mira, Sofia Ortuno, Vincent Peigne, Marie-Cécile Poncet, Sylvain Renolleau, Jean-Philippe Rigaud, Bérengère Vivet, Khaldoun Kuteifan, the French Intensive Care Society (FICS), the French National Council of Intensive Care Medicine (CNP MIR, Conseil National Professionel de Médecine Intensive Réanimation)

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Identification and validation of respiratory subphenotypes in patients with COVID-19 acute respiratory distress syndrome undergoing prone position by Mônica R. da Cruz, Pedro Azambuja, Kátia S. C. Torres, Fernanda Lima-Setta, André M. Japiassú, Denise M. Medeiros

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Correction: Identification and validation of respiratory subphenotypes in patients with COVID-19 acute respiratory distress syndrome undergoing prone position by Monica R. da Cruz, Pedro Azambuja, Katia S. C. Torres, Fernanda Lima‑Setta, Andre M. Japiassu, Denise M. Medeiros

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Impact of mechanical ventilation on severe acute kidney injury in critically ill patients with and without COVID-19 – a multicentre propensity matched analysis by Fabian Perschinka, Timo Mayerhöfer, Teresa Engelbrecht, Alexandra Graf, Paul Zajic, Philipp Metnitz, Michael Joannidis

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Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications by Anaïs Curtiaud, Toshiaki Iba, Eduardo Angles-Cano, Ferhat Meziani, Julie Helms

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The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome by Carline N. L. Groenland, Adinde H. Siemers, Eric A. Dubois, Diederik Gommers, Leo Heunks, Evert-Jan Wils, Vivan J. M. Baggen, Henrik Endeman

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Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies by Mu-Hsing Ho, Yi-Wei Lee, Lizhen Wang

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Fluid accumulation syndrome in sepsis and septic shock: pathophysiology, relevance and treatment—a comprehensive review by Carmen Andrea Pfortmueller, Wojciech Dabrowski, Rob Wise, Niels van Regenmortel, Manu L. N. G. Malbrain

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Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study by Xiang Si, Hao Yuan, Rui Shi, Wenliang Song, Jiayan Guo, Jinlong Jiang, Tao Yang, Xiaoxun Ma, Huiming Wang, Minying Chen, Jianfeng Wu, Xiangdong Guan, Xavier Monnet

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Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study by Sumeet Rai, Dale M. Needham, Rhonda Brown, Teresa Neeman, Krishnaswamy Sundararajan, Arvind Rajamani, Rakshit Panwar, Mary Nourse, Frank M. P. van Haren, Imogen Mitchell, for the PRICE study investigators

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Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome by Lianlian Jiang, Hui Chen, Wei Chang, Qin Sun, Xueyan Yuan, Zongsheng Wu, Jianfeng Xie, Ling Liu, Yi Yang

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Response to: 500 mg as bolus followed by an extended infusion of 1500 mg of meropenem every 8 h failed to achieve in one-third of the patients an optimal PK/PD against nonresistant... by Amol Kothekar, Jigeeshu Vasishtha Divatia, Sheila Nainan Myatra, Vikram Gota

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The use of Guyton’s approach to the control of cardiac output for clinical fluid management by Sheldon Magder

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Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients by Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Dario Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, for the SIAARTI Study Group

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Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

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