“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…Approval was granted under “exceptional circumstances” based on effectiveness found in pre-clinical challenge studies in animals and safety studies in humans showing minimal side effects. …”
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A novel LC-MS/MS analysis of vitamin D metabolites in mice serum and hair: impact of diet and light exposure by Muhammad K. Hakeem, Asma Al-Menhali, Sampath K. Elangovan, Iltaf Shah

“…Further research in this area has the potential to unveil additional factors influencing vitamin D metabolism, offering valuable insights into strategies for optimizing vitamin D levels in both animal models and human subjects.…”
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Genetic diversity of the Central European wild boar (Sus scrofa scrofa) population and domestic pig (Sus scrofa domesticus) breeds based on a microsatellite DNA locus by E. A. Snegin, V. M. Makeeva, A. P. Kaledin, A. M. Ostapchuk, I. D. Alazneli, A. V. Smurov

“…The low effective size of the wild boar population (Ne = 21.8, Neb = 4.0) is probably caused by the death and shooting of animals due to Pestis africana suum.…”
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Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…Background: Glyphosate, as one of the most widely used herbicides worldwide, has been reclassified as a potential carcinogen and linked to multiple health problems. Recent data from animal experiments have proved its potential cardiovascular toxicity. …”
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Protein quality of four indigenous edible insect species in Nigeria by Florence Inje Oibiokpa, Helmina Olufunmilayo Akanya, Ali Audu Jigam, Abubakar Ndaman Abubakar, Evans Chidi Egwim

“…The finding in this work that the selected insects are nutritious and safe for consumption may alleviate the fear of entomophagy thereby reducing the overdependence on conventional animal proteins. Keywords: Protein quality, Insect species, Biochemical parameters, Haematological parameters, Entomophagy…”
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Fructose Consumption in Pregnancy and Associations with Maternal and Offspring Hepatic and Whole-Body Adiposity in Rodents: A Scoping Review by Grace Zhao, Sarah Chondon, Clint Gray, Sheridan Gentili, Meagan Stanley, Timothy RH Regnault

“…Methods: A systematic search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed up to October 4, 2024, to identify animal and human studies that focused on maternal fructose consumption pre- and during pregnancy on hepatic and whole-body adiposity in the mother, fetus, and offspring. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…Changes in the expression and secretion of cystatin C in the brain have been shown in amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and in some animal models of neurodegeneration, thus proving a protective function of cystatin C. …”
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Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway by Xing Luo, Yi Duan, Jinwei He, CongGai Huang, Jun Liu, Yifan Liu, Mengdei Xu, Qiong Dai, Zhihui Yang

“…Finally, we proved that the combined therapy of DHT and BRAF/MEK inhibitors is reliable and effective at animal and cell levels.ConclusionIn BRAF mutant melanoma cells, DHT suppresses the STAT3/SOX2 signaling pathway. …”
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Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator... by Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts

“…Participants were randomly assigned to receive an animated overdose prevention and naloxone educational video (intervention arm) or usual care (control arm). …”
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Computation and Visualization of Regional-Scale Forest Disturbance and Associated Dissolved Nitrogen Export from Shenandoah National Park, Virginia by Keith N. Eshleman, Daniel A. Fiscus, Nancy M. Castro, James R. Webb, J Jr. Deviney

“…The purposes of this analysis are to (1) test the applicability of the UNERF model using quarterly streamwater nitrate data from a group of ungaged watersheds in SNP; (2) demonstrate a park-wide application of a regional UNERF model that references the geographic distributions of bedrock geology and the timing and extent of gypsy moth defoliation over the entire SNP area; and (3) visualize the temporal and spatial patterns in vegetation disturbance and annual dissolved N export through the use of computer animation software. During water year 1992, the year of peak defoliation, our modeling study suggests that park-wide export had transiently increased by 1700% from a baseline rate of about 0.1 kg/ha/year. …”
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…To date, studies in cell cultures, animal models, and brain tissues have revealed elevated expression of MICA/B, ULPB4, and its mouse homolog murine UL16 binding protein-like transcript (MULT1), in oligodendrocytes and astrocytes from patients with MS. …”
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The use of heparin-containing lubricant in clinical practice by T.B. Romanova, M.H. Rabadanova, E.G. Rybakova, Z.U. Teviyeva, M.S. Gorshkova

“…All patients used the heparin-containing lubricant PARIN-POS («URSAFARM Artzneimittel GmbH, Germany), which is a sterile eye ointment, 1 gram of which contains 1300 IU of animal heparin. The following clinical cases of patients with DES are considered: 1. a student, an active user of electronic gadgets; 2. …”
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Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

“…The ALT concentration for all ASO combinations remained within the norm for the control animals, demonstrating the absence of any hepatotoxic effect. …”
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Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae Sargassum ilicifolium (Turner) C. Agardh: Regulation of cytokine cascade by Ramamoorthi Lavanya, Jeyabalan Srikanth, Sankar Seethalakshmi, Begum M. Yasmin, Duraipandian Chamundeeswari, Sekar Mahendran, Wong Ling Shing, Subramaniyan Vetriselvan

“…The acute toxicity investigation indicated that the lethal dose of 50% (LD50) of the polysaccharide was more than 2,000 mg/kg. In addition, animals from the methotrexate and CSP (5 mg/kg, p.o.) groups had a substantial reduction in paw volume compared to other treatment groups. …”
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Combination of Mangosteen (Garcinia mangostana L.) Pericarp Extract and Physical Exercise Decreases Atherosclerotic Lesions in Atherogenic Diet-Fed Rats by Andreas Arie Setiawan, . Sugiri, Awal Prasetyo, Eirin Yovita Kurniawan, Dominikus Evano Putra

“…Following eight weeks of treatment, the animals were sacrificed and the aortic tissues were taken for histological study. …”
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The Inhibitory Effect of Connective Tissue Growth Factor Antibody on Postoperative Fibrosis in a Rabbit Model of Trabeculectomy by Kiana Hassanpour, Mozhgan Rezaei Kanavi, Narsis Daftarian, Azadeh Samaeili, Fatemeh Suri, Mohammad Pakravan, Azadeh Doozandeh, Sasha Afsar Aski, Maryam Fakhri, Afrooz Moghaddasi, Hamid Ahmadieh, Hamed Esfandiari

“…Conclusion: Based on the results of this animal study, the anti-CTGF antibody injection resulted in a significant reduction in collagenous tissue and myofibroblast cells after trabeculectomy.…”
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Imprint of ancestral and modern threats in human mind – experience of fear, disgust, and anger by Eva Landová, Eva Landová, Jakub Polák, Jakub Polák, Markéta Janovcová, Iveta Štolhoferová, Šárka Peterková, Aleksandra Chomik, Daniel Frynta

“…IntroductionThreats to our survival are often posed by the environment in which humans have evolved or live today. Animal and human ancestors developed complex physiological and behavioral response systems to cope with two types of threats: immediate physical harm from predators or conspecifics, triggering fear, and the risk of infections from parasites and pathogens leading to the evolution of the behavioral immune system (BIS) with disgust as the key emotion. …”
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Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease by Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine

“…Indeed, structural and functional abnormalities have been observed during brain development in both humans and animal models of HD. However, a concurrent study of cortical and striatal development in a genetic model of HD is still lacking. …”
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The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells by Chien-Ting Lin, Shang-Ju Wu, Cheng Hao Liao, Reyhung Roc Weng, Chun-Ming Lin

“…Functional characterization of eCD16A/anti-CD3-BFP was performed using in vitro, ex vivo, and in vivo animal assays. Combination treatments of eCD16A/anti-CD3-BFP with rituximab (anti-CD20), cetuximab (anti-EGFR), trastuzumab (anti-HER2) or anti-PD-L1 IgG1 led to specific killing of antigen-expressing tumor cells. …”
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Cannabis related side effects in otolaryngology: a scoping review by Jobanjit S. Phulka, Joel W. Howlett, Amanda Hu

“…English studies in adults were included from inception to the end of 2019. In-vitro, animal, and studies with n < 5 were excluded. Primary outcome was defined as unintended side effects (defined as any Otolaryngology symptom or diagnosis) following cannabis use. …”
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