An analysis of observed and predicted extreme heat and precipitation trends across four pulse producing regions in North America: North Dakota, Montana, Saskatchewan, and Northeast... by Sophia Weiss, Erin Coughlan de Perez

“…The consumption of plant-based proteins in lieu of animal proteins is the most important dietary shift that would be needed to keep the world under 2 °C of warming, and this shift would require a dramatic increase in the percentage of cropland devoted to nuts and pulses (Peters et al 2016 Elementa 4 000116). …”
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GluN2D-containing NMDA receptors in parvalbumin neurons in the nucleus accumbens regulate nocifensive responses in neuropathic pain by Sukanya G. Gakare, Gajanan P. Shelkar, Dinesh Y. Gawande, Ratnamala Pavuluri, Pauravi J. Gandhi, Shashank M. Dravid

“…Using conditional KO strategy, we addressed the region- and cell-type involved in GluN2D-mediated changes in CINP. Animals with conditional deletion of GluN2D receptors from parvalbumin interneurons (PVIs) or local ablation of GluN2D from nucleus accumbens (NAc) displayed reduced mechanical hypersensitivity in CINP, underscoring the pivotal role of accumbal GluN2D in PVIs in neuropathic pain. …”
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Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity by Diego Ortega-Pacheco, María Marcela Jiménez-Pérez, Jeanet Serafín-López, Juan Gabriel Juárez-Rojas, Arturo Ruiz-García, Ursino Pacheco-García

“…Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. …”
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Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems by Nhat Minh Phan, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Trong Tuan Nguyen, Quoc Luan Ngo, Trong Duc Tran, Quan Hien Nguyen, Bui Linh Chi Huynh, Diep Xuan Ky Nguyen, Trong Dat Bui, Dinh Tri Mai, Tan Phat Nguyen

“…The results show that CCSM and CVSM significantly expressed in vitro hepaprotective activity on HepG2. Therefore, the animals were daily treated with these extracts at the doses of 15, 30, and 45 mg/kg body weight for 5 days, and CCl4 was injected (2 ml/kg body weight, i.p.) on the 2nd and 3rd days. …”
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Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain by Qian Wang, Jing Lin, Peng Yang, Yingye Liang, Dongming Lu, Kailong Wang, Wei Gan, Jianping Fu, Zhenbao Gan, Mingchen Ma, Pingting Wu, Fengshi He, Jun Pang, Hongliang Tang

“…The control group consisted of intact animals. The rats in the massage group underwent massage using a massage simulation machine once a day for 14 d in succession; the hind limbs of the rats in the sham massage group were gently touched with a cloth bag once a day for 14 continuous days. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Whereas FNDC5 overexpression in murine heart was cardioprotective, introduction of FNDC5-targeted shRNA into the myocardium was sufficient to trigger Bax up-regulation, ATR/Chk1 activation, oxidative stress, cardiac fibrosis, loss of ventricular function, and compromised animal survival. The detrimental impact of FNDC5 depletion on heart function could be mitigated via treatment with a Chk1 inhibitor identifying Chk1 hyperactivity as a causative factor in cardiac disease. …”
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Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus by S. N. Shchelkunov, T. V. Bauer, S. N. Yakubitskiy, A. A. Sergeev, A. S. Kabanov, S. A. Pyankov

“…Therefore, the development of new safe vaccines against orthopoxviral infections of humans and animals is an important problem. VACV attenuation by modern approaches carried out by targeted inactivation of certain virus genes and usually leads to a decrease in the effectiveness of VACV in vivo propagation. …”
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The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hor... by Temidayo S. Omolaoye, Surendra Singh Rawat, Naglaa Gamil Shehab, Eslam El Nebrisi, Stefan S. Du Plessis

“…Methods: Eighteen male Wistar rats were randomly divided into three groups. Animals were orally (oral gavage) administered MSG (900 mg/kg/day for 45days), MSG and Maca (900 mg/kg/day of MSG and 500 mg/kg/day of black Lepidium meyenii root extract), or water only (control group), for a total period of 80 days. …”
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Evaluation of the possibility of Spirulina Spirulina platensis culture in the deep aquifer well, Seistan, Southeastern Iran by Abdolali Rahdari, Ali Khosravanizadeh, Sahel Pakzad Toochaei, Roghayeh Karami

“…In addition to human consumption, Spirulina is used in aquaculture for feeding the larval stages of crustaceans and some other types of aquatic animals, to prepare livestock and poultry feed, and for cosmetic and industrial purposes. …”
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Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…These findings contribute to understanding the mechanisms of stress responses in aquatic animals, potentially aiding in the development of strategies to enhance health and productivity in aquaculture.…”
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Threshold effects of sleep duration and cognitive function in older adults with BMI ≥ 25 kg/m2 by Kunyu Qiu, Kunyu Qiu, Yilei Liu, Chengwei Hu, Jie Gu, Yanyan Huang

“…Additionally, subgroup analysis and interaction tests were conducted.ResultsResults showed that a negative association was found between sleep duration and scores in the fully adjusted model in the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). …”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…Deoxygenation can be fatal for many marine animals; however, some sponge species are tolerant of hypoxia and anoxia. …”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…It was also shown that FGF21 dramatically reduces the expression of CDK1, which may help diabetic nephropathy by averting mitotic catastrophe and changing the renal cell cycle.ConclusionIn short, FGF21 improved the development of diabetic nephropathy in diabetic nephropathy-affected animals by reducing glomerular filtration damage, inflammation, and oxidative stress, inhibiting the formation of thrombus, and controlling the cell cycle through CDK1.…”
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Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

“…Poly adenosine diphosphate (ADP) ribose polymerase‐1 (PARP1) is implicated in the parthanatos and secondary neuroinflammation. Animal studies indicate the over‐activation of PARP1 as a significant downstream event underlying the neurological sequelae of several traumatic and neurodegenerative disorders, irrespective of the mode of cell death. …”
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Can Thinning Foster Forest Genetic Adaptation to Drought? A Demo‐Genetic Modelling Approach With Disturbance Regimes by Victor Fririon, Hendrik Davi, Sylvie Oddou‐Muratorio, Gauthier Ligot, François Lefèvre

“…Considering plausible genetic variation and contrasting drought regimes, the predicted evolutionary rates for both traits aligned with documented rates in wild plant and animal populations. Thinning considerably reduced natural selective pressures caused by competition and drought compared to unthinned stands. …”
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Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study by Zihao Wang, Yu Zhang, Wenwen Yang, Mengfei Xu, Beini Li, Ping Wu, Zhongqiang Cao, Wei Wu

“…Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. …”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…The (-)THC F1 generation embryos at 1 dpf showed reduced coiling activity, while swimming after touch-evoked responses was reduced in 2 dpf animals but basal swimming at 5 dpf remained similar to controls. …”
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Bosques tropicales estacionalmente secos son importantes para ganaderos en el noroeste costarricense by Florent Godinot, Eduardo Somarriba, Bryan Finegan, Diego Delgado-Rodríguez

“…La decisión de usar el bosque para ramoneo parecía basarse en un trade-off entre bienestar animal y facilidad de manejo. El conocimiento de los finqueros sobre el comportamiento del ganado en bosques era variable y limitado a los márgenes del bosque y pasturas. …”
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Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle by Giorgia Di Muro, Carlotta Tessarolo, Giulia Cagnotti, Alessandra Favole, Sara Ferrini, Ugo Ala, Claudio Bellino, Giuliano Borriello, Marina Gallo, Giulia Iamone, Barbara Iulini, Marzia Pezzolato, Cristina Casalone, Maria Caramelli, Lorenzo Capucci, Patrizia Cavadini, Cristiano Corona, Antonio D’Angelo

“…CSF Nf-L levels were higher in samples from animals with degenerative (median Nf-L 49971 pg/mL) and infectious central nervous system (CNS) disorders (median Nf-L, age < 2 months 8863 pg/mL; age 2–12 months 17474 pg/mL; age 1–6 years 3546 pg/mL), CNS anomalies and metabolic/toxic disorders. …”
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PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Here we show that monotherapy with selective PRMT5 inhibitors induced a potent anti-tumor activity across several cellular and animal models of ACC, which was paralleled by downregulation of genes associated with ACC tumorigenesis, including MYB and MYC (the recognized drivers of ACC progression). …”
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