Effect of prolonged starvation on nutrition utilization and transcriptional responses in Pacific oyster (Crassostrea gigas) by Mingkun Liu, Chenchen Wei, Wenwen Xu, Lintao Tan, Li Li, Guofan Zhang

“…Emaciation syndrome due to starvation is a significant cause of mortality in marine animals, yet the underlying mechanisms in non-feeding and weak/no-mobility marine bivalves remain poorly understood. …”
Get full text

Ewing sarcoma – pathomechanisms, standard treatment and new therapeutic perspectives by Wojciech Zezuliński, Filip Woliński, Julia Zyśk, Mateusz Korga, Jakub Klas, Jacek Baj, Eliasz Dzierżyński

“…Findings: The studies cited vary depending on the phase of the clinical trial they are on, of which teprotumumab, robatumumab, and a combination of cixutumumab/temsyrolimus, ivodesinib, Nivolumab (a PD-1 inhibitor), and Ipilimumab (a CTLA-4 inhibitor) are quite advanced as well as those conducted only on animals and in vitro like YK-4-279 molecule, mithramycin 2'-oxime, NK cells, siRNAs with cationic detonation nanodiamonds (DNDs) and Il-12 by means of lentiviruses. …”
Get full text

LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model by Po-Cheng Chang, Shien-Fong Lin, Yen Chu, Hung-Ta Wo, Hui-Ling Lee, Yu-Chang Huang, Ming-Shien Wen, Chung-Chuan Chou

“…Although a clinical trial (PARADISE-MI Trial) has been ongoing to examine the effects of LCZ696 in myocardial infarction (MI) patients, the effects of LCZ696 on remodeling of cardiac electrophysiology in animal models remain largely unclear. Methods. We performed coronary artery ligation to create MI in Sprague-Dawley rats. …”
Get full text

In vitro and in vivo anti-hyperglycemia effects of extract of Faloak (Sterculia quadrifida R.Br.) leaves by Velia Andrestia Dias, Laurenza Celine Dinanda, Charles Conrad Rambung, Maria Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Jeffry Julianus, Phebe Hendra

“…This research focused on identifying the ingredients of Faloak leaves that could lower blood sugar levels and confirm these effects in laboratory and animal models. At various concentrations, the in vitro evaluation assessed the inhibitory effect of α-amylase and α-glucosidase enzymes. …”
Get full text

Synergistic effects of PGPRs and fertilizer amendments on improving the yield and productivity of Canola (Brassica napus L.) by Haji Muhammad, Muhammad Ijaz, Abdul Sattar, Sami Ul-Allah, Ahmad Sher, Muhammad Asif, Muhammad Dilshad, Khalid Mahmood, Muhammad Waheed Riaz, Muhammad Saqlain Zaheer, Muhammad Rizwan, Salim Manoharadas

“…We applied Azotobacter salinestris and Bacillus subtilis with biochar, compost, animal manure, poultry manure, and NPK fertilizer. …”
Get full text

Comparison of reverse-transcriptase polymerase chain reaction (rt-pcr) and rapid test for the detection of bovine rotavirus and bovine coronavirus in anatolian water by Oya Bulut, Gülşah Uyunmaz Saklı, Mustafa Hasöksüz, Irmak Dik, Hasan Hüseyin Hadimli, Mustafa Hitit

“…<b>Aim:</b> Coronaviruses and Rotaviruses are important virologic factors for both animal and human health in Turkey and the world. Bovine Rotavirus (BRV) and Bovine Coronavirus (BCoV) in cattle cause significant economic losses. …”
Get full text

Особистий досвід виживання в умовах російської окупації (24 лютого – 31 березня 2022) by Ігор Шихненко

“…Another living space was the yard and the street, where food was prepared and food was exchanged, property was protected from marauders, domestic animals were cared for. All this, according to the author, contributed to the emergence of a sense of unity and indomitability in people.…”
Get full text

Does Mycobacterium tuberculosis var. bovis Survival in the Environment Confound Bovine Tuberculosis Control and Eradication? A Literature Review by Adrian R. Allen, Tom Ford, Robin A. Skuce

“…The possibility that classical pulmonary TB can be simulated and recapitulated in laboratory animal models by ingestion of contaminated feed is a further intriguing indication of potential environmental risk. …”
Get full text

Peri-Traumatic Near-Infrared Light Treatment Attenuates the Severity of Noise-Induced Hearing Loss by Rescuing (Type I) Spiral Ganglion Neurons in Mice by Max Meuser, Susanne Schwitzer, Parisa Faraji, Arne Ernst, Dietmar Basta

“…Hearing protection in these animals significantly exceeded the effect of an exclusive pre- or post-treatment across all frequencies. …”
Get full text

hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts by Yifei Wang, Yaqin Zhang, Bing Lu, Jianbo Xi, Dickson Kofi Wiredu Ocansey, Fei Mao, Donglin Hao, Yongmin Yan

“…Having observed that the extracellular-signal-regulated kinase (ERK) pathway in intestinal fibrosis can be inhibited by hucMSC-Ex, we treated intestinal fibroblasts with an ERK inhibitor to emphasize the potential target of ERK phosphorylation in the treatment of IBD-associated intestinal fibrosis. Results. In the animal model of IBD-related fibrosis, hucMSC-Ex alleviated inflammation-related fibrosis as evident in the thinning of the mice’s intestinal wall and decreased expression of related molecules. …”
Get full text

On occurrence of some avian bacterial diseases and biosafety provision by T. V. Kurmakaeva, S. S. Kozak, E. S. Baranovich

“…The data obtained indicate the need for a retrospective analysis of the occurrence of some avian bacterial infections in order to study the animal disease situation in poultry farms for the purpose of improving the set of measures to ensure the disease freedom in poultry industry, while addressing the laboratory test results.…”
Get full text

Management of intraocular pressure and inflammation using febuxostat film: in vitro - in vivo correlation by Mouli Das, Sk Habibullah, Tanisha Das, Rakesh Swain, Subrata Mallick

“…Disappearance of ocular inflammation was also observed in the test animals after 2.5 h of film application, whereas acute inflammation was continued in the group without treatment for more than 4 h. …”
Get full text

Differential gene expression during recall of behaviorally conditioned immune enhancement in rats: a pilot study [version 3; peer review: 1 approved, 3 approved with reservations] by Marcus Picard-Mareau, Markus Rueckels

“…Following stimulus re-exposure, animals were sacrificed at different time points, and neural tissues along the HPA axis was analyzed with a rat genome array together with plasma protein using Luminex analysis. …”
Get full text

Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects by Bruno C. Menarim, DVM, PhD, Chan Hee Mok, PhD, Kirsten E. Scoggin, PhD, Alexis Gornik, DVM, Emma N. Adam, DVM, PhD, Shavahn C. Loux, PhD, James N. MacLeod, VMD, PhD

“…Studies grafting IZN or ANL tissues in larger animal models with regular immune functions may provide additional insights into improving osteochondral regeneration.…”
Get full text

Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility by Mausumi Das, Maha Gumssani, Julia Mullaney, Ralf Henkel, Suks Minhas, Marie Claire Aquilina, Channa N Jayasena

“…We included 28 studies reporting sperm parameters linked to LE and excluded non-English articles, reviews and animal studies. Data collected included study details, methods, population, LE levels, sperm characteristics and pregnancy outcomes. …”
Get full text

Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…Mice were divided into control group (vehicle), COE group, cisplatin group and cisplatin plus COE (2.5, 5 and 20mg/kg, i.p.). Animal body weight, serum creatinine, blood urea nitrogen (BUN), and proteinuria were measured. …”
Get full text

Application of stem cells alone and in combination with low-level laser therapy for sciatic nerve repair in rats by Mohsen Shalalvand, Hamidreza Mahaseni Aghdam, Ahmad Asghari, Siamak Nehzat, Fatemeh Shahsavari, Rojin Ardalani

“…Abstract This study evaluated the efficacy of tubular constructs containing stem cells and Type I collagen, both independently and in conjunction with low-level laser therapy (LLLT), in repairing the sciatic nerve in a rat model. In this animal study, the right sciatic nerve of 30 male Wistar rats, each weighing 250–300 g, was surgically excised to a length of 8 mm. …”
Get full text

Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s dise... by Anett Futácsi, Anett Futácsi, Anett Futácsi, Kitti Rusznák, Kitti Rusznák, Gergely Szarka, Gergely Szarka, Gergely Szarka, Béla Völgyi, Béla Völgyi, Ove Wiborg, Boldizsár Czéh, Boldizsár Czéh, Boldizsár Czéh

“…BackgroundAnimal models of Alzheimer’s disease (AD) are essential tools for investigating disease pathophysiology and conducting preclinical drug testing. …”
Get full text

Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…The results demonstrated that complex coacervation-mediated PME nanoformulations exhibited equivalent or superior antibacterial activity, increased maximum tolerant dose, and fewer adverse reactions in animal tests. <b>Conclusions:</b> Utilizing complex coacervation, PME nanoformulations were developed, demonstrating efficacy in the formulation process. …”
Get full text

Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases by Rommaneeya Leela‐arporn, Karah Burns DeMarle, Cailin R. Heinze, Cynthia R. L. Webster

“…Objectives To determine if plasma hypoaminoacidemia occurs in dogs with non‐HCS CLD, compare plasma amino acid (PAA) profiles between dogs with non‐HCS CLD and HCS, and define a sensitive and specific PAA pattern for diagnosing HCS. Animals Data were collected from client‐owned dogs, a prospective cohort of 32 with CLD and 1 with HCS, and a retrospective cohort of 7 with HCS. …”
Get full text