Transcription factor TCF4: structure, function, and associated diseases by R. R. Savchenko, N. A. Skryabin

“…We discuss its potential target genes and the possible loss-of-function pathogenetic mechanisms identified in animal and cellular models of Pitt–Hopkins syndrome. …”
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Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats by D. I. Peregud, S. V. Freiman, A. O. Tishkina, L. S. Sokhranyaeva, N. A. Lazareva, M. V. Onufriev, M. Y. Stepanichev, N. V. Gulyaeva

“…We suggest that specific alterations in BDNF expression may be involved in the susceptibility to the development of behavioral impairments of animals subjected to early proinflammatory stress.…”
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Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique by Phuong Thi Thanh Nguyen, Hieu Trung Nguyen, Uyen Nhat Phuoc Tran, Ha Manh Bui

“…Hospital wastewater contains a complex mixture of bioactive substances and microorganisms that are deleterious to humans and aquatic animals. In this study, four antibiotics, namely, ofloxacin, ciprofloxacin, cefuroxime, and amoxicillin, respectively, from the wastewater of seven hospitals in Ho Chi Minh City, Vietnam, were monitored. …”
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Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats by Gérard Bessan Dossou-Agoin, Maxime Machioud Sangaré-Oumar, Téniola Isabelle Sacramento, Mariette Sindété, Egnon Jacques Hougbénou-Houngla, Nounagnon Darius Tossavi, Simon Azonbakin, Adam Gbankoto

“…In the repeated dose 28-day oral toxicity test, both extracts did not alter animal’s behavior. However, both extract administration led to proteinuria and renal damages. …”
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Fermentation optimization and pilot production of Bacillus subtilis ZY1 producing CpxP by Rongrong DONG, Huan ZHANG, Xinran YU, Hao LIU, Xiaohui ZHOU

“…The research results can provide basic materials for further research on the biocontrol function of CpxP protein in animal bacterial diarrhea disease.…”
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Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…First, this review provides a brief introduction to the current state-of-the-art for neuro-ectoderm brain organoid development, emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal models. However, despite their usefulness for developmental studies, a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal origin. …”
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Exploring the catalytic hydrothermal liquefaction of Namibian encroacher bush by Luis Cutz, Nikos Bias, Majd Al-Naji, Wiebren de Jong

“…These encroachments damage ecosystems, pose a threat to biodiversity, and outcompete local plants and animals. This article focuses on converting Acacia Mellifera from Namibia, commonly known as encroacher bush (EB) into high-quality drop-in intermediates for the chemical and transport industry via hydrothermal liquefaction (HTL). …”
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Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult... by Stuart I. Hodgetts, Jun Han Yoon, Alysia Fogliani, Emmanuel A. Akinpelu, Danii Baron-Heeris, Imke G. J. Houwers, Lachlan P. G. Wheeler, Bernadette T. Majda, Sreya Santhakumar, Sarah J. Lovett, Emma Duce, Margaret A. Pollett, Tylie M. Wiseman, Brooke Fehily, Alan R. Harvey

“…Cortical neurons were transduced with a bicistronic adeno-associated viral vector (AAV1) expressing a secretory form of CNTF coupled to mCHERRY (AAV-CNTFmCherry) or with control AAV only (AAV-GFP) two weeks prior to SCI. In some animals, viable or nonviable F344 rat mesenchymal precursor cells (rMPCs) were injected into the lesion site two weeks after SCI to modulate the inhibitory environment. …”
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Potential of Lactiplantibacillus Plantarum 20174 for Vitamin B12 Production in Pineapple: An Enhanced Nutritional Quality and Storage Stability of Processed Jelly by Mayuri Rastogi, Bushra Shaida, Vandana Singh, Zoobiya Islam, Saleem Siddiqui

“…Background: Vitamin B12 is the micronutrient, present naturally in animal products. The present study was conducted with the aim of developing a naturally fortified vitamin B12 rich fruit product, which can easily be consumed by vegan population. …”
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RETROSPECTIVE ASSESSMENT OF CONTROL RESULTS WITH REGARD TO COMPLETENESS AND QUALITY OF IMPLEMENTATION BY VETERINARY SERVICES OF THE SUBJECTS OF THE RUSSIAN FEDERATION OF POWERS TRA... by M. A. Shibayev, A. S. Oganesyan, A. V. Belchikhina, K. N. Gruzdev, A. K. Karaulov

“…It was shown that in the period from 2014 to 2016 the veterinary services of the RF subjects implemented 21,337 measures on establishment and lifting of restrictive measures/quarantine based on the occurrence of animal diseases. The study revealed that in quite a significant number of cases on establishment and lifting of restrictive measures and quarantine the veterinary services of the subjects of the Russian Federation violated the legislation of the Russian Federation. …”
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Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells by Xinlu Wang, Yanyang Xu, Haiqi Yu, Yushun Lu, Yongzhong Qian, Meng Wang

“…Deoxynivalenol (DON), fumonisin B₁ (FB₁), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans and animals. Single and combined exposure of DON, FB₁, and ZEN leads to intestinal toxicity but the toxicology mechanism research is still limited. …”
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Stress-Related Gene Expression in Liver Tissues from Laying Hens Housed in Conventional Cage and Cage-Free Systems in the Tropics by María Paula Herrera-Sánchez, Roy Rodríguez-Hernández, Iang Schroniltgen Rondón-Barragán

“…The liver serves various metabolic functions, such as glycogen storage, and plays a crucial role in animals’ adaptation to environmental changes. Consequently, both internal and external conditions can influence liver functions. …”
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Potential therapeutic effects of apigenin for colorectal adenocarcinoma: A systematic review and meta‐analysis by Koohyar Ahmadzadeh, Shayan Roshdi Dizaji, Fatemeh Ramezani, Farnad Imani, Jebreil Shamseddin, Arash Sarveazad, Mahmoud Yousefifard

“…The few in vivo studies indicate that apigenin decreases tumor size while showing no effects on the body weight of animal colorectal adenocarcinoma models. Conclusion Our results demonstrated that apigenin, through reducing cell viability, inducing growth inhibition, apoptosis, and cell cycle arrest, and also by decreasing the tumor size, can be considered as a possible adjuvant agent in the management of colorectal adenocarcinoma. …”
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A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

“…These techniques have recently been used to reproduce the structure and function of organs in vitro and are expected to be promising alternatives for animal experiments in the future. In the present study, we designed and fabricated an organ-on-a-chip system for mounting organoids from mammary tumor-affected cats (FMT organoids) and normal intestinal organoids from mice (MI organoids) and perfused them with anti-cancer drugs. …”
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Investigation of Effects of Local Vitamin C Application on Inflammatory Response and Periodontal Tissue Destruction in Rat Periodontitis Model by Kübra Karaçam, Ayşe Toraman, Zeliha Aytekin

“…Methods: A total of 21 animals, 7 rats in each group, were used in the study: 1- Non-ligation (NL), 2-experimental periodontitis (EP), and 3- local vitamin C (VtC) groups. …”
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Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic... by Jeeraporn Pekkoh, Apiwit Kamngoen, Antira Wichaphian, May Thu Zin, Supakit Chaipoot, Kamon Yakul, Wasu Pathom-aree, Wageeporn Maneechote, Benjamas Cheirsilp, Kuan Shiong Khoo, Sirasit Srinuanpan

“…Microalgae have gained significant traction as sustainable substitutes for conventional animal-derived proteins, demonstrating remarkable potential as reservoirs of bioactive peptides. …”
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A light microscopic investigation on the histology and alpha-naphthyl acetate esterase (anae)- and acid phosphatase (acp-ase) positive lymphocyte localization in the hemal nodes of... by Nariste Kadıralieva, Emrah Sur, Tuğba Özaydın, Şamil Sefergil

“…<p> <b>Conclusions: </b> Yaks are very important animals for Krygyzstan economi as food source because they provide milk, milk products, meat, and meat products. …”
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Evaluating the Mechanisms of Improved Glucose Homeostasis after Bariatric Surgery in Ossabaw Miniature Swine by Jonathan G. Sham, Vlad V. Simianu, Andrew S. Wright, Skye D. Stewart, Mouhamad Alloosh, Michael Sturek, David E. Cummings, David R. Flum

“…Roux-en-Y gastric bypass (RYGB) is the most common bariatric operation; however, the mechanism underlying the profound weight-independent effects on glucose homeostasis remains unclear. Large animal models of naturally occurring insulin resistance (IR), which have been lacking, would provide opportunities to elucidate such mechanisms. …”
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Spatiotemporal variations in integrated trophic positions of stream macroinvertebrate communities by Naoto F. Ishikawa, Yoshitoshi Uehara, Takuya Ishida, Tohru Ikeya, Satoshi Asano, Chia-Ying Ko, Tomoya Iwata, Ichiro Tayasu, Naohiko Ohkouchi, Noboru Okuda

“…We also found that the iTP values of stream macroinvertebrate communities (2.37 ± 0.24) (n = 43), marine mesozooplankton communities (2.33 ± 0.34) (n = 14), and animal communities with various taxonomic groups (2.42 ± 0.21) (n = 158) are all comparable with each other, suggesting that partial communities involving macroinvertebrates well represent the configuration of total ecological pyramid. …”
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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial by Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer

“…Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. …”
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