Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in differen... by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…The inhibitory effect on the malignant characteristics of MG-63 (P53−) cells was more obvious, indicating that the potential anticancer effect of Pt NCs was not dependent on P53. Animal experiments have substantiated the in vivo anticancer properties of Pt NCs, while also revealing their lower toxicity on cells and tissues. …”
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Scaffolded Antigens in Yeast Cell Particle Vaccines Provide Protection against Systemic Polyoma Virus Infection by Donald J. Tipper, Eva Szomolanyi-Tsuda

“…Current YCP formulations, therefore, are not suitable for human use but have considerable potential for use in feed animal vaccines. Significantly, a YCP vaccine expressing a GFP fusion to VP1, the murine polyoma virus major capsid protein, after either oral or subcutaneous administration, protected mice against an intraperitoneal polyoma virus challenge, reducing viral DNA levels in spleen and liver by >98%.…”
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Effect of Human Bone Marrow Mesenchymal Stem Cells on Burn Healing in Granulation Tissue Formation in Diabetic Rats by Gusti Revilla, Deddy Saputra, Dini Nurhasanah

“…Tissue collection was carried out after the termination of the experimental animals on the 3rd, 7th and 14th days and then histological preparations were made to assess the formation of granulation tissue. …”
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Dexamethasone Suppressed LPS-Induced Matrix Metalloproteinase and Its Effect on Endothelial Glycocalyx Shedding by Na Cui, Hao Wang, Yun Long, Longxiang Su, Dawei Liu

“…Male Sprague-Dawley rats were given either a bolus intraperitoneal injection of a nonlethal dose of LPS (Escherichia coli 055:B5, 10 mg/kg, Sigma) or vehicle (pyrogen-free water). Animals of treatment groups were also given either dexamethasone (4 mg/kg, 30 min prior to LPS injection) or the matrix metalloproteinases (MMPs) inhibitor doxycycline (4 mg/kg, 30 min after LPS injection). …”
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Temporally and Spatially Controlled Age-Related Prostate Cancer Model in Mice by Sen Liu, Keyi Shen, Zixuan Li, Seleste Rivero, Qiuyang Zhang

“…In the history of age-related PCa research, mice have become a more popular animal model option than any other species due to their short lifespan and rapid reproduction. …”
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Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains by Elizaveta Anisimova, Dina Yarullina

“…Lactobacillus fermentum colonizing gastrointestinal and urogenital tracts of humans and animals is widely used in manufacturing of fermented products and as probiotics. …”
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The role of Ca2+ signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy by Dan Pan, Mengting Jiang, Guoxian Tao, Jinmei Shi, Zhiwei Song, Ren Chen, Dongguo Wang

“…Background In order to contribute new insights for future prevention and treatment of intrahepatic cholestasis of pregnancy (ICP), and to promote positive pregnancy outcomes, we evaluated serum Ca2+ levels and inositol 1,4,5-trisphosphate receptor (InsP3R) expression in the liver tissue of a rat ICP model.Methods After establishing the model by injection of oestradiol benzoate and progesterone into pregnant rats, animals were divided into normal control (n = 5) and ICP model groups (n = 5). …”
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Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples by Marta Sosnowska, Tomasz Łęga, Marcin Olszewski, Beata Gromadzka

“…The primary concern is the exposure of humans and animals to heavy metal ions through contaminated water. …”
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Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis by Lie Huang, Juan Fan, Yan-Xiang Chen, Jian-Hui Wang

“…A NEC rat model was established and treated with A2BR agonist-BAY60-6583 or A2BR antagonist-PSB1115. Animals in the control group were free from any interventions. …”
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Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q by Sukesh Manthri, Naresh K. Vasireddy, Sindhura Bandaru, Swati Pathak

“…Elliptocytosis in the setting of MDS has rarely been reported, and association with 20q deletion is even rarer. Animal studies have shown that haploinsufficiency of L3MBTL1 contributes to some (20q−) myeloproliferative neoplasms and myelodysplastic syndromes by affecting erythroid differentiation. …”
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Bio-indicator Bacteria Levels in Riva Stream, an Important Stream in İstanbul, Türkiye by Serap Koşal Şahin, Selma Dilara Karaman Baş, Meryem Öztaş, Gülşen Altuğ, Pelin Saliha Çiftçi Türetken

“…These bacteria originate from a variety of sources, including human and animal waste, agricultural runoff, and untreated sewage. …”
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Glutamine and Its Effects on the Intestine by Paul E Hardy, Richard N Fedorak, Alan BR Thomson, Olin G Thurston

“…Glutaminc has been shown to improve gut morphology and outcome in animal models of encerocolitis. It may play a similar role in aiding repair of human intestinal injury in persons with sufficient glutamine in their diet compared to those who arc glutamine deficient. …”
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Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats by Yuka Toyoshima, Katsuyuki Nakamura, Yusuke Taguchi, Reiko Tokita, Shiho Takeuchi, Hayato Osawa, Naomi Teramoto, Hidetoshi Sugihara, Fumiaki Yoshizawa, Keitaro Yamanouchi, Shiro Minami

“…The physiological functions of these proteins have been intensively investigated in mice, while little is known in other animals. Our previous study showed that the disruption of IRS-2 impairs body growth but not glucose tolerance or insulin sensitivity in rats, which led us to hypothesize that IRS-1 plays more pivotal roles in insulin functions than IRS-2. …”
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Prevalence and Risk Factors of Lungworm Infection in Small Ruminants in Selected Districts of Wolaita Zone, Southern Ethiopia by Wondimu Tessema, Minale Getachew, Ephrem Tora

“…Thus, measures like deworming, early treatment, and improving animal husbandry should be practiced.…”
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Understanding the impacts of drought on peanuts (Arachis hypogaea L.): exploring physio-genetic mechanisms to develop drought-resilient peanut cultivars by Sameer Pokhrel, Prasanna Kharel, Swikriti Pandey, Stephanie Botton, Gema Takbir Nugraha, Corley Holbrook, Peggy Ozias-Akins

“…Peanuts under drought stress exhibit higher levels of pre-harvest aflatoxin contamination, a toxic fungal metabolite detrimental to both humans and animals. One way to sustain peanut production in drought-prone regions and address pre-harvest aflatoxin contamination is by developing drought-tolerant peanut cultivars, a process that can be accelerated by understanding the underlying physiological and genetic mechanisms for tolerance to drought stress. …”
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Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism by E. R. de Kloet, M. L. Molendijk

“…In the past decade however the switch from active to passive “coping” was used increasingly to describe the phenotype of an animal that has been exposed to a stressful history and/or genetic modification. …”
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Basic fibroblast growth factor helps protect facial nerve cells in a freeze-induced paralysis model. by Shinji Iwata, Hiroyuki Yamada, Masato Teraoka, Takemichi Tanaka, Takuya Kimura, Tomonori Joko, Yasuhiko Tabata, Hiroyuki Wakisaka, Naohito Hato

“…A severe facial paralysis model was induced in Hartley guinea pigs by freezing the facial canal. Animals were divided into two groups: one group was treated with gelatin hydrogel impregnated with bFGF (bFGF group) and the other was treated with gelatin hydrogel impregnated with saline (control group). …”
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Study on the infection characteristics and pathogenesis of duck circovirus 1 in Cherry Valley meat ducks by Hanqing Li, Guige Xu, Hui Yan, Lei Bei, Mingrui Zhao, Ruihua Zhang, Yu Meng, Yanli Zhu, Liangmeng Wei, Zhijing Xie, Shijin Jiang

“…This study developed an animal model to investigate the pathogenesis of DuCV-1 in vivo by infecting 84 one-day-old Cherry Valley meat ducklings. …”
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Multi-modality Imaging Identifies Key Times for Annexin V Imaging as an Early Predictor of Therapeutic Outcome by Stefanie J. Mandl, Carina Mari, Matthias Edinger, Robert S. Negrin, Jonathan F. Tait, Christopher H. Contag, Francis G. Blankenberg

“…To address this issue, we obtained simultaneous in vivo measurements of tumor burden and uptake of radiolabeled annexin V in the syngeneic orthotopic murine BCL 1 lymphoma model using in vivo bioluminescence imaging (BLI) and small animal single-photon emission computed tomography (SPECT). …”
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Determination of Species‐Specific Differences in Intracranial Volume of Tuj Sheep and Hair Goats Using Stereology and Computed Tomography Methods by Ali Koçyiğit, Betül Kanik, İsmail Demircioğlu, Yasin Demiraslan

“…The aim of this study was to determine the differences between the intracranial cavities of different species of animals by using stereology and tomography methods, volume calculations and morphometric measurements. …”
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