Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…This review synthesizes findings from genetic studies, as well as cellular and animal models, to provide a holistic understanding of <i>RNF213</i>’s involvement in cerebrovascular diseases. …”
Get full text

Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer by Sangsang Tang, Yangyang Li, Yifeng Fang, Mengyan Tu, Shenglong Wu, Yixuan Cen, Junfen Xu

“…More importantly, the therapeutic efficacy of Ga2S3-BSA NMs and their ability to enhance the sensitivity to carboplatin and fluzoparib with negligible toxicity were further confirmed in a platinum-resistant OC animal model. Altogether, our results demonstrated a potentially safe and practical strategy by using Ga2S3-BSA NMs to combat drug resistance in platinum-resistant OC. …”
Get full text

NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats by Ablikim Abliz, Chen Chen, Wenhong Deng, Weixing Wang, Rongze Sun

“…PCBs, widespread endocrine disruptors, cause the disturbance of thyroid hormone (TH) homeostasis in humans and animals. However, the exact mechanism of thyroid dysfunction caused by PCBs is still unknown. …”
Get full text

Diversity and Conservation of Carnivores in Saudi Arabia by Ali Al Ahmari, Farah Neyaz, Faisal Shuraim, Abdul Rahman Al Ghamdi, Ahmad Al Boug, Mesfer Alhlafi, Sharif Al Jbour, Francesco M. Angelici, Saleh Alaamri, Khalid Al Masabi, Zuhair Sami Amr

“…Major threats affecting carnivores include killing and animal trade. The status of the critically endangered species, <i>Panthera pardus nimr</i>, was discussed. …”
Get full text

Determining of &#946;-lactamase activity and resistanee against some antibiotics of staphyloeoeeus strains isolated from bovine mastilis by Durmuş Ali Sevinti, Mitat Şahin

“…This study was carried out in 256 cows which were in lactation period in Sarıkamış town of Kars. The animals were examined c1inically in the point of mastitis and inflamational changes of udders were determined with California Mastitis Test (CMT). …”
Get full text

A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis by Chiara Spinsante, Federica Carducci, Elisa Carotti, Adriana Canapa, Davide Bizzaro, Maria Assunta Biscotti, Marco Barucca

“…Most of these are involved in the transduction of key signals during embryonic development and in the regulation of cholesterol homeostasis. In oviparous animals, the VLDL receptor is also known as VTGR since it facilitates the uptake of vitellogenin in ovary. …”
Get full text

Blood transcriptome resources of chinstrap () and gentoo () penguins from the South Shetland Islands, Antarctica by Bo-Mi Kim, Jihye Jeong, Euna Jo, Do-Hwan Ahn, Jeong-Hoon Kim, Jae-Sung Rhee, Hyun Park

“…Because blood and tissues of penguins have been used to monitor pollution in Antarctica, immune parameters in blood could be important indicators for understanding the health status of penguins and other Antarctic animals. In the blood transcriptomes, KEGG analyses detected many essential genes involved in the major innate immunity pathways, which are key metabolic pathways for maintaining homeostasis against exogenous infections or toxins. …”
Get full text

Selected Parameters of Nutritional and Pro-Health Value in the Common Carp (Cyprinus carpio L.) Muscle Tissue by J. Kłobukowski, K. Skibniewska, K. Janowicz, F. Kłobukowski, E. Siemianowska, E. Terech-Majewska, J. Szarek

“…In all analysed cases, the values of these indices were very favourable and several times lower than for other animal fats.…”
Get full text

Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment by Katherine M. Ranard, Bruce Appel

“…However, the underlying cellular mechanisms involved are largely unknown, and advancements in the field have been limited by the existing tools and animal models. Zebrafish are an excellent model for studying neurodevelopmental mechanisms. …”
Get full text

Genotoxicity Assessment and Protective Effect of Anogeissus leiocarpus Roots against Cyclophosphamide-Induced DNA Damage In Vivo by Aku Enam Motto, Povi Lawson-Evi, Aboudoulatif Diallo, Kwashie Eklu-Gadegbeku

“…The administration of A. leiocarpus did neither increase the ratio of the polychromatic erythrocyte (PCE) nor the frequency of micronucleated PCE (MNPCE) significantly in the bone marrow cells of the mice, compared to the vehicle control animals. However, a significant increase in the incidence of MNPCE in the bone marrow cell of the cyclophosphamide-treated mice was found. …”
Get full text

Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy by Jie Ma, Hongtao Wang, Zhengwei Gui, Yuanrong Yang

“…The effect of SYNGR4 on immune infiltration of breast cancer was analyzed using GSVA, and the effects of SYNGR4 on breast cancer proliferation, migration, and tumor-associated macrophage polarization in cancer foci were verified by cellular and animal experiments, respectively.ResultsSYNGR4 is highly expressed in a variety of malignant tumors, including breast cancer, and affects the prognosis of breast cancer patients. …”
Get full text

Development of Asthma Mouse Model By Dermal Sensitization by Isameldin Abdalla, Amir A. Bashir

“…Extensive research has been done on the prevalence and triggering factors of asthma, however, no experimental research using animal models has been done. Thus, this study aims to develop asthma phenotype in mice with TDI sensitization. …”
Get full text

The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin by Jin Zeng, Fuyang Song, Yi Yang, Chenjie Ma, Guangcun Deng, Yong Li, Yujiong Wang, Xiaoming Liu

“…Clostridium perfringens (C. perfringens) beta2 toxin (CPB2) is an important virulent factor of necrotic enteritis in both animals and humans. However, studies of its pathogenic roles and functional mechanisms have been hampered due to the difficulty of purification and lack of specific antibodies against this toxin. …”
Get full text

Analysis of somatic piRNAs in the malaria mosquito Anopheles coluzzii reveals atypical classes of genic small RNAs by Sergei Funikov, Alexander Rezvykh, Natalia Akulenko, Jiangtao Liang, Igor V. Sharakhov, Alla Kalmykova

“…Piwi-interacting small RNAs (piRNA) play a key role in controlling the activity of transposable elements (TEs) in the animal germline. In diverse arthropod species, including the pathogen vectors mosquitoes, the piRNA pathway is also active in nongonadal somatic tissues, where its targets and functions are less clear. …”
Get full text

Phenotypic Plasticity in Gut Length in the Planktivorous Filter-Feeding Silver Carp (Hypophthalmichthys molitrix) by Zhixin Ke, Xie Ping, Longgen Guo

“…Phenotypic plasticity widely exists in the external morphology of animals as well as the internal traits of organs. …”
Get full text

Comparative Biotypic and Phylogenetic Profiles of Escherichia coli Isolated from Resident Stool and Lagoon in Fresco (Côte d’Ivoire) by Nadége Kouadio-Ngbesso, Koua Atobla, Paul Yao Attien, Mireille Kouame-Sina, René Ahua Koffi, Antoinette Ama Adingra, Adjehi Dadié

“…The diversity of E. coli biotypes observed in this study revealed animal and human origins of contaminations. A close relationship was found between water and human strains, and the presence of commensal and extraintestinal pathogenic E. coli in all samples could represent a potential reservoir of extraintestinal infections for resident populations.…”
Get full text

Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice by Jialu Shi, Yan Xu, Cheng Liu, Shizhi Wang, Jin Wang, Vijaya Raghavan

“…Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated. …”
Get full text

Comparison of bison and elk susceptibility to experimental challenge with Brucella abortus strain 2308 by S. C. Olsen, P. M. Boggiatto, E. J. Putz

“…In elk or bison that aborted, mean colonization in placentome tissues were typically more than 5 logs higher than in animals that did not abort.DiscussionThe results of our study suggest differences in disease pathogenesis between these two wildlife reservoirs of B. abortus.…”
Get full text

CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

“…However, the function of CDK14 during organ development and regeneration has not been investigated in genetically-modified animals. Here, we found that genetic ablation of Cdk14 influenced pulmonary vascular endothelial cells and alveolar epithelial cells during mice embryonic development as well as repair of lung after bleomycin or lipopolysaccharide induced injury. …”
Get full text

Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus by Yuan Liu, Liping Dai, Weihong Liu, Guixiu Shi, Jianying Zhang

“…MDM2 has been reported to be overexpressed in SLE animal model and to promote SLE. Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE patients. …”
Get full text