Effect of l-carnıtıne used ın regular exercıse ın elderly obesıs rats by Aynur Başalp, İbrahim Kubilay Türkay

“…This experimental study was carried out on experimental animals in a scientific laboratory environment, under defined conditions and according to the method of application. …”
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment by Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest

“…Intrinsic host mechanisms that control virus-driven cellular expansion are incompletely defined. Using a small-animal model of gammaherpesvirus pathogenesis, we demonstrate in vivo that the tumor suppressor p53 is activated specifically in B cells latently infected by murine gammaherpesvirus 68. …”
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Genome-scale evolution in local populations of wild chimpanzees by Takashi Hayakawa, Takushi Kishida, Yasuhiro Go, Eiji Inoue, Eri Kawaguchi, Tomoyuki Aizu, Hinako Ishizaki, Atsushi Toyoda, Asao Fujiyama, Tetsuro Matsuzawa, Chie Hashimoto, Takeshi Furuichi, Kiyokazu Agata

“…Abstract Analysis of genome-scale evolution has been difficult in large, endangered animals because opportunities to collect high-quality genetic samples are limited. …”
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Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees by Pramod Nehete, Elizabeth R. Magden, Bharti Nehete, Patrick W. Hanley, Christian R. Abee

“…We also observed an obesity-related effect on immune function as demonstrated by lower mitogen induced proliferation, and natural killer activity and higher production of IFN-γ by PBMC in Elispot assay, These findings suggest that lean, overweight, and obese chimpanzees share circulating inflammatory cytokines and metabolic hormone levels with humans and that chimpanzees can serve as a useful animal model for human studies.…”
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EFFECTIVENESS EDGE DETECTION OPERATOR CANNY TO IMPROVE IMAGE QUALITY THORAX CT SCAN IN CASES COVID-19 by Prima Selvia Megawati, M. Choiroel Anwar, Fatimah, Sudiyono, Darmini, Saifudin

“…Canny operator edge detection technique is one solution to animate noise. Purpose: Analyzing differences in image quality and anatomical information on thorax CT scan images in COVID-19 patients before and after the application of canny operator edge detection techniques. …”
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Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae. by Md Nahian, Muhammad Shahab, Md Rasel Khan, Shopnil Akash, Tanjina Akhtar Banu, Murshed Hasan Sarkar, Barna Goswami, Sanjana Fatema Chowdhury, Mohammad Ariful Islam, Ahmed Abu Rus'd, Shamima Begum, Ahashan Habib, Aftab Ali Shaikh, Jonas Ivan Nobre Oliveira, Shahina Akter

“…Docking analysis of the vaccine candidate by ClusPro demonstrated robust and stable binding interactions between the MEV and toll-like receptor 4 in both humans and animals. The iMOD server and Amber v.22 tool has verified the stability of the docking complexes. …”
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Optimizing infrared drying of black soldier fly larvae for sustainable cricket feed production by Nuntawat Butwong, Sarawut Saenkham, Adisak Pattiya, Anuwat Saenpong, Chinnapat Turakarn, Aphichon Mungchu, Shenghua Hu, Sopa Cansee

“…As global demand for animal-derived protein surges, Black soldier fly larvae emerge as a promising sustainable feed source, particularly for cricket farming. …”
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Increasing food sustainability by utilization of biowaste to grow mealworms and their nutrient profile as human food by Nariman Ktil, Ida Holásková, Yong-Lak Park, Cangliang Shen, Kristen E. Matak, Jacek Jaczynski

“…Mealworms, particularly larvae are dense source of animal protein and fat for isolation and extraction to develop human food. …”
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How Significant Are Marine Invertebrate Collagens? Exploring Trends in Research and Innovation by Mariana Almeida, Tiago Silva, Runar Gjerp Solstad, Ana I. Lillebø, Ricardo Calado, Helena Vieira

“…Globally, key applications registered are mostly in medical, dental and toiletry areas, with peptide preparations spanning multiple animal groups. The food domain is notably relevant for molluscs and sea cucumbers. …”
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Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine by Alberto Fragoso, Mérida Pedraza-Jiménez, Laura Espinoza-González, María Luisa Ceja-Mendoza, Hugo Sánchez-Mercado, Gloria Robles-Pérez, Julio Granados, Emilio Medina-Rivero

“…A complex mixture of peptides plays a key role in the regulation of the immune system; different sources as raw materials mainly from animals and vegetables have been reported to provide these extracts. …”
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Sugemule-7 alleviates oxidative stress, neuroinflammation, and cell death, promoting synaptic plasticity recovery in mice with postpartum depression by Qiang Fu, Rui Qiu, Jiaquan Liang, Shuai Wu, Dezhi Huang, Yuxiang Qin, Qiaosheng Li, Xiaojie Shi, Xiyue Xiong, Zhongyong Jiang, Yuewen Chen, Yong Cheng

“…To investigate its preventive effects on PPD, we established an animal model and administered the drug Sugemule-7. …”
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Comprehensive Update on Rabies: A Neglected Zoonotic Disease of Public Health Concern by Kavitha Guladahalli Manjunatha, Chethana Chandrahasa, Sadanand Dangari Akshay, Akhila Dharnappa Sannejal, Rajeshwari Vittal, Govindaiah Kavitha, Khang Wen Goh, Shrikrishna Isloor, Devananda Devegowda

“…The virus targets the central nervous system of warm-blooded animals and claims the lives of over 60,000 individuals annually. …”
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Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes by Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus

“…These enzymes have demonstrated remarkable protective and antidotal value against some different organophosphorus compounds in vivo in animal models. Apart from that, enzyme treatments have also been applied for decontamination purposes. …”
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The ultradian rhythm of glucocorticoid secretion and the time course of target gene regulation by V. M. Merkulov, N. V. Klimova, T. I. Merkulova

“…This review summarizes the current scarce information, obtained in experiments mimicking the ultradian mode of natural hormone secretion in cultured cells and in animal models. The results of these experiments clearly demonstrate that ultradian stimulation by natural hormones induces rapid GR exchange with glucocorticoid response elements and leads to cyclic GR mediated transcriptional regulation (gene pulsing) at the level of nascent RNA. …”
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An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers of Pheretima by Ye Shang, Suyi Liu, Chunxiao Liang, Kunze Du, Shujing Chen, Jin Li, Hua Jin, Yanxu Chang

“…Pheretima, one of the animal-derived traditional Chinese medicines, has been wildly used in various cardiovascular and cerebrovascular diseases, including stroke, coronary heart disease, hyperlipidemia, and hyperglycemia. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…Substantial theoretical feasibility has been demonstrated at the levels of gene expression, molecular interactions, and intercellular dynamics, complemented by numerous successful animal studies. However, a robust model and carrier that closely resemble human physiology are still lacking for translating these theories into practice. …”
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In-Vitro Anthelminthic Potential of Ethanolic and Methanolic Stem Bark Extract of Adansonia digitata Linn (Baobab Tree) on earthworms (Pheritima posthuma) by A. A. Biu, J. Wasagwa, T. E. Onyiche, F. M. Muhammad

“… Medicinal plants have been used for decades by rural dwellers to alleviate suffering due to parasitic diseases and interest have grown in recent times on their application as alternatives for deworming of animals. Hence, this study was undertaken to investigated the in vitro anthelminthic potential of ethanolic and methanolic stem bark extracts of activity of Adansonia digitata Linn (Baobab Tree) on earthworms (Pheritima posthuma) using 12.5, 25.0, 50.0 and 100.0 mg/mL ethanolic and methanolic extract concentrations. …”
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Breeding and selection of mini-pigs in the ICG SB RAS by S. V. Nikitin, S. P. Knyazev, K. S. Shatokhin, V. I. Zaporozhets, V. I. Ermolaev

“…It turned out that effective evaluation of the genetic potential of mini-pigs in growth rate and fnal size of individuals is only possible under the condition of a rich and full feeding of young animals. The time scale of estimation of growth of live weight of the ICG mini-pigs for three weight categories allocated in the selection group is presented. …”
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Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus) by Giuseppe Magro

“…The objective of this review is to provide pathophysiological and pre-clinical evidence, mostly from animal studies, for the different approach of combined polytherapy from the start for those cases of SE falling in the definition of Stage 1 Plus.…”
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Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway by Meng Liu, Hui Liu, Hong Kang, Juan Wu, Puhua Xing, Xiaorui Ding, Yangyang Wei, Xiaomei Kong

“…This study aimed to examine the effects of anisodamine (ANI) on pulmonary inflammation and fibrosis in silicosis, as well as to elucidate the underlying molecular mechanisms. Animal experiments demonstrated that ANI significantly reduced alveolar structure damage and the formation of silicosis nodules in affected mice, as confirmed by pathological slides. …”
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