A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…AS1411-HSA-LDP-AE exhibited a strong cell-killing activity in esophageal cancer cells, inhibited cell migration and invasion, and induced cell apoptosis. The animal studies confirmed that AS1411-HSA-LDP-AE exhibited a strong anti-tumor effect. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. …”
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Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health by Jacopo Logiudice, Maria Alberti, Andrea Ciccarone, Benedetta Rossi, Giorgio Tiecco, Maria Antonia De Francesco, Eugenia Quiros-Roldan

“…By emphasizing the importance of interconnected human, animal, and environmental health, integrated One Health strategies are crucial in addressing this complex issue. …”
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…Pharmacological inhibition or siRNA depletion of GSK3β selectively suppressed the growth of FHIT-deficient lung cancer tumors in vitro and in animal models. We further showed that FHIT inactivation leads to the activation of DNA damage repair pathways, including the HRR and NHEJ pathways, in lung cancer cells. …”
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The effect of yeast on the treatment and prevention of experimentally induced cerebrocortical necrosis in lambs by Mahmut Ok, Kemal Irmak, Mustafa Ortatatlı, Veysi Aslan, Kemal Çiftçi, ismail Şen, Fatih M. Birdane

“…Nine lambs were divided into 3 groups. Each group had 3 animals. Amprolium (600 mg/kg/ day) was given to induce CCN orally to all the groups during experiment by stomach tube. …”
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Investigation of some hematological parameters in the hamdani sheep by Ayşegül Bildik, Fatmagül Yur, Ferda Belge, Yeter Değer, Semiha Dede

“…In addition, haematocrit was determinated by using microhaematocrit technique. Animals having over 25 mg/dl glutathione were designated as high glutathione type (GSH^H). …”
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¿Es la crueldad constitutiva del ser humano? Meditaciones a partir de Nietzsche y Freud by Víctor Ignacio Coronel Piña

“…En el segundo, se muestran los aspectos fundamentales de la concepción nietzscheana de la crueldad en la que se pone de manifiesto que el hombre es el animal más cruel. En el tercero, se aborda la concepción del hombre que surge de la teoría psicoanalítica freudiana, en la que la pulsión de destrucción es clave. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…Despite harmful studies on both subjects, there are few studies on how temperature increases plastics’ adverse effects on aquatic animals, mainly freshwater species. So, this study aims to clarify the potential impact of temperature increases on the toxicological properties of polyvinyl chloride nano-plastics (PVC-NPs) in Nile tilapia (Oreochromis niloticus) by measuring biochemical and oxidative biomarkers. …”
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Evaluation of the effects of maintaining a moderate humidity (50–60%) and increased air movement on litter moisture and footpad health in a commercial broiler house by C.T. Mou, M. Czarick, III, B.D. Fairchild

“…Although there are methods to help reduce the occurrence of high litter moisture, such as ventilation and proper drinker management, these methods need to evolve due to increasing consumer demands and more stringent animal welfare guidelines. A potentially cost-effective method may be ventilating houses to maintain a moderate RH level (60% or lower) and increasing the amount of air movement (150 ft/min) over the litter surface through circulation fans. …”
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Biochemical and Molecular Analysis of Staphylococcus aureus Clinical Isolates from Hospitalized Patients by Amit Karmakar, Parimal Dua, Chandradipa Ghosh

“…Staphylococcus aureus is opportunistic human as well as animal pathogen that causes a variety of diseases. …”
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Research priorities for improving cognitive and neuropsychological outcomes in hydrocephalus by Nickolas Dasher, T. Andrew Zabel, Maria Garcia-Bonilla, Lauren L. Jantzie, Mark G. Hamilton, Michael A. Williams, Monica J. Chau

“…These topics included cognitive and neuropsychological assessments and daily-life function of children and adults living with hydrocephalus, biomarkers of cognitive function, animal modeling of hydrocephalus, and the longitudinal impact of hydrocephalus treatment. …”
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Recent advances in small molecule LpxC inhibitors against gram-negative bacteria (2014–2024) by Pengpeng Ji, Meng Ma, Xiaoyue Geng, Jian Zhang

“…This paper mainly focuses on the structure optimization, conformational relationship and animal toxicity of small molecule LpxC inhibitors over the past 10 years, especially in the last 5 years, in order to provide ideas for the development and clinical research of LpxC inhibitors.…”
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OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy by Zeev Dvashi, Keren Ben-Yaakov, Tamir Weinberg, Yoel Greenwald, Ayala Pollack

“…This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods. Antifibrotic effect of OM-101 was investigated in vivo. …”
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Ichnologic and sedimentologic datasets from the Ediacaran–Cambrian Chapel island formation, Newfoundland, CanadaMendeley Data by Romain Gougeon, M. Gabriela Mángano, Luis A. Buatois, Guy M. Narbonne, Brittany A. Laing, Maximiliano Paz

“…The datasets are of importance to researchers interested in the palaeoecological signals depicted in this classic Ediacaran–Cambrian succession or in the compilation of worldwide data for deciphering macro-evolutionary trends in early animal life.…”
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How to Deal with Pulpitis: An Overview of New Approaches by Jakub Fiegler-Rudol, Wojciech Niemczyk, Katarzyna Janik, Anna Zawilska, Małgorzata Kępa, Marta Tanasiewicz

“…<b>Methods:</b> A narrative review was conducted using PubMed, Scopus, and Embase to identify studies published between 2010 and 2023. In vitro, animal, and clinical studies focusing on innovative regenerative endodontic techniques were analyzed. …”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

“…Parchment was used as a writing material in the Middle Ages and was made using animal skins by liming them with Ca(OH)2. During liming, collagen peptides containing Glutamine (Q) undergo deamidation resulting in a mass shift of 0.984 Da. …”
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Bacterial wilt disease alters the structure and function of fungal communities around plant roots by Jiemeng Tao, Jingjing Jin, Peng Lu, Shizhou Yu, Mengli Gu, Jinbang Wang, Jianfeng Zhang, Peijian Cao

“…Functional predictions based on FUNGuild suggested that with the pathogen infection, saprotrophic fungi were increased in the bulk soil, but pathotrophic fungi (potential plant and animal pathogens) were increased in the rhizosphere, rhizoplane and endosphere. …”
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Validity of Visible Ectoparasite Intensity As a Non-invasive Biomarker for Fish welfare: Parasitic Copepod, Lernantropus kroyeri in Sea Bass As an Example by Hijran Yavuzcan

“…The presence of reliable welfare assessment schemes is of utmost importance to appraise the well-being of animals in aquaculture and uphold stringent welfare standards. …”
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. …”
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A Simple Method for Generating Narrowly-dispersed Bioaerosols in Various Sizes by Young-Su Jeong, Hyunsoo Seo, Sang-Soo Han, Young-Jin Koh, Kibong Choi

“…Abstract Biological warfare agents (BWAs) cause disease in humans, animals, and plants when purposefully dispersed in an area. …”
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