Inhibiting H3K27 Demethylases Downregulates CREB‐CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia by Juan Lazaro‐Navarro, Clara Alcon, Mathurin Dorel, Lina Alasfar, Lorenz Bastian, Claudia Baldus, Kathy Astrahantseff, Marie‐Laure Yaspo, Joan Montero, Cornelia Eckert

“…Anti‐tumor effects have previously been demonstrated for GSK‐J4, a selective H3K27 histone demethylase inhibitor, in several animal models of cancers. Methods To characterize the effect of GSK‐J4, drug response profiling, CRISPR‐Dropout Screening, BH3 profiling and immunoblotting were carried out in ALL cell lines or patient derived samples. …”
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Ultrasound evaluation of colic in horses: Diagnosis and severity assessment by Mahmood K. Ali, Osamah M. Aliraqi

“…Considered as the control group, animals in both groups are more than one year old and are of both sexes. …”
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The Role of IL-33 in Gut Mucosal Inflammation by Luca Pastorelli, Carlo De Salvo, Maurizio Vecchi, Theresa T. Pizarro

“…In 2010, four different research groups consistently described the upregulation of IL-33 in patients with inflammatory bowel disease (IBD). Animal models of IBD were subsequently utilized in order to mechanistically determine the precise role of IL-33 in chronic intestinal inflammation, without, however, reaching conclusive evidence demonstrating whether IL-33 is pathogenic or protective. …”
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The Role of Cyclooxygenase in Multiplication and Reactivation of HSV-1 in Vestibular Ganglion Neurons by Yuehong Liu, Shufeng Li, Zhengmin Wang

“…Due to the difficulties of constructing in vivo animal models, in this study, we developed a vestibular ganglion culture system, in which vestibular neurons were latently or lytically infected with HSV-1. …”
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Limited benefits of organic management and fungicide reduction to ground beetles in vineyards by Julia T. Gieser, Sebastian Kolb, Jo Marie Reiff, Kai Riess, Maura Hunke, Martin H. Entling, Jens Schirmel

“…Abstract The use of fungicides in agriculture can reduce animal biodiversity. Such non‐target effects could be mitigated through fungus‐resistant cultivars that reduce the need for fungicide applications. …”
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Effects of polymethylmethacrylate nanoplastics on the swimming behaviour and gut microbiome of the freshwater amphipod Gammarus pulex by Sareh Yaripour, Mandar Bandekar, Jiri Vihavainen, Kuldeep More, Aslak Eronen, Manuela Faria Durão, Mikhail Daneliya, Tuure Houni, Tia Halonen, Jari T.T. Leskinen, Jaakko Haverinen, Hannu Huuskonen, Ulrika Candolin, Jukka Kekäläinen, Raine Kortet

“…Nanoplastic particles (NPs: <1000 nm) have been drawing attention for their potential toxicological implications on organisms. Aquatic animals are increasingly exposed to NPs but their effects on many aquatic invertebrates remain inadequately known. …”
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A localized tracing technique to explore intra-amygdala functional and structural correlates of individual variability in behavioral response by Allie Lipshutz, Allie Lipshutz, Victoria Saltz, Victoria Saltz, Victoria Saltz, Kristin R. Anderson, Kristin R. Anderson, Alessia Manganaro, Alessia Manganaro, Dani Dumitriu, Dani Dumitriu, Dani Dumitriu

“…While these studies are necessary to untangle largescale connectivity, most social behaviors are mediated and fine-tuned by local subregional circuitry.MethodsIn order to probe this local, interregional connectivity, we present a new combination of a neuronal tracing system with immediate early gene immunohistochemistry for examining structural and functional connectivity within the same animal. Specifically, we combine a retrograde transsynaptic rabies tracing system with cFos colocalization immediately after an acute stressor to elucidate local structural and stress-activated connectivity within the amygdala complex in female and male mice.Results and discussionWe show how specific structural and functional connections can predict individual variability along a spectrum of social approach/avoidance following acute social defeat stress. …”
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A Case Report of Dextrocardia with Situs Inversus: A Rare Condition and Its Clinical Importance by Girma Deshimo, Haile Abebe, Getiye Damtew, Enguday Demeke, Seife Feleke

“…Aristotle initially described situs inversus in animals, while Fabricius first characterized it in humans. …”
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The Role of the IL-20 Subfamily in Glaucoma by Mary K. Wirtz, Kate E. Keller

“…Several studies suggest a possible link between glaucoma and inflammation in humans and animal models. In particular, our lab recently identified a T104M mutation in IL-20 receptor-B (IL-20RB) in primary open angle glaucoma patients from a large pedigree. …”
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Memory consolidation from a reinforcement learning perspective by Jong Won Lee, Min Whan Jung, Min Whan Jung

“…Over the past two decades, studies in humans and animals have demonstrated that the hippocampus is crucial not only for memory but also for imagination and future planning, with the CA3 region playing a pivotal role in generating novel activity patterns. …”
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Tumor Metastasis to the Liver, and the Roles of Proteinases and Adhesion Molecules: New Concepts from In Vivo Videomicroscopy by Alan C Groom, Ian C MacDonald, Eric E Schmidt, Vincent L Morris, Ann F Chambers

“…In vivo videomicroscopy permits direct observations of sequential steps in hematogenous metastasis as they occur in living animals over time. These steps include initial arrest of cells in the microcirculation, extravasation, postextravasation migration and growth in the target organ. …”
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Exploration of the mechanism of fermented turmeric preventing glucolipid metabolic disorder: Insights into signaling of microbiota-SCFAs-brown adipose tissue axis in mice by Xingliang Xiang, Yukun Liu, Zhaoxiang Zeng, Xueyan Zhao, Qingxin Shi, Xing Huang, Haijun Yang, Chengwu Song, Shunqing Xu, Shuna Jin

“…In this study, the activity of FT on GMD involving brown adipose tissue (BAT) was investigated. The results of animal experiment suggested that 4-week FT supplement comprehensively improved the characteristic symptoms of GMD, showing better therapeutic efficacy than crude turmeric. …”
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Structurally sophisticated 3D-printed PCL-fibrin hydrogel meniscal scaffold promotes in situ regeneration in the rabbit knee meniscus by Hebin Ma, Bowen Xie, Hongguang Chen, Lifang Hao, Haigang Jia, Dengjie Yu, Yuanbo Zhou, Puzhen Song, Yajing Li, Jing Liu, Kaitao Yu, Yantao Zhao, Yadong Zhang

“…Physical and chemical characterization, biocompatibility testing, and in vivo animal experiments revealed the excellent biomechanical properties and biocompatibility of the scaffold, which enhanced in situ meniscal regeneration and reduced osteoarthritis progression. …”
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Tailoring IPM plans to fight a cloaked pest: helping smallholder farmers combat the sweetpotato weevil in sub-Saharan Africa by Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema

“…In sub-Saharan Africa (SSA), sweetpotato serves as an important year-round source of calories and nutrition, a form of income for smallholder and pre-commercial farmers, and is increasingly used as silage for animal feed. However, yield per hectare is considerably lower in SSA than from other regions primarily due to sweetpotato weevils (SPW, Cylas spp., Coleoptera: Brentidae). …”
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Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phas... by Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W. Nielsen, Rasmus Møgelvang, Klaus F. Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-Sørensen, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond

“…It is produced without animal products, in closed bioreactor systems and cryopreserved as an off-the-shelf product ready to use. …”
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Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain by Anton Pikhovych, Nina Paloma Stolberg, Lea Jessica Flitsch, Helene Luise Walter, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

“…Furthermore, data suggest that the effects of tDCS may be animal- and polarity-specific.…”
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A Novel Platelet Activating Factor Receptor Antagonist Reduces Cell Infiltration and Expression of Inflammatory Mediators in Mice Exposed to Desiccating Conditions after PRK by Salomon Esquenazi, Jiucheng He, Na Li, Nicolas G. Bazan, Isi Esquenazi, Haydee E. P. Bazan

“…The other twenty mice underwent bilateral PRK and were divided in two additional groups: ten mice remained under normal conditions (NC) and the other ten were exposed to DE. After 1 week all animals underwent in vivo confocal microscopy, immunostaining and western blotting analysis. …”
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CHANGES IN AMINO ACID COMPOSITION OF BLOOD PROTEIN HYDROLYSATE DEPENDING ON THE RAW MATERIAL PREPARATION MATERIAL by M. N. Guseva, М. A. Shevchenko, D. S. Bolshakov, M. I. Doronin, D. V. Mikhalishin, A. A. Shishkova, V. V. Mikhalishin

“…The raw material for blood protein hydrolysate preparation is whole animal blood, its clots and other serum production wastes. …”
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MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication by Jonathan Cahn, Michael Regulski, Jason Lynn, Evan Ernst, Cristiane de Santis Alves, Srividya Ramakrishnan, Kapeel Chougule, Sharon Wei, Zhenyuan Lu, Xiaosa Xu, Umamaheswari Ramu, Jorg Drenkow, Melissa Kramer, Arun Seetharam, Matthew B. Hufford, W. Richard McCombie, Doreen Ware, David Jackson, Michael C. Schatz, Thomas R. Gingeras, Robert A. Martienssen

“…Integrated analysis with chromatin modifications results in the identification of a comprehensive set of regulatory regions in each tissue of each inbred, and notably of distal enhancers expressing non-coding enhancer RNAs bi-directionally, reminiscent of “super enhancers” in animal genomes. Furthermore, the morphological traits selected during domestication are recapitulated, both in gene expression and within regulatory regions containing enhancer RNAs, while highlighting the conflict between enhancer activity and silencing of the neighboring transposable elements.…”
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Dystrophic Adipocytes Mimicking Metastatic Signet Ring Cell Adenocarcinoma: A Diagnostic Pitfall in a Cachectic Patient by Xin Zhang, Jennifer J. Findeis-Hosey

“…While pathological changes of cachectic conditions on adipose tissue have been studied and documented in tumor-bearing animal models, similar morphological changes in human surgical specimens are rare. …”
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