Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…The scope of this review article is to comprehensively review the literature on the possible role of adrenergic receptors in neurodegenerative diseases, stemming from the use of agonists and antagonists including antihypertensive and asthma drugs acting on the adrenergic receptors, but also from animal models and in vitro models where these receptors have been studied. …”
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

“…Therefore, this paper will focus on considerations for several key aspects of preclinical stroke studies including the selection and execution of the animal stroke model, drug/experimental treatment administration, and outcome measures to improve experimental validity and translation potential. …”
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Viral Transgene Expression Delivered by Repeat Intraocular Adenoviral Vector Injection: in Vivo Live Imaging Study by Peter L. Gehlbach, Roy S. Chuck, Chung-Gyu Park, Choul Yong Park

“…In vivo live imaging technology was able to assess dynamically intraocular luciferase expression in a single animal population throughout the entire experiment period. …”
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Effectiveness of natural coagulants in water and wastewater treatment by S. Nimesha, C. Hewawasam, D. Jayasanka, Y. Murakami, N. Araki, N. Maharjan

“…Natural coagulants are derived from either plants, animals, or microorganisms. This study has elaborated on the nature and mechanisms, and types of natural coagulants. …”
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Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease by Marius Vital, Jack R. Harkema, Mike Rizzo, James Tiedje, Christina Brandenberger

“…After challenge, the animals were sacrificed, blood serum was collected for cytokine analysis, and the lungs were processed for histopathology. …”
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Significance of Persistent Inflammation in Respiratory Disorders Induced by Nanoparticles by Yasuo Morimoto, Hiroto Izumi, Etsushi Kuroda

“…Pulmonary inflammation, especially persistent inflammation, has been found to play a key role in respiratory disorders induced by nanoparticles in animal models. In inhalation studies and instillation studies of nanomaterials, persistent inflammation is composed of neutrophils and alveolar macrophages, and its pathogenesis is related to chemokines such as the cytokine-induced neutrophil chemoattractant (CINC) family and macrophage inflammatory protein-1α and oxidant stress-related genes such as heme oxygenase-1 (HO-1). …”
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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. …”
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Dehydration-Induced Anorexia Reduces Astrocyte Density in the Rat Corpus Callosum by Daniel Reyes-Haro, Francisco Emmanuel Labrada-Moncada, Ricardo Miledi, Ataúlfo Martínez-Torres

“…Anorexia nervosa is an eating disorder associated with severe weight loss as a consequence of voluntary food intake avoidance. Animal models such as dehydration-induced anorexia (DIA) mimic core features of the disorder, including voluntary reduction in food intake, which compromises the supply of energy to the brain. …”
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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus. We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases.…”
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Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes by Hudiyanti Dwi, Hidayati Salma Nur, Siahaan Parsaoran, Ngadiwiyana Ngadiwiyana, Nur Abidin, Sari Ratna Indria, Amalia Indrian Rizka, Christa Sherllyn Meida, Patrechia Amanda Chindy, Maharani Adinda Eka

“…Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. …”
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Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention by Shoko Horita, Motonobu Nakamura, Nobuhiko Satoh, Masashi Suzuki, George Seki

“…TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at least, in experimental animals. However, TZDs have side effects, such as edema, congestive heart failure, and bone fracture, and may increase bladder cancer risk. …”
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Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Diseas... by Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter

“…We now report that delayed post lesion treatment with 2R,4R-APDC (10 nmol), results in robust neuroprotection of the nigrostriatal system, which translated into functional recovery as measured by improved forelimb use asymmetry and reduced (+)-amphetamine-induced rotation compared to vehicle treated animals. Interestingly, these beneficial effects were associated with a decrease in microglial markers in the SNc, which may suggest an antiinflammatory action of this drug.…”
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Efficacy of Oregano Extract Ointment on Fibroblast Cells and Epidermis in Albino Rats with Excisional Wound Model by Muhammad Arfan Lesmana, Indah Amalia Amri, Ardilla Rachma Cahyanissa, Kartika Myrnandari Geoputri, Agri Kaltaria Anisa, Andreas Bandang Hardian

“…This study aimed to determine the effect of oregano extract ointment therapy on the number of fibroblast cells and the epidermal thickness in excised wounds. The experimental animals used were 20 male Wistar strain albino rats, 12 weeks old, weighing 100–150 g, divided into 5 treatment groups i.e., (C-) not excised and without ointment, (C+) excised and without ointment, and the treatment group were excised using a 5 x 5 mm biopsy punch and treated with oregano extract ointment using concentrations of (T1) 3%, (T2) 6% and (T3) 9% twice daily for 14 days in an excised wound. …”
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Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster by Yi Zhang, Hongfei Cai, Zhu Tao, Cheng Yuan, Zhaojian Jiang, Juyan Liu, Hiroshi Kurihara, Wendong Xu

“…Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models.…”
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Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila by Bryon Silva, Claudia Molina-Fernández, María Beatriz Ugalde, Eduardo I. Tognarelli, Cristian Angel, Jorge M. Campusano

“…This effect is not explained by an alteration in the ability of animals to respond to odorants or to execute motor programs. …”
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Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk by Fang Zhou, Peerzada Tajamul Mumtaz, Haluk Dogan, Roland Madadjim, Juan Cui, Janos Zempleni

“…Here, we report that small extracellular vesicles (sEVs) in milk mediate the communication between bacteria and animal kingdoms, increase the divergence of bacteria in the intestine, and alter metabolite production by bacteria. …”
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Domestic Horse Bite: An Unusual Etiology of Crush Injury of the Fourth Finger—How to Manage? by Naoufal Elghoul, Youssef Jalal, Ayoub Bouya, Ali Zine, Abdeloihab Jaafar

“…Almost 2% of all emergency admissions involve an animal bite. While horses bite humans very rarely, their bites are mostly associated with fatalities. …”
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Paleoclimatic Changes and their Influence on Cultural and Historical Processes during the Neolithic – Eneolitic in the Caspian and Lower Volga Regions by Marianna A. Kulkova, Alexander A. Vybornov

“…Eneolithic communities of the Khvalynsk culture, in whose economy appeared copper production together with animal domestication, begin to spread already at the end of a short-term aridization of the climate around 4700 BC in semi-desert and steppe zones.…”
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Prémisses de la critique textuelle dans la culture écrite du XVIII-e siècle by Eugen Pavel

“…There are written proofs of the attempts done at the royal court of Nicholas Mavrocordatos, among which the ones made by Transylvanian Hellenist specialist Stephan Bergler to critically edit some medieval manuscripts, followed by the hard work of some typographic correctors, such as the Greek monk Mitrofan Gregoras, or as the monks Rafail, Anatolie and Lavrentie, from the Hurezi convent, and also Mihalcea Litterati or Cozma Vlahul, who prove their incipient qualities of editors. An animator and mentor of the editing process would also be the Moldavian hierarch Leon Gheuca. …”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Daily treatment with OB-002 altered immune gene transcription in the lungs, and reduced pathology following infection, but did not prevent weight loss or viral replication in the lungs of infected animals, even in combination with the antiviral drug remdesivir. …”
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