Clinical outcomes and long-term efficacy of high tibial osteotomy in treating knee instability: An updated systematic review by Mustamsir Edi, Aji Aulia Pandu, Adiwangsa Ahmad Abdilla, Akmalizzan Azfar Ahnaf

“…Exclusion criteria included animal studies, non-knee joint studies, and reviews. …”
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Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats by Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Zhou, Yaqin Liu, Shentao Wu

“…The present study is aimed at evaluating a Chinese medicinal formula, Tangduqing granules (TDQ), with multifaceted actions against lipid and glucose metabolism disorder and IR of type 2 diabetes. An animal model of type 2 diabetes was developed by high-fat diet feeding plus low-dose streptozotocin injection. …”
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Recovery response of coenzyme Q10 to exercise-related physiological muscle damage, inflammation and oxidative stress: A systematic review by Muhammet Enes Yasul, Vedat Çınar, Yavuz Yasul, Büşra Yılmaz, Ömer Şenel

“…In the analysis, one study was conducted with experimental animals, two studies were conducted with male and female participants, and 12 studies were conducted with only male participants. …”
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Fermentation of poultry manure for improving its quality and safety as ruminant feed by Sharmeen Islam, A. K. M. Ahsan Kabir, Md. Rokibul Islam Khan

“…Conclusion: To summarize all properties, it could be noted that the quality and safety of PM were improved after 7 days of fermentation with a fermentation mixture of PM (90%) and molasses (10%) inoculating 10% IMO under an anaerobic condition which could be used for animal feeding. Research Highlights: Utilization of poultry manure by fermentation process Use of Saccharomyces cerevisiae and indigenous microorganisms (IMO) Improving quality and safety as ruminant feed…”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Using a preclinical murine sepsis model, we found that both PKCα knockout and the use of a PKCα-inhibitor midostaurin successfully restored liver function without hindering the host’s response or ability to clear the pathogen, highlighting PKCα’s vital role in excretory liver failure. In septic animals, both approaches significantly boosted survival rates. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…The most potent inhibitor was evaluated in vivo in two animal models and the mechanisms of action were investigated by RNA sequencing, Western blotting and immunofluorescence staining. …”
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Hybrid and/or mixed infection by pig and human Ascaris in a Guarani indigenous village in southern Brazil. by Veridiana Lenartovicz Boeira, Renata Coltro Bezagio, Marina Silva de Carvalho, Rinaldo Ferreira Gandra, Ana Paula de Abreu, Cristiano Lara Massara, Cristiane Maria Colli, Max Jean de Ornelas Toledo

“…<h4>Conclusions/significance</h4>The results of this study confirm the necessity of a One Health approach with the correct disposal of both human and animal feces to control the spread of human and swine ascariasis.…”
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Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model by Emma Steijvers, Yunshong Shi, Hong Lu, Weixin Zhang, Yitian Zhang, Feihu Zhao, Baichuan Wang, Louise Hughes, Jake E. Barralet, Giulia Degli-Alessandrini, Igor Kraev, Richard Johnston, Zengwu Shao, Frank H. Ebetino, James T. Triffitt, R. Graham G. Russell, Davide Deganello, Xu Cao, Zhidao Xia

“…Rapid intramembranous bone formation was observed at 14 days, with 4- to 8-fold increases in bone thickness and callus volume in comparison with sham-operated animals (p < 0.0001), followed by bone remodelling and a new layer of cortical bone formation by 28 days after implantation. …”
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Seasonal activities, morphological characteristics, and veterinary importance of Haemaphysalis mageshimaensis in Ishigaki and Yonaguni, Okinawa, Japan by Satoko Nakao, Thillaiampalam Sivakumar, Yuko Takakuwa, Hajime Suzuki, Keiichiro Ohta, Keiko Nakamura, Osamu Tsuha, Yuzuru Ikehara, Sanae Ikehara, Syota Ohki, Mizue Inumaru, Yukiko Higa, Rika Umemiya-Shirafuji, Naoaki Yokoyama

“…Ticks are of veterinary importance as they transmit various pathogens to animals. In Yaeyama, Okinawa, Japan, Haemaphysalis longicornis became the dominant tick species after the eradication of Rhipicephalus (Boophilus) microplus in the 1990s. …”
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Assessing the role of selenium in Minamata disease through reanalysis of historical samples by Mineshi Sakamoto, Masumi Marumoto, Koichi Haraguchi, Takashi Toyama, Yoshiro Saito, Steven J. Balogh, Chiharu Tohyama, Masaaki Nakamura

“…Before MeHg was recognized as the cause, selenium (Se) was suspected of being the potential cause owing to elevated Se levels in patients’ organs. Subsequent animal studies indicated that Se mitigates MeHg toxicity; however, its role in Minamata disease remains unexplored. …”
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Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model by Zhiliang Chen, Tony C. H. Chow, Shicong Wang, Gigi C. T. Leung, Sharon L. Y. Wu, David T. Yew

“…Methods. Comparisons of animals treated with the three drugs were carried out: serum aspartate transaminase (AST), alanine transaminase (ALT), and albumin were measured; liver tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta (TGF beta-1) levels were evaluated; proliferative cells were detected via immunohistochemistry (IHC) targeting on proliferating cell nuclear antigen (PCNA) and minichromosome maintenance complex component 2 (MCM2); for apoptosis, IHC targeting on activated caspase-3 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were employed; and histopathology was also documented in all groups. …”
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Characterization of post‐ictal clinical signs in dogs with idiopathic epilepsy: A questionnaire‐based study by Aran Nagendran, Julie A. Nettifee, Dani Carter, Karen R. Muñana

“…Objectives To further characterize PI signs and their relation to other parts of a seizure, and understand the owner's perception of how PI signs affect the quality of life (QOL) of the dog. Animals Eight‐seven dogs with a diagnosis of idiopathic epilepsy from a single institution. …”
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Deer antler velvet (Cervus elaphus sibiricus) promotes fracture healing via partial BMP2-Smad mediated osteoblast differentiation by Ji Hyang Gu, Min-Young Chae, Jeong June Choi, Thanh Chu Duc, Chang Gue Son, Eun-Jung Lee

“…The aim of this study investigated the bone-union properties of CES in a femoral fracture animal model and its corresponding molecular mechanisms. …”
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Development of a novel encystment medium: Enhancing diagnostic potential of Acanthamoeba spp. by Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Alok K. Paul, Sonia M. Rodrigues Oliveira, Maria L. Pereira, Tajudeen O. Jimoh, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Ajoy K. Verma, Veeranoot Nissapatorn

“…Background and Aim: Acanthamoeba spp. are pathogenic microorganisms linked to severe infections in humans and animals, requiring a deeper understanding of their encystation process for effective diagnostics and research. …”
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Investigation of the effcets of prostaglandin f2&#945;, furosenıid and indomethacin on testosterone levels in rams by İbrahim Pirinçci, İzzet Karahan, Ferit Gürsu, Tanzer Bozkurt, Osman Güler

“…PGFa< (0.1, 0.2 and 0.3 mg/kg), furosemid (2.0, 4.0 and 6.0 mg/kg), indomethacin (3.0, 6,0 and 9,0 mg/kg) and the combinations of these drugs were intramuscularly given the animals in one dose and in doses lollowmg on each other's (our days. …”
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Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

“…However, the mechanism of disease development and effective treatment of IBD have not yet been found. Animal models help address these problems. The most popular model is considered to be transgenic models in which individual genes are knocked out. …”
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Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction by Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy

“…Strikingly, there was no significant difference between the extracts treated animals and their counterparts treated with sildenafil citrate. …”
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Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trialsResearch in context by Yue Zhao, Zuguo Zheng, Xuexiao Jin, Shaoshan Liang, Changming Zhang, Mingchao Zhang, Yue Lang, Ping Li, Zhihong Liu

“…Findings: AZD1152 significantly attenuated systemic immune activation and renal injury in MRL/lpr mice, demonstrating efficacy comparable to MT regimens in animal studies. AZD1152 treatment modulated immune-inflammatory pathways in the kidney. …”
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Use of climate smart agriculture technologies in West Africa peri-urban Sahel in Niger by Tinawaen Tambol, Emmanuel K. Derbile, Moussa Soulé

“…These technologies eradicate pests and disease outbreaks of crops, vegetables and farm animals. The other technologies included fertilizer micro-dose, organic manure and compost application, flood-tolerant improved varieties, irrigation based on green energy, tele-irrigation, early maturing varieties and planting pits. …”
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Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway in vitro and in vivo by Guanqi Liu, Jiahui Lin, Xiaoyan Chen, Runheng Liu

“…Additionally, the expression of key factors of WNT/β-catenin signaling pathway were investigated. In vivo animal experiments were conducted to assess the effect of gingival fibroblasts on BSM-mediated bone regeneration.ResultsGingival fibroblasts and BSMs co-culture environment did not affect MMSCs proliferation but significantly inhibited ALP expression and activity, as well as osteogenic gene and protein expression, while promoting expression of fibrogenic markers. …”
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