Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modeling by Han Zhang, Jiaxing Dai, Qiuqiao Mu, Xiaojiang Zhao, Ziao Lin, Ziao Lin, Kai Wang, Meng Wang, Meng Wang, Daqiang Sun

“…BackgroundMacrophages play a dual role in the tumor microenvironment(TME), capable of secreting pro-inflammatory factors to combat tumors while also promoting tumor growth through angiogenesis and immune suppression. This study aims to explore the characteristics of macrophages in lung adenocarcinoma (LUAD) and establish a prognostic model based on macrophage-related genes.MethodWe performed scRNA-seq analysis to investigate macrophage heterogeneity and their potential pseudotime evolutionary processes. …”
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Role of nurses in prevention and nursing of diabetic foot disease (回顾护士在糖尿病足预防和护理中的作用) by GAN Lu (甘露), XIE Wei (谢薇), LIU Qing (刘青), JIANG Yonghong (江永红), YUAN Zheng (袁铮), XIAO Mengyun (肖孟云), MO Mei (莫梅), YUAN Dan (袁丹), CHEN Hongyi (陈红伊), JIANG Qingxia (江青霞), XU Tengfei (徐腾飞), LIU Qiulin (李秋林)

“…Diabetic foot disease is a common and serious complication for diabetes and is characterized with impaired angiogenesis. Nurses are the primary providers of prevention and early diagnosis of diabetes and its complications. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Conversely, MSCs derived from DM2 individuals are usually dysfunctional, exhibiting higher rates of senescence and apoptosis and a decrease in clonogenicity, proliferation, and angiogenesis potential. Therefore, more studies in humans are needed to reach a conclusion if autologous MSCs from DM2 individuals are effective for treatment of DM-related complications. …”
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Construction and high-throughput screening of gradient nanowire coatings on titanium surface towards ameliorated osseointegration by Ruiyue Hang, Yuyu Zhao, Huanming Chen, Xiaomei Li, Runhua Yao, Yonghua Sun, Xiaohong Yao, Long Bai, Huaiyu Wang, Yong Han, Ruiqiang Hang

“…Simultaneously, small-sized nanowires with diameter of 5.63–14.25 nm and inter-spacing of 29.42–57.97 nm were conductive to angiogenesis of endothelial cells (ECs) and osteogenesis of bone marrow mesenchymal stem cells (BMSCs), which may share similar mechanisms of MФs. …”
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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction by Zhi-rong Luo, Han Li, Zhong-xin Xiao, Shui-jin Shao, Tian-tian Zhao, Yue Zhao, Fang-fang Mou, Bo Yu, Hai-dong Guo

“…Compared with the model group, THSWD significantly increased the expression of IGF-1 and bFGF, reduced collagen deposition, promoted angiogenesis, reduced cell apoptosis, and activated the PI3K/Akt signaling pathway. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…These include the induction of apoptosis, regulation of the cell cycle, inhibition of angiogenesis, and suppression of metastasis. The compounds have demonstrated efficacy in vitro and in vivo, affecting various cancer cell lines with minimal toxicity to normal cells. …”
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Assessment of Clinical Analgesic Levels and Serum Biomarkers in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Comparing the Efficacy of Diclofenac and Methotrex... by Mei Zhang, Zhongyuan Ma, Rinkiko Suguro, Menglin Zhu, Esther Xinyi Chen, Xin Dong, Meixiu Chen, Linling Cheng, Bolun Su, Yizhun Zhu

“…Furthermore, ESWT produced a more immediate and noteworthy anti-inflammatory impact by regulating NRP-1 expression, a trophic factor receptor that facilitates vascular endothelial cell migration and tissue repair through angiogenesis, and regulating RGS-1 to limit inflammatory signal transmission and immune cell activation.…”
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Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions by Soumilee Chaudhuri, Minyoung Cho, Julia C. Stumpff, Paula J. Bice, Özkan İş, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho

“…Dysregulated transcriptional pathways in AD involve multiple pathways, notably immune responses, and angiogenesis common to both endothelial and mural cells. …”
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Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain by Christian Kirschneck, Erika Calvano Küchler, Michael Wolf, Gerrit Spanier, Peter Proff, Agnes Schröder

“…Etoricoxib at 3.29 μM and 5.49 μM significantly inhibited PG-E2 synthesis, but not COX-2 and IL-6 gene expression nor RANK-L-/OPG-mediated osteoclastogenesis or angiogenesis (VEGF-A). Extracellular matrix remodeling (COL1A2, FN1) and bone anabolism (ALPL), by contrast, were significantly stimulated particularly at 5.49 μM. …”
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Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells by Jun Ying, Qinwen Ge, Songfeng Hu, Cheng Luo, Fengyi Lu, Yikang Yu, Taotao Xu, Shuaijie Lv, Lei Zhang, Jie Shen, Di Chen, Peijian Tong, Luwei Xiao, Ju Li, Hongting Jin, Pinger Wang

“…Chondrogenesis and subsequent osteogenesis of mesenchymal stem cells (MSCs) and angiogenesis at injured sites are crucial for bone fracture healing. …”
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MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence by Yugang Zhuang, Hu Peng, Victoria Mastej, Weiguo Chen

“…These regulations directly affect VE-cadherin-β-catenin complex stability and further affect embryo and tumor angiogenesis, vascular development, and so forth. miR-155 and miR-126 have been shown to regulate PECAM-1 and affect neutrophil rolling and EC junction integrity. …”
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Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats by Qiujiang Li, Bowen Hu, Linan Wang, Lei Wang, Cong Feng, Zhuang Zhang, Zhipeng Deng, Yang Xiao, Bo Yuan, Xiangdong Zhu, Xiangfeng Li, Xi Yang, Yueming Song, Xingdong Zhang

“…In vitro experiments showed that biomineralized PEEK cages and CaP bioceramics regulate immunity and promote angiogenesis and bone integration via activation of hypoxia-inducible factor 1-alpha and cyclic guanosine monophosphate/protein kinase G signaling pathways. …”
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Vitamin D and exercise improve VEGF-B production and IGF-1 levels in diabetic rats: insights the role of miR-1 suppression by Fatemeh Mazaheri, Rastegar Hoseini, Ahmad Gharzi

“…The study concludes that the combination of AT and Vit D has cardio-protective effects in T2DM rats, counteracting abnormal angiogenesis induced by diabetes. These effects are mediated, at least in part, by the upregulation of IGF-1 and VEGF-B, and the downregulation of miR-1.…”
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Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages by Jiayi Mao, Wenzheng Xia, Yanglin Wu, Minxiong Li, Yun Zhao, Peisong Zhai, Yuguang Zhang, Tao Zan, Wenguo Cui, Xiaoming Sun

“…In vivo experiments demonstrated that BHB-dABs enhance the recovery of diabetic wound inflammation and angiogenesis, accelerating wound healing. These functionalized apoptotic bodies efficiently deliver NLRP3 inflammasome inhibitors using a dual strategy of targeting macrophages and promoting lysosomal escape. …”
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Enhanced effect of radiofrequency ablation on HCC by siRNA-PD-L1-endostatin Co-expression plasmid delivered by Pengfei Chen, Kun Li, Jinwei Chen, He Hei, Jiaxin Geng, Nannan Huang, Mengyu Lei, Huijie Jia, Jianzhuang Ren, Chenwang Jin

“…The combination therapy significantly reduced tumor growth, angiogenesis, and PD-L1/VEGF expression in tumor tissues post-RFA. …”
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Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach by Luailik Madaniyah, Saidun Fiddaroini, Elok Kamilah Hayati, Moh. Farid Rahman, Akhmad Sabarudin

“…AgNPs exhibit anti-inflammatory properties and the ability to inhibit angiogenesis while counteracting drug resistance mechanisms. …”
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mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…Studies have exhibited the mammalian TORC1 (mTORC1) signaling is of potent angiogenesis effects. The mTOR protein kinase has two distinct multiprotein complexes mTORC1 and mTORC2 that regulate different branches of the mTOR network. …”
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Secreted LGALS3BP facilitates distant metastasis of breast cancer by Seung-Su Kim, Issac Park, Jeesoo Kim, Na-Lee Ka, Ga Young Lim, Mi-Ye Park, Sewon Hwang, Ji-Eun Kim, So Yeon Park, Jong-Seo Kim, Hyun-Woo Rhee, Mi-Ock Lee

“…Results TAMR secretome analysis revealed that 176 proteins were secreted at least 2-fold more from MCF7/TAMR cells than from sensitive cells, and biological processes such as cell adhesion and angiogenesis were associated with the TAMR secretome. …”
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Remodeling of tumor microenvironments by EGFR tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer by Soomin Kim, Jaemoon Koh, Tae Min Kim, Songji Oh, Soyeon Kim, Jeonghwan Youk, Miso Kim, Bhumsuk Keam, Yoon Kyung Jeon, Dong-Wan Kim, Dae Seog Heo

“…Our results shed light on the immunomodulatory effects of osimertinib treatment and suggest that co-targeting angiogenesis and anti-programmed death (ligand) 1 might be effective in EGFR-TKI-resistant non-small cell lung cancer.…”
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iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…However, there is a lack of effective means for early diagnosis due to the heterogeneity of tumors and the complexity of tumor microenvironment. αvβ 3 integrin, a crucial role in the growth and spread of tumors, is not only an effective biomarker for cancer angiogenesis, but also highly expressed in many tumor cells. …”
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