Hyperbaric oxygen therapy for the treatment of a crush injury of the hand: a case report by Pedro Henry Neto, Zamara Brandão Ribeiro, Adriano Bastos Pinho, Carlos Henrique Rodrigues de Almeida, Carlos Alberto de Albuquerque Maranhão, Joaquim da Cunha Campos Goncalves

“…Posttraumatic compartment syndrome responds well to HBOt, which reduces edema and contributes to angiogenesis, as well as promoting the cascade of healing events. …”
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Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability by Adil Elrayah, Ke Duan, Xiong Lu, Xiaob Lu, Jie Weng

“…Thus, it can provide an appropriate micro/nano-structure approach supporting angiogenesis capacity, which is a necessity to accelerate the time of bone healing and regeneration. …”
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Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer by Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

“…A broad spectrum of new promising drugs is currently under investigation in clinical phase III studies targeting mainly the hallmarks “self-sufficiency in growth signals,” “genomic instability,” and “angiogenesis.” The benefit of immune checkpoint inhibitors in ovarian cancer has been demonstrated for the first time. …”
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Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes? by Cai-Guo Yu, Ning Zhang, Sha-Sha Yuan, Yan Ma, Long-Yan Yang, Ying-Mei Feng, Dong Zhao

“…We then discuss how abnormal angiogenesis develops in eyes and kidneys under diabetes condition, focusing on “VEGF uncoupling with nitric oxide” and “competitive angiopoietin 1/angiopoietin 2” mechanisms that are shared in both organs. …”
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The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review by Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco

“…The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection. This comprehensive review explores the dual nature of OSM and other IL-6 family members in retinal pathophysiology, highlighting their contribution to both degenerative and regenerative processes. …”
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Using platelet concentrates to treat maxillofacial tissue lesions by Ruijia Liu, Siqi Chen, Peng Wang, Peng Wang, Ruiye Bi, Ruiye Bi

“…This review will provide some recent progress of the use of platelet concentrates to treat lesions on maxillofacial tissues.SubjectsWe reviewed the mechanisms by which PCs promote wound healing and tissue recovery and summarized the application of PCs in the treatment of lesions on maxillofacial tissues, including medication-related osteonecrosis of the jaw, post-extraction wound healing, implant surgery, temporomandibular joint diseases, and periodontal tissue restoration.ResultsPC promotes the attachment and proliferation of osteoblasts, as well as the synthesis and deposition of collagen fibers by stimulating the AFK pathway and releasing growth factors and cytokines, such as secreting GFs, VEGF, TGF-β, etc. They also induce angiogenesis, inhibit bone resorption, promote the healing of soft tissues, relieve symptoms, reduce postoperative complications and maintain implant stability.ConclusionPCs may be used as an adjuvant therapy in the treatment of lesions on maxillofacial tissues. …”
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Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity by Erin Burke Quinlan, Lucy Dodakian, Jill See, Alison McKenzie, Jill Campbell Stewart, Steven C. Cramer

“…We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity. …”
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From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review by Anca Badoiu, Smaranda Ioana Mitran, Bogdan Catalin, Tudor Adrian Balseanu, Aurel Popa-Wagner, Florin Liviu Gherghina, Carmen Valeria Albu, Raluca Elena Sandu

“…This modulation includes the reduction of the inflammatory response, autophagy suppression, antiapoptotic effects, angiogenesis enhancement, alterations in the blood-brain barrier permeability, attenuation of oxidative stress, influence on neurotransmitter metabolism, neurogenesis, and enhanced structural neuroplasticity. …”
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The Angiogenic Potential of DPSCs and SCAPs in an In Vivo Model of Dental Pulp Regeneration by Petra Hilkens, Annelies Bronckaers, Jessica Ratajczak, Pascal Gervois, Esther Wolfs, Ivo Lambrichts

“…Similar results were found after eight weeks, which suggests both osteogenic/odontogenic differentiation of the transplanted stem cells and the promotion of angiogenesis in this particular setting. In conclusion, this is the first study to demonstrate the successful formation of vascularized pulp-like tissue in 3D-printed scaffolds containing dental stem cells, emphasizing the promising role of this approach in dental tissue engineering.…”
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S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling by Ashok Kumar, Jesus Zamora-Pineda, Emilie Degagné, Julie D. Saba

“…Sphingosine-1-phosphate (S1P) is a potent lipid signaling molecule that regulates pleiotropic biological functions including cell migration, survival, angiogenesis, immune cell trafficking, inflammation, and carcinogenesis. …”
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Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies by Antonia Reale, Assunta Melaccio, Aurelia Lamanuzzi, Ilaria Saltarella, Franco Dammacco, Angelo Vacca, Roberto Ria

“…It was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis. Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis. …”
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The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets by M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor

“…In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance. Therefore, the chemokine system is becoming a target in cancer therapeutics. …”
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Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing by Yuan Li, Wei Wang, Wensheng Xu

“…Ginsenoside Rb1 enhances local blood supply and facilitates tendon-bone tissue repair through angiogenesis, anti-inflammatory, and antioxidant pathways. …”
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A Review on the Role of Human Solute Carriers Transporters in Cancer by Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

“…Results The overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. …”
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Comparison of Proangiogenic Effects of Adipose-Derived Stem Cells and Foreskin Fibroblast Exosomes on Artificial Dermis Prefabricated Flaps by Jiachao Xiong, Zhixiao Liu, Minliang Wu, Mengyan Sun, Yu Xia, Yuchong Wang

“…Large prefabricated flaps often suffer from necrosis or poor healing due to a lack of new blood vessels and related factors that promote angiogenesis. The innovative use of adipose-derived stem cell exosomes (ADSC-Exo) resolves the problem of vascularization of prefabricated flaps. …”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…This review provides a comprehensive overview of the pathophysiological roles of gelatinases in CRC, highlighting their contribution to tumor microenvironment modulation, angiogenesis, and the metastatic cascade. We also critically evaluate recent advancements in the development of gelatinase inhibitors, including small molecule inhibitors, natural compounds, and novel therapeutic approaches like gene silencing techniques. …”
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Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue by Zhang Xin Loo, Wijenthiran Kunasekaran, Vijayendran Govindasamy, Sabri Musa, Noor Hayaty Abu Kasim

“…These TF genes fall under several cardiovascular categories with higher expressions which were observed in growth and development of blood vessel, angiogenesis, and vasculogenesis categories. Further induction into cardiomyocyte revealed ASC to express more significantly cardiomyocyte specific markers compared to SHED during the differentiation course evidenced by morphology and gene expression profile. …”
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Mechanism of Nerve Regeneration after Ischemic Stroke Induced by Exercise Intervention by TENG Lili, ZHANG Mei, SONG Wenjing, ZHU Luwen

“…Based on the plasticity of the central nervous system, exercise intervention can play a neuroprotective role in the brain through multi-levels, multi-pathways and multi-targets, such as regulating synaptic budding, connection and transmission efficiency, improving the functional connection between regenerative axons and target cells, promoting angiogenesis and protecting the integrity of neurovascular units, regulating related inhibitory nerve regeneration factors, and inducing the expression of various nerve growth factors related to nerve regeneration and promoting the proliferation of neural stem cells, so as to participate in the regulation of central nervous rege-neration environment, and improve the damaged nerve function after ischemia.…”
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Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu

“…Meta-analysis showed that cell therapy significantly increased the probability of ulcer healing (RR = 1.73, 95% CI = 1.45–2.06), angiogenesis (RR = 5.91, 95% CI = 2.49–14.02), and reduced the amputation rates (RR = 0.59, 95% CI = 0.46–0.76). …”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…Instead of hypoxia, sometimes even in normoxia, HIF-1α translocates into the nucleus, dimerizes with HIF-1β to generate HIF-1, and then activates genes involved in adaptive responses such as angiogenesis, metabolic reprogramming, and cellular survival, which presents new challenges and insights into its role in cellular processes. …”
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