Simultaneous Viewing of Individual Cells and Ambient Microvasculature Using Optical Absorption and Fluorescence Contrasts by Zhixing Xie, Sung-Liang Chen, Mario L. Fabiilli, J. Brian Fowlkes, K. Kirk Shung, Qifa Zhou, Paul L. Carson, Xueding Wang

“…Viewing individual cells and ambient microvasculature simultaneously is crucial for understanding tumor angiogenesis and microenvironments. We developed a confocal fluorescence microscopy (CFM) and photoacoustic microscopy (PAM) dual-modality imaging system that can assess fluorescent contrast and optical absorption contrast in biologic samples simultaneously. …”
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Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). …”
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Protocol for inducing beige adipocytes in white adipose tissue of mouse using cold exposure and CL316,243 injection by Yalan Wu, Chenguang Wang, Xiao Yu Tian

“…This protocol can be used for subsequent analysis to explore the mechanisms governing beige WAT induction in experimental settings, particularly the evaluation of angiogenesis.For complete details on the use and execution of this protocol, please refer to Wang et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature by Carlos Zagalo, Francesca Pierdomenico, José Cabeçadas, Pedro David Santos

“…Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.…”
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Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…NRP1 expression in human cancers is associated with prominent angiogenesis and advanced progression stage. However, the molecular mechanisms underlying NRP1 activity in the tumor microenvironment remain unclear. …”
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Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling by Katherine A. Kentistou, Brandon E. M. Lim, Lena R. Kaisinger, Valgerdur Steinthorsdottir, Luke N. Sharp, Kashyap A. Patel, Vinicius Tragante, Gareth Hawkes, Eugene J. Gardner, Thorhildur Olafsdottir, Andrew R. Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R. Day, Susan E. Ozanne, Andrew T. Hattersley, Stephen O’Rahilly, Kari Stefansson, Ken K. Ong, Robin N. Beaumont, John R. B. Perry, Rachel M. Freathy

“…To conclude, our analysis of rare coding variants identifies regulators of fetal adipose tissue and fetoplacental angiogenesis as determinants of birth weight, and further evidence for the role of insulin-like growth factors.…”
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Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion by Liguo Zhang, Zhao Li, Yajing Fu, Haoyang Tian, Ting Wang, Hongrui Liu, Jianhua Li, Hong Liu, Shaohua Ge, Baojin Ma

“…Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, and osteogenesis. Herein, a phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. …”
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Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy by Almut Heinken, John M. Asara, Gopalan Gnanaguru, Charandeep Singh

“…Especially, induction of hyperoxia driven anaplerosis in neurovascular tissues such as the retina during early stages of development could deplete biosynthetic precursors from newly proliferating endothelial cells impeding physiological angiogenesis and leading to vasoobliteration. Using an oxygen-induced retinopathy (OIR) mouse model, we investigated the metabolic differences between OIR-resistant BALB/cByJ and OIR susceptible C57BL/6J strains at system levels to understand the molecular underpinnings that potentially contribute to hyperoxia-induced vascular abnormalities in the neural retina. …”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Besides having prodifferentiation, antiproliferative, and proapoptotic effects, PPARγ agonists have been shown to prevent cancer cells from acquiring the migratory and invasive capabilities essential for successful metastasis. Angiogenesis and secretion of certain matrix metalloproteinases and extracellular matrix proteins within the tumor microenvironment are also regulated by PPARγ. …”
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Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma by Murat Özgür Kılıç, Büşra Aynekin, Mikdat Bozer, Adem Kara, Hacer Haltaş, Duygu İçen, Kadir Demircan

“…Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various biological processes such as ECM remodelling and anti-angiogenesis. Aim : To investigate the expression of ADAMTS1, 8, 9, and 18 proteinases in pancreas adenocarcinoma and its nodal metastasis. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…In addition to their effects on migration, chemokines can also activate effector function in leukocytes and are involved in cell proliferation and angiogenesis. Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. …”
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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management by Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest

“…In clinical trials for the treatment of advanced and/or recurrent EC are the topoisomerase I inhibitor Topotecan, mTOR-inhibitor Rapamycin, and angiogenesis inhibitor Bevacizumab. Preliminary data shows encouraging results for these agents. …”
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Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy by Shuyan He, Lu Zheng, Chunjian Qi

“…In addition to their immunosuppressive functions, MDSCs also promote tumor growth and metastasis through non-immunological mechanisms, such as angiogenesis and the formation of pre-metastatic niches. …”
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Pengaruh Bone Marrow Mesenchymal Stem Cells Terhadap Sekresi VEGF pada Penyembuhan Luka Bakar Tikus by Gusti Revilla

“…The conclusion of this study is the administration of BM-MSCs were the influence levels of VEGF which has into differentiate to cells that contribute to angiogenesis was can to granulation tissue.…”
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The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing by Yos Adi Prakoso, Kurniasih

“…The result showed that topical application of 1% and 2% Aloe vera cream significantly reduced the percentage of the wound, leucocytes infiltration, angiogenesis, and expression of CD8+ lymphocytes and increased the epidermal thickness and the expression of CD4+ lymphocytes (p ≤ 0,05). …”
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Vascular cytoprotection, autoimmune disease, and premature atherosclerosis by Justin C Mason

“…A healthy vascular endothelium is critical to health, and interference with endothelial homeostasis disrupts hemostasis, regulation of vascular tone and blood pressure, leukocyte trafficking, angiogenesis and tissue repair. Endothelial injury and apoptosis leads to endothelial dysfunction, which is closely associated with increased generation of reactive oxygen species, reduced endothelial nitric oxide (NO) synthase, increased consumption, and impaired synthesis of NO. …”
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Does SIRT-1 Mediate Calorie Restriction and Prolong Life? – A Mini Review by Kordala Anna, Pietrzak Bogusława

“…SIRT1 increases glucose production, enhances fat mobilization, stimulates angiogenesis, prevents neuronal degeneration and rises insulin sensitivity. …”
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Role of microglia in the pathogenesis of multiple sclerosis and links to immunomodulatory therapy by P. Valiukevičius, R. Liutkevičienė, R. Balnytė

“…The latest advanced cell therapy drugs have a broader spectrum of action – they inhibit inflammation, promote angiogenesis, perform trophic function, and inhibit oxidative damage. …”
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Role of Subcutaneous Adipose Tissue in the Pathogenesis of Insulin Resistance by Pavankumar Patel, Nicola Abate

“…Decreased capacity for adipocyte differentiation and angiogenesis along with adipocyte hypertrophy can trigger vicious cycle of inflammation in subcutaneous adipose tissue and subsequent ectopic fat deposition. …”
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Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment by Wu S, Hu Y, Sui B

“…This review aims to explore the mechanisms through which stromal cells in the tumor microenvironment promote lung cancer development, with a particular focus on how immune cells, tumor-associated fibroblasts, and endothelial cells contribute to immune suppression, inflammation, and angiogenesis. The goal is to provide new insights and potential strategies for the diagnosis and treatment of lung cancer.Keywords: tumor microenvironment, lung cancer, stromal cells, immune cells, cancer-associated fibroblasts, endothelial cells…”
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