Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System by Roberto Reif, Jia Qin, Lin An, Zhongwei Zhi, Suzan Dziennis, Ruikang Wang

“…The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. …”
Get full text

The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Glioblastoma (GBM) is the most malignant human brain tumour, characterized by rapid progression, invasion, intense angiogenesis, high genomic instability, and resistance to therapies. …”
Get full text

The role of laminins in cancer pathobiology: a comprehensive review by Elena Nonnast, Emilia Mira, Santos Mañes

“…Beyond their direct effects on tumor cells, LMs influence stromal interactions and modulate tumor microenvironment dynamics, affecting processes such as angiogenesis, immune cell infiltration, cancer-associated fibroblast activation, and immune evasion. …”
Get full text

Pancreatic Cancer: What the Oncologist Can Offer for Palliation by Malcolm J Moore

“…Some novel biological agents, including angiogenesis inhibitors, matrix metalloproteinase inhibitors, antisense compounds, inhibitors of cell signalling such as epidermal growth factor and vascular endothelial growth factor, and inhibitors of oncogene activation, are undergoing phase II and III trials in patients with pancreatic cancer. …”
Get full text

Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…The TGF-β signaling pathway affects various biological processes of cancers, including proliferation, invasion, metastasis, angiogenesis, and immune escape. Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. …”
Get full text

Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. …”
Get full text

Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat by Jasińska-Stroschein Magdalena, Owczarek Jacek, Wesołowska Anna, Orszulak-Michalak Daria

“…The results of biochemical measurements may suggest that statins play a positive role in right ventricle function or the process of angiogenesis in pulmonary hypertension development.…”
Get full text

miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery by Vojtech Sprincl, Vojtech Sprincl, Nataliya Romanyuk

“…We highlight the molecular cargo of MSC-derived EVs, including miRNAs, and their role in enhancing angiogenesis, promoting the BBB and neural repair, and mitigating apoptosis. …”
Get full text

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…HIF is a transcription factor that orchestrates cellular responses to low oxygen levels, driving angiogenesis, metabolic adaptation and immune regulation. …”
Get full text

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease by Emma V. Jones, David S. Bouvier

“…These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.…”
Get full text

Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression by Guido Valente, Giuseppina Nicotra, Marisa Arrondini, Roberta Castino, Lorena Capparuccia, Maria Prat, Simonetta Kerim, Luca Tamagnone, Ciro Isidoro

“…Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. …”
Get full text

Release of Copper / Magnesium Ions from Hydroxyapatite-Based Fiber Scaffolds Hasten Bone Healing and Regeneration by Adil Elrayah, Jie Weng, Dongqin Xiao, Azher S Barrak

“…A low amount of Mg and Cu ions could improve vascular endothelial growth factor (VEGF) and angiogenesis around bone, thus can hasten bone healing and regeneration. …”
Get full text

Neuroprotective Effects of Stem Cells in Ischemic Stroke by Weilin Xu, Jingwei Zheng, Liansheng Gao, Tao Li, Jianmin Zhang, Anwen Shao

“…The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. …”
Get full text

Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). …”
Get full text

Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature by Carlos Zagalo, Francesca Pierdomenico, José Cabeçadas, Pedro David Santos

“…Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.…”
Get full text

Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…NRP1 expression in human cancers is associated with prominent angiogenesis and advanced progression stage. However, the molecular mechanisms underlying NRP1 activity in the tumor microenvironment remain unclear. …”
Get full text

Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling by Katherine A. Kentistou, Brandon E. M. Lim, Lena R. Kaisinger, Valgerdur Steinthorsdottir, Luke N. Sharp, Kashyap A. Patel, Vinicius Tragante, Gareth Hawkes, Eugene J. Gardner, Thorhildur Olafsdottir, Andrew R. Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R. Day, Susan E. Ozanne, Andrew T. Hattersley, Stephen O’Rahilly, Kari Stefansson, Ken K. Ong, Robin N. Beaumont, John R. B. Perry, Rachel M. Freathy

“…To conclude, our analysis of rare coding variants identifies regulators of fetal adipose tissue and fetoplacental angiogenesis as determinants of birth weight, and further evidence for the role of insulin-like growth factors.…”
Get full text

Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion by Liguo Zhang, Zhao Li, Yajing Fu, Haoyang Tian, Ting Wang, Hongrui Liu, Jianhua Li, Hong Liu, Shaohua Ge, Baojin Ma

“…Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, and osteogenesis. Herein, a phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. …”
Get full text

PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Besides having prodifferentiation, antiproliferative, and proapoptotic effects, PPARγ agonists have been shown to prevent cancer cells from acquiring the migratory and invasive capabilities essential for successful metastasis. Angiogenesis and secretion of certain matrix metalloproteinases and extracellular matrix proteins within the tumor microenvironment are also regulated by PPARγ. …”
Get full text

Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…In addition to their effects on migration, chemokines can also activate effector function in leukocytes and are involved in cell proliferation and angiogenesis. Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. …”
Get full text