Editorial: Vascular- and immuno-metabolism as drivers of cardiovascular disease: insights obtained from omics approaches by Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Raquel Guillamat-Prats, Raquel Guillamat-Prats, Raquel Guillamat-Prats, Yvonne Döring, Yvonne Döring, Yvonne Döring, Yvonne Döring

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The role of dietary sugars in cancer risk: A comprehensive review of current evidence by Nazmul Hasan, Omid Yazdanpanah, Barbod Khaleghi, David J. Benjamin, Arash Rezazadeh Kalebasty

“…Fructose increases angiogenesis by VEGF overexpression while glucose stimulates cancer cell growth by the Warburg effect. …”
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Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways by Xiao Chen, Luping Lin, Qiaoling Wu, Sang Li, Huihui Wang, Yang Sun

“…Cell viability was measured using the cell counting kit-8 (CCK-8) assay, and angiogenesis was detected using a tube formation assay. …”
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Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway by Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale

“…The angiopoietin-like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as angiopoietins. At first, ANGPTL4 has been identified as an adipokine exclusively involved in lipid metabolism, because of its prevalent expression in liver and adipose tissue. …”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…In Phase II, NPs modulate multiple pathways and mediators regulating gastric mucosal cell cycle, apoptosis, autophagy, and angiogenesis to reverse gastric precancerous lesions. …”
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Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival by Guona Chen, Xiaoting Liang, Qian Han, Cong Mai, Linli Shi, Zhuang Shao, Yimei Hong, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang

“…Moreover, transplantation with Apelin-13-pretreated MSCs improved heart function and increased angiogenesis accompanied by decreased fibrosis compared with MSC transplantation at 28 days following MI. …”
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High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease by Maria Vittoria Arcidiacono, Montserrat Martinez-Alonso, Montserrat Belart, Ana Vilar, Marisa Martín, Lourdes Craver, Àngels Betriu, Dídac Mauricio, José Manuel Valdivielso, Elvira Fernández, Mercè Borràs

“…Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…Furthermore, the protective mechanisms involving neurogenesis, angiogenesis, and AKT-GSK3β-VEGF signaling pathway were analyzed. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…Preclinical studies highlight its dual role in renal protection and injury through anti-inflammatory and antioxidant pathways, while other evidence suggests that it may exacerbate DKD through podocyte damage and angiogenesis. Similarly, the VEGF/VEGFR axis demonstrates a complex contribution to DKD, where VEGF-A promotes pathological angiogenesis and glomerular damage, but its inhibition requires careful modulation to prevent adverse effects. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Topical FTY720 induces M2 predominance and impairs angiogenesis. Therefore, its local immunosuppressive mechanisms differ from those of conventional immunosuppressive agents. …”
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ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…These results indicated that ERK5 depletion contributes to glucose induced increased VEGF production and angiogenesis. Hence, ERK5 may be a putative therapeutic target to modulate VEGF expression in diabetic retinopathy.…”
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In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma by Joaquín Yanes-Díaz, Raquel Palao-Suay, Francisca Inmaculada Camacho-Castañeda, Juan Riestra-Ayora, María Rosa Aguilar, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

“…EGFR and angiogenesis marker (Factor VIII) expression were significantly lower in the NP-427 group compared to other experimental groups. …”
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The effect of cacao bean extracts on the prevention of periodontal tissue breakdown in diabetic rats with orthodontic tooth movements by Nuzulul Hikmah, Mohamad Hidayat, Nur Permatasari, Aulanni'am Aulanni'am, Achmad Rudijanto

“…Cacao bean extracts (CBE) are known to reduce the inflammatory response and increase synthesis and angiogenesis in periodontitis. Therefore, this study aims to examine the effect of CBE on preventing periodontal tissue breakdown in diabetes with orthodontic force. …”
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Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

“…Exosomal microRNAs (exomiRs) play a critical role in intercellular communication, especially in cancer, where they regulate key cellular processes like proliferation, angiogenesis, and metastasis, highlighting their significance as potential diagnostic and therapeutic targets. …”
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circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD by Xiao-Lin Fu, Fu-Tao He, Mo-Han Li, Chun-Yan Fu, Jian-Zhi Chen

“…It was found that HG treatment accelerated EndMT process, facilitated cell migration and angiogenesis, and enhanced PIK3CD and p-AKT levels in HRMECs, whereas si-circZNF532 transfection neutralized these effects. …”
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CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…BackgroundAngiogenesis is closely associated with tumor growth and metastasis, and microvascular density (MVD) is currently the clinical standard for evaluating tumor angiogenesis. …”
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Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp by Chung-Min Kang, Hyunok Kim, Je Seon Song, Byung-Jai Choi, Seong-Oh Kim, Han-Sung Jung, Seok-Jun Moon, Hyung-Jun Choi

“…Genes related to cell proliferation, angiogenesis, and immune responses were expressed at higher levels in UC, whereas genes related to growth factor and receptor activity and signal transduction were more highly expressed in DP. …”
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PPAR-δ in Vascular Pathophysiology by Nanping Wang

“…Most recently, the direct effects of PPAR-δ on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.…”
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Advances in Molecular Imaging with Ultrasound by Ryan Gessner, Paul A. Dayton

“…However, in preclinical studies, ultrasonic molecular imaging has shown promise in assessing angiogenesis, inflammation, and thrombus. In this review, we discuss recent advances in microbubble-type contrast agent development, ultrasound technology, and signal processing strategies that have the potential to substantially improve the capabilities and utility of ultrasonic molecular imaging.…”
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Corrigendum: New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count by Rocío del Campo-Pedrosa, Rocío del Campo-Pedrosa, Alfonso Martín-Carnicero, Ana González-Marcos, Alfredo Martínez

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