Showing 241 - 260 results of 901 for search '"Alzheimers"', query time: 0.09s Refine Results
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    Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition by Jianying Zeng, Jenny Libien, Fatima Shaik, Jason Wolk, A. Iván Hernández

    Published 2016-01-01
    “…Synaptic dysfunction is thought to play a major role in memory impairment in Alzheimer’s disease (AD). PARP-1 has been identified as an epigenetic regulator of plasticity and memory. …”
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    Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease by Alexa L. Wright, Aldis P. Weible, Olivia B. Estes, Michael Wehr

    Published 2025-02-01
    “…This raises the possibility that ketamine could slow down or prevent network disruption and the ensuing sensory and behavioral deficits in Alzheimer's. Here we tested this idea in the 5XFAD mouse model of Alzheimer's, using either an acute single injection of ketamine, or chronic daily injections over 15 weeks. …”
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    Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPARγ by Ning Li, Yan Wang, Wensheng Li, Haiyan Li, Liu Yang, Jun Wang, Hazem A. Mahdy, Ahmed B. M. Mehany, Dareen A. Jaiash, Eman Y. Santali, Ibrahim H. Eissa

    Published 2020-01-01
    “…In the last few decades, Alzheimer’s disease (AD) has emerged as a serious global problem, and it has been considered as the most common type of dementia. …”
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    The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

    Published 2025-01-01
    “…Lipid-droplet-accumulating microglia were identified in the aging mouse and human brain; however, little is known about the formation and role of lipid droplets in microglial neuroinflammation of Alzheimer’s disease (AD). Here, we report a striking buildup of lipid droplets accumulation in microglia in the 3xTg mouse brain. …”
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    Structural Alteration of Medial Temporal Lobe Subfield in the Amnestic Mild Cognitive Impairment Stage of Alzheimer’s Disease by Pan He, Hang Qu, Ming Cai, Weijie Liu, Xinyi Gu, Qiang Ma

    Published 2022-01-01
    “…Volume reduction and structural abnormality is the most replicated finding in neuroimaging studies of Alzheimer’s disease (AD). Amnestic mild cognitive impairment (aMCI) is the early stage of AD development. …”
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    The Takeda Three Colors Combination Test: A Screening Test for Detection of Very Mild Alzheimer’s Disease by Shinya Takeda, Kayo Tajime, Toshiatsu Taniguchi

    Published 2014-01-01
    “…Background. Alzheimer’s disease (AD) is the most common type of dementia and is prevalent worldwide. …”
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    Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease by Jing Jiang, Gang Liu, Suhua Shi, Zhigang Li

    Published 2016-01-01
    “…To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer’s disease. Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer’s disease animal model. …”
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    A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease by Jorge I. Vélez, Dora Rivera, Claudio A. Mastronardi, Hardip R. Patel, Carlos Tobón, Andrés Villegas, Yeping Cai, Simon Easteal, Francisco Lopera, Mauricio Arcos-Burgos

    Published 2016-01-01
    “…We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. …”
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    Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations by Alejandro Soto-Ospina, Pedronel Araque Marín, Gabriel de Jesús Bedoya, Andrés Villegas Lanau

    Published 2021-01-01
    “…Alzheimer’s disease manifests itself in brain tissue by neuronal death, due to aggregation of β-amyloid, produced by senile plaques, and hyperphosphorylation of the tau protein, which produces neurofibrillary tangles. …”
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