Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases by Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin

“…RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. …”
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Susceptibility to Aneuploidy in Young Mothers of Down Syndrome Children by Lucia Migliore, Francesca Migheli, Fabio Coppedè

“…We also discuss the increased risk of developing Alzheimer's disease (AD) later in life that was observed in women who had a DS child at a young age. …”
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Roles of Brain Angiotensin II in Cognitive Function and Dementia by Masaki Mogi, Jun Iwanami, Masatsugu Horiuchi

“…Particularly, in dementia, epidemiological studies indicate a preventive effect of RAS blockade on cognitive impairment in Alzheimer disease (AD). Moreover, basic experiments suggest a role of brain angiotensin II in neural injury, neuroinflammation, and cognitive function and that RAS blockade attenuates cognitive impairment in rodent dementia models of AD. …”
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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. …”
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Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives by Marjan Talebi, Alireza Ghassempour, Afsoon Feizi, Seyed Abdulmajid Ayatollahi, Mehrdad Faizi

“…The role of the genus Dracocephalum was investigated in relation to various neurological conditions such as Alzheimer's disease, insomnia, Parkinson's disease, vascular dementia, cerebral ischemia, pain, depression, and glioblastoma. …”
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Inhibition of carboxymethyllysine in walnut cookies via food additives by Wenfeng Han, Po Qiu, Songtao Ge, Taoying Wei

“…Carboxymethyllysine(CML) is one of advanced glycation end products(AGEs), which is associated with the occurrence and development of chronic diseases such as diabetes, cardiovascular disease, Alzheimer's disease, etc. This study focused on assessing the CML formation pattern in walnut cookies and the related impact of food additives on the CML content and sensory characteristics. …”
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One Size Does Not Fit All: Face Emotion Processing Impairments in Semantic Dementia, Behavioural-Variant Frontotemporal Dementia and Alzheimer’s Disease Are Mediated by Distinct Co... by Laurie A. Miller, Sharpley Hsieh, Suncica Lah, Sharon Savage, John R. Hodges, Olivier Piguet

“…Patients with frontotemporal dementia (both behavioural variant [bvFTD] and semantic dementia [SD]) as well as those with Alzheimer's disease (AD) show deficits on tests of face emotion processing, yet the mechanisms underlying these deficits have rarely been explored. …”
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Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…In addition to helping improve isolated insomnia, Suvorexant helps improve sleep in patients that have other comorbidities such as obstructive sleep apnea, Alzheimer's disease, dementia, acute stroke, and delirium. …”
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Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City by Ezzuldin sulaiman, Hind Suhail Abdulhay

“…Iron is one of the heavy metals around which there is much controversy regarding their role as neurotoxins in the development of autism, its excess in the brain may cause Alzheimer's disease or Parkinson's disease, while iron deficiency in the blood may increase levels of other heavy metals in the blood and brain, such as cadmium and lead. …”
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Clinical Correlates of Awareness for Balance, Function, and Memory: Evidence for the Modality Specificity of Awareness by Megan E. O'Connell, Vanina Dal Bello-Haas, Margaret Crossley, Debra Morgan

“…Awareness of function was higher for participants with mild cognitive impairment (aMCI and non-aMCI) than for those with dementia (due to Alzheimer disease; AD and non-AD), whereas awareness of memory was higher for both non-aMCI and non-AD dementia patients than for those with aMCI or AD. …”
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Posterior AD-Type Pathology: Cognitive Subtypes Emerging from a Cluster Analysis by Antonella Cappa, Nicoletta Ciccarelli, Eleonora Baldonero, Marialuisa Martelli, Maria Caterina Silveri

“…“Posterior shift” of the neuropathological changes of Alzheimer's disease (AD) produces a syndrome (posterior cortical atrophy) (PCA) dominated by high-level visual deficits. …”
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A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ışgın (Rheum telianum) as an edible plant by Ahmet Zafer Tel, Kubra Aslan, Mustafa Abdullah Yılmaz, İlhami Gulcin

“…The inhibition effects of both leaves and the seeds of the R. telianum extracts on acetylcholinesterase and butyrylcholinesterase, α-glycosidase and human carbonic anhydrases II isoenzyme enzymes, which associated with some global diseases including Alzheimer's disease, type-2 diabetes mellitus and glaucoma were determined. …”
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Cerebrospinal Fluid Biomarkers and Prediction of Conversion in Patients with Mild Cognitive Impairment: 4-Year Follow-Up in a Routine Clinical Setting by Alessia Lanari, Lucilla Parnetti

“…Several investigations have shown the usefulness of cerebrospinal fluid (CSF) biomarkers (Aβ42, total tau [T-tau], and phosphorylated tau [P-tau]) in predicting the progression to Alzheimer's disease (AD). We report a 4-year follow-up of MCI patients who underwent CSF evaluation for biomarker assessment, in order to further evaluate the usefulness of CSF analysis in predicting the conversion to dementia in a routine clinical setting. …”
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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization. by Gowtham A Rao, Azza Shoaibi, Rupa Makadia, Jill Hardin, Joel Swerdel, James Weaver, Erica A Voss, Mitchell M Conover, Stephen Fortin, Anthony G Sena, Chris Knoll, Nigel Hughes, James P Gilbert, Clair Blacketer, Alan Andryc, Frank DeFalco, Anthony Molinaro, Jenna Reps, Martijn J Schuemie, Patrick B Ryan

“…We test our framework by evaluating one PA for systemic lupus erythematosus (SLE) and two PAs for Alzheimer's disease (AD) across 10 different observational data sources.…”
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Dietary Fatty Acids and Predementia Syndromes by Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D' Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza

“…However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non–Vapolipoprotein E (APOE) ε4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE ε4 carriers. …”
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C/EBPβ in Alzheimer’s disease: An integrative regulator of pathological mechanisms by Xiaoting Luo, Junyi Liang, Xue Lei, Fengqi Sun, Minghai Gong, Bin Liu, Zhongguang Zhou

“…Alzheimer's disease (AD) stands as one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function, neuroinflammation, amyloid-beta (Aβ) plaques, and neurofibrillary tangles (NFTs). …”
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Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation by Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadia

“…This approach might be helpful to understand the selectivity of the given drug molecule in the treatment of Alzheimer's disease. The study provides evidence for consideration of C28H34N2O6 as a valuable small ligand molecule in treatment and prevention of AD associated disorders and further in vitro and in vivo investigations may prove its therapeutic potential.…”
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Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review by Feixuan Wang, Jingqiong Wan, Yangzhen Liao, Shangyu Liu, Yuan Wei, Zhen Ouyang

“…Furthermore, they reduce neurotoxicity, alleviate brain injury and neuropathy, and prevent neurodegenerative conditions including stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease in humans and/or rodents. …”
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Classifying Dementia Using Local Binary Patterns from Different Regions in Magnetic Resonance Images by Ketil Oppedal, Trygve Eftestøl, Kjersti Engan, Mona K. Beyer, Dag Aarsland

“…We explored the use of 2D local binary pattern (LBP) extracted from FLAIR and T1 MR images of the brain combined with a Random Forest classifier in an attempt to discern patients with Alzheimer's disease (AD), Lewy body dementia (LBD), and normal controls (NC). …”
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc receptor complexes that contain an immunoreceptor tyrosine-based activation motif (ITAM). …”
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