Measurement Report: Changes in ammonia emissions since the 18th century in south-eastern Europe inferred from an Elbrus (Caucasus, Russia) ice-core record by M. Legrand, M. Legrand, M. Vorobyev, D. Bokuchava, S. Kutuzov, S. Kutuzov, A. Plach, A. Stohl, A. Khairedinova, V. Mikhalenko, M. Vinogradova, S. Eckhardt, S. Preunkert

Get full text

Transcriptomic and metabolomic analysis of recalcitrant phosphorus solubilization mechanisms in Trametes gibbosa by Yulan Chen, Akasha Farooq, XieLuyao Wei, Leitao Qin, Yong Wang, Lingzi Zhang, Quanju Xiang, Ke Zhao, Xiumei Yu, Qiang Chen, Xue Gao, Tashi Nyima, Petri Penttinen, Yunfu Gu

“…Compared with the Ca-P treatment, T-41 demonstrated a stronger alkaline phosphatase (ALP) production capacity under Phytin-P treatment (34.5 ± 1.2 μmol/L/h vs. 19.8 ± 0.8 μmol/L/h, p < 0.05). …”
Get full text

Dietary tea tree (Melaleucae Aetheroleum) oil fortifies growth, biochemical, immune-antioxidant trait, gene function, tissue reaction, and Aeromonas sobria resistance in Nile tilap... by Mohamed Shaalan, Heba H. Mahboub, Ahmed Hosny Abdelgawad, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Ahmed A. Elnegiry, Asmaa W. Basher, Walaa El-Houseiny, Sherif M. Shawky, Sahar H. Orabi, Simon J. Davies, Yasmina K. Mahmoud

“…Lower levels of urea, creatinine, AST, ALP, ALT, cortisol, glucose, triglycerides, cholesterol and body crude lipids were observed in the fish that were fed a 2.0 mL TTO/kg diet. …”
Get full text

Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats by Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

“…CSCs-exosomes induced a significant increase in liver relative weight and serum levels of cancer markers (AFP and GGT) and liver enzymes (ALT, AST, and ALP), intensive immunostaining for the HCC marker GST-P, and an increased number and area of tumor nodules as compared to HCC rats injected by PBS. …”
Get full text

Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

“…Cyclophosphamide increased ALT (52.3 U/L), AST (48.7 U/L), ALP (46.5 U/L), total bilirubin (1.4 mg/dL), conjugated bilirubin (0.8 mg/dL), creatinine (0.8 mg/dL), urea (45.6 mg/dL), and BUN (15.7 mg/dL), with a reduction in the albumin (4.8 g/dL) level. …”
Get full text

Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis by Alessio Gerussi, Oliver Lester Saldanha, Giorgio Cazzaniga, Damiano Verda, Zunamys I. Carrero, Bastian Engel, Richard Taubert, Francesca Bolis, Laura Cristoferi, Federica Malinverno, Francesca Colapietro, Reha Akpinar, Luca Di Tommaso, Luigi Terracciano, Ana Lleo, Mauro Viganó, Cristina Rigamonti, Daniela Cabibi, Vincenza Calvaruso, Fabio Gibilisco, Nicoló Caldonazzi, Alessandro Valentino, Stefano Ceola, Valentina Canini, Eugenia Nofit, Marco Muselli, Julien Calderaro, Dina Tiniakos, Vincenzo L’Imperio, Fabio Pagni, Nicola Zucchini, Pietro Invernizzi, Marco Carbone, Jakob Nikolas Kather

“…A multivariate explainable ML model revealed that PBC cases misclassified as AIH more often had ALP values between 1 × upper limit of normal (ULN) and 2 × ULN, coupled with AST values above 1 × ULN. …”
Get full text

The potential of supplementing compound organic trace elements at lower levels in Chinese yellow-feathered broiler diets, Part I: Impacts on plasma biochemical parameters, antioxid... by Xiaoyan Nie, Yucheng Yin, Qi Lu, Fei Zhao, Yang Dai, Rui Wang, Yiwen Ji, Huihua Zhang, Cui Zhu

“…The results showed that the alkaline phosphatase (ALP) activity of the OTM300 group was significantly higher than that of the NC, PC, and ITM300 groups (P < 0.05). …”
Get full text

Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…A consistent increase in plasma AST and ALT activities with a decline in ALP activity was found following 14 °C and 7 °C cold stress compared with the control group. …”
Get full text

Nivolumab plasma concentration and clearance associated with overall survival in patients with renal cell carcinoma by Aurélien Marabelle, Laurence Albiges, Angelo Paci, Cécile Dalban, David Combarel, Sophie Broutin, Christophe Maritaz, Louis Blondel

Get full text

Estimation of Apolipoprotein A1, Haptoglobin and Alpha 2macroglobulin with some Biochemical Metabolic Markers in Nonalcoholic Fatty Liver Disease Iraqi Patients by hiba abid Al-hussein hassan, Dawood Salman Dawood, Raghad Jawad Hussein

“…NAFLD subjects had a highly significant elevation (p=0.000) in the mean ± SD of BMI, FBS, HbA1c, AST, ALP, cholesterol, triglyceride, LDL, VLDL, and Alpha 2 macroglobulin compared with the healthy control. …”
Get full text

Effects of in ovo feeding of vitamin C on embryonic development, hatching process, and chick rectal temperature of broiler embryos by Shan Du, Jianchuan Zhou, Xiang Ao, Xiang Ao, Yufei Zhu, Yufei Zhu

“…Compared to the NS group, the plasma biochemical indicators in the VC group showed significantly lower levels of alkaline phosphatase (ALP), total protein (TP), albumin (ALB), GLB, total bilirubin (TBIL), TBA, uric acid (UA), high-density lipoprotein cholesterol (HDL-C), and corticosterone (CORT) (p &lt; 0.05). …”
Get full text

Robotic Assistance in Simultaneous Bilateral Medial Unicompartmental Knee Arthroplasty: A Retrospective Cohort Study of 126 Knees Demonstrating Enhanced Radiographic Accuracy and C... by Valentina Rossi, MD, Constant Foissey, MD, Andreas Fontalis, MD, MSc, MRCS, Gabriel Gaggiotti, MD, Stefano Gaggiotti, MD, Elvire Servien, MD, PhD, Sébastien Lustig, MD, PhD

Get full text

Associations between Life’s Essential 8 and liver function: a cross-sectional study by Qiaoli Liang, Menglong Zou, Ziming Peng

“…The relationship between LE8 scores and liver function markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and ALT/AST ratio, was evaluated using multivariable linear regression, smoothed curve fitting, threshold effect analysis, and weighted quantile sum (WQS) regression. …”
Get full text

吴茱萸次碱通过Sirt1改善血管平滑肌细胞钙化 by 邵静, 陈安, 张秀丽, 杨平珍

“…使用吴茱萸次碱明显降低血管平滑肌细胞成骨样分化的分子标志物ALP活性，下调Runx2（2.85±0.25、1.75±0.18、1.62±0.13、1.36±0.16、P<0.05），BMP2（3.2±0.32、1.85±0.17、1.65±0.15、1.43±0.12，P<0.05）和Osterix（2.60±0.27、1.82±0.16、1.55±0.15、1.36±0.17；P<0.05）的表达水平，说明吴茱萸次碱可抑制血管平滑肌细胞成骨样分化过程。…”
Get full text

Is Amanita phalloides Nephrotoxicity due to Mitochondrial Toxicity? by Jules Weinhard, Justine Serre, Perrine Frère, Clovis Adam, Marie Camille Lafargue, David Buob, Cédric Rafat

Get full text

Management of sleep apnoea syndrome (SAS) in patients with vasovagal syncope (VVS): a protocol for the VVS-SAS cohort study by Jean Louis Pepin, Nicolas Molinari, Frédéric Gagnadoux, Carey Meredith Suehs, Frédéric Roche, Vincent Puel, Isabelle Godard, Georgios Papaioannou, Philippe Gosse, Fabrice Thoin, Jean Claude Deharo, Naïma Zarqane

Get full text

Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees by Benoît Quesnel, Marie-Christine Boiron, Michel Cathelineau, Laurent Truche, Thomas Rigaudier, Gérard Bardoux, Pierre Agrinier, Michel de Saint Blanquat, Emmanuel Masini, Eric C. Gaucher

Get full text

Association between the use of daily injury risk estimation feedback (I-REF) based on machine learning techniques and injuries in athletics (track and field): results of a prospect... by Karsten Hollander, David Blanco, Pascal Edouard, Laurent Navarro, Antoine Bruneau, Alexis Ruffault, Joris Chapon, Pierre-Eddy Dandrieux, Christophe Ley, Spyridon (Spyros) Iatropoulos

Get full text

Dietary Thymol Improved Growth, Body Composition, Digestive Enzyme Activities, Hematology, Immunity, Antioxidant Defense, and Resistance to Streptococcus iniae in the Rainbow Trout... by Hafsan Hafsan, Marwan Mahmood Saleh, Rahman S. Zabibah, Rasha Fadhel Obaid, Hijran Sanaan Jabbar, Yasser Fakri Mustafa, Mohammed Q. Sultan, Gamal A. Gabr, Andrés Alexis Ramírez-Coronel, Mohammad Khodadadi, Mahnaz Dadras

“…TYM at dietary levels of 1.5-2.5 g significantly enhanced liver antioxidant enzyme activity [superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT)], immune components in blood [alternative complement activity (C3), total immunoglobulin (Ig), lysozyme activity, bactericidal activity, and total protein], and in mucus [alkaline phosphatase (ALP), protease activity, lysozyme activity, bactericidal activity, and total protein] compared to other diets (P<0.05). …”
Get full text

Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants by Nikos Stratakis, Augusto Anguita-Ruiz, Lorenzo Fabbri, Léa Maitre, Juan R. González, Sandra Andrusaityte, Xavier Basagaña, Eva Borràs, Hector C. Keun, Lida Chatzi, David V. Conti, Jesse Goodrich, Regina Grazuleviciene, Line Småstuen Haug, Barbara Heude, Wen Lun Yuan, Rosemary McEachan, Mark Nieuwenhuijsen, Eduard Sabidó, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Theano Roumeliotaki, Marina Vafeiadi, John Wright, Mariona Bustamante, Martine Vrijheid

Get full text