Intestinal microbiota dysbiosis contributes to the liver damage in subchronic arsenic-exposed mice by Dong Ling, Luo Peng, Zhang Aihua

“…Treatment with arsenic results in pathological and histological changes in the liver, such as inflammatory cell infiltration and decreased levels of TP and CHE but increased levels of ALP, GGT, TBA, AST, and ALT. …”
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A Gradual Approach for Multimodel Journey Planning: A Case Study in Izmir, Turkey by Feriştah Dalkılıç, Yunus Doğan, Derya Birant, Recep Alp Kut, Reyat Yılmaz

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Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat by Nazar M. Shareef Mahmood

“…Paraquat administration showed significant decrease in BW, food intake, liver, kidney weight also PQ increased malondialdehyde (MDA), low density lipoprotein (LDL), alkaline phosphatase (ALP) and, uric acid (UA) significantly. Therefore, the current results indicate that, the herbicide PQ showed adverse effects through initiation of lipid peroxidation, while T.vulgaris extract produced a significant recovery in ameliorating some aspects of PQ toxicity. …”
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Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma by Masume Farhadi, Farshad Sohbatzadeh, Akbar Hajizadeh Moghaddam, Yasaman Firouzjaei, Cheng Cheng

“…We investigated an ineffective dose of NAC and its parallel effect through the administration of PTN on liver and kidney morphology and several biochemical factors including ALT, AST, and ALP. Additionally, we examined oxidative stress, antioxidant parameters, and glutathione (GSH) levels. …”
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Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant by Manzoor Ullah, Sultan Mehmood, Rehmat Ali Khan, Maroof Ali, Fozia Fozia, Muhammad Waqas, Riaz Ullah, Amal Alotaibi, Mujeeb A. Sultan

“…An elevated level of blood glucose level, lipids (Cholesterol, TG, LDL), liver function marker enzymes (ALT, AST, ALP), and kidney function markers (bilirubin, creatinine, urea) were observed in alloxan-induced diabetic rats; however, a HDL level was decreased. …”
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Scaffolds fabricated via two-photon polymerisation for regulating cell morphology and differentiation by Zheyu Yao, Xiuzhen Zhang, Wenhui Yu, Zhen Xiao, Wenli Zhou, Dongfeng Qi, Wuhong Xin, Weilong Cao, Hongyu Zheng

“…Notably, compared to the control group, the cells on the scaffolds exhibited smaller nucleus areas, lower circularity, and aspect ratios, but these values increased as pore size increased. Furthermore, ALP staining showed a greater tendency for osteogenic differentiation with larger pore sizes. …”
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RESPONSE OF BROILERS TO DIMETHYLGLYCINE ADDITION TO NORMAL AND LOW-ENERGY DIET ON PHYSIOLOGICAL PERFORMANCE AND ANTIOXIDANT STATUS by A. A. Hazaa, H. H. Nafe

“…Birds were fed on two dietary systems: the first bishop feature that included transactions (T1, T2, T3), the first transaction T1 was control without adding (normal diet), the second transaction T2 and the third T3 (adding DMG at 300 and 600 mg/ kg ordinary diet sequential First treatment without adding (T1, T2, T3). 300 and 600 mg/kg low-energy rations, respectively). an improvement (P < 0.05) in favor of the low-energy diet with the addition of DMG at the level of 600 mg / kg feed for ALP enzyme, and a significant improvement (P < 0.05) was observed in the number of lymphocytes in favor of the normal and low-energy diet when adding DMG at the level of 600 mg / kg feed. …”
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Effect of nanoparticulate CaCO3 on the biological properties of calcium silicate cement by Quang Canh Vo, Gitae Son, Gyeung Mi Seon, Sun Woo Um, Sang Hoon Choi, Hyeong-Cheol Yang

“…Regarding osteogenic activity, CSC-NPCCs (5%, 10%, 20%) enhanced the expression of osteogenic genes, including runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), type I collagen (COL-1), and osteocalcin (OCN). …”
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Low-Intensity Pulsed Ultrasound Modulates RhoA/ROCK Signaling of Rat Mandibular Bone Marrow Mesenchymal Stem Cells to Rescue Their Damaged Cytoskeletal Organization and Cell Biolog... by Rong Zhang, Zhaoling Wang, Guoxiong Zhu, Gaoyi Wu, Qingyuan Guo, Hongchen Liu, Lei Chen

“…In this study, the effects of LIPUS on cytoskeletal reorganization, cell viability, and osteogenic differentiation capacity of rat mandible-derived bone marrow mesenchymal stem cells (M-BMMSCs) induced by radiation were determined by immunofluorescence staining, CCK-8 cell proliferation assay, quantification of alkaline phosphatase (ALP) activity, alizarin red staining, and real-time RT-PCR, respectively. …”
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Collaborative Effects of Caloric Restriction and Quercetin on Age-related Oxidative Stress Reduction through NQO1/Sirt1 Gene Regulation by Fereshte Ghorbani, Arezou Biyabani, Darya Ghadimi, Keivan Nedaei, Hadi Khodabandehloo, Mina Hemmati

“…Results: We showed higher liver enzymes (aspartate aminotransferase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP]), increased atherogenic lipids, and reduced PON1 activity in 20-week-old rats compared with eight-week-old rats, and the administration of QUER and CR restored these values to the normal range. …”
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Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells by Weili Xu, Pan He, Shenghua He, Pengju Cui, Yaqing Mi, Yang Yang, Yang Li, Shaobo Zhou

“…Our results showed that γ-tocotrienol (2–8 μmol/L) significantly improved the cell proliferation (p<0.05), but it did not affect cell cycle progression. γ-Tocotrienol significantly increased alkaline phosphatase (ALP) activity (p<0.05), secretion levels of osteocalcin (OC) and osteonectin (ON), and mRNA levels of collagen type I (Col I) of MC3T3-E1 cells. …”
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The molecular prevalence of Theileria equi in the Arabian stallion in Egypt with special reference to biochemical parameters by Noora F. Thabet, Omaima M. Kandil, Omnia M. Kandil, Khalid M. Fararh

“…Total bilirubin, direct bilirubin, indirect bilirubin, GGT, GOT (AST), urea, and creatinine were significantly increased in the serum of the infected group compared with the healthy group; total protein, albumin, and globulin were found to be decreased in the serum of the infected group when compared to the healthy group. The ALP and albumin: globulin (A: G) ratio changes weren&rsquo;t significant in this study. …”
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CADD based designing and biological evaluation of novel triazole based thiazolidinedione coumarin hybrids as antidiabetic agent by Anchal Sharma, Anmol Narang, Nitish Kumar, Rupali Rana, Megha, Pooja, Muskan Dhir, Harmandeep Kaur Gulati, Jyoti, Aanchal Khanna, Jatinder Vir Singh, Sukhraj Kaur, Preet Mohinder Singh Bedi

“…Furthermore, Compound I-1, like Acarbose, resulted in significant reductions in ALT, AST, ALP, urea, LDH, and creatinine levels, suggesting improved liver and kidney function.…”
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Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling by Wei Qin, Qi-Ting Huang, Michael D. Weir, Zhi Song, Ashraf F. Fouad, Zheng-Mei Lin, Liang Zhao, Hockin H. K. Xu

“…In addition, EtOH downregulated the alkaline phosphatase activity, attenuated the mineralized nodule formation, and suppressed the expression of odontoblastic markers including ALP, DSPP, DMP-1, Runx2, and OCN. Moreover, the pretreatment with rapamycin, a specific mTOR inhibitor, markedly reversed the EtOH-induced odontoblastic differentiation and cell mineralization. …”
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Mitigative Effect of Erythromycin on PMMA Challenged Preosteoblastic MC3T3-E1 Cells by Yi Shen, Weili Wang, Xiaomiao Li, David C. Markel, Weiping Ren

“…Cell differentiation was determined by activity of alkaline phosphatase (ALP). Gene expression was measured via real-time quantitative RT-PCR. …”
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Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin by Yufeng Zhang, Huaxin Deng, Zhiqiang Yang, Zhe Chen, Sheng Zhang, Yufan Zhu, Min Yang, Houcheng Zhong, Fuling Zhou, Yuanlong Xie, Lin Cai

“…The differentiation of osteoblasts was measured by ALP and Alizarin red staining and transmission electron microscopy. …”
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Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep by Fulya Altınok Yipel, Hüseyin Güngör

“…In addition, hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV, PDW, PCT, PLT) and biochemical parameters (AST, ALT, ALP, GGT, TP, UREA, CREA, CHOL, TRIG, ALB) ) and the levels of coagulation parameters (PT, APTT, INR, FIB) were determined.…”
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Effect of precise health management combined with physical rehabilitation on bone biomarkers in senile osteoporosis patients by Litao Chen, Xiaojing Yan, Yongjian Liu, Yongbin Pei, Jin Zhou, Lei Zhang, Zhixing Du

“…Additionally, scores on the Osteoporosis Knowledge Scale, Osteoporosis Self-Efficacy Scale, bone mineral density (BMD), ALP levels, and calcium levels were significantly higher in the observation group compared to the control group (P < 0.05). …”
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Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis by Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou

“…In the presence of S. aureus, the secreted MNase preferentially cut the nucleobase AT-rich regions of DNA sequences on magnetic beads (MBs) to release alkaline phosphatase (ALP), which subsequently mediated the oxTMB reduction for inducing the colorimetric/SERS signal fade away. …”
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Biomedical application of gelatin-PVA-silk fibre composite reinforced with copper and manganese substituted hydroxyapatite by Sabareeswari Kalidas, Shanmugam Sumathi

“…The cell-viability study showed that MG-63 cells had successfully attached and grown on the scaffold surface. From the ALP activity it was found that osteoblast mineralization on the scaffolds increased as increasing the time interval. …”
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