Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…The identity of phenolic compounds of the hydroethanolic extract of S. deserti was conducted through HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) analyses.ResultsOral administration of hydroethanolic extract of S. deserti at 200 and 400 mg/kg for 14 days significantly decreased blood glucose and restored the hepatic and renal function by reducing the levels of ALT, AST, ALP, GGT, LDH, urea and creatinine. An improved lipid profile as revealed by the reduced levels of TC, TG and LDL coupled with increased level of HDL was also observed. …”
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Investigating processes influencing simulation of local Arctic wintertime anthropogenic pollution in Fairbanks, Alaska, during ALPACA-2022 by N. Brett, N. Brett, K. S. Law, S. R. Arnold, J. G. Fochesatto, J.-C. Raut, T. Onishi, R. Gilliam, K. Fahey, D. Huff, G. Pouliot, B. Barret, E. Dieudonné, R. Pohorsky, J. Schmale, A. Baccarini, A. Baccarini, S. Bekki, G. Pappaccogli, F. Scoto, S. Decesari, A. Donateo, M. Cesler-Maloney, W. Simpson, P. Medina, B. D'Anna, B. Temime-Roussel, J. Savarino, S. Albertin, S. Albertin, J. Mao, B. Alexander, A. Moon, P. F. DeCarlo, V. Selimovic, R. Yokelson, E. S. Robinson

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Investigating processes influencing simulation of local Arctic wintertime anthropogenic pollution in Fairbanks, Alaska, during ALPACA-2022 by N. Brett, N. Brett, K. S. Law, S. R. Arnold, J. G. Fochesatto, J.-C. Raut, T. Onishi, R. Gilliam, K. Fahey, D. Huff, G. Pouliot, B. Barret, E. Dieudonné, R. Pohorsky, J. Schmale, A. Baccarini, A. Baccarini, S. Bekki, G. Pappaccogli, F. Scoto, S. Decesari, A. Donateo, M. Cesler-Maloney, W. Simpson, P. Medina, B. D'Anna, B. Temime-Roussel, J. Savarino, S. Albertin, S. Albertin, J. Mao, B. Alexander, A. Moon, P. F. DeCarlo, V. Selimovic, R. Yokelson, E. S. Robinson

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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Results: Cadmium (Cd) exposure caused anemia and hepatorenal damage, as evidenced by increased serum levels of urea, creatinine, uric acid, total bilirubin (including its direct and indirect fractions), and elevated activities of liver enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). However, total protein and albumin levels decreased. …”
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Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin by Hamad Abdulsalam Hamad Alfarisi, Muhammad Bin Ibrahim, Zenab B. Hamad Mohamed, Nuraniza Azahari, Asmah Hanim Bt. Hamdan, Che Anuar Che Mohamad

“…Serum lipids and liver function test (LFT) were measured prior to and at the endpoint of the experiment for total cholesterol (TC), low-density lipoprotein (LDL-c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and total bilirubin (T. …”
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The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and Obesity by Jun Li, Ya Li, Yunqiu Lu, Siyuan Li, Yecheng Zhu, Chuanbing Sun, Partab Rai, Xuehai Jia

“…Multifactorial logistic regression analysis revealed that BMD (OR 3.755; 95% CI, 1.215-11.608) and triglyceride-glucose (TyG) index (OR 2.855; 95% CI, 1.361-5.986) were risk factors for T2DM in postmenopausal women, whereas alkaline phosphatase (ALP; OR 0.970; 95% CI, 0.945-0.995) and rs4988331 mutation (OR 0.018; 95% CI, 0.006-0.060) were protective factors. …”
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Effects of using different levels of dietary chitosan on some immune indices and antioxidant defense system in Vannamei shrimp, Litopenaeus vannamei by Saeed Dayani, Valiallah Jafari, Roghayeh Safari, Seyed Hossein Hoseinifar

“…Also, the results of the serum biochemical analyses exhibited that only ALP enzyme recorded a significant difference (p<0.05), so that the highest value was observed in T3. …”
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration by Lingling E, Rongjian Lu, Jianwei Sun, Hongbo Li, Wen Xu, Helin Xing, Xing Wang, Tao Cheng, Shuo Zhang, Xiaocao Ma, Rong Zhang, Hongchen Liu

“…In the in vitro two-dimensional culture microenvironment, OMD or OMD with rhBMP-7 significantly enhanced hUC-MSCs’ osteocalcin immunofluorescence staining, alkaline phosphatase, and Alizarin red staining; OMD with rhBMP-7 exhibited the highest ALP secretion and mineralized matrix formation. …”
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Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral hea... by Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo

“…Subsequently, the effect of exosomal miR-122 on the osteogenic differentiation ability of BMSCs was detected, including cell proliferation, expression of osteogenic-related genes (RUNX2, BMP2, OPN, ALP), and calcium nodule formation. Finally, the therapeutic effect of M2-Exo was analyzed in a rat model of AIONFH, and bone repair and pathological damage were evaluated by Micro-CT, RT-qPCR, HE, Masson staining, and immunohistochemistry (COL I). …”
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Trends in Air Pollution in Europe, 2000–2019 by Wenche Aas, Hilde Fagerli, Andres Alastuey, Fabrizia Cavalli, Anna Degorska, Stefan Feigenspan, Hans Brenna, Jonas Gliß, Daniel Heinesen, Christoph Hueglin, Adéla Holubová, Jean-Luc Jaffrezo, Augustin Mortier, Marijana Murovec, Jean-Philippe Putaud, Julian Rüdiger, David Simpson, Sverre Solberg, Svetlana Tsyro, Kjetil Tørseth, Karl Espen Yttri

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Assessment of Hydrologic Data Estimates From ERA5 Reanalyses in Benin, West Africa by René Bodjrènou, Luc Ollivier Sintondji, Yekambessoun M' Po N'Tcha, Diane Germain, Francis Esse Azonwade, Fernand Sohindji, Gilbert Hounnou, Edid Amouzouvi, Arthur Freud Segnon Kpognin, Françoise Comandan

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Five decades of Abramov glacier dynamics reconstructed with multi-sensor optical remote sensing by E. Mattea, E. Berthier, A. Dehecq, T. Bolch, T. Bolch, A. Bhattacharya, A. Bhattacharya, S. Ghuffar, M. Barandun, M. Hoelzle

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Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network by Vincent Poindron, Benjamin Terrier, François Maillot, Jean-Pierre Gangneux, Nassim Kamar, Valéry Salle, Lilia Hasseine, François Danion, Lilia Merabet, Guillaume Desoubeaux, Éric Bailly, Milène Sasso, Antoine Néel, Simon Galmiche, Benjamin Thoreau, Stéphane Bretagne, Alexandre Alanio, André Paugam, Valérie Letscher-Bru, Sophie Cassaing, Hélène Guegan, Loïc Favennec, Alida Minoza, Florent Morio, Julie Bonhomme, Odile Eloy, Laurence Millon, Anne-Pauline Bellanger, Philippe Poirier, Maxime Moniot, Taieb Chouaki, Antoine Huguenin, Frédéric Dalle, Bernard Bouteille, Muriel Nicolas, Nicole Desbois-Nogard, Marie-Elisabeth Bougnoux, Karine Boukris-Sitbon, Fanny Lanternier, Caroline Mahinc, Marc Pihet, Magalie Demar, Céline Damiani, Marie-Fleur Durieux, Elena Charpentier, Cécile Nourrisson, Benoit Suzon

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Measurement Report: Changes in ammonia emissions since the 18th century in south-eastern Europe inferred from an Elbrus (Caucasus, Russia) ice-core record by M. Legrand, M. Legrand, M. Vorobyev, D. Bokuchava, S. Kutuzov, S. Kutuzov, A. Plach, A. Stohl, A. Khairedinova, V. Mikhalenko, M. Vinogradova, S. Eckhardt, S. Preunkert

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Transcriptomic and metabolomic analysis of recalcitrant phosphorus solubilization mechanisms in Trametes gibbosa by Yulan Chen, Akasha Farooq, XieLuyao Wei, Leitao Qin, Yong Wang, Lingzi Zhang, Quanju Xiang, Ke Zhao, Xiumei Yu, Qiang Chen, Xue Gao, Tashi Nyima, Petri Penttinen, Yunfu Gu

“…Compared with the Ca-P treatment, T-41 demonstrated a stronger alkaline phosphatase (ALP) production capacity under Phytin-P treatment (34.5 ± 1.2 μmol/L/h vs. 19.8 ± 0.8 μmol/L/h, p &lt; 0.05). …”
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Dietary tea tree (Melaleucae Aetheroleum) oil fortifies growth, biochemical, immune-antioxidant trait, gene function, tissue reaction, and Aeromonas sobria resistance in Nile tilap... by Mohamed Shaalan, Heba H. Mahboub, Ahmed Hosny Abdelgawad, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Ahmed A. Elnegiry, Asmaa W. Basher, Walaa El-Houseiny, Sherif M. Shawky, Sahar H. Orabi, Simon J. Davies, Yasmina K. Mahmoud

“…Lower levels of urea, creatinine, AST, ALP, ALT, cortisol, glucose, triglycerides, cholesterol and body crude lipids were observed in the fish that were fed a 2.0 mL TTO/kg diet. …”
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Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats by Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

“…CSCs-exosomes induced a significant increase in liver relative weight and serum levels of cancer markers (AFP and GGT) and liver enzymes (ALT, AST, and ALP), intensive immunostaining for the HCC marker GST-P, and an increased number and area of tumor nodules as compared to HCC rats injected by PBS. …”
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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

“…Cyclophosphamide increased ALT (52.3 U/L), AST (48.7 U/L), ALP (46.5 U/L), total bilirubin (1.4 mg/dL), conjugated bilirubin (0.8 mg/dL), creatinine (0.8 mg/dL), urea (45.6 mg/dL), and BUN (15.7 mg/dL), with a reduction in the albumin (4.8 g/dL) level. …”
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Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis by Alessio Gerussi, Oliver Lester Saldanha, Giorgio Cazzaniga, Damiano Verda, Zunamys I. Carrero, Bastian Engel, Richard Taubert, Francesca Bolis, Laura Cristoferi, Federica Malinverno, Francesca Colapietro, Reha Akpinar, Luca Di Tommaso, Luigi Terracciano, Ana Lleo, Mauro Viganó, Cristina Rigamonti, Daniela Cabibi, Vincenza Calvaruso, Fabio Gibilisco, Nicoló Caldonazzi, Alessandro Valentino, Stefano Ceola, Valentina Canini, Eugenia Nofit, Marco Muselli, Julien Calderaro, Dina Tiniakos, Vincenzo L’Imperio, Fabio Pagni, Nicola Zucchini, Pietro Invernizzi, Marco Carbone, Jakob Nikolas Kather

“…A multivariate explainable ML model revealed that PBC cases misclassified as AIH more often had ALP values between 1 × upper limit of normal (ULN) and 2 × ULN, coupled with AST values above 1 × ULN. …”
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The potential of supplementing compound organic trace elements at lower levels in Chinese yellow-feathered broiler diets, Part I: Impacts on plasma biochemical parameters, antioxid... by Xiaoyan Nie, Yucheng Yin, Qi Lu, Fei Zhao, Yang Dai, Rui Wang, Yiwen Ji, Huihua Zhang, Cui Zhu

“…The results showed that the alkaline phosphatase (ALP) activity of the OTM300 group was significantly higher than that of the NC, PC, and ITM300 groups (P < 0.05). …”
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