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  1. 441

    Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity by Dalia Ali, Elna P. Chalisserry, Muthurangan Manikandan, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M. Alajez

    Published 2018-01-01
    “…The results of chromatin immunoprecipitation combined with quantitative polymerase chain reaction indicated a significant increase in H3K9Ac epigenetic markers in the promoter regions of peroxisome proliferator-activated receptor gamma (PPARγ) and KLF15 (related to adipogenesis) or SP7 (Osterix) and alkaline phosphatase (ALP) (related to osteogenesis) in romidepsin-treated BMSCs. …”
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  2. 442

    Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

    Published 2025-02-01
    “…Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. No epidemiological links to Q fever were identified in these cases. …”
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  3. 443

    Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

    Published 2018-03-01
    “…The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT),alkaline phosphatase(ALP), creatine kinase-MB (CK-MB) and creatinine of two experimental groups were significantly elevated while compared to the control groups (p < 0.05–0.001). …”
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  4. 444

    Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

    Published 2016-01-01
    “…Serum bilirubin was 26.5 mg/dL and ALP was 552 CT. Abdomen and pelvis showed diffuse infiltrative neoplastic process of the liver with a mass effect and stretching of the hepatic and portal veins, in addition to bile duct dilatation. …”
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  5. 445

    Haematological, Liver Function Parameters and Heavy Metal Assessment of KWMC Workers at Roadside and Mixed Waste Dumpsites in Kwara State, Nigeria by D.T. Ogundele, V.T. Olayemi, F.M. Folaranmi, O.E. Oludele, A.A. Oladejo

    Published 2019-08-01
    “…Samples were analysed for haematological parameters White Blood Cell (WBC), neutrophils, lymphocytes, Liver function parameters aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP). Mixed solid waste samples from dumpsites and road soils were analysed by Atomic Absorption Spectroscopy. …”
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  6. 446

    Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study by Du-Bois Asante, Emmanuel Effah-Yeboah, Precious Barnes, Heckel Amoabeng Abban, Elvis Ofori Ameyaw, Johnson Nyarko Boampong, Eric Gyamerah Ofori, Joseph Budu Dadzie

    Published 2016-01-01
    “…Similarly, the higher dose (300 mg/kg) of both extracts significantly (p<0.05) reduced serum ALT, AST, and ALP levels as compared to the diabetic control rats. …”
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  7. 447

    Composition, cellularity and biochemical profile of milk from primiparous and pluriparous Holstein cows during the stages of lactation by D.D. Alves, D.G. Silva, G.A. Aguiar, G.S. Nogueira, M.F. Silva, R.V.R.S. Leite, J.C. Lacerda-Neto

    Published 2025-01-01
    “…Two hundred negative milk samples in strip cup test and in CMT and with SCC < 200,000 cells/mL were allocated into three groups: milk samples from females with one lactation (G1; n=76), milk samples from females with two or three lactations (G2; n=73) and milk samples from females with four to six lactations (G3; n=51) according with the phase of lactation (initial, intermediate and final). GGT and ALP activities, and total protein, albumin, total Ca, P, Mg, Fe, Cl, Na, K and ionized Ca concentrations were determined. …”
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  8. 448

    Uroprotective and Hepatoprotective Potential of Anagallis arvensis against the Experimental Animal Model by Ushna Shabbir, Irfan Anjum, Muhammad Naveed Mushtaq, Muhammad Nasir Hayat Malik, Sana Ismail, Joham Javed, Saeeda Noreen, Ayesha Pervaiz, Anika Tariq, Misbah Wazir, Zeenat Islam, Muhammad Majid, Sehrish Mansha, Zaka Ur Rehman

    Published 2022-01-01
    “…In hepatoprotective activity, pretreatment with A. arvensis significantly decreased the level of liver markers (Bilirubin, ALT, AST, and ALP) and lipid profile (cholesterol, TG, LDL, and VLDL). …”
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  9. 449

    CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway by Yu Ye, Yue Ke, Liu Liu, Tong Xiao, Jinhua Yu

    Published 2021-01-01
    “…The abilities of circFAT1 and miR-4781-3p in regulating PDLSC differentiation were analyzed by western blot, reverse transcription-polymerase chain reaction (RT-PCR), alkaline phosphatase (ALP), and Alizarin red staining (ARS). A nucleocytoplasmic separation experiment was utilized for circFAT1 localization. …”
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  10. 450

    Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

    Published 2025-01-01
    “…After 4 days, the biochemical response of fish exposed to PVC-NPs and elevated temperatures showed a significant increase in the levels of plasma total proteins, albumin, globulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, and uric acid. Additionally, the level of oxidative stress biomarkers in the liver, gills, and brain was found to have a significant increase in malondialdehyde (MDA) concentration and a decrease in glutathione reduced (GSH) concentration and catalase (CAT) activity in all studied groups. …”
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  11. 451

    Characterization of jamun (Syzygium cumini) juice fortified with nanoemulsified vitamin D3: In vitro and in vivo assessment of its nutraceutical value and anti-diabetic potential by Yasmeena Jan, Reem Binsuwaidan, Muneeb Malik, Mifftha Yaseen, Sayeed Ahmad, Nawaf Alshammari, Mohd Adnan, Syed Amir Ashraf, Bibhu Prasad Panda

    Published 2025-01-01
    “…After 4 weeks of VDFJJ intervention in vitamin D-deficient animal models, serum levels of 25-OHD, PTH, calcium, phosphorus, and ALP were significantly improved. Vitamin D3 demonstrated stability within the matrix, showing a slight reduction from 4000 IU to 2440 IU over a three-month period. …”
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  12. 452

    Thiacloprid exposure disrupts the gut-liver axis and induces liver dysfunction in the Reeves' turtles (Mauremys reevesii) by Shuqin Lin, Yunjuan Xiao, Siyu Li, Liyan Tang, Haitao Shi, Meiling Hong, Li Ding

    Published 2025-01-01
    “…Furthermore, elevated levels of liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bile acid (TBA), and triglyceride (TG), were positively correlated with increased THI concentrations. …”
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  13. 453

    Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes by Peng Duan, Min Yang, Meilin Wei, Jia Liu, Ping Tu

    Published 2017-01-01
    “…In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. …”
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  14. 454

    Bone Formation from Porcine Dental Germ Stem Cells on Surface Modified Polybutylene Succinate Scaffolds by Nergis Abay, Gorke Gurel Pekozer, Mustafa Ramazanoglu, Gamze Torun Kose

    Published 2016-01-01
    “…Besides, alkaline phosphatase (ALP) assay, von Kossa staining, real-time PCR, CM-Dil, and immunostaining were applied to analyze osteogenic potentials of pDGSCs. …”
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  15. 455

    The Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia by Kay-Lee E. Strauss, Wendy N. Phoswa, Kabelo Mokgalaboni

    Published 2024-12-01
    “…However, its use has been associated with adverse liver conditions, particularly hepatotoxicity, often marked by elevated liver enzymes (LEEs) as demonstrated by an increased aspartate transferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) in PWLWHIV on ART. Morever, there is limited evidence about the effect of ART on liver function among PWLWHIV and PE. …”
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