Combining Serum DNA Methylation Biomarkers and Protein Tumor Markers Improved Clinical Sensitivity for Early Detection of Colorectal Cancer by Guoying Zhang, Fang He, Guodong Zhao, Zihui Huang, Xiang Li, Xia Xia, Yidi Guo, Weiping Xu, Shangmin Xiong, Yong Ma, Minxue Zheng, Wanli Liu

“…Among these samples, the levels of three circulating tumor markers, CEA, AFP, and CA19-9, were also measured for 106 CRC, 28 advanced adenoma, and 20 small polyp patients and all control subjects. Results. Due to the smaller volume and extended storage in nonfrozen state, the ColoDefense test with these samples exhibited reduced performance for all stages of CRC and advanced adenomas. …”
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Long-term impact of different prevalent cropping systems on soil physico-chemical characteristics under subtropical climate conditions of Punjab, Pakistan by Fahad Ali Fayyaz, Irfan Aziz, Muhammad Ansar, Muhammad Akmal, Saud Alamri, Alanoud T. Alfagham, Renata Gamrat, Abdul Qayyum

“…Deficiencies in OM were widespread across all cropping systems, with only 3.1% of samples under mix cropping system being in the medium range. …”
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Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients by Yuqing Qu, Haoming Li, Xianling Wang, Yulong Chen, Qinghua Guo, Yu Pei, Jin Du, Jingtao Dou, Jianming Ba, Zhaohui Lv, Yiming Mu

“…Nine patients were diagnosed with multiple endocrine neoplasia type 1 (MEN1) in which all the associated functional PanNENs were insulinomas. …”
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Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes in Advanced Melanoma Patients by Mélanie Saint-Jean, Anne-Chantal Knol, Christelle Volteau, Gaëlle Quéreux, Lucie Peuvrel, Anabelle Brocard, Marie-Christine Pandolfino, Soraya Saiagh, Jean-Michel Nguyen, Christophe Bedane, Nicole Basset-Seguin, Amir Khammari, Brigitte Dréno

“…Nine women and 1 man were treated for unresectable stage IIIC (n=4) or IV (n=6) melanoma. All but 1 patient with unresectable stage III melanoma (1st line) had received at least 2 previous treatments, including anti-CTLA-4 antibody for 4. …”
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Prevalence of depression, anxiety, and stress among students enrolled at King Khalid University: a cross-sectional study by Abdulaziz M. Al-Garni, Ayed A. Shati, Nora A. Almonawar, Ghadi M. Alamri, Lujain A. Alasmre, Thamraa N. Saad, Faisal M. Alshehri, Esraa Abdellatif Hammouda, Ramy Mohammed Ghazy

“…The correlations between depression and anxiety (0.75), depression and stress (0.83), and anxiety and stress (0.81) all indicate very strong positive correlations, with all tests being highly significant (P < 0.001). …”
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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Maria Fernanda Setúbal Destro Rodrigues, Ana Eliza Castanho Garrini dos Santos, Marcelo Mendes Pinto, Dácio Antonio Pantano Junior, Aldo Brugnera Jr, Fátima Antonia Aparecida Zanin

“…Sensitivity after whitening will be measured using the Visual Analogue Scale at baseline and at each session in all groups and in all follow-ups. The tissue removed during gingivoplasty (G4) will be submitted to immunohistochemical analysis for the determination of inflammatory changes caused by violet LED. …”
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Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture by Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo

“…Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. …”
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The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration by Shi G, Yu P, Wang Z, Xu M, Guo M, Wang X, Zhou R

“…Patients with END were categorized into subgroups based on the presence or absence EOI.Results: Serum levels of mBDNF, proBDNF, and the mBDNF/proBDNF ratio were significantly lower in END patients compared to those in HCs (all p < 0.05). Among the 232 END patients, 82 (35.3%) developed EOI. …”
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Use of Texture Analysis on Noncontrast MRI in Classification of Early Stage of Liver Fibrosis by Ru Zhao, Xi-Jun Gong, Ya-Qiong Ge, Hong Zhao, Long-Sheng Wang, Hong-Zhen Yu, Bin Liu

“…Eight features with high correlation were selected by the maximum relevance method in each sequence, and all had a good diagnostic performance. ROC analysis of the final models showed that all sequences had a preferable performance with AUCs of 0.87, 0.90, and 0.96 in T2W and in-phase and out-of-phase T1W, respectively. …”
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Enhanced renoprotective effects of combined glucagon‐like peptide‐1 receptor agonists and sodium‐glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: Real‐world evidence... by Jian‐Yu Jhu, Yu‐Wei Fang, Chung‐Yen Huang, Hung‐Hsiang Liou, Mon‐Ting Chen, Ming‐Hsien Tsai

“…The GLP‐1 RA plus SGLT2i group had significantly lower risk of MAKE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.69–0.77), AKI (HR: 0.82, 95% C0I: 0.77–0.87), ESKD (HR: 0.61, 95% CI: 0.47–0.78), and all‐cause mortality (HR: 0.54, 95% CI: 0.50–0.58) compared to the SGLT2i‐only group. …”
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Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria by Bingyang Ma, Yan Zhao, Liping Liu, Jianguo Xu, Qingping Hu, Saisai Feng, Liangliang Zhang

“…The overall detection rates of ILA among all tested strains (including both <i>Lactiplantibacillus</i> and other genus strains) were 17.9% (21/117) and 26.1% (18/69). …”
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Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing by Noura Alsufyani, Andre Isaac, Manisha Witmans, Paul Major, Hamdy El-Hakim

“…On bivariate analysis, neuropsychiatric diagnosis (r = 0.286, p = 0.042), history of sleepwalking or enuresis (r = 0.103, p = 0.044), MOS (r = 0.123, p = 0.033), presence of DNS (r = 0.107, p = 0.036), and presence of laryngomalacia (r = 0.122, p = 0.017) all positively correlated with treatment failure. …”
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Compositional changes of dissolved organic matter during high flow events in headwater catchments along a gradient of climate and land use by Jeanneau, Laurent, Fovet, Ophélie, Faucheux, Mikaël, Gruau, Gérard,  Liotaud, Marine, Pierret, Marie-Claire, Cotel, Solenn, Molénat, Jérôme,  Lagacherie, Manon, Dessert, Céline, Probst, Anne

“…The %VEG increased for all flood events studied. As this parameter is linked to the aromaticity of DOM, these increases are in line with worldwide observations. …”
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Preharvest Factors Affecting Quality on “Abate Fetel” Pears: Study of Superficial Scald with Multivariate Statistical Approach by Alessandro Bonora, Enrico Muzzi, Cristiano Franceschini, Alexandra Boini, Gianmarco Bortolotti, Kushtrim Bresilla, Giulio Demetrio Perulli, Melissa Venturi, Luigi Manfrini, Luca Corelli Grappadelli

“…Nevertheless, in 2018, all the producers showed SS at the end of the storage season, but in 2019 some of them did not exhibit SS for up to 5 months. …”
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Development and Validation of a Machine Learning Model for the Prediction of Bloodstream Infections in Patients with Hematological Malignancies and Febrile Neutropenia by Antonio Gallardo-Pizarro, Christian Teijón-Lumbreras, Patricia Monzo-Gallo, Tommaso Francesco Aiello, Mariana Chumbita, Olivier Peyrony, Emmanuelle Gras, Cristina Pitart, Josep Mensa, Jordi Esteve, Alex Soriano, Carolina Garcia-Vidal

“…Validation cohort results were similar: Cluster 3 had a BSI rate of 38.1%, including 78% of all MDR-GNB BSIs, while Cluster 1 had no GNB-related BSIs. …”
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Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…Moreover, consortia and ART7 enhanced remarkable biomass in all four environments viz., normal (41.78 %, 29.05 %), drought (62.91 %, 29.37 %), salinity (35.15 %, 23.71 %), and waterlogging (48.37 %, 39.52 %); as well as artemisinin content in normal (51.61 %, 41.16 %), drought (32.87 %, 28.76 %), salinity (25.64 %, 19.23 %), and waterlogging (31.57 %, 28.07 %) compared to control. …”
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To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy by Qingchun Zhao, Hui Du, Jinghao Liu, Yu Hua, Xiaoyu Niu, Jun Chen

“…The levels of G-CSF and GM-CSF were considerably lowered in all three groups, although the drop in the study group was more significant (P>0.05) when compared to that in the control group. …”
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Effects of the land use change on ecosystem service value by J. Zhou, L. Sun, S.Y. Zang, K. Wang, J.Y. Zhao, Z.X. Li, X.M. Liu, X.R. Liu

“…The sensitivity coefficient of eco-service values of all types of land utilization to their value coefficients were all less than 1 in Daqing area. …”
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Prevalence of Hypertension and Associated Factors in Lubumbashi City, Democratic Republic of Congo: A Community-Based Cross-Sectional Study by Jacques Mbaz Musung, Placide Kambola Kakoma, Clarence Kaut Mukeng, Stéphane Lubamba Tshimanga, Jeef Paul Munkemena Banze, Nathalie Kayomb Kaj, Martin Kazadi Kamuna, Jimmy Kasali Mwamba, Dophra Ngoy Nkulu, Philippe Bianga Katchunga, Olivier Mukuku, Emmanuel Kiyana Muyumba

“…Logistic regression was used to identify the relative effects of hypertension risk factors and all statistical tests were declared significant at a p value <0.05. …”
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WORLD EXPERIENCE IN ADMINISTRATIVE AND LEGAL SUPPORT OF FOOD SECURITY by Yuliya Pustovit, Olena Dragan, Alina Berher

“…Each country has a unique approach to food security, depending on domestic policies, resources and global market conditions. However, all the countries analysed share the common goal of ensuring safe, high-quality and affordable food for their populations, while developing a sustainable agricultural sector. …”
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