Angiogenesis Regulated by Electroacupuncture Combined with Rehabilitation Training in Cerebral Ischemia Involved in PI3K/Akt Signaling Pathway by Wenchao YAO, Mengxing LI, Qing LIU, Mingyue TONG, Peng HE, Wei TANG

“…The expression of protein in the combined acupuncture group was higher than that of the other two groups, and the difference was statistically significant respectively (<italic>P</italic>&lt; 0.01); the trend of each variable at different time points was significantly different respectively (<italic>F</italic>_Time=100.462, 53.714, 106.552, 75.381, <italic>P</italic>&lt; 0.001), the expression of VEGF and Akt protein in the model group increased on the 7th day, and the difference was statistically significant compared with 3 d and 14 d respectively (<italic>P</italic>&lt; 0.05); the expression of BDNF and PI3K increased on the 7th day in the model group, compared with that on the 3rd day, the difference was statistically significant (<italic>P</italic>&lt; 0.01); the expression of VEGF, BDNF, PI3K, Akt protein increased significantly on the 14th day of the combined acupuncture group, and the difference was statistically significant compared with 3 d and 7 d respectively (<italic>P</italic>&lt; 0.05); The expression group×time all had a significant interaction (<italic>P</italic>&lt; 0.001). (4) The analysis of variance of repeated measurements of VEGF, BDNF, PI3K, Akt mRNA in rat brain tissues in ischemic area showed that the variables were statistically significant in different groups respectively (<italic>F</italic>_Intergroup=445.845, 427.743, 918.388, 543.814, <italic>P</italic>&lt; 0.001), the combined acupuncture group expression was higher than the other two groups, the difference was statistically significant respectively (<italic>P</italic>&lt; 0.01); the change trend of each variable at different time points was significantly different (<italic>F</italic>_Time=100.343, 13.984, 9.162, 32.931, <italic>P</italic>&lt; 0.001), the expression of BDNF and PI3K mRNA in the model group increased on the 7th day, and the difference was statistically significant respectively (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01); the expression of VEGF mRNA in the model group increased on the 7th day, compared with that on the 14th day, the difference was statistically significant (<italic>P</italic>&lt; 0.01); the expression of VEGF, BDNF, PI3K, Akt mRNA increased significantly on the 7th day in the combined acupuncture group, and the difference was statistically significant compared with 3 d and 14 d respectively (<italic>P</italic>&lt; 0.05, <italic>P</italic>&lt; 0.01); the mRNA expression group×time had significant interaction (<italic>P</italic>&lt; 0.001).Conclusion:Under the influence of intervention effect, time effect and the interaction of the two, the combination of electroacupuncture and rehabilitation training can play a protective role in cerebral ischemia, which may be related to the control of the expression of VEGF and BDNF and the downstream transduction pathway PI3K/Akt, which mediates the angiogenesis after cerebral ischemia.…”
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The burden of acute respiratory infection attributable to fine particulate matter brought by dust storms among children under 5 years of age in low- and middle-income countries by Hong Lu, Mingkun Tong, Ruohan Wang, Ning Kang, Xueqiu Ni, Jianyu Deng, Jiajianghui Li, Pengfei Li, Tianjia Guan, Tong Zhu, Tao Xue

“…The long-term dust PM2.5 exposure contributed to 12–13% of all the children affected by U5-ARI between 2000 and 2017. …”
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The prognosis and metabolite changes of NSCLC patients receiving first‐line immunotherapy combined chemotherapy in different M1c categories according to 9th edition of TNM classifi... by Liang Zheng, Fang Hu, Wei Nie, Jun Lu, Bo Zhang, Jianlin Xu, Shuyuan Wang, Ying Li, Xiaoxuan Zheng, Wei Zhang, Yinchen Shen, Runbo Zhong, Tianqing Chu, Baohui Han, Hua Zhong, Xueyan Zhang

“…Serum samples were obtained from all patients before treatment initiation for untargeted metabolomics analysis, aiming to identify differential metabolites. …”
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Critical reflection on the indication for computed tomography: an interdisciplinary survey of risk and benefit management in patients with sepsis by Maria Isabel Opper Hernando, Denis Witham, Ann-Christine Stahl, Peter Richard Steinhagen, Stefan Angermair, Wolfgang Bauer, Friederike Compton, Andreas Edel, Jan Matthias Kruse, York Kühnle, Gunnar Lachmann, Susanne Marz, Holger Müller-Redetzky, Jens Nee, Oliver Paul, Damaris Praeger, Carsten Skurk, Miriam Stegemann, Alexander Uhrig, Stefan Wolf, Myrto Bolanaki, Kerstin Rubarth, Joachim Seybold, Elke Zimmermann, Marc Dewey, Julian Pohlan

“…Results While physicians with all levels of work experience were included, the largest group (35.0%, n = 130/371) had 3–7 years of experience. …”
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Diseño de losas de hormigón con geometría optimizada Design of concrete pavement with optimized slab geometry by Juan Pablo Covarrubias V.

“…Test segments have been built on a large scale and they have been tested under accelerated loads, with concrete thickness of 8, 15 and 20 cm, all of them having a gravel base and non-adhered asphaltic layers. …”
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Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Correlations between NPQ/NPQ-R and (1) disease-specific questionnaires were rs= 0.712 and rs= 0.752 (DHI), rs=0.426 and rs= 0.0.462 (VSS-V), rs= -0.500 and rs= -0.545 (ABC-Scale), (2) anxiety-specific subscales rs = 0.394 and rs = 0.430 (VSS-A) and rs= 0.354 and rs= 0.430 (HADS-A), (3) depression-related subscales rs=0.438 and rs= 0.487 (HADS-D), and (4) general health rs ranged between rs= -0.216 and −0.578 (all SF-36 subscales). Internal consistency, test-retest reliability, SEM and MDC calculated for NPQ/NPQ-R were α = 0.88/α = 0.91, ICC=0.83 (CI 0.77 to 0.0.87), SEM 5.55/8.37, and MDC 15/23 points.ConclusionThe German versions of NPQ and NPQ-R are valid and reliable patient-reported outcome measures for assessing PPPD, demonstrating satisfactory psychometric measurement properties including convergent construct validity and reliability parameters: internal consistency, test-retest reliability, SEM, and MDC as an evaluative measure. …”
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Carotid Artery Stenting Outcomes by Neurointerventional Surgeons (CASONI) by Mohamad Ezzeldin, Ameer E. Hassan, Ali Kerro, Maria Martucci, Muhammad Shazam Hussain, Osman Mir, Faheem G. Sheriff, Peter Kan, Chizoba Ezepue, Nazli A. Janjua, Kaiz S. Asif, Ramesh Grandhi, Ali Alaraj, Muhammad Niazi, Ossama Yassin Mansour, Michael Chen, Saif Bushnaq, Omar Tanweer, Adnan H. Siddiqui, Adam Delora, Rime Ezzeldin, Bains Navpreet, Varun Chaubal, Mohammad Ammar Abdulrazzak, Hamzah Saei, Gustavo J. Rodriguez, Mohammad AlMajali, Gautam Edhayan, Amer Al Shekhlee, Christopher Hadjialiakbari, Musaab Froukh, Walid K. Salah, Elsa Nico, Adrusht Madapoosi, Yazan Radiaideh, Darko Quispe‐Orozco, Oz Haim, Noel Garza, Alberto Maud, Morgan Rolon‐Newton, Benan Barakat, Tejas Gowda, Muhammad Monk, Zuhair Ali, Tunmi Anwoju, Osama O. Zaidat, Farhan Siddiq

“…A statistically significant increase in all outcomes correlated with advanced age (P = 0.001), women (P = 0.013), aortic arch type 3 (P = 0.01), and higher preprocedural modified Rankin score (P = 0.006). …”
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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

“…Furthermore, 6-keto-PGF1alpha had its peak shortly before initiation of continuous veno-venous hemodialysis (at least in 5 of the observed patients), 2-AG was elevated in all our nine patients during (right) heart failure in the context of either re-opening patient’s chest, implementation of veno-arterial ECMO or at least while significantly increasing the amount of catecholamines.DiscussionIn this pilot trial we identified several evaluated lipids in critically ill patients representing either potentially (patho-) physiologically relevant mediators of the pro-inflammatory processes and during heart failure or possible markers preceding veno-venous hemodialysis.…”
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A Universal Break in Energy Functions of Three Hyperactive Repeating Fast Radio Bursts by Q. Wu, F. Y. Wang, Z. Y. Zhao, P. Wang, H. Xu, Y. K. Zhang, D. J. Zhou, J. R. Niu, W. Y. Wang, S. X. Yi, Z. Q. Hua, S. B. Zhang, J. L. Han, W. W. Zhu, K. J. Lee, D. Li, X. F. Wu, Z. G. Dai, B. Zhang

“…Observations show that at least some FRBs are produced by magnetars. All magnetar-powered FRB models require some triggering mechanisms, among which the most popular is the cracking of the crust of a neutron star, which is called a starquake. …”
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Research of efficiency of ferrous metallurgy slag use in pavement base layers by S. A. Chernov, E. V. Lekontsev, V. S. Schreiner, A. V. Fuchs, A. I. Piskunov

“…Steelmaking slags of ferrous metallurgy can contribute to the production of organomineral mixtures with increased physical, mechanical and operational properties due to the increased content of calcium compounds, microporous additions of the crystal structure and active hydration processes, which can have a beneficial effect on the durability of the structural layer of the pavement when used.Materials and methods. All materials used in this study were subjected to tests to determine their physical and mechanical parameters, and materials representing industrial by-products were additionally subjected to chemical analysis. …”
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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

“…Consistently across the Moderna and Pfizer-BioNTech vaccine platforms and across all variant Spike inserts assessed, both peak and exposure-proximal (“predicted-at-exposure”) titers correlated with lower Omicron COVID-19 risk in individuals previously infected with SARS-CoV-2, albeit significantly less so in naïve individuals [e.g., exposure-proximal hazard ratio per 10-fold increase in BA.1 titer 0.74 (95% CI 0.59, 0.94) for naïve vs. 0.41 (95% CI 0.23, 0.64) for non-naïve; interaction p = 0.013]. …”
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Cow Hoof Slippage Detecting Method Based on Enhanced DeepLabCut Model by NIAN Yue, ZHAO Kaixuan, JI Jiangtao

“…[Results and Discussion]After all ten models reached convergence, the loss values ranked from smallest to largest were found in the EfficientNet series, ResNet series, and MobileNet-V2 series, respectively. …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…Trial UG (NCT02354404) enrolled 90 participants, including 60 EVD vaccine-naïve and 30 DNA Ebola vaccine-experienced participants (February-April 2015). All tested vaccines and regimens were safe and well tolerated with no serious adverse events reported related to study products. …”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…The median treatment duration in cohort 2 (n=4) was 13 days; all discontinued treatment early. In cohort 1, respiratory failure-free survival and the estimated rates of not returning to breathing room air by day 28 were not significantly different between treatments. …”
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Investigation of GAM zonal flows near the pedestal region of H-mode on EAST tokamak by Xi Feng, AhDi Liu, Ge Zhuang, Chu Zhou, X.L. Zou, HaiQing Liu, Lei Ye, ZongLiang Dai, FeiFei Long, S.X. Wang, L. Wang, L.Q. Xu, H.L. Zhao, J. Zhang, X.M. Zhong, M.Y. Wang, S.F. Wang, L.T. Gao, W.X. Shi, S.C. Qiu, L.X. Li, Y.F. Feng, X.Y. Chen, Y.Y. Zhang, T. Lan, H. Li, W.Z. Mao, Z.X. Liu, W.X. Ding, J.L. Xie, W.D. Liu, Z.B. Shi

“…Statistical evidence indicates that GAMs with such characteristics display a proclivity for a large q _95 and low collisionality in all instances of H-mode accompanied by QCM. Based on the Gyro-kinetic simulation, the QCM is the low n trapped electron mode (TEM) and that the GAM is driven by TEM. …”
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A comparative study on disinfection effect of three different disinfectants for oral dental chair water lines (三种不同消毒剂对口腔综合治疗台水路消毒效果的比较)... by WANG Wenjuan (王文娟), LI Yajuan (李雅娟), LI Pei (李培), KONG Li (孔莉), WANG Ting (王婷)

“…Results The bacterial colony counts of pre-disinfection DUWLs had exceeded the standard ( all＞4500 cfu/mL). The total number of bacterial colonies of the three disinfectants immediately after disinfection and 1 day after disinfection decreased remarkably, and were lower than that of the pre-disinfection and control group. …”
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Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells by Simon N. Chu, Eric Soupene, Devesh Sharma, Roshani Sinha, Travis McCreary, Britney Hernandez, Huifeng Shen, Beeke Wienert, Chance Bowman, Han Yin, Benjamin J. Lesch, Kun Jia, Kathleen A. Romero, Zachary Kostamo, Yankai Zhang, Tammy Tran, Marco Cordero, Shota Homma, Jessica P. Hampton, James M. Gardner, Bruce R. Conklin, Tippi C. MacKenzie, Vivien A. Sheehan, Matthew H. Porteus, M. Kyle Cromer

“…Summary: The most severe form of α-thalassemia results from loss of all four copies of α-globin. Postnatally, patients face challenges similar to β-thalassemia, including severe anemia and erythrotoxicity due to the imbalance of β-globin and α-globin chains. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…Living with family was associated with the recovery of all functions and QOL, while extracorporeal membrane oxygenation (ECMO) was associated with the recovery of cognitive function and mental health. …”
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A China dataset of soil properties for land surface modelling (version 2, CSDLv2) by G. Shi, W. Sun, W. Shangguan, Z. Wei, H. Yuan, L. Li, X. Sun, Y. Zhang, H. Liang, D. Li, F. Huang, Q. Li, Q. Li, Y. Dai

“…The prediction accuracy of soil properties at all depth intervals ranged from good to moderate, with median model efficiency coefficients for most soil properties ranging from 0.29 to 0.70 during data-splitting validation and from 0.25 to 0.84 during independent-sample validation. …”
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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…In all epithelial cells, the adherent junctions (AJs) with cadherin as the core play an important role in the maintenance of the connection and the formation of apical-basal polarity. …”
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