Improving the hydrological consistency of a process-based solute-transport model by simultaneous calibration of streamflow and stream concentrations by J. Salmon-Monviola, O. Fovet, M. Hrachowitz

“…Evaluation using independent datasets indicated that the model usually reproduced dynamics of groundwater level and soil moisture in upslope and riparian zones correctly for all calibration scenarios. Using daily stream concentrations of DOC and NO<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M3" display="inline" overflow="scroll" dspmath="mathml"><mrow><msubsup><mi/><mn mathvariant="normal">3</mn><mo>-</mo></msubsup></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="9pt" height="16pt" class="svg-formula" dspmath="mathimg" md5hash="0aaab3ee324d7a9ba8e4b96f67d8036e"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="hess-29-127-2025-ie00003.svg" width="9pt" height="16pt" src="hess-29-127-2025-ie00003.png"/></svg:svg></span></span> along with streamflow to calibrate the model did not improve its ability to predict streamflow for calibration or evaluation periods. …”
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Association between short-term exposure to air pollutants and daily stroke incidence among residents in Qingdao city: a time series analysis of disease surveillance, environmental,... by Nan GE, Lu PAN, Xin ZHANG, Dandan LI, Yin WANG, Jingya YIN, Hui ZHOU, Haoyan YU, Xiuqin ZHANG, Chunsheng XU, Yuan FANG, Yan MA, Bingling WANG, Haiping DUAN

“…The exposure-response relationship analysis showed that the risk of stroke incidence increased when ambient PM2.5 concentration was higher than 121.90 μg/m3, CO concentration was higher than 1.56 μg/m3, but O3 concentration was lower than 64.00 μg/m3, while the risk of stroke incidence showed an up-and-down fluctuating trend when O3 concentration was higher than 64.00 μg/m3 (all P<0.05). The single-pollutant model analysis showed that the sensitive Lag periods for increased risk of stroke incidence were from Lag day 2 to Lag day 5 for ambient PM2.5 and CO exposure, from Lag day 3 to Lag day 6 for O3 exposure, from Lag day 3 to Lag day 4 for PM10 exposure, and from Lag day 6 for SO2 exposure. …”
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Reduced p63 expression is linked to unfavourable prognosis in muscle‐invasive urothelial carcinoma of the bladder by Kira Furlano, Henning Plage, Sebastian Hofbauer, Sarah Weinberger, Bernhard Ralla, Annika Fendler, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Martina Kluth, Maximilian Lennartz, Niclas C. Blessin, Andreas H. Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Joachim Weischenfeldt, Tobias Klatte, Thorsten Schlomm, David Horst, Henrik Zecha

“…Results Nuclear p63 staining was seen in all cells of normal urothelium and at elevated levels in pTaG2 tumours. …”
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A Historical Study of the Effects of the 1930 Earthquake on the Human Geography and History of Selmas City and its Surrounding Region by Zeinab Ahmadvand, Tohid Malekzadeh Dilmaghani

“…Analysis of the ancient remnants in Selmas indicated that the structures situated in mountainous regions, such as ancient castles and Urartoi crypts, or those constructed using stone exhibited relatively good resistance against the powerful Selmas earthquake with a magnitude of 7.2. However, all the structures made of clay and other similar materials vanished.The Selmas earthquake of such magnitude brought about significant changes to the tectonic, seismotectonic, and geomorphological aspects of Selmas Region and the enduring impact of these changes is evident to this day. …”
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Les fours « à pain » dans les Gaules et les Germanies (ve s. av. J.-C.-ve s. apr. J.-C.), un regard technique by Nicolas Monteix, Camille Noûs

“…Before outlining the evolution of bread ovens in Gaul, it should be underscored that the various ovens included in the corpus do not all benefit from the same quality of data. Furthermore, the dates proposed in the maps representing the evolution of the distribution of the different oven types from the 5th c. …”
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The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis by Denise Vianna Machado Ayres, Sabrina Saemy Tome Uchiyama, Andréa Oliveira Prates, Rosana Aparecida Freitas Lopes, Antenor Bispo Santos Silva, Denise Rodrigues Tsukimoto, Rosimeire Alves Amorim, Taynah Souza Ribeiro, Artur Cesar Aquino Santos, André Tadeu Sugawara, André Tadeu Sugawara, Marcos Montagnini, Linamara Rizzo Battistella, Linamara Rizzo Battistella, Marta Imamura, Marta Imamura

“…The effect size was 0.7 (95% CI 0.32 to 1.07). All participants received the program well, with no drop-out rates or reported adverse events.ConclusionThe Knee-SCHOOL utilized a multidisciplinary educational approach and an exercise practice addressing multiple aspects of KOA pain. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…Aksel Sundström and Daniel Stockemer, also among the winners of the Intergenerational Justice Prize 2017/18, take a closer look at the age of parliamentarians and investigate which political parties can help to foster the election of young parliamentarians, and to what extent. After all, political parties act as gatekeepers because they are in control of the list of candidates running for election. …”
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Canopy structure modulates the sensitivity of subalpine forest stands to interannual snowpack and precipitation variability by M. Berkelhammer, G. F. M. Page, G. F. M. Page, F. Zurek, C. Still, C. Still, M. S. Carbone, M. S. Carbone, W. Talavera, L. Hildebrand, J. Byron, K. Inthabandith, A. Kucinski, M. Carlson, K. Foss, W. Brown, R. W. H. Carroll, A. Simonpietri, M. Worsham, I. Breckheimer, I. Breckheimer, A. Ryken, R. Maxwell, R. Maxwell, D. Gochis, M. S. Raleigh, E. Small, K. H. Williams, K. H. Williams

“…The trees that increased water use during the year with the large spring snowpack were all found in dense canopy stands – irrespective of species – while trees in open-canopy stands were more reliant on summer rains and, thus, more active during the years with modest snow and higher summer rain amounts. …”
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Progression and mortality of patients with cystic fibrosis in China by Wangji Zhou, Yaqi Wang, Yanli Yang, Yanyan Sun, Chongsheng Cheng, Jinrong Dai, Shuzhen Meng, Keqi Chen, Yang Zhao, Xueqi Liu, Dingding Zhang, Song Liu, Weiguo Zhu, Yaping Liu, Kai-Feng Xu, Xinlun Tian

“…Results This study included all 67 patients from the Peking Union Medical College Hospital CF cohort, with a median followed up time of 5.2 years. …”
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Regulatory Effect of Pyroptosis Related Genes Expression in Adipose Tissue of Aging Rats by Long-Time Weight-Bearing Running by GONG Lijing, TANG Shuning, YANG Luyao, SU Hao, NI Zhen, FU Pengyu

“…The IOD values of Caspase1, GSDMD and IL-1β in the resistance training group were higher than those in the baseline group (<italic>P</italic>&lt;0.05), and the IOD values of NLRP3, Caspase1 and GSDMD were all lower than those in the control group (<italic>P</italic>&lt;0.05). …”
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凉山州14个核桃品种主要经济指标 及脂肪酸组成分析" "Analysis of main economic indexes and fatty acid composition of 14 walnut cultivars in Liangshan Prefecture"... by 金银春1，任波1，胡定林2，陈善波1，余凌帆1 JIN Yinchun1, REN Bo1, HU Dinglin2, CHEN Shanbo1, YU Lingfan1

“…In conclusion, 14 walnut cultivars are all local excellent cultivars, and walnut cultivars with high fat content, high protein content, reasonable fatty acid ratio and other specific indicators can be utilized in a targeted manner. …”
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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem by Cecilia Hes, Lu Ting Gui, Alexandre Bay, Fernando Alvarez, Pierce Katz, Tanushree Paul, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Ciriaco A. Piccirillo, Paul V. Sabatini

“…Importantly, across the utilized methodologies, smFISH, genetic Gfral reporter mice and scRNA-Seq, we failed to detect Gfral-labelled cells with all three. Conclusions: Through highly sensitive and selective technologies we show Gfral expression is overwhelmingly restricted to the brainstem and expect that GDF15 and GFRAL-based therapies in development for cancer cachexia will specifically target AP/NTS cells.…”
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Mapping QTLs for early leaf spot resistance and yield component traits using an interspecific AB-QTL population in peanut by J. Gomis, J. Gomis, A. Sambou, J. R. Nguepjop, J. R. Nguepjop, J. R. Nguepjop, H. A. Tossim, M. Seye, R. Djiboune, D. Sambakhe, D. Loko, D. Loko, S. Conde, S. Conde, M. H. Alyr, D. J. Bertioli, D. J. Bertioli, S. C. M. Leal-Bertioli, S. C. M. Leal-Bertioli, J. F. Rami, J. F. Rami, A. Kane, D. Fonceka, D. Fonceka, D. Fonceka

“…Except for the QTL on chromosome B09, the wild species contributed favorable alleles at all other QTLs. One genomic region on chromosome A02 contained several relevant QTLs, contributing to ELS resistance, earliness, and increased biomass yield, potentially allowing marker-assisted selection to introduce this region into elite cultivars. …”
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Prognostic factors and outcomes of adjuvant and first-line metastatic treatments in melanoma a Turkish oncology group study by Nargiz Majidova, Hacı Arak, Faruk Recep Ozalp, Onur Bas, Gulhan Ozcelik Koker, Erkan Buket Ozmarasalı, Yasemin Sagdıc Karateke, Teoman Sakalar, Sendag Yaslikaya, Ilknur Deliktas Onur, Goncagul Akdag, Ali Ogul, Murad Guliyev, Elif Sahin, Ebru Engin Delipoyraz, Ali Alkan, Okan Aydın, Nurullah Ilhan, Ozkan Alan, Sinem Akbas, Yaprak Cağlar, Ali Kaan Guren, Nadiye Sever, Halil Ibrahim Ellez, Fatih Selcukbiricik, Mustafa Muhammed Atcı, Ahmet Bilici, Nebi Serkan Demirci, Tugba Basoglu, Cengiz Karacin, Ismail Oguz Kara, Bulent Yıldız, Turkkan Evrensel, Mustafa Karaca, Omer Dizdar, Elif Atag, Alpaslan Ozgun, Osman Kostek

“…BRAF V600E mutation, RFS > 6 months, ORR are all independent factors for OS prognosis. In our study, dabrafenib plus trametinib combination was more effective in adjuvant treatment of melanoma, while immunotherapy was more effective in metastatic first-line treatment.…”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

“…Safety, feasibility and acceptability (assessed through a 14-item questionnaire administered to all patients who completed the follow-up) were also evaluated. …”
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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

“…In 22% of seropositive patients, there was a weak or no response to both antigens. All seronegative patients did not respond to either antigen.ConclusionsTherefore, over 20% of CMV seropositive LT candidates showed weak CMV-specific cellular immune responses despite detectable serological memory against CMV. …”
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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

“…Results: The survey was completed by 130 adults (65 % females, mean age, 48.4 years). Nearly all participants (89.6 %) reported having spine symptoms in the past four weeks, with a majority experiencing activity limitations lasting one day or more due to neck (77.9 %) or low back pain (55.6 %). …”
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Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease by O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…To this end, we set out to confirm the formation of the layer of unbuffered acidic gastric juice over the gastric chyme after eating, as well as to determine the acidneutralizing effect of alginate-antacid medication upon its interaction with the acidic contents of the stomach.Materials and methods. 36 case records of GERD patients were analyzed (20 women and 16 men, mean age 47.03 years old). All patients were asked to report the heartburn intensity (according to a Likert scale) prior and during the treatment. …”
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Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Participants entering the RCT will be randomised between OCM, TAI or SNM, all with equal allocation ratios.Cohort and RCT participants will be followed up for a 24-month period, completing a series of questionnaires measuring LARS symptoms and QoL, as well as clinical review for those in the RCT. …”
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Standardised packaging, minimum excise tax, and RYO focussed tax rise implications for UK tobacco pricing. by Rosemary Hiscock, Nicole H Augustin, J Robert Branston, Anna B Gilmore

“…There was no evidence of commoditisation with prices of all FM segments (but not RYO) rising faster after the implementation of standardised packaging than immediately beforehand. …”
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