Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo by Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Irina Amorim, Rui Magalhães, Filipa João, Diogo Almeida, Sandra Amado, Justina Prada, Isabel Pires, Federica Zen, Stefania Raimondo, Ana L. Luís, Stefano Geuna, Artur S. P. Varejão, Ana C. Maurício

“…The stereological evaluation of the sciatic nerve revealed identical values in the different parameters for all therapeutic groups. In the muscle histomorphometric evaluation, the groups treated with NGCs and cells showed results close to those of the group that received traditional sutures, the one with the best final values. …”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Using structural equation modeling in a subsample (iRELATE: n = 42, 69.0% male; BeneMin: n = 102, 76.5% male) with data on structural brain metrics (cortical thickness and volume), general cognitive performance, and plasma IL-6 levels, we assessed the interrelationships between these variables on depressive and negative symptom severity in early and established schizophrenia samples combined and in early schizophrenia only. All analyses were adjusted for sex, age, and chlorpromazine equivalent dose. …”
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Économie végétale à partir des études carpologiques du boulevard Dr Henri-Henrot à Reims/Durocortorum by Véronique Matterne

“…The layers, US 1604 (Ca 225), 1608 (Ca 531), and 1609 (Ca 256), located closer to the river, provide a carpological spectrum very similar to those characterizing the streambed. They all contain high proportions of elements from wild and domestic fruit trees, with a confirmed and solid representation of domestic taxa. …”
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Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study by Pedro Puerta-Alcalde, Jessica O'Keefe, Rachel Woolstencroft, Shipraa Kaul, Néstor López, Katie Cronin, Andrew Lim, Nicole Garcia-Pouton, Míriam Álvarez, Lynette Chee, Mateu Espasa, Ignacio Grafia, Maria Suárez-Lledó, Olivia Smibert, Carolina Garcia-Vidal, Monica A. Slavin, Michelle K. Yong, Alex Soriano, Leon J. Worth

“…Methods: Retrospective analysis on all CDI episodes from 2020 to 2022 in three Australian hospitals and one Spanish hospital. …”
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Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older... by Joshua R Lakin, Na Wang, Howard J Cabral, Michael K Paasche-Orlow, Charlotta Lindvall, Angelo Volandes, Aretha Delight Davis, Michael R Winter, Edward T Moseley, Lori Henault, Sophia N Zupanc, Sophiya Das, Kate Sciacca, Edith A Burns, Maria T Carney, Jennifer Itty, Santiago Lopez, Kaitlin Emmert, Narda J Martin, Sherene Lambert, Jennifer Polo, Shreya Sanghani, Julianne N Dugas, Michele Gomez, Shira Gabry-Kalikow, Alexandra Dobie, Meredith Amshoff, Traci Cucinotta, Milton Joel, Lisa B Caruso, Ana Maria Ramirez, Kathleen Salerno, Qausarat Ogunneye

“…We estimate that over 9000 patients will be included.Ethics and dissemination The Institutional Review Board (IRB) at Boston Medical Center will serve as the single IRB of record for all regulatory and ethical aspects of this trial. …”
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Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials by Jiaxing Dai, Jiaxing Dai, Huili Shui, Huili Shui, Huili Shui, Yuan Wu, Huanghui Zhang, Huanghui Zhang, Yuanyin Li, Yuanyin Li, Shaowang Zhang, Shaowang Zhang, Bing Yang, Bing Yang, Bing Yang, Dongxin Tang, Dongxin Tang, Dongxin Tang

“…The Cochrane Risk of Bias Assessment Tool 2.0 was utilized to assess the potential biases within the studies.ResultsA comprehensive analysis was performed on 45 eligible studies, all of which were conducted within China and encompassed a total of 3,596 participants. …”
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Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

“…Following DNMT1 inhibition, the DC05 group displayed a significant decrease in methylation across all six CpG sites compared to the C57 and AS groups. …”
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Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project by Michael Taylor, Vasileios Panoulas, Jill Smith, Alex Rosenberg, Mark Mason, Ian McGovern, Majid Akhtar, Sachin Mehta, Waqas Akhtar, Anthony McKay, Sumesh Thiruthalil, Orinta Kviatkovske, Donna Hall, Eftychia Galiatsou, Sofia Pinto, Maria Comanici, Emanuele Gerlando, Timothy Pitt, Joe Hughes, Olaf Maunz, Elia Keating, Julia Gangata, Eleanor Ross, Sophie Avetoom, Jane Durrant, Ciara Collins, Anand Jothidasan, Maria Monteagudo-Vela, Jerry Mitchell, Hatem Soliman Aboumarie, Caroline Bullen, Sundeep Kaul, Clara Hernandez Caballero, Ana Hurtado, Nick Lees

“…Harefield Hospital has been performing ECPR for over a decade; however outcomes have been historically poor.Methods A retrospective analysis was performed of all ECPR cases at Harefield Hospital between April 2018 and April 2023. …”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…The molecular docking results showed that the binding energy between the active components (quercetin, apigenin, aesculetin, quercitrin) of Dracocephalum moldavica L. extract and the core targets of pulmonary fibrosis (TNF, IL-6, ALB, AKT1) were all <-29.288 kJ·mol−1, indicating good binding ability. …”
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Study on applicability of Death Attitude Profile-Revised in medical students (死亡态度描绘量表在医学生中的适用性研究) by CHEN Qiannan (陈倩楠), ZHANG Jing (张静), QIAN Zhigang (钱志刚)

“…Except for items related to natural acceptance dimensions, CR values of other items were all greater than 3 and P was less than 0. 05, and correlation coefficient (r value) between items and total scale was greater than 0. 3. …”
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Recombinant XBB.1.5 boosters induce robust neutralization against KP.2- and KP.3-included JN.1 sublineages by Jingyun Yang, Xuemei He, Huashan Shi, Cai He, Hong Lei, Heng He, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhenling Wang, Guangwen Lu, Jiong Li, Yuquan Wei

“…The GMTs of 50% neutralization against all tested pseudoviruses were significantly elevated in sera from individuals who received WSK-V102C or WSK-V102D boosters. …”
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Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…The goal of this study is to inform primary care planning by: (1) identifying values and preferences shaping the practice intentions and choices of family medicine residents and early career PCPs, (2) comparing practice patterns of early-career and established PCPs to determine if changes over time reflect cohort effects (attributes unique to the most recent cohort of PCPs) or period effects (changes over time across all PCPs) and (3) integrating findings to understand the dynamics among practice intentions, practice choices and practice patterns and to identify policy implications.Methods and analysis We plan a mixed-methods study in the Canadian provinces of British Columbia, Ontario and Nova Scotia. …”
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Determination of Zinc Requirement in Suckling Calves using Some Non-Linear Models by Mohammad Javad Elyasi, Khalil zaboli

“…Therefore, it is imperative to include Zn in the diet of all animals. However, one of the basic problems regarding for addition of Zn to the livestock diets in Iran is the lack of accurate knowledge of the livestock requirement for Zn (according to the country's geographical conditions). …”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…Pathological sections of cancer tissues and corresponding adjacent tissues from 27 PAAD patients were obtained from Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. All samples involved in this study were approved by the human ethics committee of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (ethics number: hospital ethics review[2017]No.53). …”
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Clinical observation of Shenfu injection in treating patients with internal watershed cerebral infarction (参附注射液治疗内分水岭脑梗死临床观察) by YANG Junhang (杨俊行), LI Jie (李杰), HU Zhe (胡哲), FU Jingna (付景娜), FENG Huimin (冯慧敏)

“…Methods Totally 154 patients with AIWCI admitted to the Department of Encephalopathy of Dongzhimen Hospital from October 2018 to October 2020 were divided into the experimental group (n=96)and the control group(n=58). All cases received a comprehensive treatment including anti-platelet aggregation, lowering blood lipid, regulating blood pressure, replenishing blood volume, improving microcirculation and protecting brain cells. …”
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Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis by J. Sam Meyer, MSc, Oliver K. Jawitz, MD, MHS, Yury Peysakhovich, MD, Dan Aravot, MD, Matthew G. Hartwig, MD, MHS, Yaron D. Barac, MD, PhD

“…Odds of lung non-use between DBD and DCD donors were significantly associated with blood type, alcohol use, cause of death, smoking history, drug use, death circumstance, ethnicity, gender, hypertension, cancer, age, and lung pO2 on 100% P/F ratio (P < 0.001 for all variables). A multivariable regression analysis showed that the odds of a potential DCD donating lungs is 75% lower than (P < 0.001) that of a potential DBD when the cause of death (COD) is stroke, head trauma (44% lower P = 0.076), CNS tumor (22% lower P = 0.174) or MVA (69% lower P = 0.183). …”
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Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-E3): study protocol [version 1; peer review: 2 approved] by Christopher Grundy, Simon Matthew Graham, Hannah Wilson, Samuel Hawley, Kebba Marenah, Tadios Manyanga, James Masters, Bintou Trawally, Munyardardzi Ndekwere, Prudance Mushayavanhu, Mkhululi Lukhele, Rachael Gooberman-Hill, Farhanah Paruk, Kate A. Ward, Matthew Costa, Celia L. Gregson, Rashida A. Ferrand, Sarah Drew, Anya Burton, Landing M. Jarjou, Bilkish Cassim, Nyashadzaishe Mafirakureva, Sian Noble

“…Ageing exponentially increases fragility fracture risk. Of all global regions, Africa is projected to observe the greatest increase in fragility fractures. …”
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A clinical analysis and literature review of eleven cases with primary pulmonary angiosarcoma by Tao Luan, Jianqing Hao, Yingying Gu, Ping He, Yijia Li, Liqiang Wang, Haiyi Deng, Wenhui Guan, Xinqing Lin, Xiaohong Xie, Yu Deng, Shuaiying Wang, Changchun Wang, Jingxu Li, Ru Li, Yang Luan, Gang Yang, Yunhui Zhang, Nanshan Zhong, Chengzhi Zhou

“…Initial diagnosis was correct in only 2 cases, while the remaining 9 cases were misdiagnosed as other conditions, such as lung nodules, infections, or pulmonary embolism. All patients were ultimately diagnosed via pathology, with CD31 and CD34 showing a high positivity rate of 60%. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…Methods-: This is a monocentric comparative study of before- and-after practice evaluations,conducted in the paediatric intensive care unit of the Canastel paediatric hospital in Oran.The comparative study was conducted over two periods, the first from 2014 to 2016 without a sedation assessment protocol and the second from 2017 to 2019 after the introduction of a sedation assessment protocol based on the COMFORT-B scale. All children under 15 years of age who were ventilated and sedated for 24 hours or more were included in the study. …”
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Deep anterior chamber depth may be a risk factor for axial length growth in children by Huijie Cao, Huijie Cao, Yongguo Xiang, Yongguo Xiang, Hong Cheng, Hong Cheng, Kexin Sun, Kexin Sun, Shijie Zheng, Shijie Zheng, Miaomiao Du, Miaomiao Du, Ning Gao, Ning Gao, Tong Zhang, Xin Yang, Jiuyi Xia, Wenjuan Wan, Wenjuan Wan, Ke Hu, Ke Hu

“…ObjectiveTo investigate and evaluate the progression of myopia and associated factors of axial length (AL) growth among children in Chongqing.MethodsThis six-month prospective study was conducted on students in grades 1 to 8 at a school in Chongqing, China. All participants underwent a standard ophthalmologic examination including uncorrected visual acuity (UCVA), noncycloplegic refraction, AL, and corneal topography in March 2023. …”
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