A modified screening protocol for ARDS in patients with respiratory support based on SpO2 and FiO2: A single-center prospective, observational study by Yan Xia, Qiancheng Xu, Zhiyuan Guo, Huijuan Zhang, Yingya Cao, Yupeng Qi, Qun Chen, Weihua Lu

“…Methods: This prospective observational study was conducted from August to October 2020 at the Department of Critical Care Medicine of Yijishan Hospital Affiliated with Wannan Medical College. All patients admitted during the study period and required arterial blood gas analysis and electrocardiogram monitoring were included in this study. …”
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Renal function and clinical outcomes in survivors of out-of-hospital cardiac arrest by Hao-Wei Lee, Ming-Jen Kuo, Pai-Feng Hsu, I-Hsin Lee, Chih-Yu Yang, Teh-Fu Hsu, Chorng-Kuang How, Yenn-Jiang Lin, Chin-Chou Huang

“…Clinical outcomes included neurological outcomes and all-cause mortality. Result: A total of 258 patients were enrolled, including 35 patients with underlying end-stage renal disease (ESRD). …”
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Conflict-related and sexual trauma in treatment-seeking Arabic-speaking men: a cross-sectional studyResearch in context by Max Vöhringer, Freya Specht, Christine Knaevelsrud, Birgit Wagner, Maria Böttche, Yuriy Nesterko

“…The ST + CRT group scored higher on measures of depression and posttraumatic stress disorder (PTSD) compared to all other groups; significant differences between the groups were found on both these primary outcomes (depression: F(df) = 3.65 (3, 503.33), p < 0.05; PTSD: F(df) = 5.71 (3, 507.57), p < 0.01). …”
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Exploring using HBsAg to predict interferon treatment course to achieve clinical cure in chronic hepatitis B patients: a clinical study by Fei Yan, Fei Tang, Jing Chen, YiCheng Lin, XinYu Chen, Qin Du, WeiLi Yin, Jing Liang, Lei Liu, Fang Wang, BaiGuo Xu, Qing Ye, HuiLing Xiang

“…This research aimed to develop an efficient model for predicting interferon (IFN) treatment course.MethodsPatients with chronic hepatitis B, undergoing PEG-IFN α-2b monotherapy or combined with NAs (Nucleoside Analogs), were recruited from January 2018 to December 2023 at Tianjin Third Central Hospital. All patients achieved hepatitis B surface antigen (HBsAg) clearance post-treatment.ResultThe study enrolled 176 patients with chronic hepatitis B, with the median IFN treatment course of 35.23 ± 25.22 weeks. …”
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Phenomenology of Organizational Silence (Case Study Farhangian University) by Iraj Mehdizadeh, Saeed Rajaipour, Seyed Ali Siadat

“…Eliminating discriminatory behaviors and utilizing the capacity of all individuals in proportion to their expertise and skills in university management. …”
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Multiplex immunohistochemistry to explore the tumor immune microenvironment in HCC patients with different GPC3 expression by Mingzhen Zhou, Ziyan Zhou, Lina Hu, Sidong Chen, Fanyan Meng, Jun Chen, Jie Shen

“…Further exploration of the immune microenvironment based on different GPC3 expression levels revealed that in high GPC3 expression group, the proportions of CD8+ T cells(P = 0.0435), TIM-3+ T cells(P = 0.0447), CD103+CD8+ tissue-resident T cells(P = 0.0410), CD11C+CD14−DC cells(P = 0.0497), CD11C+HLA-DR−DC cells(P = 0.0309), CD11C+CD14−HLA-DR−DC cells(P = 0.0233), and CD11C+CD14−CD66b−DC cells(P = 0.0474) were all higher compared to low expression group. At spatial distances of 10 μm, 20 μm, and 30 μm, the levels of CD8+ T cells were higher in the high expression group compared to the low expression group (high vs. low: P = 0.0281, P = 0.0236, P = 0.0220). …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Remarkably, most tumor-associated peptides and proteins are subgroup-specific, whereas shared presentation among all subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4) is rare. …”
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Surrounding Gastric Mucosa Findings Facilitate Diagnosis of Gastric Neoplasm as Gastric Adenoma or Early Gastric Cancer by Tadashi Miike, Shojiro Yamamoto, Yoshifumi Miyata, Tomoya Hirata, Yuko Noda, Takaho Noda, Sho Suzuki, Sachiko Takeda, Shuichiro Natsuda, Mai Sakaguchi, Kosuke Maemura, Kanna Hashimoto, Takumi Yamaji, Hiroo Abe, Hisayoshi Iwakiri, Yoshihiro Tahara, Satoru Hasuike, Kenji Nagata, Akira Kitanaka, Kazuya Shimoda

“…Of 146 lesions, 63 early gastric cancers and 21 gastric adenomas were ultimately evaluated and assessed. Results. Almost all gastric adenomas were accompanied by open-type gastritis, whereas 47 and 16 early gastric cancers were accompanied by open-type and closed-type gastritis, respectively (p = 0.037). …”
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A workplace organisational intervention to improve hospital nurses’ and physicians’ mental health: study protocol for the Magnet4Europe wait list cluster randomised controlled tria... by Peter Griffiths, Jonathan Drennan, Jackie Bridges, Luk Bruyneel, Jane Ball, Linda H Aiken, Douglas M Sloane, Anners Lerdal, Matthew McHugh, Herbert Smith, Anne Marie Rafferty, Reinhard Busse, Walter Sermeus, Julia Köppen, Lars E Eriksson, Kaat Siebens, Matthew D McHugh, Anne Scott, Ingeborg Strømseng Sjetne, Sydney Anstee, Peter Van Bogaert, Rikard Lindqvist, Linda Aiken, Douglas Sloane, Hans De Witte, Wilmar B Schaufeli, Hans De Witte, Simon Dello, Dorothea Kohnen, Claudia Bettina Maier, Lisa Smeds Alenius, Mary Del Guidice, Timothy Cheney, Claudia Maier, Joan Kleine, Elaine Lehane Vera McCarthy, Noeleen Brady, Monica Bukkøy Kjetland, Paul Van Aken, Danny Van Heusden

“…The process of implementation will be evaluated using qualitative data from focus group and key informant interviews.Ethics and dissemination This study was approved by the Ethics Committee Research UZ/KU Leuven, Belgium; additionally, ethics approval is obtained in all other participating countries either through a central or decentral authority. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Consequently, the detection of thousands of additional SNPs not detectable in pre-SWGA samples was facilitated after SWGA, allowing more substantial downstream population genomics analysis, particularly for the polymorphic and antimalarial genes of great interest for all the species. Furthermore, leveraging the long DNA fragments generated by SWGA, we achieved high-quality genome assemblies for P. malariae and P. ovale using PacBio long reads sequencing technology. …”
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Sex and race disparities in emergency department patients with chest pain and a detectable or mildly elevated troponin by Lucas M. Boyer, Anna C. Snavely, Jason P. Stopyra, Subha V. Raman, Jeffrey M. Caterino, Carol L. Clark, Alan E. Jones, Michael E. Hall, Carolyn J. Park, Brian C. Hiestand, Sujethra Vasu, Michael A. Kutcher, W. Gregory Hundley, Simon A. Mahler, Chadwick D. Miller

“…The primary endpoint was the composite of all-cause mortality, myocardial infarction, cardiac hospital readmission, and repeat cardiac ED. …”
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Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…Among three age groups, the largest increase in HF prevalence from 1990 to 2021 was found in individuals aged 20–24 years (AAPC = 0.61 [0.6–0.61]). Among all causes of HF, cardiomyopathy and myocarditis accounted for the highest proportion (32.7%) of prevalence cases of HF in 2021, followed by congenital birth defects (27.3%), and rheumatic heart disease (23.8%). …”
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Differentiation of Early Sacroiliitis Using Machine-Learning- Supported Texture Analysis by Qingqing Zhu, Qi Wang, Xi Hu, Xin Dang, Xiaojing Yu, Liye Chen, Hongjie Hu

“…In terms of distinguishing between the healthy control and nr-axSpA groups, both the TA models were superior to the qualitative scores of the two readers (all <i>p</i> < 0.05). In terms of distinguishing between the nr-axSpA and r-axSpA groups, the T1WI-TA model was superior to the qualitative scores of the two readers (<i>p</i> = 0.023 and <i>p</i> = 0.007), whereas there was no significant difference between the fsT2WI-TA model and the qualitative scores of the two readers (<i>p</i> = 0.134 and <i>p</i> = 0.065). …”
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Effects of Different Aging Treatments on Functional Components and Flavor Substances of Chrysanthemum Rice Wine by Wei GAO, Huaining YIN, Aiyuan WANG, Baokun DING, Yunhao ZHANG, Ling XIONG, Xinyue FENG, Maobin CHEN, Yu ZHANG

“…Following a 3 d of combined ultrasound and microwave treatment, the ABTS+ radical scavenging rate of chrysanthemum rice wine rose, while it decreased under other treatments. All three methods improved the total antioxidant capacity of chrysanthemum rice wine, with microwave treatment for 7 d yielding the highest FRAP value. …”
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Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Tra... by Michela Cioni, Stella Muscianisi, Marica De Cicco, Sabrina Basso, Hans H. Hirsch, Iris Fontana, Laura Catenacci, Jessica Bagnarino, Mariangela Siciliano, Oriana Montana Lampo, Gloria Acquafredda, Lou Tina Diana Boti, Jessica Rotella, Eleonora Bozza, Jennifer Zumelli, Kristiana Mebelli, Fausto Baldanti, Massimo Cardillo, Marco Zecca, Arcangelo Nocera, Mario Luppi, Enrico Verrina, Fabrizio Ginevri, Patrizia Comoli

“…Among the other 30 patients, 17 developed DNAuria without DNAemia and 13 always resulted as BKPyV-negative. All patients with DNAemia cleared BKPyV after having mounted a virus-specific cellular immune response, and no biopsy-proven BKPyV-nephropathy was observed. …”
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Effects of dietary Spirulina platensis supplementation on growth performance, whole body composition, antioxidant activity, histological alterations, and resistance to Vibrio parah... by Ragaa A. Ahmed, Samyah D. Jastaniah, Bothaina A. Alaidaroos, Manal E. Shafi, Ehab El-Haroun, Yasmin M. Abd El-Aziz, Ola Hasan Abd El Megeed, Mada M. AL-Qurashi, Safia M.A. Bahshwan, Mohammad Bodrul Munir, Zulhisyam Abdul Kari, Roshmon Thomas Mathew, Moaheda E.H. Eissa, El-Sayed Hemdan Eissa, Amal Elfeky

“…Shrimp in the T3 and T4 groups exhibited significantly lower malondialdehyde activity (P ≤ 0.05) compared to the other groups. All SP-supplemented groups resulted in higher levels of GPx, SOD, and CAT compared to the T0 group (P < 0.05). …”
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Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats by Xing Wei, Yaping Lin, Dongfeng Zhao, Xiaojuan Xiao, Qiao Chen, Siyi Chen, Yan Peng

“…Results. (1) After intervention, compared with blood glucose of rats in the NC group, all of the DGP, EA, and MP groups were remarkably increased (P<0.01); compared with the DGP group, the blood glucose of the EA and MP groups was decreased greatly (P<0.01). (2) Compared with gastrointestinal propulsive rate of rats in the NC group, no matter gastric emptying rate or intestinal propulsive rate, the EA and MP groups were significantly reduced (P<0.01); compared with the NC group, gastric emptying rate and intestinal propulsive rate in the EA group were obviously decreased (P<0.05, P<0.01); compared with the DGP group, the EA and MP groups were increased significantly (P<0.01). (3) Compared with the NC group, intensity of RFP and GFP in the DGP group was obviously increased (P<0.05, P<0.01), in other words, the DGP group accompanying suppression of autophagy; compared with the DGP group, intensity of RFP and GFP in the EA group was decreased significantly (P<0.05, P<0.01). (4) There was no autophagosome in the NC group, and an autophagosome existed in the DGP group. …”
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Colon Epithelial MicroRNA Network in Fatty Liver by Paule V. Joseph, Sarah K. Abey, Dan Wang, Nicolaas H. Fourie, Natnael D. Kenea, Tatyana G. Vishnyakova, Jeffrey M. Robinson, Kristen R. Weaver, Christina M. Boulineaux, Hannah R. Davidson, LeeAnne B. Sherwin, Onyinyechi Ozoji, Ana F. Diallo, Paul A. Smyser, Amy P. Patterson, Wendy A. Henderson

“…Eleven miRs with known cytoskeletal and metabolic roles were commonly altered in expression by all three miR mimics. Transfection of Caco-2 cell monolayers with each MetS-FL miR mimic induced barrier-associated TEER variations and led to structural modifications of ZO-1 and Occludin within epithelial cell junctions. …”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…However, the use of reagents based on the defined antigens eliminated or reduced the vaccine-induced diagnostic interferences in all groups. Based on these results, the use of defined antigens in the current immunodiagnostic tests appears to be suitable in a future goat TB vaccination scenario.…”
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Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans by Amr Elsawy, PhD, Tiarnan D.L. Keenan, PhD, MD, Alisa T. Thavikulwat, MD, Amy Lu, MD, Sunil Bellur, MD, Souvick Mukherjee, PhD, Elvira Agron, MS, Qingyu Chen, PhD, Emily Y. Chew, MD, Zhiyong Lu, PhD

“…En face and B-scan heatmaps of all networks were visualized and graded on 25 OCT scans with positive labels, using a scale of 1 to 4, to explore the models' decision-making. …”
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