Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…NCT02321462.Conflict of interest: this study was sponsored by Ipsen Pharma.Acknowledgements: the authors express their sincere gratitude to all the patients who participated in the study, as well as to specialists having provided medical care for the patients, researchers and employees of the participant research centres. …”
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Analysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma by Kaili Chen, Huixin Liang, Zezhong Yu, Guangyao Guo, Huijian Zheng, Yun Huang, Liping Liu, Jie Lin, Jinlan Long, Renyao Pan, Xi Chen, Changgui Wang, Wenjie Zhang, Zhenshu Xu

“…Data on efficacy (efficacy evaluation, renal function and hemoglobin recovery), immune reconstitution (B-cell subsets, immunoglobulin levels, T-cell subsets, NK cells, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR)) and hematopoietic reconstitution times were collected and analyzed. Whether in all selected patients or in groups R-ISS II-III, there was a notable increase in the proportion of patients achieving in a very good partial response (VGPR) or better (P < 0.001, P = 0.02) and a complete response (CR) or better (P = 0.007, P = 0.014) after transplantation compared to the pre-transplant status. …”
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Dry eye syndrome before corneal refractive surgery: the prevalence and pathogenesis-oriented therapy by N.V. Maychuk, I.S. Malyshev, M.R. Obraztsova

“…A standardized preoperative diagnostic examination was performed in all patients according to the protocol of refraction eye testing. …”
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Dynamics of HDL-Cholesterol Following a Post-Myocardial Infarction Cardiac Rehabilitation Program by Carlos Bertolín-Boronat, Héctor Merenciano-González, Víctor Marcos-Garcés, María Luz Martínez-Mas, Josefa Inés Climent Alberola, Nerea Pérez, Laura López-Bueno, María Concepción Esteban-Argente, María Valls Reig, Ana Arizón Benito, Alfonso Payá Rubio, César Ríos-Navarro, Elena de Dios, Jose Gavara, Juan Sanchis, Vicente Bodi

“…Background: Exercise-based cardiac rehabilitation programs (CRP) are recommended for patients following acute coronary syndrome to potentially improve high-density lipoprotein cholesterol (HDL-C) levels and prognosis. However, not all patients reach target HDL-C levels. Here we analyze the dynamics and predictors of HDL-C increase during CRP in patients following ST-segment elevation myocardial infarction or occlusion myocardial infarction. …”
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Central venous oxygen saturation changes as a reliable predictor of the change of CI in septic shock: To explore potential influencing factors by Ran An, Xi-Xi Wan, Yan Chen, Run Dong, Chun-Yao Wang, Wei Jiang, Li Weng, Bin Du

“…Methods: In this prospective, single-center study, all patients conducted from February 2023 to January 2024 received fluid challenge. …”
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Longitudinal Survey of Astrovirus infection in different bat species in Zimbabwe: Evidence of high genetic Astrovirus diversity by Chidoti, Vimbiso, De Nys, Hélène, Abdi, Malika, Mashura, Getrude, Pinarello, Valérie, Chiweshe, Ngoni, Matope, Gift, Guerrini, Laure, Pfukenyi, Davies, Cappelle, Julien, Mwandiringana, Ellen, Missé, Dorothée, Gori, Elizabeth, Bourgarel, Mathieu, Liégeois, Florian

“…Phylogenetic analysis of the RdRp Astrovirus sequences revealed a high genetic diversity of astroviruses. All the bat astroviruses tested in this study clustered with the Mamastrovirus genus. …”
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Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…We collected data on potentially pathogenic species reported by clinical metagenomics and clinical information for all patients. Latent class analysis (LCA) was applied to routine clinical parameters such as gender, age, white blood cell (WBC), lymphocytes, C-reactive protein (CRP), and Procalcitonin (PCT), identifying two optimally fitting models.ResultsA total of 569 patients were enrolled. …”
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Enzymic Activity, Metabolites, and Hematological Responses Changes of Clinical Healthy High-Risk Beef Calves During Their First 56-Days from Arrival by Octavio Carrillo-Muro, Pedro Hernández-Briano, Paola Isaira Correa-Aguado, Alejandro Rivera-Villegas, Oliver Yaotzin Sánchez-Barbosa, Rosalba Lazalde-Cruz, Alberto Barreras, Alejandro Plascencia, Daniel Rodríguez-Cordero

“…It was concluded that even when all parameters were within the range of reference intervals (RIs) determined for healthy cattle, during the period of monitoring, as the days after arrival lengthened, blood serum parameters related to health and immunity increased, and metabolites related to tissue injury decreased. …”
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KONSEP PERANCANGAN TAMAN RAMAH DIFABEL PADA TEPIAN SUNGAI MAHAKAM SAMARINDA KALIMANTAN TIMUR by Nur Husniah Thamrin, Hatta Musthafa AP

“…According to data from the provincial government of East Kalimantan (Kaltim), it is considered quite high because it reaches 7,331 people, so the government and all related parties need to prepare public facilities that are friendly to the needs of people with disabilities. …”
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The Impact of Ageing on Diaphragm Function and Maximal Inspiratory Pressure: A Cross-Sectional Ultrasound Study by Toru Yamada, Taro Minami, Takahiro Shinohara, Shuji Ouchi, Suguru Mabuchi, Shunpei Yoshino, Ken Emoto, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

“…Age was negatively associated with MIP, regardless of diaphragm thickness, TF, and DE (all <i>p</i> < 0.001). <b>Conclusions</b>: As the diaphragm thickens with age, neither thickness nor TF is associated with MIP; only DE is related to MIP. …”
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Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medic... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, M. A. Livzan, A. I. Martynov, T. L. Lapina, A. V. Paraskevova, D. N. Andreev, O. P. Alexeeva, S. A. Alekseenko, A. Yu. Baranovsky, O. V. Zayratyants, O. Yu. Zolnikova, O. B. Dronova, I. L. Kliaritskaia, N. V. Korochanskaya, Yu. A. Kucheryavyy, S. N. Mammaev, M. F. Osipenko, S. S. Pirogov, E. A. Poluektova, D. E. Rumyantseva, R. G. Sayfutdinov, O. A. Storonova, Yu. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, A. A. Sheptulin

“…When deciding on surgical treatment, all patients need to perform high-resolution esophageal manometry and 24-hour pH-impedance monitoring. …”
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Closed-cycle management strategy for hospital infection prevention and control in the designated dental hospital for the Winter (Paralympic) Olympic Games to receive emergency dent... by AN Na (安娜), CHEN Qiujing (陈秋静), HU Feng (呼峰), XUE Liang (薛亮), MA Yong (马泳), XIA Dengsheng (夏登胜)

“…For Olympic-related patients, the patient satisfaction rate was 100%; 304 environmental points were collected, all were negative, and no nosocomial infection occurred. …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…To investigate growth factors, the length and weight of all fish were measured. Fish mucus samples and blood samples were also collected. …”
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Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization by Manuel P. Kainz, Mathias Polz, Daniel Ziesel, Marta Nowakowska, Muammer Üçal, Sabine Kienesberger, Sophie Hasiba-Pappas, Raimund Winter, Nassim Ghaffari Tabrizi-Wizsy, Sarah Kager, Theresa Rienmüller, Julia Fuchs, Michele Terzano, Christian Baumgartner, Gerhard A. Holzapfel

“…On the first day, the interface strength was similar for all hydrogel compositions. On day 5, softer hydrogels showed the greatest increase (p=0.008), followed by intermediate hydrogels (p=0.020), while the denser hydrogels showed negligible changes (p=0.073). …”
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Evaluation of Some Cumin Ecotypes Based on Selection Index of Ideal Genotype by Masoud Golestani

“…Results: The results of the analysis of variance (ANOVA) revealed that ecotypes significantly affected all studied traits at the 1% probability level, except for TSW. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Such syndemic care aims to address the social determinants of health, whilst simultaneously managing all interlocked conditions.…”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…Consumption, still images, and video data were analyzed to assess uptake of vaccine DUs by deer.Results and discussionVaccine DUs were deployed in 2024 at 11 agricultural sites on private land which had previously demonstrated moderate to high deer activity and at all but two sites &gt;50% of distributed vaccine DU’s were consumed, with 100% consumed at two sites. …”
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IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…The results verified that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> significantly improved this mechanism and maintained normal pregnancy status in mice, but miR-30b-5p significantly reduced the M2 polarization by inhibiting SOCS1, which activated the NF-κB signaling pathway, and then leading to the failure of embryo implantation. All these results indicated that IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> can regulate immune tolerance during pregnancy by promoting M2 macrophage polarization through inhibiting bta-miR-30b-5p targeting SOCS1 to deactivate the NF-κB signaling pathway.…”
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Whole-genome amplification as a tool to improve bacterial detection by PCR in microbiological samples after endodontic treatment by Gabriela Ceccon Chianca, Gabriela Ceccon Chianca, Caroline Corrêa Fendeler, Caroline Corrêa Fendeler, Sérgio Pinto Chaves Junior, Sérgio Pinto Chaves Junior, Gabriella Lorena Dias Pereira, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio

“…Microbiological samples were collected before and after CMP using paper points, which were separated into two groups: (i) culture assay samples were plated onto Brucella agar with 5% defibrinated sheep's blood, menadione and hemin and incubated anaerobically for 14 days at 36°C; (ii) DNA was extracted from molecular assay samples and subject to WGA by isothermal strand displacement with Phi29 DNA polymerase followed by PCR to determine the presence of bacteria.ResultsIn both assays, samples before CMP showed the presence of bacteria in all 10 teeth. After CMP, however, bacterial detection differed in the assays performed (p = 0.0198). …”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Further investment is necessary to ensure decent work conditions in all professions in the sector. Specific training of young professionals entering the labour market should focus on increasing awareness on occupational safety and health, particularly addressing work-related psychosocial risks, and support the destigmatization of mental health at work in the medical professions, creating a supportive culture towards mental health problems. …”
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