The role of mNGS in the diagnosis of talaromycosis and case series by Jing Zhao, Hui-Ting Su, Dong Zhang, Xue-Tong Li, Min-Ya Lu, Juan Du, Jia-Yu Guo, Yi Gao, Xin-Fei Chen, Dong-Hua Wen, Shi-Yu Jia, Yao Wang, Qi-Wen Yang

“…Results Among the four patients, two were human immunodeficiency virus (HIV)-positive, and two were HIV-negative. All the participants presented with fever and varying respiratory symptoms, with distinct clinical characteristics aiding diagnosis. …”
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Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma by Nailya Kubysheva, Marina Boldina, Tatyana Eliseeva, Svetlana Soodaeva, Igor Klimanov, Anastasia Khaletskaya, Venera Bayrasheva, Valery Solovyev, Luis Alfonso Villa-Vargas, Marco Antonio Ramírez-Salinas, Moisés Salinas-Rosales, Dmitry Yu. Ovsyannikov, Ildar Batyrshin

“…IL-17 and IL-18 levels in the blood serum were comparable in all examined patients. The mean TNF-α concentrations in the circulation in COPD and ACO were significantly higher than those in BA (p<0.001). …”
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Quality of care delivery in patients with acute heart failure: insights from the international REPORT-HF registryResearch in context by Wan Ting Tay, Tiew-Hwa Katherine Teng, Wouter Ouwerkerk, Christiane E. Angermann, Kenneth Dickstein, John G.F. Cleland, Ulf Dahlstrom, Georg Ertl, Mahmoud Hassanein, Sergio V. Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Sean P. Collins, Gerasimos Filippatos, Carolyn S.P. Lam, Jasper Tromp

“…The analysis included 17,632 patients enrolled from 358 medical centres in 44 countries between 23 July 2014 and 24 March 2017, all part of the prospective REPORT-HF cohort study. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…IgG4-related interstitial nephritis (TIN, 32.3%), glomerular nephritis (GN, 7.7%), renal pelvis and ureter involvement (21.5%), abnormal radiology with quiescent clinical presentation (13.8%), and renal parenchymal lesion plus retroperitoneal fibrosis (RPF, 18.5%) were major lesion types of IgG4-RUD. All patients had elevated serum IgG4, 76.9% had hyperglobulinemia, and 92.3% had elevated serum IgE at diagnosis. …”
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Effectiveness of mDiabetes intervention in enhancing diabetes awareness and promoting healthy lifestyle changes among the general population in rural India by Padmaja Kumari Rani, Padmaja Kumari Rani, Padmaja Kumari Rani, Jachin David Williams, Nidhi Jaswal, Venkateswaralu Yandluri, Payal Sangani, Kavya Sanagavarapu, Ramya Natarajan, Sandhya Ramalingam, Nalini Saligram, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna

“…Analysis compared data from 545 subjects who participated in all the three surveys.ResultsThe cohort comprised 45.5% males and 54.5% females, aged 19–85 years (mean: 55.42; SD 10.3). …”
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Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients by Thomas Meredith, Thomas Meredith, Thomas Meredith, Farhan Mohammed, Amy Pomeroy, Sebastiano Barbieri, Sebastiano Barbieri, Erik Meijering, Louisa Jorm, David Roy, Jason Kovacic, Jason Kovacic, Jason Kovacic, Jason Kovacic, Michael Feneley, Michael Feneley, Michael Feneley, Christopher Hayward, Christopher Hayward, Christopher Hayward, David Muller, David Muller, David Muller, Mayooran Namasivayam, Mayooran Namasivayam, Mayooran Namasivayam

“…Compared to Cluster 1, Cluster 2 demonstrated significantly worse all-cause mortality at 12 months (HR 6.3, p &lt; 0.01), and was characterised by more advanced cardiac remodelling with worse indices of multi-chamber cardiac function, as quantified by strain imaging. …”
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Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Further investment is necessary to ensure decent work conditions in all professions in the sector. Specific training of young professionals entering the labour market should focus on increasing awareness on occupational safety and health, particularly addressing work-related psychosocial risks, and support the destigmatization of mental health at work in the medical professions, creating a supportive culture towards mental health problems. …”
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Abordaje y manejo médico-quirúrgico del paciente herido por traumatismo taurino by A. Martínez-Hernández, G. Jara-Benedetti, C. Roig-Martí, C. Ordóñez-Urgiles, J.M. Laguna-Sastre

“…Because of the multidisciplinary approach, this guidelines are adressed to all healthcare providers involved in the management of these patients. …”
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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

“…Background and purpose: Prior work on adaptive organ-at-risk (OAR)-sparing radiation therapy has typically reported outcomes based on fixed-number or fixed-interval re-planning, which represent one-size-fits-all approaches and do not account for the variable progression of individual patients’ toxicities. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

“…Ranges for median treatment and total intervals (days) for all patients were 15–39 (Norway, Victoria and Manitoba) and 4–78 days (Sweden, Victoria and Ontario). …”
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Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…For example, cgST 133718 was observed in Antarctica (strain 17_1myr) and in the UK, and sequence 11903, to which strain 32-1 from the northernmost point of Novaya Zemlya belonged, was previously identified in the USA. All strains studied were characterized by the presence of extensive virulence. …”
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Optimization of a micro-scale air–liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2 by Chandani Sen, Tammy M. Rickabaugh, Arjit Vijey Jeyachandran, Constance Yuen, Maisam Ghannam, Abdo Durra, Adam Aziz, Kristen Castillo, Gustavo Garcia, Arunima Purkayastha, Brandon Han, Felix W. Boulton, Eugene Chekler, Robert Garces, Karen C. Wolff, Laura Riva, Melanie G. Kirkpatrick, Amal Gebara-Lamb, Case W. McNamara, Ulrich A. K. Betz, Vaithilingaraja Arumugaswami, Robert Damoiseaux, Brigitte N. Gomperts

“…While there were heterogeneous responses across variants for host factor targeting compounds, the two direct-acting antivirals we tested, Remdesivir and Paxlovid, showed consistent efficacy in reducing infection across all variants and donors. Using the model, we characterized a new antiviral drug effective against both the parental strain and the Omicron variant. …”
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Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience by Hala Hassanain, MD, Ashton A. Connor, MD, PhD, Elizabeth W. Brombosz, PhD, Khush Patel, MD, MS, Ahmed Elaileh, MD, Tamneet Basra, MD, Sudha Kodali, MD, MSPH, David W. Victor, III, MD, Caroline J. Simon, MD, Yee Lee Cheah, MD, Mark J. Hobeika, MD, Constance M. Mobley, MD, PhD, Ashish Saharia, MD, Sadhna Dhingra, MD, Mary Schwartz, MD, Anaum Maqsood, MD, Kirk Heyne, MD, Ahmed O. Kaseb, MD, Jean-Nicolas Vauthey, MD, A. Osama Gaber, MD, Maen Abdelrahim, MD, PhD, R. Mark Ghobrial, MD, PhD

“…Adjuvant sorafenib recipients were demographically similar to nonrecipients and, on explant pathology, had greater tumor burden, lymphovascular invasion, and poorer differentiation (all P < 0.001). Adverse events were observed in 12 adjuvant sorafenib recipients (75%). …”
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Cardiac Hemodynamics, Tissue Oxygenation, and Functional Capacity in Post-COVID-19 Patients by Elizane Poquiviqui do Nascimento, Larissa Fernanda Estevam do Nascimento, Lhara de Freitas Castro, Vilena Cavalcante de Barros, Emily Rachel Pereira Bandeira, Thiago Bezerra Wanderley e Lima, Matías Otto-Yáñez, Guilherme Augusto de Freitas Fregonezi, Vanessa Regiane Resqueti

“…<i>Materials and Methods</i>: A cross-sectional study was conducted involving patients with COVID-19 and a control group who were all aged ≥18 years. Participants underwent two functional capacity tests: the one-minute sit–stand test (1-STS) and the six-minute walk test (6MWT). …”
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Crack of a helicopter main rotor actuator attachment: failure analysis and lessons learned by L. Allegrucci, F. De Paolis, A. Coletta, M. Bernabei

“…Further achieved evidences, such as grain boundary fracture propagation, the presence of corrosion products, were all in accordance with a Stress Corrosion Cracking (SCC) progressive fracture mechanism. …”
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Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…Adverse events, such as mucositis or skin ulceration, were more common with everolimus (19/21 vs. 7/21, p < 0.001). All adverse events resolved without study drug withdrawal. …”
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Shedding light on the existence of Furan fatty acids in latex lipids across a wide diversity of Hevea brasiliensis genotypes by Chaisiri Kitpaosong, Siriluck Liengprayoon, Erwann Durand, Tucksin Lerksamran, Aurélie Daval, Eric Gohet, Lim Khan Tiva, Phean Chetha, Kong Mengchheang, Phen Phearun, Ung Rattana, Kim Chandy, Pol Sokea, Un Kim Eng, Kittipong Rattanaporn, Bruno Barea, Laurent Vaysse

“…The results showed furan fatty acid exists in all lipid fractions of their latices. Its content varied significantly, ranging from 0.01% to 0.71% (w/w in latex), the highest concentrations were found in genotypes from the Institut de Recherche sur le Caoutchouc (IRCA) in Côte d'Ivoire, Prang Besar (PB) in Malaysia, and Rubber Research Institute of Vietnam (RRIV) in Vietnam breeding programs. …”
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Recording dan Pencarian Silsilah Kambing Perah Menggunakan Algoritme Depth First Search by Rizki Wahyudi, Muhammad Iqbal, Lussy Dwi Oktaviana

“…Abstract  The development of information technology has been evenly distributed to almost all fields, one of which is the field of livestock. …”
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Amplifying children’s leadership roles and voice in decision-making through co-production in outside of school hours care: qualitative findings from the connect promote and protect... by Alyssa C. Milton, Alyssa C. Milton, Alyssa C. Milton, Kristin Ballesteros, Helen Hernandez, Yenni Hwang, Nick Glozier, Nick Glozier, Tom McClean, Haley M. LaMonica, Haley M. LaMonica, Karen Thorpe, Karen Thorpe, Ian B. Hickie, Ian B. Hickie

“…The impact related sub-themes included the following: empowerment of children through meaningful engagement; we all have a role in the team (a space for growing leadership skills); a spark through engagement and enjoyment; and being and belonging (the impact on children’s social and emotional wellbeing).ConclusionThis is the first known qualitative study to examine the use and impact of co-production processes in OSHC—where children not only co-design but also co-plan, co-deliver, and co-evaluate the activity programming alongside OSHC educators and their communities. …”
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Health risk assessment through probabilistic sensitivity analysis of carbon monoxide and fine particulate transportation exposure by E. Ernyasih, A. Mallongi, A. Daud, S. Palutturi, S. Stang, R. Thaha, E. Ibrahim, W. Al Madhoun

“…Most of the fine particulate matter risk assessment results had hazard quotient values lower than 1, indicating a safe level. However, all other 30 stations had exceeded the World Health Organization standard (>1), thus demonstrating risks. …”
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