Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging by Ana Silva, Cláudia Pinto, Sara Cravo, Sandra Mota, Liliana Rego, Smeera Ratanji, Clara Quintas, Joana Rocha e Silva, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Teresa Cruz, Isabel F. Almeida

“…Antioxidant potential was screened by DPPH method and the bioactivity and safety of extracts were further explored using cell-based assays. <b>Results</b>: All extracts exhibited a reduction in age-related markers, including senescence-associated beta-galactosidase (SA-β-gal) activity. …”
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Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…Notably, two conjugative MDR plasmids included nearly all potential ARGs, conferring resistance to first-line drugs for shigellosis. …”
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HbA1c Cutoff Point of 5.9% Better Identifies High Risk of Progression to Diabetes among Chinese Adults: Results from a Retrospective Cohort Study by Kai Liang, Chuan Wang, Fei Yan, Lingshu Wang, Tianyi He, Xiuping Zhang, Chengqiao Li, Weifang Yang, Zeqiang Ma, Aixia Ma, Xinguo Hou, Li Chen

“…This article performed a retrospective cohort study to estimate the annual incidence rates of diabetes and to assess the utility of HbA1c as a predictor for progression to diabetes in Chinese community adults aged 40 years or older. Methods. In all, 2778 nondiabetic subjects (including 1901 women) underwent HbA1c testing and oral glucose tolerance test (OGTT) measurements at baseline and after 3 years. …”
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An analytical method for the desorption superposition effect in commingled production of coalbed methane and its application: A case study of the Xiaotun mine field in western Guiz... by Chen GUO, Yan JI, Chenyi ZHAO, Lingling LU, Xinhang YU, Junzhe GAO, Houqiang LI, Xuyang ZHANG, Xiang WANG, Hongbin HE, Runhan ZHANG

“…The well-controlled desorption capacities and their time-varying curves indicate that gas desorption capacities peaked in the case of the synchronous desorption of all pay intervals within the respective desorption systems. …”
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Efek Lama Penyimpanan Asi Terhadap Kadar Protein dan Lemak yang Terkandung Didalam ASI by Indri Putri Sari, Ariadi ., Ety Yerizel

“…</em></p><p><strong><em>Keywor</em></strong><strong><em>ds:</em></strong><em> </em><em>protein breast milk level, fat breast milk level, duration of storage</em><em></em></p></div><em><br clear="all" /> </em>…”
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Design and validation of a-SiC/SiN hybrid photonic platform for integrated quantum photonics by Naresh Sharma, Zizheng Li, Bruno Lopez-Rodriguez, Joey Vrugt, Stijn van der Waal, Luozhen Li, Roald van der Kolk, Philip J Poole, Dan Dalacu, Iman Esmaeil Zadeh

“…Nevertheless, no single platform satisfies all the requirements of quantum photonics, as each platform has its merits and shortcomings. …”
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Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study by Camille Legouy, Renaud Cornic, Keyvan Razazi, Damien Contou, Stéphane Legriel, Eve Garrigues, Pauline Buiche, Maxens Decavèle, Sarah Benghanem, Thomas Rambaud, Jérôme Aboab, Marina Esposito-Farèse, Jean-François Timsit, Camille Couffignal, Romain Sonneville

“…Methods We performed a retrospective multicenter study on consecutive adults diagnosed with pneumococcal meningitis requiring at least 48 h of stay in the intensive care unit (ICU) and undergoing neuroimaging, between 2005 and 2021. All neuroimaging were reanalyzed to look for intracranial complications which were categorized as (1) ischemic lesion, (2) intracranial hemorrhage (3) abscess/empyema, (4) ventriculitis, (5) cerebral venous thrombosis, (6) hydrocephalus, (7) diffuse cerebral oedema. …”
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Hubungan Lingkar Abdomen (Lingkar Perut) dengan Tekanan Darah by Marini Khairana Sari, Nur Indrawati Lipoeto, Rahmatina B. Herman

“…</em></p><p><strong><em>Keyword</em></strong><strong><em>s: </em></strong><em>abdominal circumference, blood pressure,</em><em> </em><em>hypertension</em><em></em></p></div><em><br clear="all" /> </em>…”
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Relato de uma extensão em tempos de isolamento social: Criação de um recurso educacional sobre matemática na pandemia de COVID-19 by Leila Thomazelli Thieghi, Fabio Luiz Sant'Anna Cuppo

“…Scientific reports, journal articles, YouTube videos, and original video content were also shared. All members of the Facebook group could participate in discussions, submit questions, or even suggest materials to be posted. …”
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Mechanism of DMOC in Diabetes Mellitus with Liver Fibrosis by Zizhi XIAO, Hong SHI, Huanwen RAO, Lifen LUO

“…DMOC intervention was conducted in the control group and the control intervention group at the 36th-44th week and animal samples were taken in all groups at the 44th week. DCFH-DA assay was used to detect ROS content in rat blood;ELISA was used to detect TNF-α, IL-6, and TGF-β1 content in rat blood;Masson's trichrome stain method was used to observe the changes of fibrosis in liver tissue;immunohistochemical method was used to observe the changes of Fibronectin and IV-Collagen in liver tissue;Western Blot was used to observe protein expression of Smad2, Smad3, pSmad2, pSmad3, α-SMA, MMP1, MMP2 and MMP9 in liver tissue.Results:Testing changes of anti-oxidation, anti-inflammation and anti-liver fibrosis in blood: the content of ROS, TNF-α, IL-6 and TGF-β1 in the model intervention group were significantly lower than those in the model group(<italic>P</italic>&lt;0.01).Observe the changes of fibrosis in liver tissue: liver tissue was found along the area around the portal vein with obvious hepatocyte necrosis and infiltration of inflammatory cells. …”
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Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution) by V. T. Ivashkin, V. V. Fomin, O. N. Tkacheva, O. S. Medvedev, E. A. Poluektova, D. I. Abdulganieva, S. R. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, M. S. Zharkova, O. Yu. Zolnikova, K. V. Ivashkin, I. L. Kliaritskaia, N. V. Korochanskaya, S. N. Mammaev, R. V. Maslennikov, R. G. Myazin, M. V. Perekalina, A. V. Povtoreyko, A. I. Ulyanin, M. V. Fadeeva, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin

“…Optimization of approaches to the diagnosis and treatment of SIBO, the development of domestic gas analyzers, increasing the awareness of physicians in all regions of the Russian Federation, as well as the development and optimization of clinical recommendations appear to be necessary measures to increase the effectiveness of medical care, the duration and quality of life of the Russian population. …”
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Faecal microbiota transplantation for patients with diabetes type 1 and severe gastrointestinal neuropathy (FADIGAS): a randomised, double-blinded, placebo-controlled trialResearch... by Katrine Lundby Høyer, Simon Mark Dahl Baunwall, Ditte Smed Kornum, Mette Winther Klinge, Asbjørn Mohr Drewes, Knud Bonnet Yderstræde, Louise Bruun Thingholm, Martin Steen Mortensen, Susan Mikkelsen, Christian Erikstrup, Christian Lodberg Hvas, Klaus Krogh

“…The placebo capsules contained glycerol, saline and food colouring. All patients received FMT as a second intervention. …”
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Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact by Liuqingqing Liu, Xinyao Li, Xianxiang Luo, Xiao Wang, Linjia Liu, Zixi Yuan, Cuizhu Sun, Hao Zheng, Elvis Genbo Xu, Fengmin Li

“…After a 20-day foodborne exposure at a low marine environmental concentration (1.0 μg g−1), we observed that all three PAEs significantly increased the thigmotaxis (behavioral tendency to stay close to physical boundaries) and mobility of juvenile fish by 28.2–59.4 % and 23.3–74.5 %, respectively, indicating anxiety-like behavior of fish. …”
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Effects of macitentan and selexipag across prognostic age groups in patients with pulmonary arterial hypertension by Richard Channick, MD, Sarah Medrek, MD, Marion Delcroix, MD, Sean Gaine, MD, Pavel Jansa, MD, PhD, Irene Lang, MD, Vallerie McLaughlin, MD, Sanjay Mehta, MD, Tomas Pulido, MD, Bhagavatula Sastry, MD, Rogerio Souza, MD, PhD, Adam Torbicki, MD, Carol Zhao, MS, Paul Strachan, MD, Peter Agron, PhD, Joseph Yen, PhD, Olivier Sitbon, MD, PhD

“…CONCLUSIONS: The benefit (vs placebo) of macitentan/selexipag on reducing risk of M/M events was consistent across all ages, including the younger group where significant treatment effects were observed.…”
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Identification of robust and abundant reference transcripts for EV mRNA cargo normalization by Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey

“…We identify 11 transcripts that are shared amongst the 50 most abundant in EVs from all of these cell sources. Following RT-PCR and deeper sequencing analysis, five transcripts warranted further investigation as molecular standards: TMSB4X, ACTB, GAPDH, VIM, and FTL. …”
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Last-millennium volcanic forcing and climate response using SO₂ emissions by L. R. Marshall, L. R. Marshall, L. R. Marshall, A. Schmidt, A. Schmidt, A. Schmidt, A. P. Schurer, N. L. Abraham, N. L. Abraham, L. J. Lücke, R. Wilson, K. J. Anchukaitis, G. C. Hegerl, B. Johnson, B. L. Otto-Bliesner, E. C. Brady, M. Khodri, K. Yoshida

“…Here, we use the UK Earth System Model (UKESM) to simulate the climate of the last millennium (1250–1850 CE) using volcanic <span class="inline-formula">SO₂</span> emissions. Averaged across all large-magnitude eruptions, we find similar Northern Hemisphere (NH) summer cooling compared with other last-millennium climate simulations from the Paleoclimate Modelling Intercomparison Project Phase 4 (PMIP4), run with both <span class="inline-formula">SO₂</span> emissions and prescribed forcing, and a continued overestimation of surface cooling compared with tree-ring reconstructions. …”
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Monitoring the Spread of Multidrug-Resistant <i>Escherichia coli</i> Throughout the Broiler Production Cycle by Victor Dellevedove Cruz, Danilo Henrique Rabaçal Alves, Jamile Kellen de Souza, Maísa Fabiana Menck-Costa, Bruno Henrique Dias de Oliva, Ana Angelita Sampaio Baptista, Alexandre Oba, Fabrizio Matté, Kácio Emílio Borges Baierle, Sérgio Paulo Dejato da Rocha, Kelly Cristina Tagliari de Brito, Benito Guimarães de Brito, Gerson Nakazato, Marcio Costa, Renata Katsuko Takayama Kobayashi

“…The use of these antimicrobials increased the likelihood of resistance by over three times and was associated with a 1.5-fold higher probability of multidrug resistance. Of all isolates, 95% were multidrug-resistant, raising concerns for production and public health. …”
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Mechanism of Delaying Cartilage Degeneration in Knee Osteoarthritis with Rongjin Niantong Recipe Based on lncRNA NEAT1 and Nrf2/ARE Pathway by FU Changlong, XIE Xinyu, QIU Zhiwei, HUANG Yanfeng, JIN Linglu, LI Xihai

“…After the intervention, all groups were sacrificed under anesthesia, and the right knee tissues were separated and collected; HE staining was used to observe the pathological changes; Western blot was used to detect the expression levels of Nrf2, heme oxygenase-1 (HO-1), NAD (P) H quinone oxidoreductase-1 (NQO-1), kelch like ECH-associated protein 1 (Keap1) and inducible nitric oxide synthase (iNOS) in cartilage; Real-time PCR was used to detect the expression of lncRNA NEAT1 in cartilage tissue.Results1) Pathological changes of cartilage tissue: the cartilage matrix was light red and uniform, with complete tissue structure and clear tissue margins of each layer in the blank group; in the model group, the chondrocytes grew in clusters with thinner tangent layer. …”
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Characterizing local forest structural complexity based on multi-platform and -sensor derived indicators by Patrick Kacic, Ursula Gessner, Christopher R. Hakkenberg, Stefanie Holzwarth, Jörg Müller, Kerstin Pierick, Dominik Seidel, Frank Thonfeld, Michele Torresani, Claudia Kuenzer

“…In addition, multivariate analyses revealed that ESC of gap aggregated treatments can be effectively delineated from control and distributed treatments across all considered remote sensing sensors/platforms. …”
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Relationship between vaginal and gut microbiome and pregnancy outcomes in eastern Ethiopia: a protocol for a longitudinal maternal-infant cohort study (the EthiOMICS study) by Piet Cools, Alemseged Abdissa, Abera Kenay Tura, Nega Assefa, Merga Dheresa, Kedir Teji Roba, Tara Wilfong, Tesfaye Assebe Yadeta, Fitsum Weldegebreal, Desalegn Admassu Ayana, Akewok Sime Negesa, Yohannes Mulugeta Demmu, Tewodros Tesfa, Tegbaru Nibrat Alemu, Tadesse Gure Eticha, Abraham Geremew, Abel Abera Negash

“…Written informed consent regarding the study and sample storage for biobanking will be obtained from all participants. Results will be published in international peer-reviewed journals, and summaries will be provided to the study funders. …”
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