Short-Term Effect of Air Pollution on Daily Hospital Visits for Anxiety Disorders in Southern China with Low Pollution Concentrations by Xinyuan Zhong, Tingting Guo, Jianghui Zhang, Qiong Wang, Rong Yin, Kunpeng Wu, Qing Zou, Meng Zheng, Brian J. Hall, Andre M. N. Renzaho, Kangning Huang, Wen Chen

“…Although the daily levels of most pollutants (PM₁₀, SO₂, CO, NO₂ and O₃) were consistently below China and WHO’s Ambient Air-Quality Standards, significant associations were observed between daily hospital visits for ADs and all six air pollutants. Each interquartile range increase in concentrations resulted in the largest odds ratios of 1.08 (95% <i>CI</i>: 1.01, 1.16) at lag1 for PM_2.5, 1.19 (95% <i>CI</i>: 1.05, 1.34) at lag07 for NO₂, 1.14 (95% <i>CI</i>: 1.05, 1.23) at lag02 for CO, 1.12 (95% <i>CI</i>: 1.01, 1.25) at lag07 for PM₁₀, 1.06 (95% <i>CI</i>: 1.01, 1.12) at lag7 for SO₂ and 1.08 (95% <i>CI</i>: 1.01, 1.15) at lag7 for O₃, respectively. …”
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The Effects of Oral Semaglutide on Hepatic Fibrosis in Subjects with Type 2 Diabetes in Real-World Clinical Practice: A Post Hoc Analysis of the Sapporo-Oral SEMA Study by Hiroya Kitsunai, Yuka Shinozaki, Sho Furusawa, Naoyuki Kitao, Miki Ito, Hiroyoshi Kurihara, Chiho Oba-Yamamoto, Jun Takeuchi, Akinobu Nakamura, Yumi Takiyama, Hiroshi Nomoto

“…Oral semaglutide significantly improved the hepatic steatosis index (from 46.1 to 44.6, <i>p</i> < 0.001) and FIB-4 index (from 1.04 to 0.96, <i>p</i> < 0.001) as well as several metabolic parameters in all cohorts. The efficacy of semaglutide in treating liver fibrosis was confirmed by the addition of, and switching from, existing agent groups. …”
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Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas by Junhao Zhang, Lingbo Li, Aiwei Tang, Chucheng Wang, Yupeng Wang, Yongqi Hu, Guangting He, Guangting He, Wangjun Liao, Wangjun Liao, Wangjun Liao, Rui Zhou

“…The AC-GII patients exhibited the best prognosis and were sensitive to temozolomide, while AC-GV patients had the poorest prognosis and the lowest sensitivity to temozolomide among all subtypes. Moreover, based on the Connectivity Map database analysis and experimental verification, we identified several pan-HDAC inhibitors that could serve as sensitizers for temozolomide therapy in AC-GV patients, such as panobinostat and scriptaid. …”
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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

“…Sera samples were analysed using microneutralization assays to quantify polio antibodies for all three serotypes: type 1, 2, and 3. The stool samples collected at baseline, 7, 14, and 28 days (after each tOPV dose) were tested for the presence of poliovirus. …”
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Sustainable alternative of palm wine analogue from different tiger nut milk-sugar syrup blends for local production by Adindu O. Onyeodili, Gabriel I. Okafor, Chigozie F. Okoyeuzu, Onyekachukwu Chukwuebuka Nduka, Queency N. Okechukwu, Mouandhe Imamou Hassani, Szymon Juchniewicz, Katarzyna Leicht, Charles Odilichukwu R. Okpala, Małgorzata Korzeniowska, Raquel P.F. Guiné

“…Importantly, the tiger nut milk-sugar syrup medium has been pitched with palm wine dreg (inoculum source) between fermentation time 26–30 h, and temperature 29.8°–32°C. Results: Considering all the analytical outcomes, from proximate, microbiological, physicochemical, to sensory data, the control appeared to somewhat resemble those of the experimental samples of this study. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…Results: From June 2020 to November 2023, a total of 241 patients were seen at seven multidisciplinary mobile clinics. All patients received health resources and donated items including new socks and shoes. …”
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Systemic and mammary inflammation and mammary gland development of Holstein dairy cows around dry-off and calving by J. Gao, T.N. Marins, J.O.S. Calix, Z. Qi, C.G. Savegnago, A.M. Roper, M.W. Woldemeskel, J.K. Bernard, S. Tao

“…ABSTRACT: This study evaluated systemic and mammary inflammation and the immune cell population and developmental pattern of the mammary gland in Holstein dairy cows transitioning from late lactation to the dry period (LTD, n = 6) and from the dry period to early lactation (DTL, n = 7). All cows were healthy and free of mastitis at enrollment. …”
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Characteristics and spatiotemporal changes in phenotypes and genotypes of extended-spectrum β-lactamases in Escherichia coli isolated from bloodstream infections in China from 2014... by Sayyed Salman, Hao Xu, Yunbo Chen, Jinru Ji, Zhiying Liu, Yonghong Xiao

“…A notable increase in bla CTX−M−27 was observed, particularly from 2019 to 2021, with 26.4%, 23.1%, and 25.8% in all genotypes. Regarding the geographical distribution of the ESBLs, the highest rate of ESBL genetic positivity was observed in Southwest China, accounting for 84.9% (45/53), and the lowest was observed in Northeast China, with 73.2% (30/41). …”
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Patients’ acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualita... by Tempei Miyaji, Yosuke Uchitomi, Hiroyuki Okada, Masatoshi Inagaki, Maiko Fujimori, Taichi Shimazu, Masaki Fujiwara, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Hirokazu Takahashi, Naoki Nakaya, Shiro Hinotsu, Keita Harada, Norihito Yamada, Yuto Yamada, Tsuyoshi Etoh

“…However, providing the intervention to all patients simultaneously was considered difficult with the current human resources.Conclusions This study showed that the CM intervention was perceived as acceptable by patients and acceptable and appropriate by psychiatric care providers.Trial registration number UMIN000036017.…”
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Utilization of primary tumor samples for cancer neoantigen discovery by Yong Li, Steven A Rosenberg, Paul Robbins, Billel Gasmi, Todd D Prickett, Jared J Gartner, Devikala Gurusamy, Stephanie L Goff, Vid Leko, Victoria Hill, Frank J Lowery, Bradley Sinclair White, Sivasish Sindiri, Maria Parkhust, Noam Levin, Eric Groh, Shoshana T Levi, Amy R Copeland, Sanghyun Peter Kim

“…Mutations unique to primary tumors were screened for recognition by metastasis-derived TIL and circulating T lymphocytes.Results We found that 25 (65.8%) of the 38 validated neoantigens identified in metastatic tumors from 18 patients with colorectal cancer were also present in matched primary tumor samples. This included all 12 neoantigens encoded by putative cancer driver genes, which are generally regarded as superior targets for adoptive cell therapy. …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…This is consistent with a hybrid model: the initial mutation may cause an adenoma, and the second hit in the wild-type PMS2 allele may drive the adenoma towards become cancerous with MSI. Since all mutational events are stochastic, interventions aimed at preventing or curing cancer should ideally target the initial mutational events. …”
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The Effect of Enriched Daphnia sp. with Different Source of Oil on the Survival Rate and the Growth of Oreochromis niloticus Larvae by I. Mokoginta, Dedi Jusadi, T.L. Pelawi

“…Larvae was reared in the small cages (2,25 l), and all cages was placed in the aquarium. Larvae density was 48 larvae/l. …”
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In Vitro Cultivation of Limbal Epithelial Stem Cells on Surface-Modified Crosslinked Collagen Scaffolds by Michel Haagdorens, Vytautas Cėpla, Eline Melsbach, Laura Koivusalo, Heli Skottman, May Griffith, Ramūnas Valiokas, Nadia Zakaria, Isabel Pintelon, Marie-José Tassignon

“…Cell proliferation, cell morphology, and expression of LESC markers were analyzed. All data were compared to cultures on human amniotic membrane (HAM). …”
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Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs by Claudia Schmid, Claudia Schmid, Claudia Schmid, Aline R. Steiner, Léonie Spielhofer, Léonie Spielhofer, Meltem Galfetti, Meltem Galfetti, Nikki Rentsch, Nikolay Bogdanov, Johannes Vogel, Regina Hofmann-Lehmann, Regina Hofmann-Lehmann, Sonja Hartnack, Georgy Astakhov, Reinhard Furrer, Anna Bogdanova, Anna Bogdanova, Iris Margaret Reichler

“…We found the results of the trotting test to be most reliable compared to the outcome of respiratory performance assessment using plethysmography. Of all the candidate blood parameters tested, carboxyhemoglobin and oxyhemoglobin levels were the most predictive as on-side but not self-standing indicators of BOAS severity grade. …”
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Temporal changes in Plasmodium falciparum genetic diversity and multiplicity of infection across three areas of varying malaria transmission intensities in Uganda by Alex Mwesigwa, Steven M. Kiwuwa, Benson Musinguzi, Hakiim Kawalya, James Davis Katumba, Andrew Baguma, Irene M. Mutuku, Ismail Abiola Adebayo, Samuel L. Nsobya, Pauline Byakika-Kibwika, Joan N. Kalyango, Charles Karamagi, Joaniter I. Nankabirwa

“…Polyclonal infections exceeded 50% at all sites, and mean MOI ranged from 1.7 to 2.2, with a significant reduction in Tororo (from 2.2 to 2.0, p = 0.03). …”
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Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An in vivo biomechanical study by Mingfeng Lu, Mingfeng Lu, Wei Chen, Jinpeng Lin, Jinpeng Lin, Wenhan Huang, Junqing Gao, Junqing Gao, Lilian Zhao, Shilin Li, Lilei He, Yu Zhang

“…Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.Methods35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study. All participants walked on a treadmill at a self-selected comfortable speed. …”
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Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis by Namwin Siourimè Somda, Rabbi Nyarkoh, Abel Tankoano, Ouindgueta Juste Isidore Bonkoungou, Patience B. Tetteh-Quarcoo, Eric S. Donkor

“…The meta-analysis and forest plots of Shigella species, ESBL and carbapenemases genes were done using the comprehensive Meta-Analysis software. All data were analyzed using a binary random-effects model by the DerSimonian-Laird method at a 95% confidence interval. …”
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Severity Assessment of COVID-19 Using a CT-Based Radiomics Model by Zhigao Xu, Lili Zhao, Guoqiang Yang, Ying Ren, Jinlong Wu, Yuwei Xia, Xuhong Yang, Milan Cao, Guojiang Zhang, Taisong Peng, Jiafeng Zhao, Hui Yang, Jinfeng Hu, Jiangfeng Du

“…We retrospectively analyzed the CT images of 284 COVID-19 patients. All of the patients were divided into four groups (0-3): early (n=75), progressive (n=58), severe (n=75), and absorption (n=76) groups, according to the progression of the disease and the CT features. …”
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Retrospective analysis of the occurrence, potential risk factors and medical significance of pulmonary complications after total shoulder arthroplasty from the National Inpatient S... by Mengning Dong, Huitong Liang, Jinlang Fu, Zeying Guo, Hao Xie, Qinfeng Yang, Qingmei Yu, Xiaomin Hou

“…Methods The National Inpatient Sample (NIS) was utilized to survey all patients who underwent primary elective TSA from 2010 to 2019. …”
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Assessment of the southern polar and subpolar warming in the PMIP4 last interglacial simulations using paleoclimate data syntheses by Q. Gao, Q. Gao, Q. Gao, E. Capron, L. C. Sime, R. H. Rhodes, R. Sivankutty, X. Zhang, B. L. Otto-Bliesner, M. Werner

“…The four syntheses include 99 reconstructions, and all syntheses support the presence of a warmer Southern Ocean, with reduced sea ice and a warmer Antarctica at 127 ka compared to the preindustrial. …”
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