Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study by Arthur Kavanaugh, Paul Emery, René Westhovens, Mark C Genovese, Kevin L Winthrop, Rieke Alten, Dick de Vries, Lorenzo Dagna, Patrick Verschueren, Maria Greenwald, Regina Cseuz, Robin Besuyen, Vikas Modgill, Ly Huong Le

“…Safety and efficacy analyses included all enrolled patients who received ≥1 dose of filgotinib in DARWIN 3.Results 739 patients entered the LTE. …”
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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy by Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj

“…Methods and results We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. …”
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Prediction Models of Severity in Acute Biliary Pancreatitis by Iulia Ratiu, Renata Bende, Camelia Nica, Oana Budii, Calin Burciu, Andreea Barbulescu, Tudor Moga, Bogdan Miutescu, Roxana Sirli, Mirela Danila, Alina Popescu, Felix Bende

“…In univariate analysis, the following parameterswere associatedwith at least a moderate–severe form of acute pancreatitis: Balthazar score, fasting blood glucose (mg/dL), modified CTSI score, CRP values at 48 h, BISAP score at admission, CTSI score, Ranson score, duration of hospitalization (days), and the presence of leukocytosis (×1000/µL) (all <i>p</i> < 0.05).BISAP score at admission (AUC-0.91), CRP levels at 48 h (AUC-0.92), mCTSI (AUC-0.94), and CTSI score (AUC-0.93) had the highest area under the curve (AUC) for predicting the severity of acute pancreatitis. …”
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Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

“…The efflux pump genes (<i>adeF</i>, <i>rsmA</i>, and <i>qacG</i>) were present in the genomes of all the strains used in this study. The amino acid sequences of <i>POM-1</i> in the strains shared a sequence homology with seven other sequences from different countries. …”
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Vitamin D deficiency and intracranial aneurysms: Systematic Review by Lívio Pereira de Macêdo, Glaudir Donato, Maria Eduarda d’Almeida Lins Regis, Isabela Fernandes de Melo Pereira, Gustavo Rodrigues Paulo, Kamilla Azevedo Bringel, Gabriel Carvalho Andrade Gadelha, Fábio Antônio Serra de Lima Júnior, Yally Dayanne Oliveira Ferreira, Renata de Castro Tavares, Arlindo Ugulino Netto, Kauê Franke, Pierre Vansant Oliveira Eugênio, Auricélio Batista Cezar-Junior, Igor Vilela Faquini, Eduardo Vieira de Carvalho Júnior, Nivaldo Sena de Almeida, Francisco Alfredo Bandeira e Farias, Marcelo Moraes Valença, Hildo Rocha Cirne Azevedo-Filho

“…A relationship between low vitamin D levels and IA incidence was detected in all studies. In terms of rupture and complications, there was a tendency of association with hypovitaminosis. …”
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Characteristics of base materials and acrylates used in removable prosthetics in dental practice (review) by Yu.I. Poliukhovych, A.Ye. Demkovych, Yu.I. Bondarenko, V.V. Shcherba, O.I. Lebid, K.M. Duda

“…The analysis of these literature sources showed that the percentage ratio of the composition of removable prostheses, which includes acrylic plastic, is more than 80%. However, except all existing advantages, they have a number of disadvantages. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Materials and methods. 95 children aged 3 to 73 months with liver cirrhosis of various etiologies were surveyed. All the patients underwent liver transplantation (LT) from a living related donor. …”
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The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

“…The average cell yield per cell factory at passage 1 was of 21.93±12.81×106 cells, while at passage 2, it was of 83.05±114.72×106 cells. All final cellular products were free from contamination with aerobic/anaerobic pathogens, mycoplasma, and bacterial endotoxins. …”
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Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…Mean baseline CRT ± SD for Type 4 lesions was 492.1 ± 187.0 μm, and then 333.3 ± 137.5 μm, 354.4 ± 175.0 μm, and 326.7 ± 122.4 μm at 16, 32, and 48 weeks respectively. All these changes were statistically significant (p<0.005). …”
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A Study of Real-time Detection Methods for Solar Radio Burst Identification by YongLin Yu, ChengLong Qiao, Shuo Xu, QinZheng Li, YanRui Su, HongQiang Song, FaBao Yan

“…Five solar radio burst detection methods—Continuous-3 σ , Sum Flux-3 σ , Continuous Slope, Sum Flux Slope, and Sum Flux Continuous-3 σ —are developed and validated using data from the Japanese NoRP and the Australian Learmonth Solar Radio Observatory. The results show that all five methods can detect solar radio bursts to some degree. …”
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Investigation of Moral Literacy Levels of University Students (The Case of Mus Alparslan University) by Fatma BİLDİRİCİ, Teceli KARASU

“…To determine between which groups there was a significant difference as a result of the ANOVA test, the Bonferroni test was used when the variances were equal and the sampling was not equal, Tamhane’s T2 test was used when the variances and sampling were not equal. In all tests, the significance value was accepted as 0,05. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Psychometric validation showed high internal consistency, overall high reliability, and moderate fit indices in the confirmatory factor analysis for all five domains. Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Seaweed extract of Gracilaria verrucosa as an antibacterial and treatment against Vibrio harveyi infection of Litopenaeus vannamei by Mad Rudi, Sukenda Sukenda, Dinamella Wahjuningrum, Wesly Pasaribu, Dendi Hidayatullah

“…The first results of the inhibitory test showed that all the concentration of G. verrucosa extract was able to inhibit the growth of V. harveyi and the second result showed that the extract of G. verrucosa can increase the immune responses of shrimp. …”
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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker by Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

“…The predictive value of TyG-ABSI was greater than that of the TyG index, TyG-BMI, TyG-WC, and TyG-WHtR (Harrell’s C-index: 0.710 vs 0.623 vs 0.539 vs 0.612 vs 0.622, all p < 0.001). Conclusions The simultaneous assessment of the TyG index and ABSI revealed a synergistic effect on cardiovascular mortality. …”
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Neuropsychiatric profile in tuberous sclerosis complex patients with epilepsy by Mahmoud Fawzi Osman, Mahmoud Fawzi Osman, Faisal Hadid, Tawfeg ben Omran, Tawfeg ben Omran, Tawfeg ben Omran, Munira Aden, Fatima Al-Maadid, Sondos Altaraqji, Khalid Mohamed, Ruba Benini, Ruba Benini

“…Genetic analysis was performed for all patients, and statistical analyses were used to explore correlations between epilepsy severity, TAND, and cognitive outcomes.ResultsThe majority (82%) of TSC patients had epilepsy, with a mean onset age of 9.2 months. …”
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Multiple and complex eye injuries in children by G.Sh. Arzhimatova, O.V. Karaseva, E.A. Koroleva, G.M. Chernakova

“…</p> <p> <b>Patients and Methods: </b>this study included 403 children aged 1 month to 18 years with eye injuries associated with multiple or complex injuries of varying severity on the day before hospital admission. All children were admitted between 2014 and 2020. …”
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Childhood lung function is associated with adolescent-onset and persistent asthma by Hans Jacob L. Koefoed, Anhar Ullah, Jenny Hallberg, Simon Kebede Merid, Maura M. Kere, Lesley Lowe, Angela Simpson, Clare S. Murray, Ulrike Gehring, Roel Vermeulen, Inger Kull, Anna Bergström, Judith M. Vonk, Adnan Custovic, Erik Melén, Gerard H. Koppelman

“…Persistent asthma from childhood to adolescence was observed in 8.2%, 6.4% and 7.7% of all subjects within the respective cohorts. A higher FEV1 % predicted and FEV1/FVC at age 8 years was associated with a lower odds for adolescent-onset asthma: OR 0.98 (95% CI 0.97–1.00) and 0.97 (0.94–0.99). …”
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Intermediate risk prostate tumors contain lethal subtypes by William L. Harryman, James P. Hinton, Rafael Sainz, Jaime M. C. Gard, John M. Ryniawec, John M. Ryniawec, Gregory C. Rogers, Gregory C. Rogers, Noel A. Warfel, Noel A. Warfel, Beatrice S. Knudsen, Raymond B. Nagle, Juan J. Chipollini, Benjamin R. Lee, Belinda L. Sun, Anne E. Cress, Anne E. Cress

“…In 2024, prostate cancer (PCa) remains the most common non-skin cancer in males within the United States, with an estimated 299,010 new cases, the highest increase incident trend rate (3.8%) of all cancers, and one of the eight deadliest. PCa cases are projected to double from 1.8 million to 2.9 million per year between 2020 and 2040. …”
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Social disconnectedness, subsequent medical conditions, and, the role of pre-existing mental disorders: a population-based cohort study by L. M. Laustsen, M. Lasgaard, N. C. Momen, D. Chen, J. L. Gradus, M. S. Grønkjær, M. M. Jensen, O. Plana-Ripoll

“…Individuals who were lonely and with low social support had a higher incidence rate in all 11 categories of medical conditions (interquartile range [IQR] of IRRs, respectively 1.26–1.49 and 1.10–1.14), whereas this was the case in nine categories among individuals who were socially isolated (IQR of IRRs, 1.01–1.31). …”
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Dietary patterns related to triglyceride glucose index and risk of type 2 diabetes: a large-scale cohort study by Dong Liu, Dong Liu, Ziwei Liu, Yue Wu, Yan Hong, Jinghao Fang, Ying Lu, Guangfei Xu, Peipei Kang, Tong Liu, Li-Hua Chen, Li-Hua Chen

“…The primary aim of this study was to novelly examine the associations between dietary patterns reflecting variations in circulating TyG index and the risk of type 2 diabetes mellitus (T2DM).MethodsThis study included 120,988 participants from the UK Biobank, all of whom completed multiple 24-h dietary assessments. …”
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