Evolution of human genes encoding cell surface receptors involved in the regulation of appetite: an analysis based on the phylostratigraphic age and divergence indexes by E. V. Ignatieva, S. A. Lashin, Z. S. Mustafin, N. A. Kolchanov

“…It turned out that the set of genes under consideration contains an increased number of genes with the same phylostratigraphic age (PAI = 5, the stage of vertebrate divergence), and almost all of these genes (28 out  of 31) belong to the superfamily of G-protein coupled receptors. …”
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GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential by Marlene B. Cunha, André F. Jorge, Maria João Nunes, Joana R. Sousa, Maria João Lança, Marco Gomes da Silva, Susana P. Gaudêncio

“…The identified BCFA were i-C16:0, a-C15:0, i-C15:0, i-C15:1ω6, a-C16:0, a-C14:0, and i-C17:0, which include combined branching and unsaturation and branching and odd. SFAs were present in all species, with C16:0 and C18:0 being the most representative. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study by Yuan Liu, Jianjie Ouyang, Cuicui Zhang, Pingping Niu, Pingping Niu, Baoling Shang, Baoling Shang, Gengzhen Yao, Gengzhen Yao, Yongyong Shi, Yongyong Shi, Xu Zou, Xu Zou

“…DEX doses >0.4 μg/kg/h, particularly in the range of 0.400–0.612 μg/kg/h, total doses >3.113 mg during hospitalization, and treatment durations exceeding 72 h were associated with improved mortality risk at all intervals. Regarding DEX efficacy at 28 days, our subgroup analyses indicated a significant interaction between the Sequential Organ Failure Assessment score and invasive mechanical ventilation.ConclusionDEX administration was associated with improved in-hospital mortality and reduced mortality rates at 7 days, 28 days, 90 days, and 1 year in patients with SIMI. …”
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Model Sistem Pendukung Keputusan Kelompok untuk Penilaian Gangguan Depresii, Kecemasan dan Stress Berdasarkan DASS-42 by Sri Kusumadewi, Hepi Wahyuningsih

“…Ordered Weighted Averaging (OWA) operator used to aggregation process for all decision maker preference. The OWA operator are used to aggregate into one matrix. …”
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Pengaruh Pemberian Aspartam terhadap Kadar Glukosa Darah Tikus Diabetes Melitus Diinduksi Aloksan by Ega Purnamasari R.D, Eti Yerizel, Efrida .

“…Data were analyzed using ANOVA test, p-value=0.000 ( p<0.05 ), there are differences in fasting blood glucose levels were significant in all groups. The conclusions of this study is the provision of aspartame in alloxan induced diabetic rats can cause a decrease in blood glucose levels significantly.…”
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Restoring coronal pre-arthritic alignment in mobile-bearing unicompartmental knee arthroplasty: mid- to long-term outcomes by Yankun Jiang, Changquan Liu, Qidong Zhang, Guoyuan Sun, Ran Ding, Nianfei Zhang, Cheng Huang, Weiguo Wang, Wanshou Guo

“…Although no significant differences in postoperative VAS scores were observed between groups (p = 0.147), the pre-arthritically aligned group demonstrated significantly higher HSS scores and better KOOS subscale scores for daily living activities, sports, and quality of life than the non-pre-arthritically aligned group (all p < 0.01). The PASS ratio for KOOS subscales also indicated superior outcomes in the pre-arthritically aligned group. …”
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Simulator training in focus assessed transthoracic echocardiography (FATE) for undergraduate medical students: results from the FateSim randomized controlled trial by Johannes Matthias Weimer, Franziska Marietta Sprengart, Thomas Vieth, Sebastian Göbel, Anna Dionysopoulou, Rebecca Krüger, Jan Beer, Andreas Michael Weimer, Holger Buggenhagen, Roman Kloeckner, Lukas Pillong, Johanna Helfrich, Elias Waezsada, Philipp Wand, Julia Weinmann-Menke

“…Both groups completed a theory test and a self-assessment questionnaire before the course (T1) and at the end of the training (T2). At T2, all participants also completed two Direct Observation of Procedural Skills (DOPS) tests—one on the simulator (DOPSSim) and one on humans (DOPSHuman). …”
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Safety and Efficacy of Subcutaneous Rituximab in Previously Untreated Patients with CD20+ Diffuse Large B-Cell Lymphoma or Follicular Lymphoma: Results from an Italian Phase IIIb S... by Mario Petrini, Gianluca Gaidano, Andrea Mengarelli, Ugo Consoli, Armando Santoro, Anna Maria Liberati, Marco Ladetto, Vincenzo Fraticelli, Attilio Guarini, Donato Mannina, Paola Ferrando, Paolo Corradini, Pellegrino Musto, Caterina Stelitano, Dario Marino, Andrea Camera, Marco Murineddu, Roberta Battistini, Giuseppe Caparrotti, Mauro Turrini, Luca Arcaini, Simone Santini, Manuela Cerqueti, Andres J. M. Ferreri, Nicola Cantore, Alessandro Inzoli, Giovanni Cardinale, Benedetto Ronci, Giorgio La Nasa, Stefano Massimi, Gianfranco Gaglione, Valentina Barbiero, Maurizio Martelli

“…ARRs were reported in 10 patients (6.3%), 3 (4.2%) with DLBCL and 7 (8.1%) with FL, all of mild severity, and resolved without dose delay/discontinuation. …”
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First study on molecular identification of Anaplasma ovis in sheep in southern Kazakhstan by Alexandr Ostrovskii, Madina Kadyrova, Nurdina Yerzhanova, Dinara Kamalova, Amirkhan Kassen, Nailya Tursunbay, Alexandr Shevtsov, Christian Bauer, Kassym Mukanov

“…Altitude <500 m above sea level was identified as a risk factor for Anaplasma infection. All amplification products were identified as A. ovis through sequencing. …”
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Hubungan Mobilisasi Dini dengan Proses Penyembuhan Luka pada Pasien Pasca Laparatomi di Bangsal Bedah Pria dan Wanita RSUP Dr. M. Djamil Padang by Wira Ditya, Asril Zahari, Afriwardi Afriwardi

“…<br clear="all" /><p><strong>Abstrak</strong></p><p><strong>   </strong>Mobilisasi dini merupakan kebijakan untuk secepat mungkin membimbing penderita turun dari tempat tidur dan berjalan. …”
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Immunohistochemical Expression of p53 Gene and Clinicopathological Assessment of Low-grade Serous Ovarian Cancer and High-grade Serous Ovarian Cancer: A Cohort Study by Geeta Bazard, Minakshi Vashist, Sunita Singh, Gulshan Rohilla, Nidhi Paliwal

“…Additionally, higher median CA125 levels were found in HGSOC patients (median 269 U/mL vs. 27 U/mL) and a higher rate of postsurgery residual disease (57.69% vs. 27.27%). Among all serous carcinoma cases, 17 cases (45.95%) showed null p53 expression, 16 cases (43.24%) showed diffuse p53 expression, and four cases (10.81%) had focal positive expression (wild type). …”
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Community-based models of care for management of type 2 diabetes mellitus among non-pregnant adults in sub-Saharan Africa: A scoping review. by Emmanuel Firima, Lucia Gonzalez, Fabiola Ursprung, Elena Robinson, Jacqueline Huber, Jennifer M Belus, Fabian Raeber, Ravi Gupta, Gibrilla F Deen, Alain Amstutz, Bailah Leigh, Maja Weisser, Niklaus Daniel Labhardt

“…There were no reported outcomes on end-organ damage. All four studies were rated as being at high risk for bias.…”
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Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV by Astri Nur Faizah, Daisuke Kobayashi, Faustus Akankperiwen Azerigyik, Ryo Matsumura, Izumi Kai, Yoshihide Maekawa, Yukiko Higa, Kentaro Itokawa, Toshinori Sasaki, Kris Cahyo Mulyatno, Sri Subekti, Maria Inge Lusida, Etik Ainun Rohmah, Yasuko Mori, Yusuf Ozbel, Chizu Sanjoba, Tran Vu Phong, Tran Cong Tu, Shinji Kasai, Kyoko Sawabe, Haruhiko Isawa

“…This study emphasizes the importance of remaining vigilant and continuing arbovirus surveillance in all locations.…”
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Computational and in vitro evaluation of sumac-derived ©Rutan compounds towards Sars-CoV-2 Mpro inhibition by Muzaffar Kayumov, Parthiban Marimuthu, Parthiban Marimuthu, Jamoliddin Razzokov, Jamoliddin Razzokov, Jamoliddin Razzokov, Nurkhodja Mukhamedov, Nurkhodja Mukhamedov, Akmal Asrorov, Nodir S. Berdiev, Jamolitdin F. Ziyavitdinov, Ansor Yashinov, Ansor Yashinov, Yuliya Oshchepkova, Shavkat Salikhov, Sharafitdin Mirzaakhmedov

“…Furthermore, the per-residue decomposition analysis showed C145, E166, and Q189 residues as the hotspot residues for components contributing to maximum BFE energies. All five components effectively interact with the catalytic pocket of Mpro and form stable complexes that allow the estimation of their inhibitory activity. …”
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Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial by Jillian A Johnson, Matthew J Zawadzki, Martin J Sliwinski, David M Almeida, Orfeu M Buxton, David E Conroy, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Stacey B Scott, Christopher N Sciamanna, Paige A Green, Emily M Repka, Meynard John L Toledo, Nicole L Sturges, Joshua M Smyth

“…The Pennsylvania State University Institutional Review Board approved all study procedures (STUDY00012740). …”
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Farm-to-fork changes in poultry microbiomes and resistomes in Maputo City, Mozambique by Natalie Olson, Frederica Lamar, Hermógenes Mucache, José Fafetine, Joaquim Saíde, Amélia Milisse, Denise R. A. Brito, Kelsey J. Jesser, Karen Levy, Matthew C. Freeman, Maya L. Nadimpalli

“…We also found that while all potentially pathogenic bacteria and many high-risk antimicrobial resistance genes persisted from production and market through processing, some resistance genes were detected on carcass samples only after processing, suggesting human or environmental contamination is occurring within markets. …”
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Features of development and progression of colorectal cancer on a background of ulcerative colitis by I. L. Khalif, V. N. Kashnikov, A. V. Gusev, O. V. Golovenko, K. V. Bolikhov, L. L. Kapuller, A. N. Kuznetsov, A. V. Vasilchenko

“…In 6 (6,2%) patients distant metastases were found. All patients survived for 1 year after operation (100%), 5-years survival rate was 76,9%.Conclusions. …”
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The history of childbirth: Women and doctors in the lying-in hospital of Göttingen University, eighteenth – nineteenth century by Jürgen Schlumbohm

“…Because of the much greater number of medical students, however, the opportunities for practical training per person were clearly fewer for medical students than for midwife apprentices. One third of all the medical students who took the course in obstetrics never participated hands-on in a delivery, but only watched. …”
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Clinical Features and Changes in Insulin Requirements in People with Type 2 Diabetes Requiring Insulin When Hospitalised with SARS-CoV-2 Infection by Antonella Corcillo, Aaisha Saqib, Niruthika Sithamparanathan, Amina Khanam, Jamal Williams, Abhiti Gulati, Dulmini Kariyawasam, Janaka Karalliedde

“…People requiring insulin were younger, had a higher preadmission HbA1c, were more frequently on oral medication for diabetes before the admission, and were more likely to be obese (body mass index ≥30 kg/m2), with p ≤ 0.001 for all. In multivariable logistic regression analyses, we observed that younger age and higher HbA1c before admission were independently associated with needing insulin, with one-year increase in age associated with decreased odds of needing insulin initiation (OR 0.91, 95% CI 0.83–0.99), and increasing preadmission HbA1c by 1 mmol/mol associated with an increased odds of insulin initiation (OR 1.05, 95% CI 1.002–1.11) (p < 0.05 for both). …”
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