Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell‐free RNA by Martin Metzenmacher, Gregor Zaun, Marija Trajkovic‐Arsic, Phyllis Cheung, Timm M. Reissig, Hendrik Schürmann, Nils vonNeuhoff, Grainne O'Kane, Stephanie Ramotar, Anna Dodd, Steven Gallinger, Alexander Muckenhuber, Jennifer J. Knox, Volker Kunzmann, Peter A. Horn, Jörg D. Hoheisel, Jens T. Siveke, Smiths S. Lueong

“…Three disease‐relevant cfRNA‐defined subtype markers (DEGS1, KDELC1, and RPL23AP7) that consistently associated with basal‐like tumors across all cohorts were identified. In both tumor and liquid biopsies, the overexpression of these markers correlated with poor survival. …”
Get full text

Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

“…We projected the incidence and mortality of CRC, cost, and quality-adjusted life years for 2023–2038; and performed incremental cost-effectiveness, probability acceptability, and sensitivity analyses to identify the optimal scheme and the factors affecting this choice. Results By 2038, all standard colonoscopy, colonoscopy following fecal immunochemical testing, and risk-tailored schemes were effective in reshaping China’s colorectal cancer trajectory, with relative reductions in colorectal cancer incidence and mortality rates of up to 34% and 33.7%, respectively, versus no screening. …”
Get full text

PB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model by Shixiang Wu, Ruonan Yi, Yingying Tao, Huimin Wu, Li Wu, Jiasheng Song, Xin Zhang, Beibei Yang, Xing Wu, Yulong He, Jianhong Shu, Huapeng Feng

“…Therefore, PA I21M mutation may determine the increased virulence in mice, and PA F175L + PB2 T340K may be involved in the stability of Venus insertion. Above all, we generated a mouse-adapted pdmH1N1 CA04-Venus virus with high virulence and stable green fluorescent Venus protein. …”
Get full text

Analysis of Polycyclic Aromatic Hydrocarbon in Airborne Particulate Matter Samples by Gas Chromatography in Combination with Tandem Mass Spectrometry (GC-MS/MS) by Nam Vu-Duc, Lan Anh Phung Thi, Thuy Le-Minh, Lan-Anh Nguyen, Huong Nguyen-Thi, Loan-Ha Pham-Thi, Van-Anh Doan-Thi, Huong Le-Quang, Hung Nguyen-Xuan, Thao Thi Nguyen, Phuong Thanh Nguyen, Dinh Binh Chu

“…The linearity range of all analyzed PAHs was from 5 to 2000 ng mL−1 with R2 ≥0.9990. …”
Get full text

Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid by Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang

“…Antimicrobial susceptibility testing indicated that all strains were resistant to meropenem [minimal inhibitory concentration (MICs) ≥ 8 µg/mL] and imipenem (MICs > 8 µg/mL). …”
Get full text

Subcutaneous implantation of tooth germ stem cells over the masseter muscle in mice: An in vivo pilot study by Nosrat Nourbakhsh, Ghazaleh Baniebrahimi, Sahar Talebi, Ardeshir Talebi, Mohammad Hossein Nasr Esfahani, Bijan Movahedian, Maziar Manshayi, Navid Naghdi, Fatemeh Ejeian, Elahe Masaeli, Seyed Ali Mosaddad

“…Results: H & E staining showed the formation of integrated oval structures at the implant site in all samples. Masson's trichrome staining identified dispersed accumulations of cellular mineralized matrix within the connective tissue. …”
Get full text

Frequency of remission achievement in the pre-treat-to-target decade in juvenile idiopathic arthritis by Ana Isabel Rebollo-Giménez, Angela Pistorio, Silvia Maria Orsi, Francesca Ridella, Elena Aldera, Luca Carlini, Valentina Natoli, Marco Burrone, Silvia Rosina, Roberta Naddei, Alessandro Consolaro, Esperanza Naredo, Angelo Ravelli

“…Methods The clinical charts of all JIA patients followed at the study center between 2007 and 2017 who were first seen within 6 months after disease onset and had a minimum of 6-month follow-up information available were reviewed retrospectively. …”
Get full text

Duration of Disease and Long‐Term Outcomes in Patients With Difficult‐To‐Treat Recurrent Pericarditis: A Chronic Condition Treated With Nonsteroidal Anti‐Inflammatory Drugs, Colchi... by Elisa Ceriani, Francesco Agozzino, Silvia Berra, Antonio Gidaro, Paolo Bindi, Alberto Pavarani, Silvia Macchi, Letizia Vena, Francesco Moda, Ludovico Luca Sicignano, Celeste Ambra Murace, Laura Gerardino, Elena Verrecchia, Caterina Chiara De Carlini, Silvia Maestroni, Gabriella Marinaro, Emanuele Bizzi, Antonio Brucato, Massimo Imazio

“…The remission rate was the proportion of patients who stopped all pericarditis‐related therapies for at least 6 months without recurrences. …”
Get full text

Are female athlete specific health considerations being assessed and addressed in preparticipation examinations? A scoping review and proposed framework by Jenna M. Schulz, Lois Pohlod, Samantha Myers, Jason Chung, Jane S. Thornton

“…No studies included questions on all IOC female athlete health domains. Conclusion: There is currently a gap in female athlete specific health content included in PPEs. …”
Get full text

Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile by Luz María Medrano, Carlos Taxonera, Cristina González-Artacho, Virginia Pascual, María Gómez-García, Manuel Barreiro-de Acosta, José L. Pérez-Calle, Fernando Bermejo, Antonio López-Sanromán, Dolores Martín Arranz, Javier P. Gisbert, Juan Luis Mendoza, Javier Martín, Concepción Núñez, Elena Urcelay

“…These differences were amplified in patients with colonic and ileocolonic location for all but the TNFAIP6 haplotype, which evidenced significant difference in ileal CD patients. …”
Get full text

Causally inferred evidence of the impact of green and blue spaces (GBS) on maternal and neonatal health: a systematic review and meta-analysis by Rukun K S Khalaf, Selin Akaraci, Faye D Baldwin, Rebecca S Geary, Ruwanthi Kolamunnage-Dona, Ruth F Hunter, Sarah E Rodgers

“…Most studies were conducted in either Europe or North America ( n = 41, 66%). All studies reported green space exposure as an independent variable while seven studies also included blue space exposure as an independent variable. …”
Get full text

Time-Zero Biopsies in Deceased-Donor Kidney Transplantation: Predictive Value of Histological Findings on Long-Term Graft Function by Bárbara Beirão, Henrique Borges, Joana Trigo Medeiros, Filipa Fonte Rodrigues, Ana Pena, Mário Góis, Helena Viana, Cristina Jorge

“…With the exception of Ci/Ct, all other parameters were also significantly associated with lower GFR at 5 years. …”
Get full text

Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy by Chengji Wang, Yuan Qu, Xiaoqin Shen, Xiaoxiao Tang, Xiaoxiao Tang, Gaiyu Tong, Meier Wati, Manzeremu Naibi, Manzeremu Naibi, Cheng Zhang, Shaohong Zou

“…Proton magnetic resonance spectroscopy (1H-MRS) was used to detect the ratio of biochemical metabolites in the ventromedial prefrontal cortex (vmPFC) of all patients.ResultsThere was no statistically significant difference (P>0.05) in the age, gender, only child status, residential status, education level, age of onset, disease course, family history, and 24-item Hamilton Depression Scale (HAMD) score between patients in the NSSI group and those without NSSI group. …”
Get full text

Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southw... by Li Liu, Ziyi Yan, Fumei He, Jie Chen, Linghan Kuang, Xingxin Liu, Yali Cui, Xia Wang, Chenglin Miao, Hong Li, Yongmei Jiang

“…The isolates had the highest rate of resistance to PEN, at 91.67%, with all the MRSA isolates being resistant; the next highest resistance was to ERY and CLI, both at 65.74%. …”
Get full text

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research by I. V. Chadaeva, S. V. Filonov, K. A. Zolotareva, B. M. Khandaev, N. I. Ershov, N. L. Podkolodnyy, R. V. Kozhemyakina, D. A. Rasskazov, A. G. Bogomolov, E. Yu. Kondratyuk, N. V. Klimova, S. G. Shikhevich, M. A.  Ryazanova, L. A. Fedoseeva, О. Е. Redina, О. S. Kozhevnikova, N. A. Stefanova, N. G. Kolosova, A. L. Markel, M. P. Ponomarenko, Yu. D. Oshchepkov

“…RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. …”
Get full text

Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses by Fanping Wang, Yanhua Li, Can Yang, Yonghui Mu, Yan Wang, Wei Zhang, Yonghui Yang, Chen Chen, Shijun Song, Zhifa Shen, Wenjun Wang, Junpeng Li, Jingjing Zhai, Kang Guo, Ruili Sun, Lili Yu, Mingyong Wang

“…Finally, our data showed that PGN-mediated immune responses were more severely suppressed by preincubation with MBL and indicated that MBL can combine with both TLR2 and PGN to block the inflammation cytokine expression induced by PGN. All these data suggest that MBL could downregulate inflammation by modulating PGN/TLR2 signaling pathways. …”
Get full text

Advantages of different dietary supplements for elite combat sports athletes: a systematic review and Bayesian network meta-analysis by Hua Luo, Tengku Fadilah Tengku Kamalden, Xiaolin Zhu, Changqing Xiang, Nurul Amelina Nasharuddin

“…The analysis is based on 67 randomized controlled trials that meet all the inclusion criteria, involving 1026 elite combat sports athletes randomly assigned to 26 different dietary supplements or placebos. …”
Get full text

Analysis of central retinal microcirculation in glaucoma after neuroretinoprotective treatment by N.G. Glazko, A.E. Egorov

“…Before starting treatment and during the study, all patients underwent eye exams, i.e., visual acuity measurement, autorefractometry, slit lamp exam, eye fundus exam, IOP measurement, questioning to assess subjective vision, static automated perimetry, and optical coherence tomography angiography (OCTA) to evaluate foveal avascular zone / FAZ (area, perimeter, and circularity index). …”
Get full text

Structural Vulnerability Factors and Gestational Weight Gain:  A Scoping Review on the Extent, Range, and Nature of the Literature by Labonté, Jocelyne M, Dumas, Alex, Clark, Emily, Savard, Claudia, Fournier, Karine, O’Connor, Sarah, Morisset, Anne-Sophie, Fontaine-Bisson, Bénédicte

“…Methods: Electronic searches were performed in October 2018 (updated in August 2019) in MEDLINE(R) ALL, EMBASE, PsycINFO, CINAHL, and Sociological Abstracts databases. …”
Get full text

Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: a computational study by Hossein Shamohammadi, Liam Weaver, Sina Saffaran, Roberto Tonelli, Marianna Laviola, John G. Laffey, Luigi Camporota, Timothy E. Scott, Jonathan G. Hardman, Enrico Clini, Declan G. Bates

“…When different amounts of alveolar consolidation/collapse are implemented in the model to reflect the pathophysiology of AHRF, the mPaw and PEEP produced by HFNC at all flow rates increase as the functional lung volume decreases (up to a mPaw of 11.53 and a PEEP of 11.41 cmH2O at 60 L/min with the mouth closed when 50% of the model’s alveolar compartments are non-aerated). …”
Get full text