Toward Sustainable Biocultural Ecotourism: An Integrated Spatial Analysis of Cultural and Biodiversity Richness in Colombia by Alejandra Echeverri, Natasha M. Batista, Stacie Wolny, Guido A. Herrera‐R, Federico Andrade‐Rivas, Allison Bailey, Anaid Cardenas‐Navarrete, Armando Dávila Arenas, Andres Felipe Díaz‐Salazar, Katherine Victoria Hernandez, Kelley E. Langhans, Bryam E. Mateus‐Aguilar, Dallas Levey, Andrew Neill, Oliver Nguyen, Andres Felipe Suárez‐Castro, Felipe Zapata, Natalia Ocampo‐Peñuela

“…While biocultural richness is high in the Amazon, Pacific and Caribbean regions, we found that there are no win‐win‐win locations where culture, species richness and accessibility are all high. Areas with great potential for biocultural ecotourism development largely coincide with designated Indigenous Reserves and Afro‐Colombian Territories. …”
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Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases by Tao Chen, Peng Qiu, Yixuan Li, Xinwu Lu, Zhaoyu Wu, Zhijue Xu, Hongji Pu, Jiahao Lei, Zhuojing Zhang, Xinrui Yang, Ruihua Wang

“…The mean 24-hour fluid balance was generated by subtracting the output from the intake.Outcome measures The relationship between the mean 24-hour fluid management and all-cause in-hospital death was assessed through univariate and multivariable regression analyses.Results A positive correlation was found between mean 24-hour fluid intake and in-hospital mortality among AD patients (OR 1.029, 95% CI (1.018, 1.041), p<0.001), whereas a negative correlation was revealed between mean 24-hour fluid output and in-hospital mortality (OR 0.941, 95% CI (0.914, 0.968), p<0.001). …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…The oxidative stress induced by MAP17 activates the p53, PI3K-AKT, and Wnt pathways, all of which contribute to the progression of NASH.Keywords: NASH, MAP17, macrophage infiltration, immunotherapy response, oxidative stress…”
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Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…Other outcomes included body weight, blood pressure, all-cause discontinuation, and mortality. Analyses adjusted for baseline confounders, including sociodemographics, diagnoses, concomitant medications, and cardiometabolic parameters. …”
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Photometric Analysis of the Cataclysmic Variable Star LT Eri by Qi-Bin Sun, Sheng-Bang Qian, Li-Ying Zhu, Qin-Mei Li, Fu-Xing Li, Min-Yu Li, Ping Li

“…This study investigates its outbursts, negative superhumps (NSHs), tilted-disk precession, eclipse-depth variations, and observed minus calculated ( O – C ) behavior, using photometric data from the Transiting Exoplanet Survey Satellite (TESS), the Zwicky Transient Facility, the All-Sky Automated Survey for Supernovae, and the American Association of Variable Star Observers. …”
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Effect of Soaking Treatments in Acid and Salt Solutions on Physicochemical, Structural, Thermal and Rheological Properties of Porang (Amorphophallus muelleri Blume) Flour by Lia Ratnawati, Novita Indrianti, Nok Afifah, Riyanti Ekafitri, Enny Sholichah, Dewi Desnilasari, Woro Setiaboma, Dita Kristanti, Achmat Sarifudin

“…The results of this study showed that all treatments successfully reduced the Ca-oxalate mass fraction in porang flour. …”
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Soil chemical factors contributing to differences in bacterial communities among tea field soils and their relationships with tea quality by Shuning Zhang, Shuning Zhang, Naoki Yanagisawa, Mio Asahina, Hiroto Yamashita, Hiroto Yamashita, Hiroto Yamashita, Takashi Ikka, Takashi Ikka, Takashi Ikka, Takashi Ikka

“…Differentially abundant ASVs (DAAs) among all soils were also identified including the phylum Firmicutes and families such as Paenibacillaceae, Alicyclobacillaceae, JG36-TzT-191, KF-JG30-C25, and Acidobacteriaceae_subgroup1. …”
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Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results by N. Ya. Muratova, I.  V. Kolobaev, D.  D. Kudryavtsev, E. I. Smolenov, A. B. Ryabov, V. M. Khomyakov, L. O. Petrov, S. A. Ivanov, A. D. Kaprin

“…The study included 48 patients with morphologically confirmed resectable GC and cardio esophageal transition, having at least one criterion that is a predictor of the development of peritoneal carcinomatosis, e. g. tumor spread to the serous layer (≥ T4a), diffuse tumor type, affected regional lymph nodes, large tumor, young age (up to 45 years), subtotally and totally affected stomach. 36 out of those patients received treatment according to the protocol. All patients received 4 cycles of neoadjuvant chemotherapy according to the FLOT scheme, radical surgical treatment in combination with a PIPAC session, 4 cycles of adjuvant chemotherapy according to the FLOT scheme. …”
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Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma by Jianlin Chen, Yue Zheng, Zhen Wang, Qi Gao, Kun Hao, Xiongfeng Chen, Nantian Ke, Xiang Lv, Jiamiao Weng, Yuhong Zhong, Zhixin Huang, Miao Fu, Lilan Zhao, Fan Lin, Hui Mi, Haijun Tang, Chundong Yu, Yi Huang

“…Results The RiskscoreFuc−&Sia− effectively identified ESCC across all stages, demonstrating high AUC values in training (0.980), internal validation (0.957), and external multicentre validation (0.973) cohorts, markedly higher than carcinoembryonic antigen (CEA) (AUC = 0.769, training cohort; AUC = 0.749, internal validation cohort; AUC = 0.765, external validation cohort). …”
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Morphology, phylogeography, phylogeny, and taxonomy of Cyclorhiza (Apiaceae) by Bo-Ni Song, Xueyimu Aou, Rong-Ming Tian, Jing Cai, Wei-Yan Tan, Chang-Kun Liu, Chang-Kun Liu, Xing-Jin He, Song-Dong Zhou

“…Thus, based on the morphology, plastome analyses, and phylogenetic evidence, S. purpureovaginatum should be transferred to Cyclorhiza. All these evidences further supported the monophyly of the genus after including S. purpureovaginatum. …”
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Prevalence and risk factors for long COVID among cancer patients: a systematic review and meta-analysis by Hongkun Xu, Hongkun Xu, Tingting Lu, Yajie Liu, Jingqi Yang, Simeng Ren, Baojin Han, Honghao Lai, Long Ge, Jie Liu

“…Two investigators independently screened the studies and extracted all information about long COVID in cancer patients for subsequent analysis. …”
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Ambient air pollution and Alzheimer’s disease and other dementias: a global study between 1990 and 2019 by Cui Guo, Dongze Wu, Jun Yang, Xingcheng Lu, Xiang Yan Chen, Jun Ma, Changqing Lin, Alexis K. H. Lau, Yingzhao Jin, Ruiyun Li, Shenjing He

“…Each 10 µg/m3 increase in PM2.5 was associated with a 0.118 (95% confidence interval [CI]: 0.060 − 0.175) higher ASMR and 0.966 (95%CI: 0.321 − 1.611) higher DALYs after adjusting for all the covariates. The ASMR increased by 0.112 and the DALYs increased by 1.068 for each 10 µg/m3 increase in O3. …”
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Sealing Effects on Organic Pore Development in Marine Shale Gas: New Insights from Macro- to Micro-Scale Analyses by Qiumei Zhou, Hao Xu, Wen Zhou, Xin Zhao, Ruiyin Liu, Ke Jiang

“…It was concluded that the sealing capacity is the key factor for gas pore generation in the overmature stage of marine shale gas reservoirs when the organic matter (OM) type, volume, and thermal evolution degree are all similar. The macropores and mesopores are easily affected by the sealing conditions, but the micropores are not. …”
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The effect of single and dual task training on the intracortical inhibition in young and old adults by Michael Wälchli, Craig Tokuno, Benedikt Lauber, Wolfgang Taube

“…While the ST training groups only improved in the single balance task (5.2%), the DT training groups reduced the balance sway in all 3 conditions, but mostly in the dual motor condition (19.1%). …”
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Les zones de production du fer en Bourgogne-Franche-Comté : une approche sur la longue durée par le radiocarbone by Marion Berranger, Marc Leroy, Hervé Laurent

“…With the exception of the Berthelange area, whose production is concentrated during the Merovingian period, the activity is continuous throughout the medieval period in all the other areas of production. Thus, smelting activity is more widely represented throughout the territory during this period than for the previous Roman one. …”
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Obesity and polysomnographic variables on patients with obstructive sleep apnea by Chaiane Facco Piccin, Marco Colomé Beck, Luiz Carlos Alves de Oliveira, Reinaldo Fernando Cóser Neto, Pedro Luis Cóser, Fabrício Scapini, Antônio Marcos Vargas da Silva

“…Eighty eight patients were evaluated divided in eutrophic (EG; n=21; BMI=23.4±1.3kg/m2), overweight (OWG; n=34; BMI=27.5±1.4kg/m2) and obese group (OG; n=33; BMI=33.6±2.9kg/m2) that carried out all-night basal polysomnography for the diagnosis of Obstructive Sleep Apnea (OSA). …”
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Characteristics and contributing factors of adverse drug reactions: an analytical study of patients with tuberculosis receiving treatment under the National TB Program of India [ve... by Jay Patel, Priya Bhavsar, Harsh Shah, Sandul Yasobant, Deepak Saxena, Anish Sinha, Somen Saha, Yogesh Patel

“…In order to completely eliminate TB across the country, it also emphasized the attention for a holistic and all-encompassing strategy for managing TB patients at the field level.…”
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Patients were randomized 1:1 to receive double-blinded treatment with upadacitinib 15 mg once daily (QD) or placebo for 52 weeks, after which all patients received open-label treatment with upadacitinib 15 mg QD. …”
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Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial by Bo Qiu, Bo Qiu, Haojing Song, Haojing Song, Xue Sun, Xue Sun, Congyang Ding, Congyang Ding, Runxuan Du, Wanjun Bai, Wanjun Bai, Zhanjun Dong, Zhanjun Dong

“…The 90% confidence intervals (CIs) of the geometric mean ratios of the test to reference formulations were 97.79%–118.28% for peak concentration (Cmax), 92.35%–111.78% for the area under the curve from zero to the last measurable concentration (AUC0-t) and 92.88%–111.91% for the AUC from zero to observed infinity (AUC0-∞) under fasting conditions, 88.65%–103.20% for Cmax, 95.89%–106.81% for AUC0-t and 96.02%–106.91% for AUC0-∞ under postprandial conditions, all of which were within the accepted bioequivalence range of 80.00%–125.00%. …”
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Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion by Alessandro Miani, Annamaria Colao, Prisco Piscitelli, Leonardo Setti, Fabrizio Passarini, Gianluigi De Gennaro, Pierluigi Barbieri, Sabina Licen, Maria Grazia Perrone, Andrea Piazzalunga, Massimo Borelli, Jolanda Palmisani, Alessia Di Gilio, Emanuele Rizzo

“…On March 16th 2020, we presented a position paper proposing a research hypothesis concerning the association between higher mortality rates due to COVID-19 observed in Northern Italy and average concentrations of PM10 exceeding a daily limit of 50 µg/m3.Methods To monitor the spreading of COVID-19 in Italy from February 24th to March 13th (the date of the Italian lockdown), official daily data for PM10 levels were collected from all Italian provinces between February 9th and February 29th, taking into account the maximum lag period (14 days) between the infection and diagnosis. …”
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