Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia by Tao Liu, Yang Wang, Xi-Zhou An, Jiaqi Liu, Yuqin Wu, Yan Xiang, Yong-Jie Zhang, Lan Huang, Jia-Cheng Li, Yu-Zhuo-Pu Li, Jie Yu

“…Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic leukemia (ALL). We engineer a transposon transfection system expressing the TOP2B::AFF2 transcript and introduce it into Ba/F3 cells. …”
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Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal by Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, Binod K. C., Deepak Bam, Deepak Ghimire, Uttam Raj Pyakurel, David T. S. Hayman, Basu Dev Pandey, Chuman Lal Das, Krishna Prasad Paudel

“…Leprosy-related training was significantly related to the knowledge and skills of the health workers. All identified cases (n = 187) adhered to the complete treatment and release after treatment (RFT) scheme, out of which 84.5% were satisfied with the service they were provided. …”
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Clinical Effects of Smart Phone Speech Training Combined with Scalp Acupuncture in Patients with Non-fluent Aphasia after Stroke by Mingyue XIONG, Yanyan TANG, Lihua CAO, Dian HUANG, Xiaodan LI, Jie TAN

“…The control group received acupuncture therapy and conventional speech training, and the treatment group received smart phone speech training on the basis of the control group. All treatments were given once a day, five times a week, for a total of 4 weeks. …”
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Effect of Exercise Preconditioning on Protein Expression of VEGF and NeuN in Rats with Cerebral Ischemia-reperfusion by Fei PEI, Xuedong WANG, Baolong LI, Qiang TANG, Luwen ZHU

“…Three days after cerebral ischemia-reperfusion, compared with the positive rate of the exercise model group (23.80%), the positive rate of the sham-operation group (5.40%), the positive rate of the model group (12.40%), and the positive rate of the exercise sham-operation group (14.20%) were all reduced, and the differences were statistically significant respectively (<italic>P</italic>&lt; 0.05). 3) 24 hours after cerebral ischemia-reperfusion, compared with the exercise model group, the expression of NeuN protein in the model group was less, and the difference was statistically significant (<italic>P</italic>&lt; 0.05); Three days after cerebral ischemia-reperfusion, compared with the exercise model group, the expression of the model group was less, and the difference was statistically significant (<italic>P</italic>&lt; 0.05).Conclusion:Exercise preconditioning before cerebral ischemia-reperfusion can reduce the performance of neurological deficits after cerebral ischemia-reperfusion, and improve sensorimotor dysfunction and motor behavior by enhancing the protein expression of VEGF and NeuN.…”
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Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open‐Label Trial by Orrin M. Troum, John K. Botson, Katie Obermeyer, Bo Chao, Yang Song, Jennifer Zarzoso, Kjerstina Gutierrez, Supra Verma, Lissa Padnick‐Silver, Brian LaMoreaux

“…Eight patients (73%) experienced ≥1 AE, most commonly gout flare. All AEs were mild or moderate. Conclusion Pegloticase plus MTX response rate following failed monotherapy was lower (9% vs 71%) and IR rate was higher (18% vs 4%) than in pegloticase‐naïve patients. …”
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Feasibility of a Mobile App–Based Cognitive-Behavioral Perinatal Skills Program: Protocol for Nonrandomized Pilot Trial by Andrea B Temkin-Yu, Aliza Ayaz, Ella Blicker, Michael X Liu, Ace Oh, Isabelle E Siegel, Meredith J Seewald, Alison D Hermann, Soudebah Givrad, Lara M Baez, Lauren M Osborne, Cori M Green, Maddy M Schier, Alexandra M Davis, Shasha Zhu, Avital Falk, Shannon M Bennett

“…Participants will complete all sessions of M-PSP and provide feedback. Outcome measures will include qualitative and quantitative assessments of feasibility, acceptability, and usability, passively collected program usage data, and symptom measures assessing mood, anxiety, and trauma. …”
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The Relationship between Body Mass Index and Incident Diabetes Mellitus in Chinese Aged Population: A Cohort Study by M. L. Tang, Y. Q. Zhou, A. Q. Song, J. L. Wang, Y. P. Wan, R. Y. Xu

“…BMI was measured at baseline (Jan 1, 2014, to Dec 31, 2014). All the participants were further classified into six groups: <18.5 kg/m2, 18.5 to <22.5 kg/m2, 22.5 to <25.0 kg/m2, 25.0 to <27.5 kg/m2, 27.5 to <30.0 kg/m2, and ≥30.0 kg/m2. …”
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Enhanced UV–Vis Rejection Ratio in Metal/BaTiO3/β‐Ga2O3 Solar‐Blind Photodetectors by Nathan Wriedt, Lingyu Meng, Dong Su Yu, Chris Chae, Kyle Liddy, Ashok Dheenan, Sushovan Dhara, Roberto C. Myers, Oleg Maksimov, Richard Blakeley, Sanjay Krishna, Jinwoo Hwang, Hongping Zhao, Joe McGlone, Siddharth Rajan

“…It is shown that integrating the high‐k dielectric BaTiO3 reduces the dark current by ≈104, all but eliminates illumination induced Schottky barrier lowering, and increases the UV–vis rejection ratio by a factor greater than 9 × 103 compared to a Schottky photodetector. …”
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Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice by Han Zhang, Dylan Deska-Gauthier, Colin S. MacKay, Krishnapriya Hari, Ana M. Lucas-Osma, Joanna Borowska-Fielding, Reese L. Letawsky, Vladimir Rancic, Turgay Akay, Keith K. Fenrich, David J. Bennett, Ying Zhang

“…Optical activation of V3 neurons in a single segment rapidly amplifies locomotor-related motoneuron output at all lumbar segments in in vitro spinal cord and the awake adult mouse. …”
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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines by Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse, David J. Rowlands

“…Using our previously established genetic techniques to stabilize the structural capsid proteins, we demonstrate production of poliovirus VLPs of all three serotypes, from four different recombinant expression systems. …”
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Empagliflozin-based quadruple oral therapy for type 2 diabetes: a prospective cohort study by Fatemeh Moosaie, Shiva Abedinzadeh, Soghra Rabizadeh, Kimia Daneshvar, Mohammadamin Noorafrooz, Fatemeh Alsadat Mojtahedi, Niloofar Deravi, Seyede Marzie Fatemi Abhari, Akam Ramezani, Alipasha Meysamie, Marzieh Hajibabaei, Sahar Karimpour Reyhan, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Alireza Esteghamati

“…Significant reductions were observed in all glycemic parameters after 68 months (p < 0.001). …”
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Molecular investigation reveals three hemotropic mycoplasmas in cats and three tick species in China by Hongfei Shi, Guoguang Li, Dandan Li, Hongyue Zhai, Shidong Ji, Yun Hu, Long Wang, Lunguang Yao

“…Following the morphological and molecular identification of ticks, all samples were screened for pathogens using PCR detection and sequence analysis. …”
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Whole systems approaches to diet and healthy weight: A scoping review of reviews. by Gavin Breslin, Olujoke Fakoya, Wendy Wills, Nigel Lloyd, Charis Bontoft, Amander Wellings, Sian Harding, John Jackson, Katherine Barrett, Adam P Wagner, Lisa Miners, Honey-Anne Greco, Katherine E Brown

“…<h4>Background</h4>Obesity is a global epidemic affecting all age groups, populations, and income levels across continents, though is known to disproportionately affect socioeconomically disadvantaged populations. …”
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The Public Health Service “Increased Risk” 2020 Policy Change Has not Improved Organ Utilization in the United States: A Nationwide Cohort Study by Dane C. Paneitz, MD, MPH, Stanley B. Wolfe, MD, MPH, Duc Giao, BA, Shannon N. Tessier, PhD, Leigh Anne Dageforde, MD, MPH, Nahel Elias, MD, Seyed Alireza Rabi, MD, PHD, Eriberto Michel, MD, David A. D’Alessandro, MD, Asishana A. Osho, MD, MPH

“…After multivariable adjustment, donors in the postupdate cohort had 10% decreased odds of having all organs transplanted. Conclusions:. The 2020 PHS “Increased Risk” Donor Guideline update was not associated with an increase in organ utilization rates in the first 2 years after its implementation, despite a decrease in the proportion of donors considered to be at higher risk. …”
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Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for C... by Utae Katsushima, Takuya Fukushima, Jiro Nakano, Naoya Ogushi, Kazuki Fujii, Yutaro Nagata, Keisuke Kamisako, Yukiko Okuno, Yuta Okazaki, Kentaro Nakanishi, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Yuta Yamanaka, Hiroshige Yoshioka, Kimitaka Hase, Takayasu Kurata

“…The latter encompassed all but one patient diagnosed using the EPCRC criteria. …”
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Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma by Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H

“…., Ltd, Beijing, People’s Republic of China; 5School of Computer Science and Engineering, University of Electronic Science and Technology, Sichuan, People’s Republic of ChinaCorrespondence: Hong Pu, Department of Radiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital; School of Medicine, University of Electronic Science and Technology, Chengdu, Sichuan Province, 610000, People’s Republic of China, Email ph196797@163.com Haigang Gong, School of Computer Science and Engineering, University of Electronic Science and Technology, Chengdu, Sichuan Province, 610000, People’s Republic of China, Email hggong@uestc.edu.cnObjective: This study aimed to investigate how dynamic contrast-enhanced CT imaging signs correlate with the differentiation grade and microvascular invasion (MVI) of hepatocellular carcinoma (HCC), and to assess their predictive value for MVI when combined with clinical characteristics.Methods: We conducted a retrospective analysis of clinical data from 232 patients diagnosed with HCC at our hospital between 2021 and 2022. All patients underwent preoperative enhanced CT scans, laboratory tests, and postoperative pathological examinations. …”
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Effect of humanistic care combined with risk management nursing model on the incidence of venous thromboembolism in critically ill patients with cancer (人文关怀联合风险管理干预重症肿瘤患者静脉血栓栓塞症的效... by ZHEN Yuhong (郑玉红), PEI Xiaolu (裴晓璐)

“…Methods Totally 100 critically ill patients with cancer were randomly divided into the study group and the control group, with 55 cases in each group. All patients received routine care during the hospitalization period, and those in the study group received humanistic care combined with risk management nursing model. …”
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Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…The whole-genome sequencing revealed rare variants in three out of five analyzed patients: a heterozygous variant (rs760657350) located in a splicing acceptor site in the PLD1 gene (c.2430-1G&gt;A), a previously undescribed single-nucleotide deletion in the SIDT1 gene [c.2426del (p.Leu809CysfsTer2)], new missense variant c.10313C&gt;G (p.Pro3438Arg) in the LRP1B gene, and single-nucleotide deletion variant rs753876598 [c.165del (p.Ser56AlafsTer11)] in the CETP gene. All these variants were found for the first time in patients with a clinical diagnosis of familial hypercholesterolemia. …”
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Growth response of koi fish fed on the diet containing Euchema cottoni by Edison Saade, Dody D Trijuno, , Haryati, , Zainuddin

“…According to ANOVA results, the effect of treatments on all tested parameters were similar or not significant (P>0.05). …”
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The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired p... by Huamei Zhou, Xuelei Zhu, Yi Zhang, Wenjuan Xu, Shiqun Li

“…AST/ALT also predicted outcomes for all the CAP patients enrolled (OR = 1.771, 95% CI, 1.231–2.549, p = 0.002). …”
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