Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules by Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Martin Bareš, Alemeh Zamani, Parisa EmamiAref, Andrea Joukal, Lucie Kubíčková, Erik Kročka, Klaudia Hašanová, Marek Joukal

“…Accumulation of macrophages positive for CCR2 and CX3CR1 was found in all periods after subarachnoid hemorrhage as well as after the application of artificial cerebrospinal fluid.DiscussionOur results suggest that the inflammation develops in the choroid plexus and blood-cerebrospinal fluid barrier in response to blood components as well as acutely increased intracranial pressure following subarachnoid hemorrhage. …”
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Risk prediction modeling for cardiorenal clinical outcomes in patients with non-diabetic CKD using US nationwide real-world data by Christoph Wanner, Johannes Schuchhardt, Chris Bauer, Meike Brinker, Frank Kleinjung, Tatsiana Vaitsiakhovich

“…Female gender and normal-to-mildly increased albuminuria-A1 were found to be associated with lower risk in all prediction models for patients with non-diabetic CKD stage 3 or 4. …”
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Effects of the Early Start Denver Model on emotional dysregulation and behavior problems in children with Autism spectrum disorder by Wan-Xia Liu, Ling Shan, Chun-Li Li, Yu-Mo Liu, Yang Xue, Yu-Ling OuYang, Fei-Yong Jia

“…Methods A total of 319 children aged 1.5 to 5 years were included in this study and received treatment based on the ESDM intervention program Baseline assessment (T0) was conducted before intervention, including Children Behavior Checklist (CBCL), Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS). All children with ASD were examined in the assessment (T1) after 12 weeks of treatment. …”
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Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…It points out that almost all organ injuries use classic modeling methods, and different organ injury models have additional modifications according to their different pathogenesis. …”
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Water, Sanitation and Hygiene in a Conflict Area: A Cross-Sectional Study in South Kordofan, Sudan by Rofida Asmally, Abdelmalik A. Imam, Abdullatif Eissa, Abubakr Saeed, Ahmed Mohamed, Eahaa Abdalla, Mariam Alazraa M. Esmaeel, Mariam Elbashir, Mohamed H. Elbadawi, Mohammed Omer, Raghad Eltayeb, Ranya Mohammed, Tibyan Abdalhamed, Tina Merghani

“…Sanitation issues and open defecation persist, emphasizing the need for comprehensive interventions. All these negative consequences can be attributed to the armed conflict which resulted in poor awareness about the safety of drinking water, what safe water looks like and proper hygiene practices. …”
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Biofilm Formation among Clinical and Food Isolates of Listeria monocytogenes by Joana Barbosa, Sandra Borges, Ruth Camilo, Rui Magalhães, Vânia Ferreira, Isabel Santos, Joana Silva, Gonçalo Almeida, Paula Teixeira

“…At 37°C for 24 h, most food isolates were classified as weak or moderate biofilm formers whereas all the clinical isolates were biofilm producers, although the majority were weak. …”
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Overall Survival of Patients with Metastatic Renal Cell Carcinoma Following the Introduction of Targeted and Immunotherapies: A Norwegian Retrospective, Real-World Registry Data St... by Puco K, Notland CS, Szulkin R, Jonasson C, Beisland C, Johannesen TB, Solli O, Oldenburg J, Heinrich D

“…Primary endpoint was to evaluate overall survival (OS) in all included patients. Secondary endpoints included further analysis of treatment patterns and possible impact on OS. …”
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Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats’ Disease by Qingshan Chen, Saying Liang, Xizhen Wang, Chenli Hu, Jieting She, Zi Li

“…The medical records of all included patients with a minimum follow-up of 6 months were reviewed. …”
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Effect of moxibustion combined with cupping therapy in the treatment of lumbar disc herniation of Qi-stagnation and Blood-stasis type (艾灸联合拔罐治疗血瘀气滞型腰椎间盘突出症临床疗效观察)... by ZHANG Xi (张西), GENG Qingwen (耿庆文), ZHOU Dengfang (周登芳), TANG Ling (唐玲), DUAN Peihang (段培航)

“…Methods Totally 60 patients with lumbar disc herniation of Qi-stagnation and Blood-stasis type were randomly divided into the observation group and control group, with 30 cases in each group. All patients received routine care, and those in the observation group were given moxibustion combined with cupping therapy. …”
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Development of Primer Panels for Whole-Genome Amplification and Sequencing of Human Seasonal Coronaviruses: hCoV-OC43, hCoV-HKU1, hCoV-229E, and hCoV-NL63 by Tamila Musaeva, Artem Fadeev, Maria Pisareva, Veronika Eder, Andrey Ksenafontov, Margarita Korzhanova, Valery Tsvetkov, Alexander Perederiy, Irina Kiseleva, Daria Danilenko, Dmitry Lioznov, Andrey Komissarov

“…Of these samples, 5010 (34.07%) tested positive for respiratory viruses, with 424 (2.88% of all samples) identified as seasonal human coronaviruses. …”
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Effectiveness of Video Teletherapy in Treating Obsessive-Compulsive Disorder in Children and Adolescents With Exposure and Response Prevention: Retrospective Longitudinal Observati... by Jamie D Feusner, Nicholas R Farrell, Mia Nunez, Nicholas Lume, Catherine W MacDonald, Patrick B McGrath, Larry Trusky, Stephen Smith, Andreas Rhode

“…Improvements were observed in all categories of starting symptom severity: mild (median 40.3%, IQR 8.5%-79.8%), moderate (median 38.4%, IQR 13.3%-63.6%), and severe (median 34.1%, IQR 6.6%-58.5%). …”
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Inducing salt stress tolerance in bitter gourd (Momordica chanrantia) through seed treatment with chitosan by Ahsan Ali, Fiaz Hussain Ferdosi, Mubeen Sarwar, Sumreen Anjum, Zain Mushtaq, Mehwish Liaquat, Muhammad Taqqi Abbas, Moazzam Anees, Muhammad Rizwan Tariq, M. Irfan Ashraf, Abdulrahman Alasmari, Md Sabir Ahmed Mondol, Gholamreza Abdi

“…It was observed that pre-sowing treatments with an optimized dose of 0.04% chitosan exhibited significant effects on all the bitter gourd plants and improved the germination rate by improving the salt stress tolerance potential of plants under high salinity. …”
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Novel nonsense mutation in gene CHRNA2 identified by whole-genome sequencing in infant with epilepsy disorder: A case report by Sultan Makhmetov, Kamila Temirkhanova, Saule Rakhimova, Nazerke Satvaldina, Ruslan Kalendar, Ulan Kozhamkulov, Aidos Bolatov, Mirgul Bayanova, Assiya Bazenova, Lyazzat Nazarova, Ainur Akilzhanova, Ulykbek Kairov

“…Epilepsy is one of the most common neurological disorders affecting approximately 50 million people worldwide. It impacts people of all genders and ages, but evidence suggests a higher incidence rate in children and the elderly.Given that childhood epilepsy has the risk of causing developmental epileptic encephalopathy, which is associated with intellectual, behavioral, and/or motor disabilities, proper assessment of children with new-onset epilepsy at an early stage is essential to prevent threats affecting neurodevelopmental processes. …”
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High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretrov... by Shabani Iddi, Caroline A. Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R. Kidenya, Stephen E. Mshana, Mariam M. Mirambo

“…A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. …”
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Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) by Jinyu Zhang, Liying Zou, Li Wang, Dongchao Zhang, Ao Shen, Yongqi Lei, Maoni Chao, Xinjuan Xu, Zhiwei Xue, Zhongwen Huang

“…The Sec14 family is characterized by a highly conserved Sec14 domain, and is ubiquitously expressed in all eukaryotic cells and has diverse functions. …”
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Health Economic Evaluation of Patients With Colorectal Liver Metastases Randomized to ALPPS or TSH: Analysis From the LIGRO Trial by Kristina Hasselgren, MD, PhD, Martin Henriksson, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Magnus Rizell, MD, PhD, Anna Lindhoff Larsson, RN, Per Sandström, MD, PhD, Bergthor Björnsson, MD, PhD

“…Costs are estimated from resource use, including all surgical interventions, length of stay after interventions, diagnostic procedures and chemotherapy, and applying Swedish unit costs. …”
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COMPETENZE CHIAVE PER IL CURRICOLO VERTICALE: L’OPINIONE DEGLI INSEGNANTI E I MATERIALI DIDATTICI by Matteo La Grassa, Monica Barni

“…In questo contributo si presentano i primi risultati di una indagine qualitativa, condotta in istituti scolastici della Toscana, che ha inteso verificare quale conoscenza e quale importanza sia data in ambito educativo alle Competenze chiave per l’apprendimento permanente descritte dalla Raccomandazione europea del 2006 e aggiornate dalla Raccomandazione del 2018 e se è presente all’interno di scuole una progettualità sistematica su tali competenze e se siano date le condizioni per un loro effettivo sviluppo in ottica verticale e trasversale alle varie discipline.  …”
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Effects of Chemical Fertilizer Reduction Combined with Straw and Organic Fertilizer Application on Soil Acidification Mitigation and Erosion Control by SHEN Mengxue, HAO Rui, LIU Xinwei, WEI Wanhao, CAO Yunfei, SHU Hujia, HAO Zongyu, WANG Huyu, WANG Ling, SHI Zhihua

“…Under FSM2 treatment, the shear strength, cohesion, and internal friction angle all reached their peak values, with a respective increase of 22.22%, 20.06% and 11.38% relative to CK. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…We used phage display libraries of 23ME–00610 variants with individual CDR residues randomized to all 20 amino acids, from which we identified mutations that switched on MfCD200R1 binding. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…Written consent will be obtained from all participants. Findings from the cohort study will be disseminated by publication of peer-reviewed manuscripts, presentations at scientific meetings and conferences with local stakeholders.…”
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