Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin

“…In addition to the reported ion channels, INa, ICa-L, ICa-T, If, INCX, IK1, Ito, IKr, IKs IKATP, IK-pH, ISK1–3, and ISK4, we detected both the expression and currents of ACh-activated (KACh) and Na+-activated (KNa) K+, volume-regulated and calcium-activated (Cl-Ca) Cl−, and TRPV channels. All the detected ion currents except IK1, IKACh, ISK, IKNa, and TRPV1 currents contribute to AP duration. …”
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Transprofessional education in the student discourse: Demand, expectations, risks by A. N. Pinchuk, S. G. Karepova, D. A. Tikhomirov

“…At the same time, the students spoke most of all about the need for experience in mastering the related branches of specialisation. …”
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Application of dynamic systems modeling approach to rank optimal urban waste management strategies using SWOT method by Hamid Shahbandarzadeh, Mohammad Hossein Kabgani

“…Environmental issues are also at the top of all human problems.Originality/Value:  In this research, an attempt has been made to examine innovation from three aspects: theoretical, technical and practical gaps, which can be mentioned as the strengths of the current research compared to other research. …”
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The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients with Rheumatoid Arthritis by Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang, Ping Wu

“…∆RAI, ∆SJC, ∆CXCL1, ∆β-EP, ∆TNF-α, and ∆IL-1β in the treatment group were superior to the control group (13.50 [14.50] versus 6.00 [13.00] in ∆RAI, 4.00 [3.00] versus 2.00 [4.00] in ∆SJC, 0.04 ± 0.79 ng/mL versus -0.01 ± 0.86 ng/mL in ∆CXCL1, -2.43 [5.52] pg/mg versus -0.04 [4.09] pg/mg in ∆β-EP, 3.45 [5.90] pg/mL versus 1.55 [8.29] pg/mL in ∆TNF-α, and 6.15 ± 8.65 pg/mL versus 1.28 ± 8.51 pg/mL in ∆IL-1β; all P < 0.05). Conclusion. Moxibustion can improve the joint swelling and pain symptoms in patients with RA, which may be related to the fact that moxibustion can reduce the release of inflammatory factors in patients with RA and downregulate the level of CXCL1 and increase the level of β-EP at the same time. …”
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Insecticidal Activity of Some Traditionally Used Ethiopian Medicinal Plants against Sheep Ked Melophagus ovinus by Negero Gemeda, Walelegn Mokonnen, Hirut Lemma, Ashenif Tadele, Kelbessa Urga, Getachew Addis, Asfaw Debella, Mesaye Getachew, Frehiwot Teka, Kidist Yirsaw, Kissi Mudie, Solomon Gebre

“…Strong antiparasitic activity was recorded by aqueous extract of Calpurnia aurea (80% mortality) at a concentration of 200 mg/mL within 24 h among aqueous extracts of 9 medicinal plants. The results indicated all the four medicinal plants, particularly those tested essential oils, can be considered as potential candidates for biocontrol of M. ovinus sheep ked.…”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Methods: Twenty rats were equally divided into four groups: a control group, a Cd group treated with 15 mg/kg b.wt CdCl₂, a CLO group administered 200 mg/kg b.wt CLO, and a Cd+CLO group. All groups were orally treated for 4 weeks. Results: Cadmium (Cd) exposure caused anemia and hepatorenal damage, as evidenced by increased serum levels of urea, creatinine, uric acid, total bilirubin (including its direct and indirect fractions), and elevated activities of liver enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). …”
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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

“…Adverse events will be collected and recorded during each treatment.Ethics and dissemination Ethics approval was obtained from the Ethics Committee of the Sports Trauma Specialist Hospital of Yunnan Province (2021-01). All participants will provide written informed consent before randomisation. …”
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PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil by Albert L. Juhasz, Farzana Kastury, Ruby Jones, Mahima Seeborun, Tanya Caceres, Carina Herde, Michelle Cavallaro, Sarah Dilmetz, Joshua Hutchings, Yevgeniya Grebneva, Chris Desire, Peter Hoffmann

“…Two spiked (14C-PFOA: 4360 ± 218 µg kg−1) and two PFAS impacted soils (PFOS: 1880–2250 µg kg−1; PFHxS: 61.2–65.5 µg kg−1) were utilized to measure PFAS relative bioavailability in soil matrices. In all soils, PFAS relative bioavailability was > 86 % (PFOA: 87.0–90.9 %; PFOS: 86.1–90.4 %; PFHxS: 86.5–97.0 %) although the method could quantify bioavailability reductions (25.6–88.9 %) when hydrophobic and electrostatic interactions were enhanced through the addition of carbon-based amendments (5–10 % w/w).…”
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Predicting risk factors for Epstein-Barr virus reactivation using Bayesian network analysis: a population-based study of high-risk areas for nasopharyngeal cancer by Zhiwen Zeng, Kena Lin, Xueqi Li, Xueqi Li, Tong Li, Xiaoman Li, Jiayi Li, Zule Ning, Qinxian Liu, Shanghang Xie, Sumei Cao, Sumei Cao, Jinlin Du

“…The results showed that the BN model slightly outperformed the traditional logistic regression model in all metrics.ConclusionsBN not only reflects the complex interaction between factors but also visualizes the prediction results. …”
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Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies by Sigal Fleisher-Berkovich, Nitzan Sharon, Yvonne Ventura, Valeria Feinshtein, Jonathan Gorelick, Nirit Bernstein, Shimon Ben-Shabat

“…CN4 contained cannabidiolic acid (CBDA) and tetrahydrocannabidiolic acid (THCA), with significant amounts of THC: CBD in a 1:1 ratio, as well as sesquiterpenes and some monoterpenes; and CN6 contained primarily CBDA and THCA, as well as THC and CBD in a 2:1 ratio, with some sesquiterpenes and no monoterpenes. All extracts were not cytotoxic in glial cells up to 50 µg/ml. …”
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Komparasi Data Mining Naive Bayes dan Neural Network memprediksi Masa Studi Mahasiswa S1 by Azahari Azahari, Yulindawati Yulindawati, Dewi Rosita, Syamsuddin Mallala

“…According to the data mining algorithm Naive bayes, there are 3229 students; 1769 as training data, 321 as testing data, and 1139 as target data. All data is taken from students enrolled in undergraduate program and does not include data on diploma students and transfer student. …”
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Experimental and computational approach on the corrosion inhibition properties of two newly pyrazole derivatives on carbon steel in acid medium by Nawal Setti, Asma Barrahi, Mohamed Maatallah, Yassine Kaddouri, Taibi Ben Hadda, Halima Outada, Abhinay Thakur, Rachid Touzani, Khalid Karrouchi, Hatem A. Abuelizz, Burak Dikici, Abdelkader Zarrouk, Ali Dafali

“…These results were supported by elemental analysis of the metal/solution interface using X-ray photoelectron spectroscopy (XPS), for the two molecules tested. All studies demonstrated that the compound Tetra-Pz-Ortho is the most effective inhibitor. …”
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A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon by Junfeng Liu, Mickaël Lelek, Yunfeng Yang, Audrey Salles, Christophe Zimmer, Yulong Shen, Mart Krupovic

“…ABSTRACT Cell division is a fundamental process ensuring the perpetuation of all cellular life forms. Archaea of the order Sulfolobales divide using a simpler version of the eukaryotic endosomal sorting complexes required for transport (ESCRT) machinery, composed of three ESCRT-III homologs (ESCRT-III, -III-1, and -III-2), AAA+ ATPase Vps4 and an archaea-specific component CdvA. …”
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Pre-pregnancy BMI modifies the associations between triglyceride–glucose index in early pregnancy and adverse perinatal outcomes: a 5-year cohort study of 67,936 women in China by Li Li, Yulai Zhou, Huan Li, Juan Li, Lishi Huang, Weibin Wu

“…Results Positive associations between maternal early pregnancy TyG index and APOs, including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), large for gestational age (LGA) and preterm birth (PTB) were demonstrated (all P < 0.001). Besides, there was a significant interaction effect of maternal pre-pregnancy BMI and TyG on the risk of GDM, HDP and LGA (P < 0.05). …”
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Designing and Modeling Digital Transformation in the Automotive Industry: Leveraging the Fourth Industrial Revolution by Mohammad Saeed Mozafari Mehr, Mohammad Taghi Taghavifard

“…Professors and experts contributed their perspectives, leading to the utilization of 58 indicators to elucidate the digital transformation model rooted in the fourth-generation industrial revolution at Iran Khodro Company, drawn from all indicators derived through qualitative analysis of interview content.   …”
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Research on the mechanism of the anti-myocardial infarction effect of the Qiliqiangxin capsule on heart failure rats via nontargeted metabolomics and lipidomics by Kuangyi Liu, Yanting Xiong, Yingli Fan, Shunhui Li, Lijuan Wu, Hui Chen, Xiaomin Wang

“…In addition, in the metabolomics analysis, a total of 17 plasma metabolites were significantly different between heart failure rats and normal rats, all of which recovered significantly after QLQX treatment. …”
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Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial by Aleksandra Gąsecka, Rafał Kaczorowski, Katarzyna Pomykała, Tomasz Kucharski, Magdalena Gajewska, Dominika Siwik, Katarzyna Karoń, Maciej Małyszko, Jaromir Hunia, Jakub Michal Zimodro, Paweł Kowalczyk, Oliwia Zagrocka-Stendel, Małgorzata Dutkiewicz, Katarzyna Koziak, Ceren Eyileten, Marek Postuła, Mateusz Wondołkowski, Marcin Grabowski, Mariusz Kuśmierczyk, Radosław Wilimski

“…Platelet reactivity and oxidative stress parameters were comparable in all groups. Patients treated with ASA 2 × 75 mg had higher CD39 levels at 7 days and 1 month (p = .049, p = .033), compared to the control group. …”
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Analysis of the efficacy and factors affecting the prognosis of intracranial dissecting aneurysm treated with multi-stent overlap technique by Xiaolin Li, Huojun Hu, Lei Wang, Gao Yuan, Changtao Fu, Jinyang Ma, Quan Shao, Zhao Kang

“…Hunt-Hess classification (χ2 = 25.503a, P = < 0.01), hospitalization days (t=-3.873, P < 0.01), operation time (t=-1.970, P = 0.049), and aneurysm height (t=-1.969, P = 0.049) were all significant. 62 patients were discharged with 4 postoperative recurrences and 58 without recurrences in patients treated with multiple stents, with significant differences in the largest diameter (t=-2.235, P = 0.025), basal length (t=-2.149, P = 0.032), and position(located in pica base or not ) (χ2 = 10.955a, P = 0.001). …”
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Concentrations and exposure risks of per- and polyfluoroalkyl substances in human milk from Southern China during the first 400 days of lactation by Meng-Tao Yang, Fei Yang, Qiu-Ye Lan, Si-Yu Huang, Xiao-Yan Chen, Ying-Zhen Qiu, Hui-Lian Zhu

“…Therefore, this study aimed to address this gap by investigating the concentrations and exposure risks of legacy and emerging PFASs in human milk collected during the first 400 days postpartum from Southern China. We detected all the target 23 PFASs compounds, with 22 PFASs found in more than half of the samples. …”
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Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network m... by Ruiyuan Tao, Yijian Yang, Mark Wilson, Jeremy R. Chang, Chang Liu, Cindy H. P. Sit

“…AE demonstrated non-significant effectiveness for all outcomes. MBE emerges as particularly advantageous for attention. …”
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