Aetiology and Outcomes of Thrombocytopenia in Pregnancy: A Cross-Sectional Study in a University Hospital, India by Sudha V. Hooli, Neelima Shah, Prashant Shah, Shrradha Suresh, Bali Sukeshani Sunil

“…Patient-related data such as menstrual and obstetric history, presenting complaints, obstetric examination, and basic investigations were collected in a pre-designed, pre-tested proforma. All cases were followed until delivery to record any maternal complications, or any other morbidities. …”
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Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

“…Methods: A retrospective review of all recoveries of adult cardiac allografts from brain dead donors for a single academic transplant center between 1/2020 and 12/2021 was performed. …”
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Sofosbuvir-Based Therapies for Patients with Hepatitis C Virus Infection: Real-World Experience in China by Chengguang Hu, Guosheng Yuan, Junwei Liu, Huaping Huang, Yanyu Ren, Yinping Li, Xuefu Chen, Wei Li, Tao Wu, Hong Deng, Yanzhong Peng, Yong-Yuan Zhang, Yuanping Zhou

“…The primary observation point was the percentage of patients with a sustained virologic response (SVR) at posttreatment week 12 (SVR12), and all adverse events were monitored during treatment and follow-up period. …”
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Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain by Qian Wang, Jing Lin, Peng Yang, Yingye Liang, Dongming Lu, Kailong Wang, Wei Gan, Jianping Fu, Zhenbao Gan, Mingchen Ma, Pingting Wu, Fengshi He, Jun Pang, Hongliang Tang

“…Fourteen days after modelling, the expression levels of TLR4, IRAK1, TRAF6, TNF-α, and IL-6 were detected in all rats. The PWTL and PWMT of SNL rats were decreased, while these parameters were elevated after massage. …”
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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general popu... by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

“…Higher LECT2 levels positively correlated with homeostatic model assessment for insulin resistance (HOMA‐IR) values and negatively correlated with the quantitative insulin sensitivity check index (QUICKI) among all participants (HOMA‐IR; non‐standardized β (B) = 6.38, P < 0.01: QUICKI; B = −161, P < 0.01). …”
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Community health system capacities and capabilities within an evolving community health policy framework: mixed methods study of stakeholders in central Uganda by Raymond Tweheyo, Diana Atwine, Richard Kabanda, Ronald Miria Ocaatre, Bounggui Kim, Simon Erisa Waiswa, Prichard Denzel Kavuma, Yeni Lee, Loretah Mutoni, Solyi Kim, Yein Park, Monica Okuga

“…While descriptive and stratified analyses were conducted for quantitative data in Stata I/C 15.0: proportions for the varied geographical entities were compared using the t-test with p values &lt;0.05 considered significant, one-way ANOVA was used to compare means.Results Overall, all sites had relatively strong governance of community health only challenged by multiple implementing partners that were weakly coordinated. …”
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Rancang Bangun Sistem Konversi Mata Kuliah (Studi Kasus : Prodi Informatika, Fasilkom, UPN "Veteran" Jawa Timur) by Henni Endah Wahanani, Made Hanindia Prami Swari, Fawwaz Ali Akbar

“…The development of the conversion system has challenges, especially in designing the KHS data input menu interface which must be easy to use and ensure that all data is correct in accordance with KHS. Based on the results obtained from basic path testing, 48 functions are included in the category of low risk level for defects or errors that have a simple and well structured and stable type of procedure with a percentage of 100%. …”
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Morphological characterization and yield of pepper (Piper nigrum L.) types grown in Morogoro District, Tanzania by Abdul Jafari Shango, Ramadhani Omari Majubwa, Amon Petro Maerere

“…Babu kubwa had longer spikes (12.4 cm), leaves blade (17.9 cm), leaf petiole (2.8 cm), wider leaves (12.9 cm) and larger berries (5.8 mm) than all other pepper types. Babu kubwa and Babu kati had cordate and acute leaf bases, respectively while other types had round leaf base shapes. …”
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La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…Thus, in the lack of political willingness to follow through on the IER’s recommendation to transform the site into a project for the preservation of memory, all those who have been in contact with the CDS-DMC from near or far refer to "blocked memory" (mémoire empêchée - Ricoeur, 2000, p. 83), preventing the work and duty of remembrance from being fully carried out.…”
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Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM)... by Seshagiri Rao Nandula, Arad Jain, Sabyasachi Sen

“…Conclusions Several parameters showed significant improvement with both Dapa alone and Combo compared to placebo. However, when all outcome measures were taken into account, other than glycemic control the Combo didn’t seem to offer any further benefit, over Dapa alone. …”
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Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free by Francis T. Kimani, Kelvin K. Thiongó, Maureen A. Otinga, Lewis K. Mbabu, Mary N. Ombati, Stanley K. Kitur, Sarah A. Ochieng’, Lucy N. Wachira, Damaris K. Matoke-Muhia, Luna Kamau

“…Results Anopheles funestus mosquitoes were the predominant vectors at 76.35% of all larvae collections (N = 148). Only two non-blood fed, parasites negative adult mosquitoes were collected from houses sampled. …”
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Impact of a positive end-expiratory pressure on oxygenation, respiratory compliance, and hemodynamics in obese patients undergoing laparoscopic surgery in reverse Trendelenburg pos... by Gulfairus A. Yessenbayeva, Aizhan M. Meyerbekova, Sergey I. Kim, Murat B. Zhumabayev, Gulbanu S. Berdiyarova, Sanzhar B. Shalekenov, Dinara S. Zharlyganova, Irina Y. Mukatova, Yekaterina A. Yukhnevich, Dmitriy A. Klyuyev, Andrey I. Yaroshetskiy

“…HR did nit differ between all comparisons. Conclusion In patients with obesity undergoing surgery in the reverse Trendelenburg position HPEEP and iPEEP may improve oxygenation, decrease driving pressure, and increase dynamic compliance compared to LPEEP with high variation of true effect without relevant hemodynamic compromise. …”
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Bronchiectasis Exacerbation Increases the Risk of Adverse Renal Outcomes—Results From a Large Territory‐Wide Cohort Study by Wang Chun Kwok, Chung Ki Tsui, Leung Sze Him Isaac, Chun Ka Emmanuel Wong, Terence Chi Chun Tam, James Chung Man Ho, Desmond Yat Hin Yap

“…Methods A territory‐wide retrospective cohort study was conducted in Hong Kong between 1/1/1993 and 31/12/2017. All patients with bronchiectasis followed in the public healthcare system in 2017 were classified as “Exacerbators” or “Non‐Exacerbators,” and their adverse renal outcomes (renal progression [decrease in eGFR by 30 mL/min lasted for more than 12 months during follow up], acute kidney injury [AKI], and annual rate of eGFR decline) in the ensuing 7 years were compared. …”
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Changes in health related quality of life in mothers with inflammatory joint disease from year 2000 to 2020 – a comparative cross-sectional study by Hege Svean Koksvik, Ingrid Nilssen, Bente Jakobsen, Hilde Bjørngaard, Marianne Wallenius, Marianne Wallenius, Kjersti Grønning, Kjersti Grønning

“…Compared to the calculated norm scores, the 2020 cohort had significantly lower scores on all scales (p &lt; 0.01) except on the MH scale (p = 0.37).ConclusionMothers with IJD were affected in most dimensions of RAND-36 (SF-36) both in year 2000 and year 2020. …”
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Characterization of Thirty Germplasms of Millet Pepper (<i>Capsicum frutescens</i> L.) in Terms of Fruit Morphology, Capsaicinoids, and Nutritional Components by Ruihao Zhang, Mengjuan Li, Junheng Lv, Pingping Li, Yunrong Mo, Xiang Zhang, Hong Cheng, Qiaoling Deng, Min Gui, Minghua Deng

“…Further hierarchical group analysis was carried out using all the index data. The results showed that 30 millet pepper germplasms were divided into three new categories: M5, M9, M18, and M24 formed one group (C1), M10, M14, M16, M19, M20, M22, M25, M26, M28, M29, and M30 formed another cluster (C2), and the remaining germplasms formed a third cluster (C3). …”
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Distinct Impacts of Clinicopathological and Mutational Profiles on Long-Term Survival and Recurrence in Medullary Thyroid Carcinoma by Moon Young Oh, Kyong Yeun Jung, Hoonsung Choi, Young Jun Chai, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Eun-Jae Chung, Do Joon Park, Young Joo Park, Han-Kwang Yang

“…The disease-specific survival (DSS) rates for all MTC patients at 5-, 10-, 20-, and 30-year intervals were 92.7%, 89.4%, 74.3%, and 68.1%, respectively. …”
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The potential benefits of radiotherapy in elderly patients with early-stage triple-negative breast cancer by Zheng Xu, Zheng Xu, Chengdong Qin, Binxiao Cao, Binxiao Cao, Pengcheng Ruan, Pengcheng Ruan, Mianhao Zhang, Mianhao Zhang, Guidong Chen, Guidong Chen

“…Subsequently, a nomogram was developed to stratify patients and found that RT significantly improved OS and BCSS in the intermediate-risk (OS, HR = 0.49, 95% CI = 0.34–0.71, p = 0.001; BCSS, HR = 0.40, 95% CI = 0.21–0.77, p = 0.018) and high-risk group (OS, HR = 0.67, 95% CI = 0.55–0.81, p &lt; 0.001; BCSS, HR = 0.61, 95% CI = 0.45–0.83, p = 0.007), while showing no significant benefit in the low-risk group (all p-values &gt; 0.05).ConclusionRT significantly improves OS and BCSS in early-stage TNBC patients after BCS, particularly for intermediate to high-risk individuals, while low-risk patients may omit it.…”
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Balancing legume-cereal proportions in cover crop mixtures to minimize N2O emissions by Guillermo Guardia, Diego Abalos, Emanuele Ribatti, Federico Ardenti, Federico Capra, Giacomo Mortella, Vincenzo Tabaglio, Miguel Ángel Ibáñez, Ji Chen, Andrea Fiorini

“…Mixing rye with vetch increased total dry biomass and N yield for all mixtures compared to rye alone. In mixtures, the proportion of fine roots, root length density, and the root C:N ratio decreased compared to rye. …”
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Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study by Zhao X, Zhao H, Chen R, Zhou J, Li N, Li J, Yan S, Liu C, Zhou P, Chen Y, Song L, Yan H

“…Initially, participants were stratified into three groups according to the tertile levels of FABP4, followed by further categorization based on various lipid profiles and specific inflammatory markers.Results: On follow-up (median 751 days, maximum 1506 days), a total of 158 ischemic events were recorded. 1) In multivariable models meticulously adjusted for age, gender, traditional coronary heart disease factors, Killip classification, and discharge medications, the association of elevated levels of FABP4 (Tertile 3 HR 1.618 [1.061 to 2.468], p=0.026), augmented concentrations of PTX3 (Tertile 3 HR 1.811 [1.211 to 2.710], p=0.004), or LL-37 (Tertile 3 HR 0.651 [0.433 to 0.981], p=0.040) with ischemic risk was markedly intensified. 2) Multivariate HRs associated with 1 standard deviation (SD) (mg/dL) increase in the FABP4 parameters were as follows in different subgroups. 1-SD difference in FABP4 was associated with a 23%, 23%, 21 and 29% increase in ischemic events over after fully adjusted the confounding risk factors among male, patients with hyperlipidemia, hypertension and diabetes respectively. 3) The Kaplan-Meier curve demonstrated significant differences between the tertiles of FABP4 index levels among all enrolled participants (p=0.0180).Conclusion: This study reinforces the utility of FABP4 for enhancing risk stratification specifically among older patients diagnosed with ST-elevation myocardial infarction.Keywords: FABP4, lipid profile, PTX3, LL-37, ischemic vascular events…”
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Identification of a novel disulfidptosis-related gene signature in osteoarthritis using bioinformatics analysis and experimental validation by Mingjie Wei, Xiangwen Shi, Wenbao Tang, Qian Lv, Yipeng Wu, Yongqing Xu

“…Further analysis of the scRNA dataset revealed that SLC3A2 and NDUFC1 were predominantly expressed in the preHTC subpopulation. All 10 DR-DEGs exhibited notably higher expression in the EC subpopulation across various cell types. …”
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