Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Furthermore, two particular variants, namely, Bcl-2G101V and Bcl-2F104L, were found to be the most deleterious across all analyses. Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study by Huaxing Meng, Bo Liu, Xiaoting Lu, Yan Tan, Shanshan Wang, Baolong Pan, Hui Zhang, Qiao Niu

“…Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and an auditory-verbal learning test (AVLT). All participants underwent magnetic resonance imaging scans. 3D T1-weighted anatomical images and resting-state functional magnetic resonance imaging data were acquired, and voxel-based morphometry and ROI-based FC were used for analysis. …”
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Alpha EEG Spectral Characteristics in the Parieto-Occipital lobe of Elderly Patients with Chronic Insomnia and Mild Cognitive Impairment by GUO Zhenxing, BAI Linxin, ZHANG Lin, GAO Jiahui, RAO Ting, LIU Zhizhen

“…Additionally, the topographical maps of the alpha spectral power in the parietal and occipital lobes were notably stronger in the CI-MCI group compared to the HC group. （4）Correlation between changes in occipital alpha spectral power and cognitive function：The alpha spectral power at site P6 in the right parietal lobe （r =0. 444, P =0. 023）, at site POZ in the occipital lobe （r =0. 444, P =0. 023）, and at site PO4 in the right parietal lobe （r =0. 478, P =0. 014） all showed a positive correlation with visuospatial executive function.ConclusionThe changes in Parieto-Occipital lobe alpha spectral power are indicative of cognitive impairment in elderly individuals with chronic insomnia and mild cognitive impairment （MCI）. …”
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Technical note: “U–Th Analysis” – open-source software dedicated to MC-ICP-MS U-series data treatment and evaluation by I. K. Kerber, F. Kontor, A. Mielke, A. Mielke, S. Warken, S. Warken, N. Frank

“…Result files are saved automatically and contain all relevant settings used. We demonstrate the relevance of adequate data outlier treatment and generally recommend using the median instead of the mean of calculated ratios. …”
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Cross-sectional association among dietary habits, periodontitis, and uncontrolled diabetes in Hispanics: the LLIPDS study by Hunter Smith, David Travis Thomas, Gabriela Nicole Vázquez-Morales, Lakin Puckett, María Del Mar Rodriguez, Arnold Stromberg, Luciana Macchion Shaddox, Mauro Pedrine Santamaria, Kevin Pearce, Oelisoa Mireille Andriankaja

“…This study aimed to explore whether food choices were linked to higher prevalence of adverse periodontal parameters and poorly controlled glucose levels among Hispanic adults with T2D.MethodsA cross-sectional study was conducted with 260 Puerto Rican adults aged 40–65 years, all diagnosed with T2D. Dietary habits were assessed by weekly frequencies of food choices deemed healthy or unhealthy over the past year. …”
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Could kDNA-PCR in Peripheral Blood Replace the Examination of Bone Marrow for the Diagnosis of Visceral Leishmaniasis? by Natalia Souza de Godoy, Marcos Luiz Alves Andrino, Regina Maia de Souza, Erika Gakiya, Valdir Sabbaga Amato, José Ângelo Lauletta Lindoso, Lucia Maria Almeida Braz

“…However, the parasitological examination of buffy coat was insensitive, being able to detect only 4 cases from Group 1. All samples from Group 2 were negative. We concluded that, for the diagnosis of visceral leishmaniasis, the parasitological examination of peripheral blood was not useful; however, molecular diagnosis by kDNA-PCR, performed in peripheral blood, could be useful to replace the parasitological examination of bone marrow.…”
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Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents by Wantang Su, Jianming Liu, Jianming Liu, Aozhe Wang, Haifeng Zhang, Yaqi Sun, Zhiyi Yan, Michael Svensson, Ji-Guo Yu, Li Zhao

“…In MICT, 21 lipids, including sphingolipid (SP) and phospholipid (PL), decreased, while 7 lipids increased. In SIT, all 5 lipids, which were free fatty acid (FFA), decreased.ConclusionAlthough both MICT and SIT induced similar and significant improvements in VO2peak, serum lipid adaptations to the training differed. …”
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Value of original and modified pathological scoring systems for prognostic prediction in paraffin-embedded donor kidney core biopsy by Jinghong Tan, Huanxi Zhang, Longshan Liu, Jun Li, Qian Fu, Yan Li, Chenglin Wu, Ronghai Deng, Jiali Wang, Bowen Xu, Wenfang Chen, Shicong Yang, Changxi Wang

“…Total-score-based models had similar predictive capacities for eGFR in all scoring systems, except MAPI and Ugarte. Score of glomerulosclerosis (GS), interstitial fibrosis (IF), tubular atrophy (TA), and arteriolar hyalinosis (AH) had good eGFR predictive capacities. …”
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Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial by Djawid Hashemi, Ludwig Dettmann, Tobias D. Trippel, Volker Holzendorf, Johannes Petutschnigg, Rolf Wachter, Gerd Hasenfuß, Burkert Pieske, Antonia Zapf, Frank Edelmann

“…Methods and results The aldosterone receptor blockade in diastolic HF trial is a multicentre, prospective, randomized, double‐blind, placebo‐controlled trial conducted between March 2007 and April 2011 at 10 sites in Germany and Austria that included 422 ambulatory patients [mean age: 67 years (standard deviation: 8); 52% women]. All subjects suffered from chronic New York Heart Association (NYHA) class II or III HF and preserved left ventricular ejection fraction of 50% or greater. …”
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Stability and Efficacy of Live-Attenuated Vibrio harveyi Vaccines Under Different Storage Conditions in Zebrafish (Danio rerio) Models by Mohd Hafiz Ngoo Muhamad-Sofie, Aslah Mohamad, Mohamad Azzam-Sayuti, Mohammad Noor Azmai Amal, Mohd Zamri-Saad, Md Shirajum Monir, Ina Salwany Md Yasin

“…The results showed that a modest dosage of 1 x 104 CFU/mL of LAVh vaccine from all storage conditions provided 80% survival upon intraperitoneal challenge with pathogenic strains of pathogenic V. harveyi, V. alginolyticus, and V. parahaemolyticus. …”
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Data-driven Dynamics with Orbital Torus Imaging: A Flexible Model of the Vertical Phase Space of the Galaxy by Adrian M. Price-Whelan, Jason A. S. Hunt, Danny Horta, Micah Oeur, David W. Hogg, Kathryn Johnston, Lawrence Widrow

“…The vertical acceleration profile in the vicinity of the disk, along with the orbital actions, angles, and frequencies for individual stars, can all be derived from that orbit foliation. We show that this framework—“orbital torus imaging” (OTI)—is rigorously justified in the context of dynamical theory, and does a good job of fitting orbits to simulated stellar abundance data with varying degrees of realism. …”
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Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses by Chanasorn Poodendaen, Poonikha Namwongsakool, Sitthichai Iamsaard, Nareelak Tangsrisakda, Rarinthron Samrid, Chadaporn Chaimontri, Worrawit Boonthai, Suthat Duangchit

“…The discriminant function and regression analyses were used for sex determination and stature estimation. Results: All parameters showed significant difference of sexual dimorphism with greater in male dimensions compared to those of females (p < 0.01). …”
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JAUNOSIOS KARTOS KATALIKŲ INTELEKTUALŲ POŽIŪRIS Į FAŠIZMĄ IR NACIONALSOCIALIZMĄ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…This salvation ought to be realized through a mass extermination of races of lower level, first of all, Jews. The theory of race inferiority preached by the Nazi and used by them as foundation of their activities, was antiscientific, and this was persuasively proved in the study of M. …”
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Unveiling Hidden Aspects of Intermediary Organizations in Innovation: A Systematic Review through the Lens of Industry Taxonomy by Mostafa Mohseni kiasari, ‌Javad Soltanzadeh, Amirhossein Azizi Hasanabadi, Hamed Talebi

“…Methods In this study, using the Systematic Literature Review (SLR) method, all related qualitative and quantitative studies, including articles published in journals and conferences until 2022, were examined, and finally 77 articles were found and analyzed in the field of innovative intermediary institutions. …”
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Lung ultrasound for assessing disease progression in UIP and NSIP: a comparative study with HRCT and PFT/DLCO by Nasrollahzadeh Milad, Idani Esmaeil, Abedini Atefeh, Malekshoaar Mehran, Sadeghi Mohsen, Kasravi Maryam, Tofighi Rozhin, Roostaei Ghazal, Kiani Arda

“…Methods A cross-sectional study was conducted on 35 UIP and 30 NSIP patients at a referral hospital. All patients underwent LUS, HRCT, and PFT. LUS findings such as B-lines, pleural fragmentation, and pleural thickening were compared with HRCT-based lung involvement and PFT parameters. …”
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The association between 24-h movement behaviours and adiposity among Australian preschoolers: a compositional data analysis by Marga Decraene, Kar Hau Chong, Ty Stanford, Dorothea Dumuid, Penny Cross, Greet Cardon, Vera Verbestel, Marieke De Craemer, Anthony Okely

“…As such, reallocating 10 min from sleep or from MVPA, proportionally to all other behaviours was associated with a difference of + 0.031 (95%CI = 0.004,0.06) and -0.085 (95%CI = -0.15,-0.02) in BMI z-score, respectively. …”
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Inflammatory burden index as a prognostic marker in patients with advanced gastric cancer treated with neoadjuvant chemotherapy and immunotherapy by Jiao-Bao Huang, Zhi-Yong Zhou, Jun Lu, Ji-Yun Zhu, Bin Lai, Sheng-Xun Mao, Jia-Qing Cao

“…IBI is the best predictor of OS (C-index: 0.82, 95% CI: 0.78-0.87) among all inflammatory indexes. The IBI cutoff value was 52.1. …”
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Integrative Bioinformatics Analysis to Identify Key Ferroptosis-Related Genes and Immune Infiltration in Aortic Aneurysm and Dissection: Implication of PTGS2 by An W, Luo J, Zhang C, Xiao Q

“…Protein–protein interaction network analyses identified 8 hub FRGs including EZH2, EGFR, HIF1A, IL6, PTGS2, MAPK1, IL1B and SRC. All these FRGs were significantly increased in patients with aortic aneurysm. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…Results Primary vectors, including Anopheles baimaii, Anopheles dirus, Anopheles maculatus, and Anopheles minimus, constituted 11.1% of all female mosquitoes, while 12 secondary vector species represented 29.4% of the overall collection. …”
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Ocular surface treatment in dry eye patients before corneal refractive surgery by O.A. Klokova, R.O. Damashauskas, M.S. Geidenrich

“…</i> </p> <p> <i><b>Patients and Methods:</b> 1,762 patients with ametropias were examined. In addition to all of the standard eye checks, vital conjunctival and corneal staining, Scheimpflug corneal topography, and anterior segment OCT as well as patient survey were performed. …”
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