Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…Ziwei Yang,1,2,* Xiao Liang,1,2,* Yuqi Ji,1,2 Wei Zeng,1,2 Yao Wang,1,2 Yong Zhang,3 Fuqing Zhou1,2 1Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Nanchang, 330006, People’s Republic of China; 3Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Zhang, Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5036, Email zy830226@163.com Fuqing Zhou, Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5132, Email ndyfy02301@ncu.edu.cnPurpose: To investigate whether functional radiomic features in bilateral hippocampi can identify the cognitively impaired patients from low-back-related leg pain (LBLP).Patients and Methods: For this retrospective study, a total of 95 clinically definite LBLP patients (40 cognitively impaired patients and 45 cognitively preserved patients) were included, and all patients underwent functional MRI and clinical assessments. …”
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Modeling a Telemedicine Screening Program for Diabetic Retinopathy in Iran and Implementing a Pilot Project in Tehran Suburb by Sare Safi, Hamid Ahmadieh, Marzieh Katibeh, Mehdi Yaseri, Homayoun Nikkhah, Saeed Karimi, Ramin Nourinia, Ali Tivay, Mohammad Zareinejad, Mohsen Azarmina, Alireza Ramezani, Siamak Moradian, Mohammad Hossein Dehghan, Narsis Daftarian, Davood Abbasi, Afshin Eshghi Fallah, Bahareh Kheiri

“…Registered patients in IDS branch were recalled for fundus photography; images were transferred to the reading center via IRTOS to be graded by GPs, and patients were informed about the results via mobile messaging. All images were independently reviewed by a retina specialist as the gold standard. …”
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Prevalence and associated factors of malaria among the displaced population in refugee camps in Africa: a systematic review and meta-analysis by Habtu Debash, Ermiyas Alemayehu, Melaku Ashagrie Belete, Hussen Ebrahim, Ousman Mohammed, Daniel Gebretsadik, Mihret Tilahun, Alemu Gedefie

“…Results The overall random-effects pooled prevalence of malaria infection (comprising symptomatic and asymptomatic cases) across all included studies was 35.93% (95% CI 24.71–47.15). …”
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Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…Methods A QPOP-specific protocol was applied to RR-HNC models to rank and compare all possible drug combinations from a 12-drug set comprising standard chemotherapy, small molecule inhibitors and targeted therapies specific to HNC. …”
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Assessment of borehole water quality in Nwadzekudzeku village, Giyani, Limpopo Province, South Africa: Implication for potential human health risks by Tsakane Patience Maluleke, Sifelani Dube, Emmanuel Daanoba Sunkari, Abayneh Ataro Ambushe

“…Most borehole water samples were found to have all physicochemical parameters above the maximum permissible levels (MPLs) set by the World Health Organization (WHO) and South African National Standards (SANS) except for pH and temperature. …”
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Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors by Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Yu Cui, Yaping Guan, Weiwei Nie, Qi Xie, Jisheng Li, Baocheng Wang, Bicheng Zhang, Jun Wang

“…A protective irAE burden score based on organ-specific irAEs was further developed to show the significant protective effect of total irAEs on patient outcomes. Conclusions Not all irAEs are associated with prolonged survival. …”
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Analysis of changes in the genome of the Omsk hemorrhagic fever virus (Flaviviridae: <i>Orthoflavivirus</i>) during laboratory practices for virus preservation by Zhanna S. Tyulko, Artem V. Fadeev, Aleksei G. Vasilenko, Ekaterina A. Gradoboeva, Valerii V. Yakimenko, Andrey B. Komissarov

“…It has been shown that point substitutions during adaptation of OHF viruses to the mouse organism occur in all parts of the genome. Many of these substitutions are included in the pattern of linked substitutions identified in the genome of the OHF virus. …”
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Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…Evaluation measures (except walk test) were achieved by all participants at baseline, and most (&lt;90%) at end of phase 2 and phase 3, but &lt;20% at end of phase 1. …”
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Association between moderate-to-vigorous physical activity trajectories and academic achievement in Chinese primary school children: a 3-year longitudinal study by Junyu Wang, Yong Yang, Jun Wu, Ting Xie, Xuejun Guo, Xun Yuan, Ting Li, Yu Zhang, Huiying Zhao, Jie Zhuang

“…Covariates such as demographics, sleep duration, and attitudes towards sports were adjusted in the Generalized Estimating Equations (GEEs) used to examine associations with academic achievement. All statistical analyses were conducted using R and SAS 9.4 software. …”
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Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model by Rongkun Dai, Changlai Xiao, Xiujuan Liang, Lin Jia, Yi Jia, Jiarui Yao, Weifei Yang, Jiang Zhang, Linzuo Zhang, Weifeng Li

“…Among them, geological disaster susceptibility has a negative driving effect on the EGECC, while landform, human activity impact index, and population density all display bidirectional effects. Overall, this study provides essential guidance for formulating ecological protection and restoration plans for the national territorial space in the Luoyang area of the YRB. …”
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Trends in genome diversity of small populations under a conservation program: a case study of two French chicken breeds by Bortoluzzi, Chiara, Restoux, Gwendal, Rouger, Romuald, Desnoues, Benoit, Petitjean, Florence, Bosse, Mirte, Tixier-Boichard, Michèle

“…Livestock biodiversity is declining globally at rates unprecedented in human history. Of all avian species, chickens are among the most affected ones because many local breeds have a small effective population size that makes them more susceptible to demographic and genetic stochasticity. …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

“…Our results rule out models (for eRO-QPE2) invoking (i) a classic active galactic nucleus accretion disk and (ii) no accretion disk at all. For orbiter models, the expected radius derived from the timing properties would naturally lead to disk-orbiter interactions for both quasi-spherical and eccentric trajectories. …”
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Late-season source limitation practices to cope with climate change: delaying ripening and improving colour of Cabernet-Sauvignon grapes and wine in a hot and arid climate by Luca Pallotti, Guadalupe Partida, Eve Laroche-Pinel, Vania Lanari, Miguel Pedroza, Luca Brillante

“…In this two-year Cabernet-Sauvignon trial, we compared the application of pinolene (P) to late shoot topping (T) and late above-bunch zone leaf removal (LR), all performed during the late stages of ripening, with an untreated control (C). …”
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Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials by Guangyao Lin, Stella Lim Jin Yie, Shanshan Guo, Xuanling Li, Lianwei Xu

“…The overall quality of the evidence, as appraised by the GRADE criteria, was very low or low for all outcomes. Conclusions: The evidence from 15 RCTs demonstrated that acupuncture interventions are effective in ameliorating cognitive function in people with aMCI. …”
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Long-term survival analysis of ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma conforming to the Milan criteria: primary versus recurrent HCC by Jing Zhang, Guanya Guo, Tao Li, Changcun Guo, Ying Han, Xinmin Zhou

“…Background This study compared long-term outcomes between patients with initial hepatocellular carcinoma (IHCC) and those with recurrent HCC (RHCC) treated with microwave ablation (MWA).Methods This retrospective study included 425 patients with HCCs (294 IHCCs and 131 RHCCs) within the Milan criteria who were treated with ultrasound-guided percutaneous MWA between January 2008 and November 2021. All patients with RHCC had previously undergone MWA for initial HCC. …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Methods Conducted in a hospital serving a socioeconomically deprived population, this study included all adults hospitalised with COVID-19 from 1st November 2023 to 31st August 2024. …”
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The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study by Zhiwen Liu, Shaoming Cai, Yuzhen Chen, Zijing Peng, Huanling Jian, Zhihai Zhang, Hongxing Huang

“…Participants in the highest quartile of omega-3 intake had a significantly lower risk (OR = 0.71, 95% CI: 0.53–0.93) compared to those in the lowest quartile, with a consistent trend across all adjusted models (p for trend &lt;0.05). Subgroup analyses indicated stronger associations in individuals under 60 years of age, female and non-smokers. …”
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Molecular Patterns of MEFV Gene Mutations in Egyptian Patients with Familial Mediterranean Fever: A Retrospective Cohort Study by Amal R. Mansour, Ayman El-Shayeb, Nihal El Habachi, Mohamad A. Khodair, Doaa Elwazzan, Nermeen Abdeen, Marwa Said, Riham Ebaid, Noha ElShahawy, Amr Seif, Nadia Zaki

“…The most commonly encountered gene mutation associated with abdominal pain, fever, and high serum Amyloid A was E148Q allele (37.5%). Conclusions. Unlike all previous publications, E148Q allele was found to be the most frequent in the studied patients. …”
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Characteristics of subacute stroke patients who achieve earlier independence in real-life walking performance during hospitalization by Kenji Kawakami, Shigeo Tanabe, Daiki Kinoshita, Ryo Kitabatake, Hiroo Koshisaki, Kenta Fujimura, Yoshikiyo Kanada, Hiroaki Sakurai

“…Age ≤64 years (hazard ratio 1.92, 95% confidence interval 1.21–3.06), FIM-C ≥25 (hazard ratio 2.42, 95% confidence interval 1.52–3.86), and FAC ≥3 (hazard ratio 1.98, 95% confidence interval 1.22–3.21) significantly affected earlier walking independence (all p < 0.01). Impeding factors were FIM-M ≤38 (hazard ratio 0.23, 95% confidence interval 0.13–0.40; p < 0.01) and FAC = 0 (hazard ratio 0.184, 95% confidence interval 0.06–0.62; p < 0.01). …”
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A Novel Multiplex LAMP Assay for the Rapid and Accurate Diagnosis of Visceral Leishmaniasis Caused by Leishmania infantum from Iran by Sahar Samsami, Sahar Namavari, Saeed Ataei, Abdolmajid Ghasemian, Ava Yazdanpanah, Neda Sepahi, Gholamreza Hatam, Hossein Faramarzi, Hadi Mirzaei, Razie Ranjbar, Ali Ghanbariasad

“…The alignment was performed using MEGA5, and the primers were further adjusted utilizing GENE Runner software. All molecular methods were tested on the serial dilution of cloned plasmid containing ITS region from standard strains of L. infantum, L. tropica, and L. major. …”
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