Tetrodotoxin, fungal pathogen infection, and bacterial microbiome associations are variable in the skin microecosystems of two Taricha newt species by Talon Jost, Talon Jost, Alysha Henderson, Brandon LaBumbard, Krisztian Magori, Amber Stokes, Danica Bergin, Autumn Holley, Autumn Holley, Molly Bletz, Molly Bletz, Obed Hernández-Gómez, Gary Bucciarelli, Douglas C. Woodhams, Jonah Piovia-Scott, Jenifer B. Walke

“…These taxa (ASVs matching Aeromonas, Pseudomonas, Shewanella, and Sphingopyxis) were associated with all body sites of previously sampled T. granulosa, but not found in soil samples. …”
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Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…We collected data through desk reviews, stakeholder interviews and focus group discussions with stakeholders from government, academia and civil society from six purposefully selected countries: Nigeria, Singapore, South Africa, Bangladesh, Jordan and the UK.Results Regardless of political, geographic and economic context, all six countries adopted common strategies to make decisions under three types of uncertainties. …”
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How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis by Eline M. L. van der Does de Willebois, MD, Vittoria Bellato, MD, Marjolijn Duijvestein, MD, PhD, Susan van Dieren, MD, PhD, Silvio Danese, MD, PhD, Pierpaolo Sileri, MD, PhD, Christianne J. Buskens, MD, PhD, Andrea Vignali, MD, PhD, Willem A. Bemelman, MD, PhD

“…The weighted mean of ER rates in all included studies was 44.0% (95% confidence interval, 43.56–44.43). …”
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Comprehensive Sepsis Risk Prediction in Leukemia Using a Random Forest Model and Restricted Cubic Spline Analysis by Kou Y, Tian Y, Ha Y, Wang S, Sun X, Lv S, Luo B, Yang Y, Qin L

“…Furthermore, we examined the interactions among predictors to better understand their potential interrelationships.Results: The random forest (RF) model outperformed all others, achieving an AUC of 0.765 in the training cohort and 0.700 in the validation cohort. …”
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Association between controlling nutritional status score and the prognosis of patients with acute myocardial infarction: a systematic review and meta-analysis by Lei Peng, Jian Tang, Ningjun Zhang, Zhongnan Zhang, Deqi Wang, Youfu He

“…Moreover, the GRADE system was leveraged to appraise the quality of evidence for all outcomes.ResultsFifteen studies were included in our analysis. …”
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Biological Impact of Exposure to Extremely Fine-Grained Volcanic Ash by Cristina Aguilera, Marco Viteri, Rachid Seqqat, Ligia Ayala Navarrette, Theofilos Toulkeridis, Ana Ruano, Marbel Torres Arias

“…These results associated with compounds contained in Pichincha volcanic ash are considered hazardous elements which induce inflammation leading to activate inflammasome NRLP, releasing reactive oxygen species, and producing changes in cell morphology and density, all of which are expression of cytotoxicity.…”
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Impact of in-hospital COVID-19 quarantine policy changes on quality of acute stroke care: a single center experience by Minkyung Kim, Keon-Joo Lee, Seong-Eun Kim, Hokyu Kim, Jung Hoon Han, Han Jun Kim, Kyungmi Oh, Sung-Jun Park, Chi Kyung Kim, Young-Duck Cho

“…The purpose of this study was to determine effects of changes in in-hospital quarantine policies on quality of care for acute stroke patients.MethodsHyperacute ischemic stroke patients who were admitted to Korea University Guro Hospital between January 2019 and February 2021 via the emergency department were included in this study. All had neurological symptoms within 6 h before arrival. …”
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A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response by Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider‐Daum, Claus‐Michael Lehr

“…For validating the in vitro model, three different protocols have been developed to demonstrate the clinically established anti‐inflammatory effect of glucocorticoids to reduce certain inflammatory markers after different pro‐inflammatory stimuli: (1) an inflammation caused by bacterial LPS (lipopolysaccharides) to simulate an LPS‐induced acute lung injury measured best with cytokine IL‐6 release; (2) an inflammation caused by LPS at ALI (air‐liquid interface) to investigate aerosolized anti‐inflammatory treatment, measured with chemokine IL‐8 release; and (3) an inflammation with a combination of human inflammatory cytokines TNFα and IFNγ to simulate a critical cytokine storm leading to epithelial barrier disruption, where the eventual weakening or protection of the epithelial barrier can be measured. In all cases, the presence of macrophages appeared to be crucial to mediating inflammatory changes in the alveolar epithelium. …”
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Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus by Yi-Ching Weng, Sung-Sheng Tsai, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Chiung-Mei Chen, Jawl-Shan Hwang, Hung-Chou Kuo

“…The modified Michigan Neuropathy Screening Instrument (mMNSI) and Douleur Neuropathique 4 were used to evaluate the severity of DSPN and DPNP, respectively. In all, 30% of participants had DSPN and 11% had DPNP. …”
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The Prognostic Value of CRP/Alb Ratio in Predicting Overall Survival for Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Combined with Molecular-Targeted... by Huang X, Peng G, Kong Y, Cao X, Zhou X

“…The CRP/Alb ratio demonstrated significantly higher AUCs than PLR and SII at 24 months (all p < 0.05) and showed comparable AUCs to CRAFITY score and mGPS at 12, 24, and 36 months.Conclusion: The CRP/Alb ratio is a valuable prognostic marker for predicting OS and treatment-related adverse events in HCC patients receiving transcatheter intra-arterial therapy combined with MTAs and PD-1/PD-L1 inhibitors. …”
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Enhanced Performance of New Scaling-Free CORDIC for Memory-Based Fast Fourier Transform Architecture by C. Paramasivam, Sandeep Singh Chauhan, Veerpratap Meena, A. Sreejagathi, B. A. V. N. Hasini, K. L. K. Kishore, T. V. N. G. Vamsikrishna, M. Durga Ananta Sai, Abdessamad Didi

“…In the FFT architecture, the CORDIC cell performs all the multiplication of twiddle factor. Therefore, the complex constant multiplier required to execute the twiddle factor multiplication is eliminated. …”
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Effect of Forbrain Cognitive Training Intervention Prescriptions Based on Risk Factors on Patients with Cognitive Impairment After Traumatic Brain Injury by ZHANG Xueru, WANG Hongbin, CUI Huiying, HAO Xijun, CHEN Changxiang

“…The control group received neurosurgical routine nursing care; the observation group 1 received Forbrain cognitive training (reading training was encouraged) in addition to the routine care; the observation group 2 received the Forbrain cognitive training intervention prescriptions based on the risk factors of cognitive dysfunction (insomnia, headache, depression, low social support and upper limb motor dysfunction) in addition to the routine care. For all of the three groups, the interventions were provided for 20 minutes a time, twice a day, lasting for two weeks. …”
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Evaluation of Inflammatory Cytokine Secretion by Human Alveolar Macrophages by J. E. Losa García, F. M. Rodríguez, M. R. Martín de Cabo, M. J. García Salgado, J. P. Losada, L. G. Villarón, A. J. López, J. L. P. Arellano

“…The alveolar macrophage (AM) secretes interleukin 1β (IL-1β), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8), all of them inflammatory cytokines involved in the pathogenesis of many lung diseases. …”
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Beyond support: exploring the dynamic and static biomechanical changes induced by preventive ankle taping: a novel cross-sectional study by María Bravo-Aguilar, Vanesa Abuín-Porras, María Blanco-Morales, Carlos Romero Morales, Jaime Almazán-Polo, Jorge Hugo Villafañe, Lorena Canosa-Carro

“…Introduction In sports, 80% of all ankle injuries are sprains of the external compartment. …”
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E-cigarettes on Instagram: Exploring vape content via an Australian vaping influencer by Jonine Jancey, Renee N. Carey, Becky Freeman, Tama Leaver, Katharina Wolf, Marilyn Bromberg, Kevin Chai, Stella Bialous, Phoebe Adams, Meghan Mcleod, Kahlia McCausland

“…These vaping-focused accounts were then further coded by two trained coders. Results All (n=369; 100.0%) of the vape content posted by these accounts was positive in sentiment. …”
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Microstructure modulation of hard carbon derived from long-flame coal to improve electrochemical sodium storage performances by Hai-Tao Zeng, Wei-Wei Kang, Bao-Lin Xing, Guang-Xu Huang, Qiang Li, Han Hu, Fang-Le Su, Jian-Bo Jia, Chuan-Xiang Zhang

“…With elevating carbonization temperature, carbon layer spacing, defect concentration and C − O, CO functional groups of hard carbon all gradually decrease. The hard carbon prepared at 1500 °C (BHC-1500) demonstrates 38 % of the pseudo-graphite carbon with an average carbon layer spacing of 0.360 nm, a specific surface area of 31.2 m2/g and appropriate defect concentration (ID1/IG of 1.50). …”
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Digital Information Exchange Between the Public and Researchers in Health Studies: Scoping Review by Nazli Soltani, Thilo Dietz, Doris Ochterbeck, Jens Dierkes, Katja Restel, Lara Christianson, Karina Karolina De Santis, Hajo Zeeb

“…ResultsOverall, 4072 records were screened, and 18 studies published between 2010 and 2021 were included. All studies evaluated or assessed the preferences for digital information exchange. …”
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Hobbit: Providing Fall Detection and Prevention for the Elderly in the Real World by Markus Bajones, David Fischinger, Astrid Weiss, Daniel Wolf, Markus Vincze, Paloma de la Puente, Tobias Körtner, Markus Weninger, Konstantinos Papoutsakis, Damien Michel, Ammar Qammaz, Paschalis Panteleris, Michalis Foukarakis, Ilia Adami, Danai Ioannidi, Asterios Leonidis, Margherita Antona, Antonis Argyros, Peter Mayer, Paul Panek, Håkan Eftring, Susanne Frennert

“…Our main contribution lies within the description of all components developed within the Hobbit project, leading to autonomous operation of 371 days during field trials in Austria, Greece, and Sweden. …”
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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye by Jayoung Moon, Enying Jiang, Jingting Liu, Hui Jin, Hee Su Yoon, Hoon-In Choi, Ji Suk Choi, Hong Qi, Hyeon-Jeong Yoon, Kyung Chul Yoon

“…<b>Results:</b> Monotherapy with 0.05% CsA and LF showed improvements in all clinical parameters compared to the EDE control (<i>p</i> < 0.05). …”
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A Physics-Based Hyper Parameter Optimized Federated Multi-Layered Deep Learning Model for Intrusion Detection in IoT Networks by Chirag Jitendra Chandnani, Vedik Agarwal, Shlok Chetan Kulkarni, Aditya Aren, D. Geraldine Bessie Amali, Kathiravan Srinivasan

“…FedRIME ensures good generalization for all clients&#x2019; data by finetuning the model&#x2019;s hyperparameters according to each client. …”
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