Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

“…We sought to identify the prevalence and predictors of subtherapeutic and therapeutic DOAC concentrations and hypothesized that increased anti-Xa levels would correlate with increased risk of bleeding and other poor outcomes.Methods A retrospective cohort study of all trauma patients on apixaban or rivaroxaban admitted to a level 1 trauma center between January 2015 and July 2021 was performed. …”
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Noninvasive diagnostic methods of liver fibrosis in patients with primary biliary cirrhosis and primary sclerosing cholangitis: role of indirect serological markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…According to routine laboratory test data and abdominal ultrasound, indexes of AST to ALT ratio (AAR); AST to platelet count ratio (APRI); platelet count to the spleen diameter ratio - PLT/ SPD and Fibrosis-4 score index (FIB-4) were calculated. All patients underwent liver biopsy with fibrosis stage assessment in biopsy specimen (METAVIR scale). …”
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Exploring the Link between Financial Reporting Models and Earnings Characteristics among Tehran Stock Exchange Listed Companies by Roya Amiri, Ali Ashtab, Mahdi Heydari

“…Because management cannot address all the requirements of financial statement users, reliance on financial information as companies' output is heightened. …”
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Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis by Chen Wang, Cheng Ma, Yuanyou Xu, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Xiakun Chu, Haichun Gao, Xing Zhang, Yunjie Chang

“…Abstract The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components have been individually characterized, the intact PDHc structure remains unclear, hampering our understanding of its composition and dynamical catalytic mechanisms. …”
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Treatment and counselling preferences of postpartum women with and without symptoms of (childbirth-related) PTSD: findings of the cross-sectional study INVITE by Rosa Hannele Horstmann, Lara Seefeld, Julia Schellong, Susan Garthus-Niegel

“…Regarding modes of service provision, women with gPTSD had a higher preference for all service modes compared to women with CB-PTSD and those without postpartum PTSD, with a stronger preference for both direct (e.g. in person, video conference) and delayed communication (e.g. chat, e-mail). …”
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Lithological and geochemical characterization of ‘adinole’ artefacts from cave deposits in southwest Wales: A material of choice during the late Middle to Upper Palaeolithic by Richard Bevins, Elizabeth A. Walker, Nick Pearce, Duncan Pirrie, Rob Ixer, Ian Saunders, Matthew Power

“…Standard petrography has been combined with automated SEM-EDS analysis for a single artefact to determine the mineralogy and textures of that artefact, while portable XRF and μXRF have been combined to establish the geochemical characteristics of all twenty-three artefacts analysed. These investigations have shown that the artefacts were manufactured from rhyolite rather than adinole, a misidentification that has been in the literature for over 100 years. …”
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Combining Cocatalyst and Oxygen Vacancy to Synergistically Improve Fe₂O₃ Photoelectrochemical Water Oxidation Performance by Chen Liu, Jiajuan Li, Wenyao Zhang, Changqing Zhu

“…The improvement in the water oxidation performance of PEC is considered to be the synergistic effect of the cocatalyst and oxygen vacancy. All outstanding PEC response characteristics show that the modification of the cocatalyst and oxygen vacancy doping represent a favorable strategy for synergistically improving Fe₂O₃ photoanode performance.…”
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Prevalence of mortality caused by injuries at Livingstone University Hospital, Zambia. A retrospective cross-sectional study. by Lukundo Siame, Malan Malumani, Chiyeñu O R Kaseya, Sergiy Ivashchenko, Leah Nombwende, Sepiso K Masenga, Benson M Hamooya, Michelo Haluuma Miyoba

“…Zambia bears a significant burden of trauma-related mortalities, contributing to 7% of all annual deaths and 1 in 5 premature deaths in the country. …”
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Utilizing the Ethereum blockchain for retrieving and archiving augmented reality surgical navigation data by Sai Batchu, Michael J. Diaz, Lauren Ladehoff, Kevin Root, Brandon Lucke-Wold

“…In a database of 350 records, the retrieval function needs about 1,026 MB to query a record with all three fields left blank, but only 970 MB to obtain the same observation from a database of 50 records. …”
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Radiofrequency ablation for solitary T1N0M0 papillary thyroid carcinoma in the danger triangle area: a preliminary analysis by Dan-ling Zhang, Sheng Chen, Yuhan Qiu, Jian-chuan Yang, Zhiliang Hong, Jianwei Li, Song-song Wu

“…Further ablation was successfully applied to all new lesions and LMN. Mild voice changes were the only complication, with a rate of 3.2% (3/94), resolved within 4 months after RFA.Conclusions Sufficient paratracheal fluid isolation combined with a low-power, short active tip radiofrequency ablation strategy is a safe and effective method for treating solitary T1N0M0 PTC in the danger triangle area.…”
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The influence of e-trust on a job performance model based on employees’ dynamic capabilities during a crisis caused by a Black Swan event by Katarzyna Tworek, Guangyan Luo, Marcin Paska, Anna Sałamacha

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Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers by Femke A. I. Ehlers, Katie E. Blise, Courtney B. Betts, Shamilene Sivagnanam, Loes F. S. Kooreman, E. Shelley Hwang, Gerard M. J. Bos, Lotte Wieten, Lisa M. Coussens

“…In comparison, NK cells, identified by CD56 or NKp46 expression, were scarce in all specimens with low granzyme B expression indicating reduced cytotoxic functionality. …”
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Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy by Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle

“…Patients with predominant LA myopathy were older, had a higher prevalence of atrial fibrillation (AF), diabetes, higher plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP), Growth differential factor 15(GDF15), high sensitivity Troponin T (hs-TNT) as well as more dilated left and right atria, and worse right atrial function compared to other groups (all p-values < 0.05). Using multivariable logistic regression adjusted for LVEF and LA size, independent predictors of predominant LA myopathy were the presence of AF, diabetes, and higher GDF15, whereas absence of diabetes independently predicted predominant LV myopathy. …”
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Prevalence, aetiology, and service mapping of dementia in rural Uganda. Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda). [version 2;... by Joseph Mugisha, Nicholas J Ashton, Claire J Steves, Racheal Alinaitwe, Josephine Prynn, Tunde Peto, Beatrice Kimono, Martin Prince

“…Methods The study is nested within the General Population Cohort run by the Medical Research Council/Uganda Virus Research Institute & London School of Hygiene and Tropical Medicine Research Unit. All adults aged 60+ (around 1400) are undergoing brief cognitive screening. …”
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Adapting the WHO Safe Childbirth Checklist: A collaborative study in West Africa by Kadidiatou R. Kourouma, Tieba Millogo, Aissatou Diallo, Wambi M.E. Yaméogo, Marie L. Agbré-Yacé, Mamadou D. Baldé, Issaka Tiembré, Alexandre Delamou, Séni Kouanda

“…Conclusion: The study emphasised the importance of engaging all stakeholders and end users in the adaptation process for a sustainable use of the tool. …”
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Temperature Is a Key Factor Affecting Total Phosphorus and Total Nitrogen Concentrations in Northeastern Lakes Based on Sentinel-2 Images and Machine Learning Methods by Haoming Qin, Chong Fang, Ge Liu, Kaishan Song, Zhuoshi Li, Sijia Li, Hui Tao, Zhaojiang Yan

“…The RF algorithm was applied to all cloud-free Sentinel-2 satellite images of these typical lakes in northeastern China during the non-glacial period from 2017 to 2023, generating spatiotemporal distribution maps of TP and TN concentrations. …”
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Imprint of ancestral and modern threats in human mind – experience of fear, disgust, and anger by Eva Landová, Eva Landová, Jakub Polák, Jakub Polák, Markéta Janovcová, Iveta Štolhoferová, Šárka Peterková, Aleksandra Chomik, Daniel Frynta

“…Gender, age, and type of education were significant moderators of emotional responses across all threat categories.DiscussionOur study reveals that while fear is more context-dependent, particularly triggered by modern threats, disgust operates on an evolutionarily hardwired basis, making it less effective against contemporary risks. …”
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…<b>Results:</b> We identified seven DDR-related genes (<i>Arid5b</i>, <i>Cox5a</i>, <i>Erbb2</i>, <i>Ube2l3</i>, <i>Gpx1</i>, <i>H2bcl2</i>, and <i>Mapk3</i>), 33 DNA methylation genes, and two DDR-related proteins (CD274 and FCGR2A) which were all causally associated with IBD and its subtypes. …”
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Magnetic resonance spectroscopy of hippocampal and striatal neurometabolites in experimental PTSD rat modeling by V. E. Tseilikman, O. B. Shevelev, N. V. Khotskin, A. S. Dotsenko, G. V. Kontsevaya, M. S. Lapshin, M. P. Moshkin, M. V. Komelkova, I. V. Feklicheva, O. B. Tseilikman, E. Dremencov, E. L. Zavjalov

“…The NAA level in the hippocampus was similar between all groups, including the control. The results obtained indicate that multiple exposures to psychological stress associated with the sense of proximity of a natural enemy in some animals cause an anxiolytic reaction. …”
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Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

“…However, considering published meta-analyses, all the outcomes were graded as very low on the GRADE criteria, and the heterogeneity was never reported. …”
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