The CYP2C19*1/*2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers by Yanti Nasyuhana Sani, Lim Sheau Chin, Lim Luen Hui, Nur Elyana Yazmin Mohd Redhuan Shah Edwin, Goh Teck Hwa, Victor L. Serebruany, Yuen Kah Hay

“…Forty-five of 90 volunteers were included in the clopidogrel response studies and triaged into three genotypes, namely, CYP2C19*1/*1 (n=17), CYP2C19*1/*2 (n=21), and CYP2C19*2/*2 (n=7). All subjects received 300 mg of clopidogrel, and platelet reactivity was assessed after a four-hour loading utilizing the VerifyNow-P2Y12 assay. …”
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Magnetic resonance imaging quantification of left ventricular mechanical dispersion and scar heterogeneity optimize risk stratification after myocardial infarction by Xiaoying Zhao, Li Zhang, Lujing Wang, Wanqiu Zhang, Yujiao Song, Xinxiang Zhao, Yanli Li

“…Spearman rank correlation analysis revealed significant linear correlations between LVMD and entropy parameters (p < 0.001 for all). Conclusions Myocardial heterogeneity, as assessed by LVMD and BZ entropy, represents reliable and reproducible parameters reflecting cardiac remodeling following MI. …”
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Preventive Adolescent Health Care in Family Practice: A Program Summary by Barry Knishkowy, Moshe Schein, Alexander Kiderman, Aliza Velber, Richard Edman, John Yaphe

“…A Community-Oriented Primary Care (COPC) program targeted all adolescent patients aged 12—18 years in two Israeli family practices. 321 teenagers were invited to participate. …”
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Multi-ancestry genome-wide association analyses: a comparison of meta- and mega-analyses in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study by Alan Kuang, Marie-France Hivert, M. Geoffrey Hayes, William L. Lowe, Denise M. Scholtens

“…For the heterogeneous ancestry mega-analysis pipeline, data for all individuals were collectively imputed to the Trans-Omics for Precision Medicine (TOPMed) cosmopolitan reference panel, and GWAS was conducted using a unified mega-analysis. …”
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Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 by Seongmin Moon, Yun-Sok Ha, Mina Kim, Hoseob Kim, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Ho Won Kang

“…There was a modest improvement in 5-year survival (both all cause- and cancer-specific) over the study period. …”
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Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves by Rashad Alsanosy, Hassan A. Alhazmi, Shahnaz Sultana, Ashraf N. Abdalla, Yassin Ibrahim, Mohammed Al Bratty, David Banji, Ibrahim Khardali, Asaad Khalid

“…Cytotoxicity investigations were also conducted on both types of leaves using three cancer cell lines, human breast adenocarcinoma, human ovary adenocarcinoma, and human colon adenocarcinoma and also normal human fetal lung fibroblast cell line was used. All extracts showed comparable cytotoxicity, IC50 ranging from 22–59 μg/mL on the cancer cells; however, we observed more cytotoxicity against normal cells (IC50: 6–41 μg/mL). …”
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Subthreshold Micropulse Treatment Laser versus Half-Dose Photo Dynamic Therapy for the Chronic Central Serous Chorioretinopathy with Parafoveal or Subfoveal Leakage STML versus PDT... by Qingshan Chen, Xia Zhao, Qiuju Yin, Zhi Li, Zimei Zhao, Jiafeng Ning

“…One hundred and forty-eight patients (148 eyes) with persistent cCSC were enrolled in this retrospective study and treated with SMTL or half-dose PDT. All patients were diagnosed according to clinical characteristics and findings on multimodal imaging. …”
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Fracture resistance, failure mode and restorability of CAD CAM Zirconia endocrowns with different pulpal extension depths bonded to maxillary molars: an in-vitro study by Sarah Salah Gaafar, Dana El Ballouli, Mohammad Rayyan, Mohamed Sayed, Doaa Gamal Basta, Maha Fouad

“…Teeth were prepared and secured in resin dies with pseudo periodontal ligament. Specimens from all groups were individually scanned using an intra oral digital scanner. …”
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Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol by Jaap Oosterlaan, Marsh Königs, Job B M van Woensel, Marc Engelen, Marjan E Steenweg, Petra J W Pouwels, Cece C Kooper, Hilgo Bruining, Arne Popma, Dennis R Buis, Maayke Hunfeld

“…Outcome measures of the prognostic models are (1) motor functioning, (2) intelligence, (3) behavioural functioning and (4) school performance, all assessed at 6 months post-injury.Ethics and dissemination Ethics has been obtained from the Medical Ethical Board of the Amsterdam UMC (location AMC). …”
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Physical Fruit Traits, Nutritional Composition, and Seed Oil Fatty Acids Profiling in the Main Date Palm (Phoenix dactylifera L.) Varieties Grown in Morocco by Mohamed Ibourki, Fadma Azouguigh, Si Mohamed Jadouali, El Hassan Sakar, Laila Bijla, Khalid Majourhat, Said Gharby, Abdelatif Laknifli

“…Corresponding values in seeds were as follows: proteins (3.20–5.00%), moisture (1.42–4.14%), ash (1.14–1.50%), lipids (6.30–7.40%), carbohydrates (83.39–85.55%), energy value (417.06–429.51 kcal/100 g), and reducing capacity (1427.71–6843.84 mg GAE/100 g dry weight). Among all minerals (K, Ca, Mg, B, Fe, Cu, Mn, Na, and Zn) found in both fruit parts, K had the highest records for both flesh (12047 mg/kg) and seed (6127.6 mg/kg), followed by Mg and Ca. …”
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Pola Sensitivitas Bakteri Penyebab Infeksi Saluran Napas Bawah Non Tuberkulosis Terhadap Kotrimoksazol di Laboratorium Mikrobiologi RSUP Dr. M. Djamil Padang Periode 1 Januari 2012... by Inez Amelinda, Aziz Djamal, Elly Usman

“…Besides that, according to the research result, bacteria that cause lower respiratory tract infection are Klebsiella pneumoniae (51,92%), Streptococcus α hemolyticus (17,78%), and Pseudomonas sp. (9,25%). All the bacteria has 18,78% sensitivity to cotrimoxazole.…”
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Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis by EBENEZER OLUWAKEMI, BODEDE OLUSOLA, AWOLADE PAUL, JORDAAN MARYAM A., OGUNSAKIN ROPO E., SHAPI MICHAEL

“…The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. …”
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Postoperative mortality in New Zealand following general anaesthetic: demographic patterns and temporal trends by James Stanley, Sarah Jackson, Jason K Gurney, Melissa McLeod, Doug Campbell, Luke Boyle, Elizabeth Dennett, Jonathan Koea, Dick Ongley, Diana Sarfati

“…As in other contexts, we observed that the likelihood of postoperative death was not proportionally distributed within our population: older patients, Māori patients, those living in areas with higher deprivation and those with comorbidity were at increased risk of postoperative death, even after adjusting for all available factors that might explain differences between these groups. …”
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Combination of Mangosteen (Garcinia mangostana L.) Pericarp Extract and Physical Exercise Decreases Atherosclerotic Lesions in Atherogenic Diet-Fed Rats by Andreas Arie Setiawan, . Sugiri, Awal Prasetyo, Eirin Yovita Kurniawan, Dominikus Evano Putra

“…The PE protocol involved daily treadmill running for 60 min at 12 m/min, 5 days/week. All rats were treated for eight weeks. Following eight weeks of treatment, the animals were sacrificed and the aortic tissues were taken for histological study. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…Tumor cells treated with RT combined with these nanoparticles displayed reduced oxidative stress, alleviated hypoxia, and normalized blood vessel formation. Notably, all mice in the RT + PD-1 + MSN@R837-Mn/ZnO2 group achieved complete tumor regression with extended survival. …”
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Space-time Characteristics of 16 PM2.5-bound Phthalates (PAEs) in Ambient Air from Shanghai: Profiles, Sources, Meteorological Effects, and Exposure Risks by Janvier Munyaneza, Md Faysal Hossain, Qilong Jia, Yusen Duan, Guangli Xiu

“…Daily mean and median concentrations comprising all the species (Σ16PAEs) were generally higher in samples collected during colder periods (38.3 and 37.5 ng m−3, respectively) rather than within samples gathered in warmer periods (31 and 26.9 ng m−3, respectively), though there wasn’t a statistically significant difference between mean concentrations for both periods (ANOVA: p > 0.05, F stat. < F critical). …”
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ASMENS TAPATUMAS by Alphonso Lingis

“…"The category of person, though a lot has been made of it in some moral philosophy, is," Bernard Williams writes, "a poor foundation for ethical thought, in particular because it looks like a sortal or classificatory notion while in fact it signals characteristics that almost all come in degrees - responsibility, self-consciousness, capacity for reflection, and so on. …”
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Personality characteristics of students in the regulation of network activity by S. E. Panshina, N. L. Sungurova, N. B. Karabushchenko

“…The Internet for students is above all a comfortable environment, where it is possible to feel calm and security, to expand social contacts, to find a new experience. …”
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Centering community-based maternal and child nutrition services in Bangladesh’s rural primary healthcare: what has potential to scale by Safina Abdulloeva, Arti Bhanot, Mohd. Aziz Khan, Md. Mofijul Islam Bulbul, Mijanur Rahman, Kaosar Afsana, Thomas Forissier, Deepika Sharma, Abul Bashar Mohammad Khurshid Alam

“…The local government contributed to strengthening nutrition services but at a small scale.DiscussionThere is potential to scale-up GMP services through EPI and merging antenatal clinics with GMP and EPI such that all maternal and childcare services are available at the same place and same time. …”
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Effects of Walking Pattern-Based Intelligent Electrical Stimulation on Outpatients with Stoke： A Randomized Controlled Study by HE Xuguang, SUN Wei, ZHOU Lu, HE Meiyan, WEI Ni

“…Finally, 52 patients completed the evaluation, including 20 patients in the control group, 15 patients in the sham stimulation group and 17 patients in the real stimulation group. All patients in the three groups received routine outpatient rehabilitation treatment and home rehabilitation guidance. …”
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